Optic nerve pH and PO2: the effects of carbonic anhydrase inhibition, and metabolic and respiratory acidosis
Research output: Contribution to journal › Journal article › Research › peer-review
Earlier studies have demonstrated that carbonic anhydrase inhibitors (CAIs) increase optic nerve oxygen tension (ONPO(2)) in pigs. We hypothesized that the mechanism of this effect was either a CO(2) increase or a pH decrease in tissue and blood. To test this hypothesis we investigated and compared how optic nerve pH (ONpH) and ONPO(2) are affected by: (1) carbonic anhydrase inhibition; (2) respiratory acidosis, and (3) metabolic acidosis. We measured ONpH with a glass pH electrode and ONPO(2) with a polarographic oxygen electrode. One of the electrodes was placed in the vitreous cavity 0.5 mm over the optic nerve in the eyes of domestic pigs.
Original language | English |
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Journal | Acta Ophthalmologica |
Volume | 84 |
Issue number | 4 |
Pages (from-to) | 475-80 |
Number of pages | 6 |
ISSN | 1755-375X |
DOIs | |
Publication status | Published - 2006 |
ID: 40149083