Migraine and the trigeminovascular system—40 years and counting

Research output: Contribution to journal › Review › Research › peer-review

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Migraine and the trigeminovascular system—40 years and counting. / Ashina, Messoud; Hansen, Jakob Møller; Do, Thien Phu; Melo-Carrillo, Agustin; Burstein, Rami; Moskowitz, Michael A.

In: The Lancet Neurology, Vol. 18, No. 8, 2019, p. 795-804.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Ashina, M, Hansen, JM, Do, TP, Melo-Carrillo, A, Burstein, R & Moskowitz, MA 2019, 'Migraine and the trigeminovascular system—40 years and counting', The Lancet Neurology, vol. 18, no. 8, pp. 795-804. https://doi.org/10.1016/S1474-4422(19)30185-1

APA

Ashina, M., Hansen, J. M., Do, T. P., Melo-Carrillo, A., Burstein, R., & Moskowitz, M. A. (2019). Migraine and the trigeminovascular system—40 years and counting. The Lancet Neurology, 18(8), 795-804. https://doi.org/10.1016/S1474-4422(19)30185-1

Vancouver

Ashina M, Hansen JM, Do TP, Melo-Carrillo A, Burstein R, Moskowitz MA. Migraine and the trigeminovascular system—40 years and counting. The Lancet Neurology. 2019;18(8):795-804. https://doi.org/10.1016/S1474-4422(19)30185-1

Author

Ashina, Messoud ; Hansen, Jakob Møller ; Do, Thien Phu ; Melo-Carrillo, Agustin ; Burstein, Rami ; Moskowitz, Michael A. / Migraine and the trigeminovascular system—40 years and counting. In: The Lancet Neurology. 2019 ; Vol. 18, No. 8. pp. 795-804.

Bibtex

@article{efe2fcfedb2346f999c4a5cd9c0788a7,
title = "Migraine and the trigeminovascular system—40 years and counting",
abstract = "The underlying causes of migraine headache remained enigmatic for most of the 20th century. In 1979, The Lancet published a novel hypothesis proposing an integral role for the neuropeptide-containing trigeminal nerve. This hypothesis led to a transformation in the migraine field and understanding of key concepts surrounding migraine, including the role of neuropeptides and their release from meningeal trigeminal nerve endings in the mechanism of migraine, blockade of neuropeptide release by anti-migraine drugs, and activation and sensitisation of trigeminal afferents by meningeal inflammatory stimuli and upstream role of intense brain activity. The study of neuropeptides provided the first evidence that antisera directed against calcitonin gene-related peptide (CGRP) and substance P could neutralise their actions. Successful therapeutic strategies using humanised monoclonal antibodies directed against CGRP and its receptor followed from these findings. Nowadays, 40 years after the initial proposal, the trigeminovascular system is widely accepted as having a fundamental role in this highly complex neurological disorder and provides a road map for future migraine therapies.",
author = "Messoud Ashina and Hansen, {Jakob M{\o}ller} and Do, {Thien Phu} and Agustin Melo-Carrillo and Rami Burstein and Moskowitz, {Michael A.}",
year = "2019",
doi = "10.1016/S1474-4422(19)30185-1",
language = "English",
volume = "18",
pages = "795--804",
journal = "The Lancet Neurology",
issn = "1474-4422",
publisher = "TheLancet Publishing Group",
number = "8",

}

RIS

TY - JOUR

T1 - Migraine and the trigeminovascular system—40 years and counting

AU - Ashina, Messoud

AU - Hansen, Jakob Møller

AU - Do, Thien Phu

AU - Melo-Carrillo, Agustin

AU - Burstein, Rami

AU - Moskowitz, Michael A.

PY - 2019

Y1 - 2019

N2 - The underlying causes of migraine headache remained enigmatic for most of the 20th century. In 1979, The Lancet published a novel hypothesis proposing an integral role for the neuropeptide-containing trigeminal nerve. This hypothesis led to a transformation in the migraine field and understanding of key concepts surrounding migraine, including the role of neuropeptides and their release from meningeal trigeminal nerve endings in the mechanism of migraine, blockade of neuropeptide release by anti-migraine drugs, and activation and sensitisation of trigeminal afferents by meningeal inflammatory stimuli and upstream role of intense brain activity. The study of neuropeptides provided the first evidence that antisera directed against calcitonin gene-related peptide (CGRP) and substance P could neutralise their actions. Successful therapeutic strategies using humanised monoclonal antibodies directed against CGRP and its receptor followed from these findings. Nowadays, 40 years after the initial proposal, the trigeminovascular system is widely accepted as having a fundamental role in this highly complex neurological disorder and provides a road map for future migraine therapies.

AB - The underlying causes of migraine headache remained enigmatic for most of the 20th century. In 1979, The Lancet published a novel hypothesis proposing an integral role for the neuropeptide-containing trigeminal nerve. This hypothesis led to a transformation in the migraine field and understanding of key concepts surrounding migraine, including the role of neuropeptides and their release from meningeal trigeminal nerve endings in the mechanism of migraine, blockade of neuropeptide release by anti-migraine drugs, and activation and sensitisation of trigeminal afferents by meningeal inflammatory stimuli and upstream role of intense brain activity. The study of neuropeptides provided the first evidence that antisera directed against calcitonin gene-related peptide (CGRP) and substance P could neutralise their actions. Successful therapeutic strategies using humanised monoclonal antibodies directed against CGRP and its receptor followed from these findings. Nowadays, 40 years after the initial proposal, the trigeminovascular system is widely accepted as having a fundamental role in this highly complex neurological disorder and provides a road map for future migraine therapies.

U2 - 10.1016/S1474-4422(19)30185-1

DO - 10.1016/S1474-4422(19)30185-1

M3 - Review

C2 - 31160203

AN - SCOPUS:85068529333

VL - 18

SP - 795

EP - 804

JO - The Lancet Neurology

JF - The Lancet Neurology

SN - 1474-4422

IS - 8

ER -

ID: 240624410