Lamotrigine increases the number of BrdU-labeled cellsinthe rat hippocampus

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Lamotrigine increases the number of BrdU-labeled cellsinthe rat hippocampus. / Kondziella, Daniel; Strandberg, Joakim; Lindquist, Catarina; Asztely, Fredrik.

In: NeuroReport, 10.12.2010.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Kondziella, D, Strandberg, J, Lindquist, C & Asztely, F 2010, 'Lamotrigine increases the number of BrdU-labeled cellsinthe rat hippocampus', NeuroReport. https://doi.org/10.1097/WNR.0b013e328342d2fa

APA

Kondziella, D., Strandberg, J., Lindquist, C., & Asztely, F. (2010). Lamotrigine increases the number of BrdU-labeled cellsinthe rat hippocampus. NeuroReport. https://doi.org/10.1097/WNR.0b013e328342d2fa

Vancouver

Kondziella D, Strandberg J, Lindquist C, Asztely F. Lamotrigine increases the number of BrdU-labeled cellsinthe rat hippocampus. NeuroReport. 2010 Dec 10. https://doi.org/10.1097/WNR.0b013e328342d2fa

Author

Kondziella, Daniel ; Strandberg, Joakim ; Lindquist, Catarina ; Asztely, Fredrik. / Lamotrigine increases the number of BrdU-labeled cellsinthe rat hippocampus. In: NeuroReport. 2010.

Bibtex

@article{7a4893ef6b1b46bbad5c567168c8b8bf,
title = "Lamotrigine increases the number of BrdU-labeled cellsinthe rat hippocampus",
abstract = "Antidepressant medication and electroconvulsive therapy stabilize mood symptoms and increase hippocampal neurogenesis. We examined whether lamotrigine, suggested to give rise to mood-stabilizing and antidepressant effects in addition to its antiepileptic properties, also increases the number of newborn cells inrat hippocampus. Rats (on day P21) received lamotrigine, valproate, or saline intraperitoneally once dailyfor 7 days. All animals received four intraperitoneal injections of bromodeoxyuridine (BrdU) on day P28 andwere sacrificed the next day. Quantification of BrdU-labeled cells in the granule cell layer of the dentate gyrus showed an increased number of newborn cells in rats receiving lamotrigine (42.6±3.5 cells/slice) compared with valproate (31.6±2.8) and controls (32.2±3.1; P",
author = "Daniel Kondziella and Joakim Strandberg and Catarina Lindquist and Fredrik Asztely",
year = "2010",
month = dec,
day = "10",
doi = "http://dx.doi.org/10.1097/WNR.0b013e328342d2fa",
language = "English",
journal = "NeuroReport",
issn = "0959-4965",
publisher = "Lippincott Williams & Wilkins",

}

RIS

TY - JOUR

T1 - Lamotrigine increases the number of BrdU-labeled cellsinthe rat hippocampus

AU - Kondziella, Daniel

AU - Strandberg, Joakim

AU - Lindquist, Catarina

AU - Asztely, Fredrik

PY - 2010/12/10

Y1 - 2010/12/10

N2 - Antidepressant medication and electroconvulsive therapy stabilize mood symptoms and increase hippocampal neurogenesis. We examined whether lamotrigine, suggested to give rise to mood-stabilizing and antidepressant effects in addition to its antiepileptic properties, also increases the number of newborn cells inrat hippocampus. Rats (on day P21) received lamotrigine, valproate, or saline intraperitoneally once dailyfor 7 days. All animals received four intraperitoneal injections of bromodeoxyuridine (BrdU) on day P28 andwere sacrificed the next day. Quantification of BrdU-labeled cells in the granule cell layer of the dentate gyrus showed an increased number of newborn cells in rats receiving lamotrigine (42.6±3.5 cells/slice) compared with valproate (31.6±2.8) and controls (32.2±3.1; P

AB - Antidepressant medication and electroconvulsive therapy stabilize mood symptoms and increase hippocampal neurogenesis. We examined whether lamotrigine, suggested to give rise to mood-stabilizing and antidepressant effects in addition to its antiepileptic properties, also increases the number of newborn cells inrat hippocampus. Rats (on day P21) received lamotrigine, valproate, or saline intraperitoneally once dailyfor 7 days. All animals received four intraperitoneal injections of bromodeoxyuridine (BrdU) on day P28 andwere sacrificed the next day. Quantification of BrdU-labeled cells in the granule cell layer of the dentate gyrus showed an increased number of newborn cells in rats receiving lamotrigine (42.6±3.5 cells/slice) compared with valproate (31.6±2.8) and controls (32.2±3.1; P

U2 - http://dx.doi.org/10.1097/WNR.0b013e328342d2fa

DO - http://dx.doi.org/10.1097/WNR.0b013e328342d2fa

M3 - Journal article

JO - NeuroReport

JF - NeuroReport

SN - 0959-4965

ER -

ID: 34158387