Michael Larsen

Michael Larsen

Clinical Professor


  1. 2024
  2. Published

    Heritability of tear fluid cytokines in healthy twins

    Bjerager, J., Magnø, M., Chen, X., Belmouhand, M., Aass, H. C. D., Reppe, S., Heegaard, Steffen, Larsen, Michael & Utheim, T. P., 2024, In: Ocular Surface. 32, p. 145-153 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Ocular and systemic associations and heritability of retinal arterial wall-to-lumen ratios in a twin cohort

    Carstensen, C. V., Bjerager, J., Belmouhand, M., Eckmann-Hansen, C., Rothenbuehler, S. P., Dabbah, S., Dalgård, C., Laigaard, P. & Larsen, Michael, 2024, In: Acta Ophthalmologica. 102, 4, p. e493-e499

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. 2023
  5. Published

    Retinal Artery Occlusion as an Early Indicator of Macrovascular Complications in Diabetes

    Ørskov, M., Vorum, H., Larsen, T. B., Larsen, Michael & Skjøth, F., Feb 2023, In: American Journal of Medicine. 136, 2, p. 179-185 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    A unidirectional mapping of ICD-8 to ICD-10 codes, for harmonized longitudinal analysis of diseases

    Pedersen, M. K., Eriksson, R., Reguant, R., Collin, C., Pedersen, H. K., Sørup, Freja Karuna Hemmingsen, Simon, C., Birch, A. M., Larsen, Michael, Nielsen, A. P., Belling, K. & Brunak, Søren, 2023, In: European Journal of Epidemiology. 38, p. 1043–1052 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Associations of pre- and postnatal exposures with optic nerve status in young adults

    Zhu, L., Munch, I. C., Pedersen, C. T., Stokholm, Jakob, Bønnelykke, Klaus, Chawes, Bo Lund Krogsgaard, Carlsson, C. J., Schoos, Ann-Marie Malby, Larsen, Michael, Bisgaard, H. & Brustad, N., 2023, In: Acta Ophthalmologica. 101, 7, p. 737-746 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Automated detection of hyperreflective foci in the outer nuclear layer of the retina

    Schmidt, M. F., Christensen, J. L., Dahl, V. A., Toosy, A., Petzold, A., Hanson, J. V. M., Schippling, S., Fredriksen, Jette Lautrup & Larsen, Michael, 2023, In: Acta Ophthalmologica. 101, 2, p. 200-206

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Diabetic papillopathy in patients with optic disc drusen: Description of two different phenotypes

    Becker, D., Larsen, Michael, Lund-Andersen, H. & Hamann, Steffen, 2023, In: European Journal of Ophthalmology. 33, 4, p. NP129-NP132 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Hyperreflective dots in the avascular outer retina in relapsing-remitting multiple sclerosis

    Schmidt, M. F., Pihl-Jensen, G., Torm, M. E. W., Passali, M., Larsen, Michael & Fredriksen, Jette Lautrup, 2023, In: Multiple Sclerosis and Related Disorders. 72, 5 p., 104617.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Nitrates and Age-Related Macular Degeneration

    Larsen, Michael, 2023, In: JAMA Ophthalmology. 141, 2, p. 139 1 p.

    Research output: Contribution to journalComment/debateResearchpeer-review

  12. Published

    Peripapillary Hyperreflective Ovoid Mass-like Structures (PHOMS) in Children: The Copenhagen Child Cohort 2000 Eye Study

    Behrens, C. M., Malmqvist, L., Jørgensen, M., Sibony, P. A., Munch, I. C., Skovgaard, A. M., Larsen, Michael & Hamann, Steffen, 2023, In: American Journal of Ophthalmology. 245, p. 212-221 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Topical treatment of diabetic macular edema using dexamethasone ophthalmic suspension: A randomized, double-masked, vehicle-controlled study

    Stefansson, E., Loftsson, T., Larsen, Michael, Papp, A., Kaarniranta, K., Munk, M. R., Dugel, P., Tadayoni, R. & DX-211 study group, D. S. G., 2023, In: Acta Ophthalmologica. 101, 1, p. 22-33

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. 2022
  15. Published

    A UNILATERAL FOVEAL VITELLIFORM LESION IN A CHOROIDEREMIA CARRIER

    Torm, M. E. W., Eckmann-Hansen, C., Christensen, S. K. & Larsen, Michael, 2022, In: Retinal Cases and Brief Reports. 16, 5, p. 663-666 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Characterization of Hyperreflective Dots by Structural and Angiographic Optical Coherence Tomography in Patients with Diabetic Retinopathy and Healthy Subjects

