Diabetic retinopathy as a potential marker of Parkinson's disease: a register-based cohort study
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Diabetic retinopathy as a potential marker of Parkinson's disease : a register-based cohort study. / Larsen, Maria E C; Thykjaer, Anne S; Pedersen, Frederik N; Möller, Sören; Laugesen, Caroline S; Andersen, Nis; Andresen, Jens; Hajari, Javad; Heegaard, Steffen; Højlund, Kurt; Kawasaki, Ryo; Schielke, Katja C; Rubin, Katrine H; Blaabjerg, Morten; Stokholm, Lonny; Grauslund, Jakob.
In: Brain Communications, Vol. 3, No. 4, fcab262, 2021.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Diabetic retinopathy as a potential marker of Parkinson's disease
T2 - a register-based cohort study
AU - Larsen, Maria E C
AU - Thykjaer, Anne S
AU - Pedersen, Frederik N
AU - Möller, Sören
AU - Laugesen, Caroline S
AU - Andersen, Nis
AU - Andresen, Jens
AU - Hajari, Javad
AU - Heegaard, Steffen
AU - Højlund, Kurt
AU - Kawasaki, Ryo
AU - Schielke, Katja C
AU - Rubin, Katrine H
AU - Blaabjerg, Morten
AU - Stokholm, Lonny
AU - Grauslund, Jakob
N1 - © The Author(s) (2021). Published by Oxford University Press on behalf of the Guarantors of Brain.
PY - 2021
Y1 - 2021
N2 - Neurodegeneration is an early event in the pathogenesis of diabetic retinopathy, and an association between diabetic retinopathy and Parkinson's disease has been proposed. In this nationwide register-based cohort study, we investigated the prevalence and incidence of Parkinson's disease among patients screened for diabetic retinopathy in a Danish population-based cohort. Cases (n = 173 568) above 50 years of age with diabetes included in the Danish Registry of Diabetic Retinopathy between 2013 and 2018 were matched 1:5 by gender and birth year with a control population without diabetes (n = 843 781). At index date, the prevalence of Parkinson's disease was compared between cases and controls. To assess the longitudinal relationship between diabetic retinopathy and Parkinson's disease, a multivariable Cox proportional hazard model was estimated. The prevalence of Parkinson's disease was 0.28% and 0.44% among cases and controls, respectively. While diabetic retinopathy was not associated with present (adjusted odds ratio 0.93, 95% confidence interval 0.72-1.21) or incident Parkinson's disease (adjusted hazard ratio 0.77, 95% confidence interval 0.56-1.05), cases with diabetes were in general less likely to have or to develop Parkinson's disease compared to controls without diabetes (adjusted odds ratio 0.79, 95% confidence interval 0.71-0.87 and adjusted hazard ratio 0.88, 95% confidence interval 0.78-1.00). In a national cohort of more than 1 million persons, patients with diabetes were 21% and 12% were less likely to have prevalent and develop incident Parkinson's disease, respectively, compared to an age- and gender-matched control population without diabetes. We found no indication for diabetic retinopathy as an independent risk factor for incident Parkinson's disease.
AB - Neurodegeneration is an early event in the pathogenesis of diabetic retinopathy, and an association between diabetic retinopathy and Parkinson's disease has been proposed. In this nationwide register-based cohort study, we investigated the prevalence and incidence of Parkinson's disease among patients screened for diabetic retinopathy in a Danish population-based cohort. Cases (n = 173 568) above 50 years of age with diabetes included in the Danish Registry of Diabetic Retinopathy between 2013 and 2018 were matched 1:5 by gender and birth year with a control population without diabetes (n = 843 781). At index date, the prevalence of Parkinson's disease was compared between cases and controls. To assess the longitudinal relationship between diabetic retinopathy and Parkinson's disease, a multivariable Cox proportional hazard model was estimated. The prevalence of Parkinson's disease was 0.28% and 0.44% among cases and controls, respectively. While diabetic retinopathy was not associated with present (adjusted odds ratio 0.93, 95% confidence interval 0.72-1.21) or incident Parkinson's disease (adjusted hazard ratio 0.77, 95% confidence interval 0.56-1.05), cases with diabetes were in general less likely to have or to develop Parkinson's disease compared to controls without diabetes (adjusted odds ratio 0.79, 95% confidence interval 0.71-0.87 and adjusted hazard ratio 0.88, 95% confidence interval 0.78-1.00). In a national cohort of more than 1 million persons, patients with diabetes were 21% and 12% were less likely to have prevalent and develop incident Parkinson's disease, respectively, compared to an age- and gender-matched control population without diabetes. We found no indication for diabetic retinopathy as an independent risk factor for incident Parkinson's disease.
U2 - 10.1093/braincomms/fcab262
DO - 10.1093/braincomms/fcab262
M3 - Journal article
C2 - 34806000
VL - 3
JO - Brain Communications
JF - Brain Communications
SN - 2632-1297
IS - 4
M1 - fcab262
ER -
ID: 304483438