Epidemiology, outcomes, and prognostic factors in submandibular gland carcinomas: a national DAHANCA study
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Epidemiology, outcomes, and prognostic factors in submandibular gland carcinomas : a national DAHANCA study. / Westergaard-Nielsen, Marie; Godballe, Christian; Eriksen, Jesper Grau; Larsen, Stine Rosenkilde; Kiss, Katalin; Agander, Tina; Ulhøi, Benedicte Parm; Charabi, Birgitte Wittenborg; Klug, Tejs Ehlers; Jacobsen, Henrik; Johansen, Jørgen; Kristensen, Claus Andrup; Andersen, Elo; Andersen, Maria; Bjørndal, Kristine.
In: European Archives of Oto-Rhino-Laryngology, Vol. 280, No. 7, 2023, p. 3405-3413.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Epidemiology, outcomes, and prognostic factors in submandibular gland carcinomas
T2 - a national DAHANCA study
AU - Westergaard-Nielsen, Marie
AU - Godballe, Christian
AU - Eriksen, Jesper Grau
AU - Larsen, Stine Rosenkilde
AU - Kiss, Katalin
AU - Agander, Tina
AU - Ulhøi, Benedicte Parm
AU - Charabi, Birgitte Wittenborg
AU - Klug, Tejs Ehlers
AU - Jacobsen, Henrik
AU - Johansen, Jørgen
AU - Kristensen, Claus Andrup
AU - Andersen, Elo
AU - Andersen, Maria
AU - Bjørndal, Kristine
N1 - Publisher Copyright: © 2023, The Author(s).
PY - 2023
Y1 - 2023
N2 - Purpose: The aim of this study is to present incidence, histological subtypes, survival rates, and prognostic factors based on a national cohort of patients with salivary gland carcinoma. Methods: All Danish patients with submandibular gland carcinoma diagnosed from 1990 to 2015 (n = 206) were included and analyzed following histological re-evaluation. Data were collected by the Danish Head and Neck Cancer Group (DAHANCA). Overall, disease-specific and recurrence-free survival were evaluated. Prognostic factors were analyzed with multivariate Cox Hazard Regression. Results: The study population consisted of 109 (53%) men and 97 (47%) women, median age 62 years (range 11–102). Adenoid cystic carcinoma was the most frequent subtype (50%). Tumour classification T1/T2 (75%) and N0 (78%) was most frequent. The mean crude incidence was 0.17/100,000/year. Most patients (n = 194, 94%) were treated with primary surgery, and 130 (67%) received postoperative radiotherapy. The 5- and 10-year survival rates were for overall survival 64% and 41%, disease-specific survival 74% and 61%, and recurrence-free survival 70% and 56%, respectively. Survival rates were higher for adenoid cystic carcinoma compared to other subtypes, but the difference was not significant in multivariate analysis. Recurrence occurred in 69 patients, and 37 (53.6%) of them had recurrence in a distant site. Advanced T-classification and regional lymph-node metastases had significant negative impact on survival rates. Conclusion: The incidence of submandibular gland carcinoma in Denmark was 0.17/100,000/year and stable during the time period. The most frequent subtype was adenoid cystic carcinoma. Half of the recurrences presented in a distant site, and multivariate analysis confirmed that advanced stage was independent negative prognostic factor for recurrence and survival.
AB - Purpose: The aim of this study is to present incidence, histological subtypes, survival rates, and prognostic factors based on a national cohort of patients with salivary gland carcinoma. Methods: All Danish patients with submandibular gland carcinoma diagnosed from 1990 to 2015 (n = 206) were included and analyzed following histological re-evaluation. Data were collected by the Danish Head and Neck Cancer Group (DAHANCA). Overall, disease-specific and recurrence-free survival were evaluated. Prognostic factors were analyzed with multivariate Cox Hazard Regression. Results: The study population consisted of 109 (53%) men and 97 (47%) women, median age 62 years (range 11–102). Adenoid cystic carcinoma was the most frequent subtype (50%). Tumour classification T1/T2 (75%) and N0 (78%) was most frequent. The mean crude incidence was 0.17/100,000/year. Most patients (n = 194, 94%) were treated with primary surgery, and 130 (67%) received postoperative radiotherapy. The 5- and 10-year survival rates were for overall survival 64% and 41%, disease-specific survival 74% and 61%, and recurrence-free survival 70% and 56%, respectively. Survival rates were higher for adenoid cystic carcinoma compared to other subtypes, but the difference was not significant in multivariate analysis. Recurrence occurred in 69 patients, and 37 (53.6%) of them had recurrence in a distant site. Advanced T-classification and regional lymph-node metastases had significant negative impact on survival rates. Conclusion: The incidence of submandibular gland carcinoma in Denmark was 0.17/100,000/year and stable during the time period. The most frequent subtype was adenoid cystic carcinoma. Half of the recurrences presented in a distant site, and multivariate analysis confirmed that advanced stage was independent negative prognostic factor for recurrence and survival.
KW - Salivary gland carcinoma
KW - Submandibular gland cancer
KW - Submandibular gland carcinoma
U2 - 10.1007/s00405-023-07940-y
DO - 10.1007/s00405-023-07940-y
M3 - Journal article
C2 - 37052687
AN - SCOPUS:85152550275
VL - 280
SP - 3405
EP - 3413
JO - Archiv fur klinische und experimentelle Ohren- Nasen- und Kehlkopfheilkunde
JF - Archiv fur klinische und experimentelle Ohren- Nasen- und Kehlkopfheilkunde
SN - 0942-8992
IS - 7
ER -
ID: 366541367