    Torm, M. E. W., Sander, B., Hornum, Mads, Krohn, P., Birn, H. & Larsen, Michael, 2022, In: Journal of Clinical Medicine. 11, 22, 6646.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Comparability of automated drusen volume measurements in age-related macular degeneration: a MACUSTAR study report

    Garzone, D., Terheyden, J. H., Morelle, O., Wintergerst, M. W. M., Saßmannshausen, M., Schmitz-Valckenberg, S., Pfau, M., Thiele, S., Poor, S., Leal, S., Holz, F. G., Finger, R. P., Agostini, H., Altay, L., Atia, R., Bandello, F., Basile, P. G., Behning, C., Belmouhand, M., Berger, M. & 31 others, Binns, A., Boon, C. J. F., Böttger, M., Bouchet, C., Brazier, J. E., Butt, T., Carapezzi, C., Carlton, J., Carneiro, A., Charil, A., Coimbra, R., Cozzi, M., Crabb, D. P., Cunha-Vaz, J., Dahlke, C., de Sisternes, L., Dunbar, H., Fletcher, E., Francisco, C., Gutfleisch, M., Hogg, R., Hoyng, C. B., Kilani, A., Krätzschmar, J., Kühlewein, L., Larsen, Michael, Lechanteur, Y. T. E., Luhmann, U. F. O., Lüning, A., Schmid, M. & MACUSTAR Consortium, M. C., 2022, In: Scientific Reports. 12, 21911.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Comparison of Spectral-Domain OCT versus Swept-Source OCT for the Detection of Deep Optic Disc Drusen

    Rothenbuehler, S. P., Malmqvist, L., Belmouhand, M., Bjerager, J., Maloca, P. M., Larsen, Michael & Hamann, Steffen, 2022, In: Diagnostics. 12, 10, 8 p., 2515.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Efficacy, durability, and safety of intravitreal faricimab with extended dosing up to every 16 weeks in patients with diabetic macular oedema (YOSEMITE and RHINE): two randomised, double-masked, phase 3 trials

    Wykoff, C. C., Abreu, F., Adamis, A. P., Basu, K., Eichenbaum, D. A., Haskova, Z., Lin, H., Loewenstein, A., Mohan, S., Pearce, I. A., Sakamoto, T., Schlottmann, P. G., Silverman, D., Sun, J. K., Wells, J. A., Willis, J. R., Tadayoni, R., Aaberg, T., Abbey, A., Abdulaeva, E. & 31 others, Abengoechea, S., Abraham, P., Ach, T., Adams, S., Adan Civera, A., Adrean, S., Agostini, H., Alam, S., Alezzandrini, A., Alfaro, V., Aliseda, D., Almony, A., Amat, P., Amini, P., Antoszyk, A., Arias, L., Asaria, R., Avila, M., Awh, C. C., Bafalluy, J., Baker, C., Bandello, F., Barakat, M., Barraza, K., Bator, G., Baumal, C., Belfort, R., Bergstrom, C., Johnson, M., Larsen, Michael & YOSEMITE and RHINE Investigators, Y. A. R. I., 2022, In: The Lancet. 399, 10326, p. 741-755 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Full-field and multifocal electroretinogram in non-diabetic controls and diabetics with and without retinopathy

    Ba-Ali, S., Larsen, Michael, Andersen, H. U. & Lund-Andersen, H., 2022, In: Acta Ophthalmologica. 100, 8, p. e1719-e1728 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Heritability and Risk Factors of Incident Small and Large Drusen in the Copenhagen Twin Cohort Eye Study: A 20-Year Follow-Up

    Belmouhand, M., Rothenbuehler, S. P., Bjerager, J., Dabbah, S., Hjelmborg, J. B., Munch, I. C., Dalgård, C. & Larsen, Michael, 2022, In: Ophthalmologica. 245, 5, p. 421-430 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Heritability of retinal drusen in the Copenhagen Twin Cohort Eye Study

    Belmouhand, M., Rothenbuehler, S. P., Hjelmborg, J. B., Dabbah, S., Bjerager, J., Sander, B. A., Dalgård, C. & Larsen, Michael, 2022, In: Acta Ophthalmologica. 100, 8, p. e1561-e1568 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Long-term development of lens fluorescence in a twin cohort: Heritability and effects of age and lifestyle

