Clinical characteristics of combined rosacea and migraine
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Clinical characteristics of combined rosacea and migraine. / Wienholtz, Nita K.F.; Christensen, Casper E.; Zhang, Ditte G.; Rechnagel, Anne Sofie A.; Byrnel, Helene V.S.; Haugaard, Jeanette H.; Ashina, Messoud; Thyssen, Jacob P.; Egeberg, Alexander.
In: Frontiers in Medicine, Vol. 9, 1026447, 2022.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Clinical characteristics of combined rosacea and migraine
AU - Wienholtz, Nita K.F.
AU - Christensen, Casper E.
AU - Zhang, Ditte G.
AU - Rechnagel, Anne Sofie A.
AU - Byrnel, Helene V.S.
AU - Haugaard, Jeanette H.
AU - Ashina, Messoud
AU - Thyssen, Jacob P.
AU - Egeberg, Alexander
N1 - Publisher Copyright: Copyright © 2022 Wienholtz, Christensen, Zhang, Rechnagel, Byrnel, Haugaard, Ashina, Thyssen and Egeberg.
PY - 2022
Y1 - 2022
N2 - Background: An overlap between the skin disease rosacea and the headache disease migraine has been established; however, the magnitude of this overlap and the distribution between subtypes/phenotypes remains unclear. Objective: The aim was to determine the magnitude of the overlap between rosacea and migraine, and to determine which subtypes/phenotypes were present in patients with concomitant rosacea and migraine. Methods: In this cross-sectional study, 604 patients with a diagnosis of either rosacea or migraine were phenotyped through a face-to-face interview with clinical examination, to determine prevalence and phenotype of rosacea, and prevalence and subtype of migraine. Results: We found a prevalence of migraine of 54% in patients with rosacea, and a prevalence of rosacea of 65% in patients with migraine. Concomitant migraine was significantly associated with the rosacea features flushing (odds ratio = 2.6, 95% confidence interval = 1.4–4.7, p = 0.002), ocular symptoms (odds ratio = 2.4, 95% confidence interval = 1.5–3.9, p < 0.001), and burning (odds ratio = 2.1, 95% confidence interval = 1.3–3.4, p = 0.002), whereas papules/pustules were inversely related with concomitant migraine (odds ratio = 0.5, 95% confidence interval = 0.3–0.8, p = 0.006). No association was found between concomitant migraine and centrofacial erythema, rhinophyma, telangiectasia, edema, or dryness. Concomitant rosacea was not associated with any specific migraine subtype in patients with migraine. Conclusion: This study highlights a substantial overlap between rosacea and migraine, particularly in patients with certain rosacea features. Individuals with rosacea should be asked about concomitant migraine, and comorbidities should be considered when choosing between treatments.
AB - Background: An overlap between the skin disease rosacea and the headache disease migraine has been established; however, the magnitude of this overlap and the distribution between subtypes/phenotypes remains unclear. Objective: The aim was to determine the magnitude of the overlap between rosacea and migraine, and to determine which subtypes/phenotypes were present in patients with concomitant rosacea and migraine. Methods: In this cross-sectional study, 604 patients with a diagnosis of either rosacea or migraine were phenotyped through a face-to-face interview with clinical examination, to determine prevalence and phenotype of rosacea, and prevalence and subtype of migraine. Results: We found a prevalence of migraine of 54% in patients with rosacea, and a prevalence of rosacea of 65% in patients with migraine. Concomitant migraine was significantly associated with the rosacea features flushing (odds ratio = 2.6, 95% confidence interval = 1.4–4.7, p = 0.002), ocular symptoms (odds ratio = 2.4, 95% confidence interval = 1.5–3.9, p < 0.001), and burning (odds ratio = 2.1, 95% confidence interval = 1.3–3.4, p = 0.002), whereas papules/pustules were inversely related with concomitant migraine (odds ratio = 0.5, 95% confidence interval = 0.3–0.8, p = 0.006). No association was found between concomitant migraine and centrofacial erythema, rhinophyma, telangiectasia, edema, or dryness. Concomitant rosacea was not associated with any specific migraine subtype in patients with migraine. Conclusion: This study highlights a substantial overlap between rosacea and migraine, particularly in patients with certain rosacea features. Individuals with rosacea should be asked about concomitant migraine, and comorbidities should be considered when choosing between treatments.
KW - interview
KW - migraine
KW - overlap
KW - prevalence
KW - rosacea
U2 - 10.3389/fmed.2022.1026447
DO - 10.3389/fmed.2022.1026447
M3 - Journal article
C2 - 36341245
AN - SCOPUS:85141357021
VL - 9
JO - Frontiers in Medicine
JF - Frontiers in Medicine
SN - 2296-858X
M1 - 1026447
ER -
ID: 335095165