Interhemispheric differences of fMRI responses to visual stimuli in patients with side-fixed migraine aura
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Interhemispheric differences of fMRI responses to visual stimuli in patients with side-fixed migraine aura. / Hougaard, Anders; Amin, Faisal Mohammad; Hoffmann, Michael B; Rostrup, Egill; Larsson, Henrik B W; Asghar, Mohammad Sohail; Larsen, Vibeke Andrée; Olesen, Jes; Ashina, Messoud.
In: Human Brain Mapping, Vol. 35, No. 6, 06.2014, p. 2714-2723.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Interhemispheric differences of fMRI responses to visual stimuli in patients with side-fixed migraine aura
AU - Hougaard, Anders
AU - Amin, Faisal Mohammad
AU - Hoffmann, Michael B
AU - Rostrup, Egill
AU - Larsson, Henrik B W
AU - Asghar, Mohammad Sohail
AU - Larsen, Vibeke Andrée
AU - Olesen, Jes
AU - Ashina, Messoud
N1 - Copyright © 2013 Wiley Periodicals, Inc.
PY - 2014/6
Y1 - 2014/6
N2 - Migraine sufferers with aura often report photosensitivity and visual discomfort outside of attacks and many consider bright or flickering light an attack-precipitating factor. The nature of this visual hypersensitivity and its relation to the underlying pathophysiology of the migraine aura is unknown. Using fMRI measurements during visual stimulation we examined the visual cortical responsiveness of patients with migraine with aura. We applied a within-patient design by assessing functional interhemispheric differences in patients consistently experiencing visual aura in the same visual hemifield. We recruited 20 patients with frequent side-fixed visual aura attacks (≥90% of auras occurring in the same visual hemifield) and 20 age and sex matched healthy controls and compared the fMRI blood oxygenation level dependent (BOLD) responses to visual stimulation between symptomatic and asymptomatic hemispheres during the interictal phase and between migraine patients and controls. BOLD responses were selectively increased in the symptomatic hemispheres. This was found in the inferior parietal lobule (P = 0.002), the inferior frontal gyrus (P = 0.003), and the superior parietal lobule (P = 0.017). The affected cortical areas comprise a visually driven functional network involved in oculomotor control, guidance of movement, motion perception, visual attention, and visual spatial memory. The patients also had significantly increased response in the same cortical areas when compared to controls (P < 0.05). We discovered a lateralized alteration of a visually driven functional network in patients with side-fixed aura. These findings suggest a hyperexcitability of the visual system in the interictal phase of migraine with visual aura.
AB - Migraine sufferers with aura often report photosensitivity and visual discomfort outside of attacks and many consider bright or flickering light an attack-precipitating factor. The nature of this visual hypersensitivity and its relation to the underlying pathophysiology of the migraine aura is unknown. Using fMRI measurements during visual stimulation we examined the visual cortical responsiveness of patients with migraine with aura. We applied a within-patient design by assessing functional interhemispheric differences in patients consistently experiencing visual aura in the same visual hemifield. We recruited 20 patients with frequent side-fixed visual aura attacks (≥90% of auras occurring in the same visual hemifield) and 20 age and sex matched healthy controls and compared the fMRI blood oxygenation level dependent (BOLD) responses to visual stimulation between symptomatic and asymptomatic hemispheres during the interictal phase and between migraine patients and controls. BOLD responses were selectively increased in the symptomatic hemispheres. This was found in the inferior parietal lobule (P = 0.002), the inferior frontal gyrus (P = 0.003), and the superior parietal lobule (P = 0.017). The affected cortical areas comprise a visually driven functional network involved in oculomotor control, guidance of movement, motion perception, visual attention, and visual spatial memory. The patients also had significantly increased response in the same cortical areas when compared to controls (P < 0.05). We discovered a lateralized alteration of a visually driven functional network in patients with side-fixed aura. These findings suggest a hyperexcitability of the visual system in the interictal phase of migraine with visual aura.
KW - Adult
KW - Brain
KW - Brain Mapping
KW - Cerebral Cortex
KW - Cerebrovascular Circulation
KW - Female
KW - Functional Laterality
KW - Humans
KW - Magnetic Resonance Imaging
KW - Male
KW - Middle Aged
KW - Migraine with Aura
KW - Oxygen
KW - Photic Stimulation
KW - Visual Pathways
KW - Visual Perception
KW - Young Adult
U2 - 10.1002/hbm.22361
DO - 10.1002/hbm.22361
M3 - Journal article
C2 - 24038870
VL - 35
SP - 2714
EP - 2723
JO - Human Brain Mapping
JF - Human Brain Mapping
SN - 1065-9471
IS - 6
ER -
ID: 138542877