    Bjerager, J., Dabbah, S., Belmouhand, M., Kessel, Line, Hougaard, J. L., Rothenbuehler, S. P., Sander, B. & Larsen, Michael, 2022, In: PLoS ONE. 17, 5 , e0268458.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Multi-modal and multi-scale clinical retinal imaging system with pupil and retinal tracking

    Shirazi, M. F., Andilla, J., Lefaudeux, N., Valdes, C., Schwarzhans, F., Durand, M., Ntatsis, K., De Jesus, D. A., Sanchez Brea, L., Gocho, K., Gautier, J., Eckmann-Hansen, C., Torm, M. E. W., Amini, A., Klein, S., Van Walsum, T., Grieve, K., Paques, M., Larsen, M., Loza-Alvarez, P. & 3 others, Levecq, X., Chateau, N. & Pircher, M., 2022, In: Scientific Reports. 12, 9577.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Prevalence of Macular Microcystoid Lacunae in Autosomal Dominant Optic Atrophy Assessed With Adaptive Optics

    Eckmann-Hansen, C., Bek, T., Sander, B., Grønskov, K. & Larsen, Michael, 2022, In: Journal of Neuro-Ophthalmology. 42, 3, p. 328-333

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Relative ellipsoid zone reflectivity and its association with disease severity in age-related macular degeneration: a MACUSTAR study report

    Saßmannshausen, M., Behning, C., Isselmann, B., Schmid, M., Finger, R. P., Holz, F. G., Schmitz-Valckenberg, S., Pfau, M., Agostini, H., Altay, L., Atia, R., Bandello, F., Basile, P. G., Behning, C., Belmouhand, M., Berger, M., Binns, A., Boon, C. J. F., Böttger, M., Bouchet, C. & 31 others, Brazier, J. E., Butt, T., Carapezzi, C., Carlton, J., Carneiro, A., Charil, A., Coimbra, R., Cozzi, M., Crabb, D. P., Cunha-Vaz, J., Dahlke, C., de Sisternes, L., Dunbar, H., Finger, R. P., Fletcher, E., Floyd, H., Francisco, C., Gutfleisch, M., Hogg, R., Holz, F. G., Hoyng, C. B., Kilani, A., Krätzschmar, J., Kühlewein, L., Larsen, Michael, Leal, S., Lechanteur, Y. T. E., Luhmann, U. F. O., Lüning, A., Marques, I. & MACUSTAR Consortium, M. C., 2022, In: Scientific Reports. 12, 14933.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Small hard drusen and associated factors in early seniority

    Belmouhand, M., Rothenbuehler, S. P., Dabbah, S., Bjerager, J., Sander, B., Hjelmborg, J. B., Dalgård, C., Jensen, R. & Larsen, Michael, 2022, In: PLoS ONE. 17, 12 December, e0279279.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Smoking in pregnancy is associated with increased adiposity and retinal arteriolar wall-to-lumen ratio in adolescence: The Copenhagen Child Cohort Study 2000

    Laigaard, P. P., Wibaek, R., Vaag, Allan, Hansen, M. H., Munch, I. C., Olsen, E. M., Skovgaard, A. M. & Larsen, Michael, 2022, In: Microvascular Research. 142, 104364.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Vision-related quality of life and visual ability in patients with autosomal dominant optic atrophy

    Eckmann-Hansen, C., Bek, T., Sander, B. & Larsen, Michael, 2022, In: Acta Ophthalmologica. 100, 7, p. 797-804 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. 2021
  31. Published

    Branch retinal vein occlusion precipitated by compression between a major retinal artery and underlying optic disc drusen

    Rothenbuehler, S. P., Maloca, P. M., Belmouhand, M., Hamann, Steffen & Larsen, Michael, 2021, In: Acta Ophthalmologica. 99, 8, p. 931-933 3 p.

