Post-traumatic headache: epidemiology and pathophysiological insights
Research output: Contribution to journal › Review › Research › peer-review
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Post-traumatic headache : epidemiology and pathophysiological insights. / Ashina, Håkan; Porreca, Frank; Anderson, Trent; Mohammad Amin, Faisal; Ashina, Messoud; Winther Schytz, Henrik; Dodick, David W.
In: Nature Reviews. Neurology, Vol. 15, No. 10, 2019, p. 607-617.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Post-traumatic headache
T2 - epidemiology and pathophysiological insights
AU - Ashina, Håkan
AU - Porreca, Frank
AU - Anderson, Trent
AU - Mohammad Amin, Faisal
AU - Ashina, Messoud
AU - Winther Schytz, Henrik
AU - Dodick, David W.
PY - 2019
Y1 - 2019
N2 - Post-traumatic headache (PTH) is a highly disabling secondary headache disorder and one of the most common sequelae of mild traumatic brain injury, also known as concussion. Considerable overlap exists between PTH and common primary headache disorders. The most common PTH phenotypes are migraine-like headache and tension-type-like headache. A better understanding of the pathophysiological similarities and differences between primary headache disorders and PTH could uncover unique treatment targets for PTH. Although possible underlying mechanisms of PTH have been elucidated, a substantial void remains in our understanding, and further research is needed. In this Review, we describe the evidence from animal and human studies that indicates involvement of several potential mechanisms in the development and persistence of PTH. These mechanisms include impaired descending modulation, neurometabolic changes, neuroinflammation and activation of the trigeminal sensory system. Furthermore, we outline future research directions to establish biomarkers involved in progression from acute to persistent PTH, and we identify potential drug targets to prevent and treat persistent PTH.
AB - Post-traumatic headache (PTH) is a highly disabling secondary headache disorder and one of the most common sequelae of mild traumatic brain injury, also known as concussion. Considerable overlap exists between PTH and common primary headache disorders. The most common PTH phenotypes are migraine-like headache and tension-type-like headache. A better understanding of the pathophysiological similarities and differences between primary headache disorders and PTH could uncover unique treatment targets for PTH. Although possible underlying mechanisms of PTH have been elucidated, a substantial void remains in our understanding, and further research is needed. In this Review, we describe the evidence from animal and human studies that indicates involvement of several potential mechanisms in the development and persistence of PTH. These mechanisms include impaired descending modulation, neurometabolic changes, neuroinflammation and activation of the trigeminal sensory system. Furthermore, we outline future research directions to establish biomarkers involved in progression from acute to persistent PTH, and we identify potential drug targets to prevent and treat persistent PTH.
U2 - 10.1038/s41582-019-0243-8
DO - 10.1038/s41582-019-0243-8
M3 - Review
C2 - 31527806
AN - SCOPUS:85072716724
VL - 15
SP - 607
EP - 617
JO - Nature Reviews. Neurology
JF - Nature Reviews. Neurology
SN - 1759-4758
IS - 10
ER -
ID: 240632653