Prognostic scoring models in parotid gland carcinoma

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Documents

  • Marie Westergaard-Nielsen
  • Møller, Søren
  • Christian Godballe
  • Jesper Grau Eriksen
  • Stine Rosenkilde Larsen
  • Katalin Kiss
  • Tina Agander
  • Benedicte Parm Ulhøi
  • Charabi, Birgitte Wittenborg
  • Tejs Ehlers Klug
  • Henrik Jacobsen
  • Jørgen Johansen
  • Claus Andrup Kristensen
  • Elo Andersen
  • Maria Andersen
  • Kristine Bjørndal

Background: The aim was to identify prognostic factors and test three prognostic scoring models that predicted the risk of recurrence in patients with parotid gland carcinoma. Methods: All Danish patients with parotid gland carcinoma, treated with curative intent, from 1990 to 2015 (n = 726) were included. Potential prognostic factors were evaluated using Cox regression and competing risk analyses. The concordance of each prognostic model was estimated using Harrel's C index. Results: The study population consisted of 344 men and 382 women, with a median age of 63 years. Age above 60 years, high grade histology, T3/T4 tumor, regional lymph node metastases, and involved surgical margins were all associated with a significant reduction in recurrence-free survival. The prognostic model that agreed best with actual outcomes had a C-index of 0.76. Conclusion: Prognostic scoring models may improve individualized follow-up strategies after curatively intended treatment for patients with parotid gland carcinoma.

Original languageEnglish
JournalHead and Neck
Volume43
Issue number7
Pages (from-to)2081-2090
Number of pages10
ISSN1043-3074
DOIs
Publication statusPublished - Jul 2021

Bibliographical note

Funding Information:
This study was supported by the Danish Head and Neck Cancer Group (DAHANCA) and by Open Patient data Explorative Network (OPEN), Odense University Hospital, Denmark. Grants were provided from the University of Southern Denmark, the Region of Southern Denmark, the Danish Cancer Research Fund, and the Danish Cancer Society.

Publisher Copyright:
© 2021 Wiley Periodicals LLC.

    Research areas

  • follow-up, parotid gland carcinoma, prognosis, prognostic scoring model, recurrence risk

ID: 284090596