    Research output: Contribution to journalLetterResearchpeer-review

  32. Published

    Incidence of cilioretinal arteries in 11-to 12-year-old children and association with maternal smoking during pregnancy: the Copenhagen Child Cohort 2000 Eye Study

    Jonsson, L. H., Larsen, Michael, Olsen, E. M., Skovgaard, A. M. & Munch, I. C., 2021, In: Acta Ophthalmologica. 99, 7, p. e1162-e1167 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Lens fluorescence and skin fluorescence in the Copenhagen Twin Cohort Eye Study: Covariates and heritability

    Bjerager, J., Dabbah, S., Belmouhand, M., Rothenbuehler, S. P., Sander, B. & Larsen, Michael, 2021, In: PLoS ONE. 16, 9 September, e0256975.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Peripheral bright streaks in tuberous sclerosis

    Eliesersdóttir, T. H., Holm, E., Eckmann-Hansen, C., Torm, M. W., Belmouhand, M. & Larsen, Michael, 2021, In: American Journal of Ophthalmology Case Reports. 22, 101050.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. 2020
  36. Published

    Cell targeting strategy affects the intracellular trafficking of liposomes altering loaded doxorubicin release kinetics and efficacy in endothelial cells

    Arta, A., Larsen, J. B., Eriksen, A. Z., Kempen, P. J., Larsen, Michael, Andresen, T. L. & Urquhart, A. J., 1 Oct 2020, In: International Journal of Pharmaceutics. 588, 10 p., 119715.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Automated Quantification of Macular Vasculature Changes from OCTA Images of Hematologic Patients

    Engberg, A. M. E., Amini, A., Willerslev, A., Larsen, Michael, Sander, B., Kessel, Line, Dahl, A. B. & Dahl, V. A., 2020, 2020 IEEE 17th International Symposium on Biomedical Imaging. IEEE, p. 1987-1991 5 p. 9098441. (Proceedings - International Symposium on Biomedical Imaging, Vol. 2020-April).

    Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

  38. Published

    Global prevalence of asteroid hyalosis and projection of its future burden: a systematic review and meta-analysis

    Møller-Lorentzen, T. B., Eckmann-Hansen, C., Faber, Carsten, Larsen, Michael & Subhi, Y., 2020, In: Acta Ophthalmologica. 98, 8, p. 755-762

    Research output: Contribution to journalReviewResearchpeer-review

  39. Published

    Low physical activity and higher use of screen devices are associated with myopia at the age of 16-17 years in the CCC2000 Eye Study

    Hansen, M. H., Laigaard, P. P., Olsen, E. M., Skovgaard, A. M., Larsen, Michael, Kessel, Line & Munch, I. C., 2020, In: Acta Ophthalmologica. 98, 3, p. 315-321 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Retinal Structure in RPE65-Associated Retinal Dystrophy

    Kumaran, N., Georgiou, M., Bainbridge, J. W. B., Bertelsen, M., Larsen, Michael, Blanco-Kelly, F., Ayuso, C., Tran, H. V., Munier, F. L., Kalitzeos, A. & Michaelides, M., 2020, In: Investigative Ophthalmology & Visual Science. 61, 4, 12 p., 47.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Retinal arteriolar wall-to-lumen ratios at 16-17 years in the Copenhagen Child Cohort 2000 Study

    Laigaard, P. P., Larsen, Michael, Hansen, M. H., Jeppesen, J., Olsen, E. M., Skovgaard, A. M. & Munch, I. C., 2020, In: Journal of Hypertension. 38, 4, p. 731-736 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Spectral-domain optical coherence tomography of retinal vessels in Waldenström's macroglobulinemia

    Willerslev, A., Larsen, Michael, Rothenbuehler, S. P., Sørensen, Torben Lykke, Hammer, T., Paques, M. & Munch, I. C., 2020, In: Acta Ophthalmologica. 98, 2, p. 153-157

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Visual benefit versus visual gain: what is the effect of baseline covariants in the treatment arm relative to the control arm? A pooled analysis of ANCHOR and MARINA

    Tufail, A., Margaron, P., Guerin, T. & Larsen, Michael, 2020, In: British Journal of Ophthalmology. 6 p., 313682.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. 2019
  45. Published

    Central serous chorioretinopathy: Towards an evidence-based treatment guideline

    van Rijssen, T. J., van Dijk, E. H. C., Yzer, S., Ohno-Matsui, K., Keunen, J. E. E., Schlingemann, R. O., Sivaprasad, S., Querques, G., Downes, S. M., Fauser, S., Hoyng, C. B., Piccolino, F. C., Chhablani, J. K., Lai, T. Y. Y., Lotery, A. J., Larsen, Michael, Holz, F. G., Freund, K. B., Yannuzzi, L. A. & Boon, C. J. F., Nov 2019, In: Progress in Retinal and Eye Research. 73, 40 p., 100770.

