TY - JOUR

T1 - Ultra-high field MR angiography in human migraine models

T2 - A 3.0 T/7.0 T comparison study

AU - Christensen, Casper Emil

AU - Younis, Samaira

AU - Lindberg, Ulrich

AU - Boer, Vincent Oltman

AU - De Koning, Patrick

AU - Petersen, Esben Thade

AU - Paulson, Olaf Bjarne

AU - Larsson, Henrik Bo Wiberg

AU - Amin, Faisal Mohammad

AU - Ashina, Messoud

PY - 2019

Y1 - 2019

N2 - Background: Sildenafil and calcitonin gene-related peptide both dilate the intradural segments of the middle meningeal artery measured with 3.0 tesla (T) MR angiography. Here we hypothesized that an increase in field strength to 7.0 T and concomitant enhanced voxel resolution would lower variance in measurements of dilation in the intradural middle meningeal artery. Methods: Five subjects completed two sessions at respectively 3.0 T and 7.0 T. Each session comprised MR angiography scans once before and twice after administration of sildenafil, calcitonin gene-related peptide or placebo in a three-way, crossover, double-blind, placebo-controlled design. Results: Standard deviations of arterial circumference revealed no difference between 3.0 T and 7.0 T measurements (p = 0.379). We found a decrease in standard deviation from our original angiography analysis software (QMra) to a newer (LAVA) software package (p < 0.001). Furthermore, we found that the dilation after sildenafil and calcitonin gene-related peptide were comparable between 3.0 T and 7.0 T. Conclusions: Our findings suggest no gain from the increase in voxel resolution but cemented dilatory findings from earlier. The implemented software update improved variance in circumference measurements in the intradural middle meningeal artery, which should be exploited in future studies. Trial registration: The study is part of a parent study, which is registered at ClinicalTrials.gov (NCT03143465).

AB - Background: Sildenafil and calcitonin gene-related peptide both dilate the intradural segments of the middle meningeal artery measured with 3.0 tesla (T) MR angiography. Here we hypothesized that an increase in field strength to 7.0 T and concomitant enhanced voxel resolution would lower variance in measurements of dilation in the intradural middle meningeal artery. Methods: Five subjects completed two sessions at respectively 3.0 T and 7.0 T. Each session comprised MR angiography scans once before and twice after administration of sildenafil, calcitonin gene-related peptide or placebo in a three-way, crossover, double-blind, placebo-controlled design. Results: Standard deviations of arterial circumference revealed no difference between 3.0 T and 7.0 T measurements (p = 0.379). We found a decrease in standard deviation from our original angiography analysis software (QMra) to a newer (LAVA) software package (p < 0.001). Furthermore, we found that the dilation after sildenafil and calcitonin gene-related peptide were comparable between 3.0 T and 7.0 T. Conclusions: Our findings suggest no gain from the increase in voxel resolution but cemented dilatory findings from earlier. The implemented software update improved variance in circumference measurements in the intradural middle meningeal artery, which should be exploited in future studies. Trial registration: The study is part of a parent study, which is registered at ClinicalTrials.gov (NCT03143465).

KW - Calcitonin gene-related peptide

KW - Dura mater

KW - Middle meningeal artery

KW - Neurovascular

KW - Sildenafil

UR - https://thejournalofheadacheandpain.biomedcentral.com/articles/10.1186/s10194-019-1014-z

U2 - 10.1186/s10194-019-0996-x

DO - 10.1186/s10194-019-0996-x

M3 - Journal article

C2 - 31060491

AN - SCOPUS:85065662996

VL - 20

JO - Journal of Headache and Pain

JF - Journal of Headache and Pain

SN - 1129-2369

M1 - 48

ER -