Prenatal detection of congenital heart disease in a low risk population undergoing first and second trimester screening
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Prenatal detection of congenital heart disease in a low risk population undergoing first and second trimester screening. / Jørgensen, Ditte E S; Vejlstrup, Niels; Jørgensen, Connie; Maroun, Lisa Leth; Steensberg, Jesper; Hessellund, Anette; Jørgensen, Finn Stener; Larsen, Torben; Shalmi, Anne-Cathrine; Skibsted, Lillian; Zingenberg, Helle; Ekelund, Charlotte; Tabor, Ann.
In: Prenatal Diagnosis, Vol. 35, No. 4, 04.2015, p. 325-30.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Prenatal detection of congenital heart disease in a low risk population undergoing first and second trimester screening
AU - Jørgensen, Ditte E S
AU - Vejlstrup, Niels
AU - Jørgensen, Connie
AU - Maroun, Lisa Leth
AU - Steensberg, Jesper
AU - Hessellund, Anette
AU - Jørgensen, Finn Stener
AU - Larsen, Torben
AU - Shalmi, Anne-Cathrine
AU - Skibsted, Lillian
AU - Zingenberg, Helle
AU - Ekelund, Charlotte
AU - Tabor, Ann
N1 - © 2014 John Wiley & Sons, Ltd.
PY - 2015/4
Y1 - 2015/4
N2 - OBJECTIVES: The prenatal detection rate of congenital heart disease (CHD) is low compared with other fetal malformations. Our aim was to evaluate the prenatal detection of CHD in Eastern Denmark.METHODS: Fetuses and infants diagnosed with CHD in the period 01.01.2008-31.12.2010 were assessed regarding prenatal detection rate and accuracy, as well as correlation with nuchal translucency (NT) thickness.RESULTS: Out of 86 121 infants, 831 were born with CHD (0.96%). The prenatal detection rate of 'all CHD' was 21.3%, of 'Major CHD' 47.4%. Full agreement between prenatal and postnatal/autopsy findings was found in 96% of prenatally detected diagnoses. An NT thickness >95(th) percentile was found in 15.0% fetuses with 'Major CHD'. Of 'Major CHDs' detected prenatally, 77% were picked up at the time of the malformation scan at weeks 18-21.CONCLUSIONS: Nearly half of 'Major CHDs' were detected prenatally. The prenatal cardiac diagnoses showed a high degree of accuracy. Increased NT thickness as a screening tool for CHD performed moderately but is an important high risk group for specialist examination. A minority of the prenatally detected CHDs was identified because of extra scans performed in high risk pregnancies. © 2014 John Wiley & Sons, Ltd.
AB - OBJECTIVES: The prenatal detection rate of congenital heart disease (CHD) is low compared with other fetal malformations. Our aim was to evaluate the prenatal detection of CHD in Eastern Denmark.METHODS: Fetuses and infants diagnosed with CHD in the period 01.01.2008-31.12.2010 were assessed regarding prenatal detection rate and accuracy, as well as correlation with nuchal translucency (NT) thickness.RESULTS: Out of 86 121 infants, 831 were born with CHD (0.96%). The prenatal detection rate of 'all CHD' was 21.3%, of 'Major CHD' 47.4%. Full agreement between prenatal and postnatal/autopsy findings was found in 96% of prenatally detected diagnoses. An NT thickness >95(th) percentile was found in 15.0% fetuses with 'Major CHD'. Of 'Major CHDs' detected prenatally, 77% were picked up at the time of the malformation scan at weeks 18-21.CONCLUSIONS: Nearly half of 'Major CHDs' were detected prenatally. The prenatal cardiac diagnoses showed a high degree of accuracy. Increased NT thickness as a screening tool for CHD performed moderately but is an important high risk group for specialist examination. A minority of the prenatally detected CHDs was identified because of extra scans performed in high risk pregnancies. © 2014 John Wiley & Sons, Ltd.
U2 - 10.1002/pd.4525
DO - 10.1002/pd.4525
M3 - Journal article
C2 - 25352400
VL - 35
SP - 325
EP - 330
JO - Prenatal Diagnosis
JF - Prenatal Diagnosis
SN - 0197-3851
IS - 4
ER -
ID: 137159642