    Research output: Contribution to journalReviewResearchpeer-review

  46. Published

    Macular perfusion velocities in the ocular ischaemic syndrome

    Klefter, O. N., Kofoed, P. K., Munch, I. C. & Larsen, Michael, 2019, In: Acta Ophthalmologica. 97, 1, p. 113-117 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Macular spatial distribution of preserved autofluorescence in patients with choroideremia

    Hariri, A. H., Ip, M. S., Girach, A., Lam, B. L., Fischer, M. D., Sankila, E-M., Pennesi, M. E., Holz, F. G., Maclaren, R. E., Birch, D. G., Hoyng, C. B., MacDonald, I. M., Black, G. C., Tsang, S. H., Bressler, N. M., Stepien, K. E., Larsen, M., Gorin, M. B., Meunier, I., Webster, A. R. & 2 others, Sadda, S. & For Natural History of the Progression of Choroideremia (NIGHT) Study Group, F. N. H. O. T. P. O. C. (. S. G., 2019, In: British Journal of Ophthalmology. 103, 7, p. 933-937

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Presbyopibehandling

    Mohamud, A., Erichsen, J., Kessel, Line, Holm, Lars Morten & Larsen, Michael, 2019, In: Ugeskrift for Laeger. 181, 5, 5 p., V06180461.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Small Hard Macular Drusen and Associations in 11-to 12-Year-Old Children in the Copenhagen Child Cohort 2000 Eye Study

    Munch, I. C., Li, X. Q., Ahmad, S. S. M., Olsen, E. M., Skovgaard, A. M. & Larsen, Michael, 2019, In: Investigative Ophthalmology & Visual Science. 60, 5, p. 1454-1460

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    The Natural History of Inherited Retinal Dystrophy Due to Biallelic Mutations in the RPE65 Gene

    Chung, D. C., Bertelsen, M., Lorenz, B., Pennesi, M. E., Leroy, B. P., Hamel, C. P., Pierce, E., Sallum, J., Larsen, M., Stieger, K., Preising, M., Weleber, R., Yang, P., Place, E., Liu, E., Schaefer, G., DiStefano-Pappas, J., Elci, O. U., McCague, S., Wellman, J. A. & 2 others, High, K. A. & Reape, K. Z., 2019, In: American Journal of Ophthalmology. 199, p. 58-70

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    Visual acuity and amblyopia prevalence in 11- to 12-year-old Danish children from the Copenhagen Child Cohort 2000

    Hansen, M. H., Munch, I. C., Li, X. Q., Skovgaard, A. M., Olsen, E. M., Larsen, Michael & Kessel, Line, 2019, In: Acta Ophthalmologica. 97, 1, p. 29-35

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. 2018
  53. Published

    Semaglutide, reduction in glycated haemoglobin and the risk of diabetic retinopathy

    Vilsbøll, Tina, Bain, S. C., Leiter, L. A., Lingvay, I., Matthews, D., Simó, R., Helmark, I. C., Wijayasinghe, N. & Larsen, Michael, 1 Apr 2018, In: Diabetes, Obesity and Metabolism. 20, 4, p. 889-897 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Published

    Treat-and-Extend versus Monthly Regimen in Neovascular Age-Related Macular Degeneration: Results with Ranibizumab from the TREND Study

    TREND Study Group, T. S. G., 1 Jan 2018, In: Ophthalmology. 125, 1, p. 57-65

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. Published

    Endothelial protein C–targeting liposomes show enhanced uptake and improved therapeutic efficacy in human retinal endothelial cells

    Arta, A., Eriksen, A. Z., Melander, F., Kempen, P., Larsen, Michael, Andresen, T. L. & Urquhart, A. J., 2018, In: Investigative Ophthalmology and Visual Science. 59, 5, p. 2119-2132 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. Published

    Isolated pigment epithelium detachment: evidence for relation to central serous chorioretinopathy and effect of photodynamic therapy

    Arif, F., Pryds, A. & Larsen, Michael, 2018, In: Acta Ophthalmologica. 96, 8, p. 821-827 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  57. Published

    Multimodal imaging of small hard retinal drusen in young healthy adults

    Pedersen, H. R., Gilson, S. J., Dubra, A., Munch, I. C., Larsen, Michael & Baraas, R. C., 2018, In: British Journal of Ophthalmology. 102, 1, p. 146-152

    Research output: Contribution to journalJournal articleResearchpeer-review

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