Carcinomas of the lacrimal drainage system

Research output: Contribution to journal › Review › Research › peer-review

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Carcinomas of the lacrimal drainage system. / Ramberg, Ingvild; Toft, Peter Bjerre; Heegaard, Steffen.

In: Survey of Ophthalmology, Vol. 65, No. 6, 2020, p. 691-707.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Ramberg, I, Toft, PB & Heegaard, S 2020, 'Carcinomas of the lacrimal drainage system', Survey of Ophthalmology, vol. 65, no. 6, pp. 691-707. https://doi.org/10.1016/j.survophthal.2020.04.001

APA

Ramberg, I., Toft, P. B., & Heegaard, S. (2020). Carcinomas of the lacrimal drainage system. Survey of Ophthalmology, 65(6), 691-707. https://doi.org/10.1016/j.survophthal.2020.04.001

Vancouver

Ramberg I, Toft PB, Heegaard S. Carcinomas of the lacrimal drainage system. Survey of Ophthalmology. 2020;65(6):691-707. https://doi.org/10.1016/j.survophthal.2020.04.001

Author

Ramberg, Ingvild ; Toft, Peter Bjerre ; Heegaard, Steffen. / Carcinomas of the lacrimal drainage system. In: Survey of Ophthalmology. 2020 ; Vol. 65, No. 6. pp. 691-707.

Bibtex

@article{0fdbeb021a76420d9b1a58636e6b97bb,
title = "Carcinomas of the lacrimal drainage system",
abstract = "Malignant tumors of epithelial origin are the most frequent neoplasms of the lacrimal drainage system (LDS). A total of 539 cases are reported in the literature from 1960 to 2019. LDS carcinoma is a disease of the middle-aged and elderly population, with a median age at diagnosis of 57 years. Overall, there is a slight male predominance. Reported risk factors are chronic inflammation, LDS papilloma, and infection with oncogenic viruses. Symptoms of an LDS carcinoma resemble those of benign, inflammatory diseases, with epiphora from obstruction of the LDS as the most frequently encountered symptom. The median time from symptoms to diagnosis is 12 months and even longer for patients reporting epiphora as the only initial symptom. This diagnostic delay leads to a substantial fraction of patients with locally advanced tumors and lymph node spread at the time of diagnosis. Surgery with adjuvant radiotherapy is the treatment of choice for most patients; however, the extension and aggressiveness of the disease and the patient's general health and preferences determine the definite treatment. Five-year overall survival is reported to range from 61 to 87.6%. A large tumor size and positive lymph node status correlate with a decreased overall and disease-free survival.",
keywords = "carcinoma, epithelium, inflammation, lacrimal drainage system, lacrimal sac, nasolacrimal duct, virus",
author = "Ingvild Ramberg and Toft, {Peter Bjerre} and Steffen Heegaard",
year = "2020",
doi = "10.1016/j.survophthal.2020.04.001",
language = "English",
volume = "65",
pages = "691--707",
journal = "Survey of Ophthalmology",
issn = "0039-6257",
publisher = "Elsevier",
number = "6",

}

RIS

TY - JOUR

T1 - Carcinomas of the lacrimal drainage system

AU - Ramberg, Ingvild

AU - Toft, Peter Bjerre

AU - Heegaard, Steffen

PY - 2020

Y1 - 2020

N2 - Malignant tumors of epithelial origin are the most frequent neoplasms of the lacrimal drainage system (LDS). A total of 539 cases are reported in the literature from 1960 to 2019. LDS carcinoma is a disease of the middle-aged and elderly population, with a median age at diagnosis of 57 years. Overall, there is a slight male predominance. Reported risk factors are chronic inflammation, LDS papilloma, and infection with oncogenic viruses. Symptoms of an LDS carcinoma resemble those of benign, inflammatory diseases, with epiphora from obstruction of the LDS as the most frequently encountered symptom. The median time from symptoms to diagnosis is 12 months and even longer for patients reporting epiphora as the only initial symptom. This diagnostic delay leads to a substantial fraction of patients with locally advanced tumors and lymph node spread at the time of diagnosis. Surgery with adjuvant radiotherapy is the treatment of choice for most patients; however, the extension and aggressiveness of the disease and the patient's general health and preferences determine the definite treatment. Five-year overall survival is reported to range from 61 to 87.6%. A large tumor size and positive lymph node status correlate with a decreased overall and disease-free survival.

AB - Malignant tumors of epithelial origin are the most frequent neoplasms of the lacrimal drainage system (LDS). A total of 539 cases are reported in the literature from 1960 to 2019. LDS carcinoma is a disease of the middle-aged and elderly population, with a median age at diagnosis of 57 years. Overall, there is a slight male predominance. Reported risk factors are chronic inflammation, LDS papilloma, and infection with oncogenic viruses. Symptoms of an LDS carcinoma resemble those of benign, inflammatory diseases, with epiphora from obstruction of the LDS as the most frequently encountered symptom. The median time from symptoms to diagnosis is 12 months and even longer for patients reporting epiphora as the only initial symptom. This diagnostic delay leads to a substantial fraction of patients with locally advanced tumors and lymph node spread at the time of diagnosis. Surgery with adjuvant radiotherapy is the treatment of choice for most patients; however, the extension and aggressiveness of the disease and the patient's general health and preferences determine the definite treatment. Five-year overall survival is reported to range from 61 to 87.6%. A large tumor size and positive lymph node status correlate with a decreased overall and disease-free survival.

KW - carcinoma

KW - epithelium

KW - inflammation

KW - lacrimal drainage system

KW - lacrimal sac

KW - nasolacrimal duct

KW - virus

U2 - 10.1016/j.survophthal.2020.04.001

DO - 10.1016/j.survophthal.2020.04.001

M3 - Review

C2 - 32304675

AN - SCOPUS:85087963787

VL - 65

SP - 691

EP - 707

JO - Survey of Ophthalmology

JF - Survey of Ophthalmology

SN - 0039-6257

IS - 6

ER -

ID: 249902887