Prevalence of right-to-left shunts on transcranial Doppler in chronic migraine and medication-overuse headache
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Prevalence of right-to-left shunts on transcranial Doppler in chronic migraine and medication-overuse headache. / Guo, Song; Shalchian, Sarvnaz; Gérard, Pascale; Küper, Michael; Katsarava, Zaza; Ashina, Messoud; Schoenen, Jean.
In: Cephalalgia : an international journal of headache, Vol. 34, No. 1, 01.2014, p. 37-41.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Prevalence of right-to-left shunts on transcranial Doppler in chronic migraine and medication-overuse headache
AU - Guo, Song
AU - Shalchian, Sarvnaz
AU - Gérard, Pascale
AU - Küper, Michael
AU - Katsarava, Zaza
AU - Ashina, Messoud
AU - Schoenen, Jean
PY - 2014/1
Y1 - 2014/1
N2 - BACKGROUND: It was suggested that right-to-left shunt (RLS) may be highly prevalent in chronic migraine (CM) patients, indicating that patent foramen ovale (PFO) might be an aggravating and chronifying factor of migraine. Since a high proportion of chronic migraineurs also have medication-overuse headache (MOH), one may wonder if they have a more severe form of the disorder and more frequently a PFO.OBJECTIVE: The objective of this study is to determine the prevalence and grade of RLS in patients suffering from CM and MOH.METHODS: A cross-sectional multicenter study of air-contrast transcranial Doppler was conducted in 159 patients with CM ( N = 57) or MOH ( N = 102) attending a tertiary headache clinic.RESULTS: The prevalence of RLS in CM was 37% (11% large shunts) and in MOH patients 31% (13% large shunts). There was no difference between the two groups ( P = 0.49).CONCLUSION: RLS prevalence in CM is within the upper range of those reported in episodic migraine without aura or in the general population, and not higher in MOH. PFO is thus unlikely to have a significant causal role in these chronic headaches.
AB - BACKGROUND: It was suggested that right-to-left shunt (RLS) may be highly prevalent in chronic migraine (CM) patients, indicating that patent foramen ovale (PFO) might be an aggravating and chronifying factor of migraine. Since a high proportion of chronic migraineurs also have medication-overuse headache (MOH), one may wonder if they have a more severe form of the disorder and more frequently a PFO.OBJECTIVE: The objective of this study is to determine the prevalence and grade of RLS in patients suffering from CM and MOH.METHODS: A cross-sectional multicenter study of air-contrast transcranial Doppler was conducted in 159 patients with CM ( N = 57) or MOH ( N = 102) attending a tertiary headache clinic.RESULTS: The prevalence of RLS in CM was 37% (11% large shunts) and in MOH patients 31% (13% large shunts). There was no difference between the two groups ( P = 0.49).CONCLUSION: RLS prevalence in CM is within the upper range of those reported in episodic migraine without aura or in the general population, and not higher in MOH. PFO is thus unlikely to have a significant causal role in these chronic headaches.
KW - Adult
KW - Chronic Disease
KW - Comorbidity
KW - Europe
KW - Female
KW - Foramen Ovale, Patent
KW - Headache Disorders, Secondary
KW - Humans
KW - Male
KW - Middle Aged
KW - Migraine Disorders
KW - Prevalence
KW - Reproducibility of Results
KW - Risk Factors
KW - Sensitivity and Specificity
KW - Ultrasonography, Doppler, Transcranial
U2 - 10.1177/0333102413497600
DO - 10.1177/0333102413497600
M3 - Journal article
C2 - 23843469
VL - 34
SP - 37
EP - 41
JO - Cephalalgia
JF - Cephalalgia
SN - 0800-1952
IS - 1
ER -
ID: 138498444