Niels Erik Skakkebæk

Niels Erik Skakkebæk

Affiliate Professor

Member of:

  • Paediatrics


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  1. Published

    Testicular dysgenesis syndrome and the origin of carcinoma in situ testis

    Sonne, Si Brask, Kristensen, D. M., Novotny, G. W., Olesen, I. A., Nielsen, J. E., Skakkebæk, Niels Erik, Rajpert-De Meyts, E. & Leffers, H., 2008, In: International Journal of Andrology. 31, 2, p. 275-87 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Testicular dysgenesis syndrome comprises some but not all cases of hypospadias and impaired spermatogenesis

    Jørgensen, N., Rajpert-De Meyts, E., Main, Katharina Maria & Skakkebæk, Niels Erik, 1 Apr 2010, In: International Journal of Andrology. 33, 2, p. 298-303 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Testicular dysgenesis syndrome: foetal origin of adult reproductive problems

    Wohlfahrt-Veje, C., Main, Katharina Maria & Skakkebæk, Niels Erik, 2009, In: Clinical Endocrinology. 71, 4, p. 459-65 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Testicular dysgenesis syndrome: mechanistic insights and potential new downstream effects

    Sharpe, R. M. & Skakkebæk, Niels Erik, 2008, In: Fertility and Sterility. 89, 2 Suppl, p. e33-e38

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Testicular dysgenesis syndrome: possible role of endocrine disrupters

    Bay, K., Asklund, C., Skakkebæk, Niels Erik & Andersson, A., 1 Mar 2006, In: Best Practice & Research: Clinical Endocrinology & Metabolism. 20, 1, p. 77-90 14 p.

    Research output: Contribution to journal › Journal article › Research

  6. Published

    Testicular function in young men in long-term remission after treatment for the early stages of Hodgkin's disease

    Specht, Lena, Geisler, C., Hansen, M. M. & Skakkebæk, Niels Erik, 1 Oct 1984, In: Scandinavian journal of haematology. 33, 4, p. 356-62 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Testicular germ cell cancer incidence in an immigration perspective, Denmark, 1978 to 2003

    Schmiedel, S., Schüz, J., Skakkebæk, Niels Erik & Johansen, C., 1 Apr 2010, In: Journal of Urology. 183, 4, p. 1378-82 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Testicular non-seminoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

    Schmoll, H., Jordan, K., Huddart, R., Pes, M. P. L., Horwich, A., Fizazi, K., Kataja, V., Rajpert-De Meyts, E., Skakkebæk, Niels Erik, ESMO Guidelines Working Group, E. G. W. G. & von der Maase, H. R. R., 1 May 2010, In: Annals of Oncology. 21 Suppl 5, p. v147-54

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Testicular seminoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

    Schmoll, H., Jordan, K., Huddart, R., Pes, M. P. L., Horwich, A., Fizazi, K., Kataja, V., Rajpert-De Meyts, E., Skakkebæk, Niels Erik, ESMO Guidelines Working Group, E. G. W. G. & von der Maase, H. R. R., 1 May 2010, In: Annals of Oncology. 21 Suppl 5, p. v140-6

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Testosteronbehandling af ældre mænd: den såkaldte andropause eksisterer ikke.

    Juul, Anders & Skakkebæk, Niels Erik, 2002, In: Ugeskrift for Laeger. 164, 42, p. 4941-2 2 p.

    Research output: Contribution to journal › Review › Research

  11. Published

    The Association of Reproductive Hormone Levels and All-Cause, Cancer, and Cardiovascular Disease Mortality in Men

    Agergaard Holmboe, S., Vradi, E., Jensen, T. K., Linneberg, Allan René, Husemoen, L. L. N., Scheike, Thomas, Skakkebæk, Niels Erik, Juul, Anders & Andersson, A., Dec 2015, In: Journal of Clinical Endocrinology and Metabolism. 100, 12, p. 4472-4480 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    The Human Eccrine Sweat Gland: A possible GRowth hormone target organ ?

    Juul, Anders, Nielsen, B., Hjortskov, N., Main, Katharina Maria & Skakkebæk, Niels Erik, 1997, The Clinical Pharmacology of Sports and Exercise.. p. 223 7 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

  13. Published

    The Testis in Childhood Between Birth and Puberty

    Meyts, E. R., Almstrup, Kristian, Nielsen, J. E. & Skakkebæk, Niels Erik, 2013, Atlas on the Human Testis.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

  14. Published

    The acid-labile subunit of human ternary insulin-like growth factor binding protein complex in serum: hepatosplanchnic release, diurnal variation, circulating concentrations in healthy subjects, and diagnostic use in patients with growth hormone deficiency

    Juul, Anders, Møller, S., Mosfeldt-Laursen, E., Rasmussen, M. H., Scheike, T. H., Pedersen, S. A., Kastrup, K. W., Yu, H., Mistry, J., Rasmussen, S., Müller, J., Henriksen, J. & Skakkebæk, Niels Erik, 1998, In: Journal of Clinical Endocrinology and Metabolism. 83, 12, p. 4408-15 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    The antidepressant Sertraline inhibits CatSper Ca2+channels in human sperm

    Rahban, R., Rehfeld, Anders Aagaard, Schiffer, C., Brenker, C., Egeberg Palme, D. L., Wang, T., Lorenz, J., Almstrup, Kristian, Skakkebæk, Niels Erik, Strünker, T. & Nef, S., 2021, In: Human Reproduction. 36, 10, p. 2638-2648

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    The association between in-utero exposure to stressful life events during pregnancy and male reproductive function in a cohort of 20-year-old offspring: The Raine Study

    Bräuner, E. V., Hansen, Åse Marie, Doherty, D. A., Dickinson, J. E., Handelsman, D. J., Hickey, M., Skakkebæk, Niels Erik, Juul, A. & Hart, R., 8 Jul 2019, In: Human reproduction (Oxford, England). 34, 7, p. 1345-1355 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    The epidemiology of cryptorchidism and potential risk factors, including endocrine disrupting chemicals

    Holmboe, S. A., Beck, A. L., Andersson, A. M., Main, Katharina Maria, Jørgensen, N., Skakkebæk, Niels Erik & Priskorn, L., 2024, In: Frontiers in Endocrinology. 15, 8 p., 1343887.

    Research output: Contribution to journal › Review › Research › peer-review

  18. Published

    The exposure of fetuses and children to endocrine disrupting chemicals: a European Society for Paediatric Endocrinology (ESPE) and Pediatric Endocrine Society (PES) call to action statement

    Skakkebæk, Niels Erik, Toppari, J., Söder, O., Gordon, C. M., Divall, S. & Draznin, M., 1 Oct 2011, In: Journal of Clinical Endocrinology and Metabolism. 96, 10, p. 3056-8 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    The faroes statement: human health effects of developmental exposure to chemicals in our environment

    Grandjean, P., Bellinger, D., Bergman, A., Cordier, S., vey-Smith, G., Eskenazi, B., Gee, D., Gray, K., Hanson, M., den, H. P. V., Heindel, J. J., Heinzow, B., Hertz-Picciotto, I., Hu, H., Huang, T. T., Jensen, T. K., Landrigan, P. J., McMillen, I. C., Murata, K., Ritz, B. & 4 others, Schoeters, G., Skerfving, S., Weihe, P. & Skakkebæk, Niels Erik, 2008, In: Basic & Clinical Pharmacology & Toxicology. 102, 2, p. 73-75 2 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    The growth hormone (GH)-insulin-like growth factor axis during testosterone replacement therapy in GH-treated hypopituitary males

    Fisker, S., Nørrelund, H., Juul, Anders, Skakkebæk, Niels Erik, Christiansen, J. S. & Jørgensen, J. O., 2001, In: Growth Hormone & I G F Research. 11, 2, p. 104-9 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    The impact of gender and puberty on reference values for urinary growth hormone excretion: a study of 3 morning urine samples in 517 healthy children and adults

    Main, Katharina Maria, Jarden, M., Angelo, L., Dinesen, B. I., Hertel, N., Juul, Anders, Müller, J. & Skakkebæk, Niels Erik, 1994, In: Journal of Clinical Endocrinology and Metabolism. 79, 3, p. 865-71 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    The possible impact of antenatal exposure to ubiquitous phthalates upon male reproductive function at 20 years of age

    Hart, R. J., Frederiksen, H., Doherty, D. A., Keelan, J. A., Skakkebæk, Niels Erik, Minaee, N. S., McLachlan, R., Newnham, J. P., Dickinson, J. E., Pennell, C. E., Norman, R. J. & Main, Katharina Maria, 2018, In: Frontiers in Endocrinology. 9, JUN, 11 p., 288.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    The ratio between serum levels of insulin-like growth factor (IGF)-I and the IGF binding proteins (IGFBP-1, 2 and 3) decreases with age in healthy adults and is increased in acromegalic patients

    Juul, Anders, Main, Katharina Maria, Blum, W. F., Lindholm, J., Ranke, M. B. & Skakkebæk, Niels Erik, 1994, In: Clinical Endocrinology. 41, 1, p. 85-93 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    The relationship between anogenital distance and reproductive hormone levels in adult men

    Eisenberg, M. L., Jensen, T. K., Walters, R. C., Skakkebæk, Niels Erik & Lipshultz, L. I., 2012, In: The Journal of Urology. 187, 2, p. 594-8 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    The sensitivity of the child to sex steroids: possible impact of exogenous estrogens

    Aksglaede, L., Juul, Anders, Leffers, H., Skakkebæk, Niels Erik & Andersson, A., 2006, In: Human Reproduction Update. 12, 4, p. 341-9 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    The syndrome of Growth Hormone Deficiency in adulthood

    Christiansen, J., Jørgensen, J., Juul, Anders, Müller, J., Skakkebæk, Niels Erik, Fisker, S. & Vahn, N., 1995, In: Journal of Clinical Endocrinology and Metabolism. p. 7-9 2 p.

    Research output: Contribution to journal › Journal article › Research

  27. Published

    The testis in childhood between birth and puberty

    Rajpert-De Meyts, E., Almstrup, H. K. & Skakkebæk, Niels Erik, 2012, Atlas on the Human Testis: Normal Morphology and Pathology. p. 69-75 6 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  28. Published

    The timing of normal puberty and the age limits of sexual precocity: variations around the world, secular trends, and changes after migration

    Parent, A., Teilmann, Grete Katrine, Juul, Anders, Skakkebæk, Niels Erik, Toppari, J. & Bourguignon, J., 2003, In: Endocrine Reviews. 24, 5, p. 668-93 26 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Thyroid function in covid-19 and the association with cytokine levels and mortality

    Clausen, C. L., Rasmussen, Å. K., Johannsen, T. H., Hilsted, Linda, Skakkebæk, Niels Erik, Szecsi, P. B., Pedersen, L., Benfield, Thomas & Juul, Anders, 2021, In: Endocrine Connections. 10, 10, p. 1234-1242 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Time to pregnancy and life expectancy: a cohort study of 18796 pregnant couples

    Lindahl-Jacobsen, R., Petersson, M. T., Priskorn, Lærke, Skakkebæk, Niels Erik, Juul, Anders, Kristensen, D. M., Eisenberg, M. L. & Jensen, T. K., 2024, In: Human Reproduction. 39, 3, p. 595-603 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Time to pregnancy and semen parameters: a cross-sectional study among fertile couples from four European cities

    Slama, R., Eustache, F., Ducot, B., Jensen, T. K., Jørgensen, N., Horte, A., Irvine, S., Suominen, J., Andersen, A. G., Auger, J., Vierula, M., Toppari, J., Andersen, A. N., Keiding, N., Skakkebæk, Niels Erik, Spira, A. & Jouannet, P., 2002, In: Human Reproduction. 17, 2, p. 503-515 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Total and free insulin-like growth factor I, insulin-like growth factor binding protein 3 and acid-labile subunit reflect clinical activity in acromegaly

    Sneppen, S. B., Lange, M. W., Pedersen, L. M., Kristensen L, L. Ø., Main, Katharina Maria, Juul, Anders, Skakkebæk, Niels Erik & Feldt-Rasmussen, Ulla, 2001, In: Growth Hormone & I G F Research. 11, 6, p. 384-91 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Transcription factor AP-2gamma is a developmentally regulated marker of testicular carcinoma in situ and germ cell tumors

    Hoei-Hansen, C. E., