Visual field defects are common in patients with optic disc drusen (ODD). Our aim was to examine whether reduced optic nerve head (ONH) microcirculation is related to visual field defects in ODD patients. Vascular and tissue area mean blur rate (MBR_V and MBR_T), measured using laser speckle flowgraphy (LSFG), was significantly lower in the 32 included ODD eyes when compared with 40 healthy eyes (p <.05). There was a moderate correlation between the difference in MBR_T and the perimetric mean defect (R² = 0.53) in ODD patients. These findings demonstrate the utility of LSFG in examining ONH blood flow in ODD patients.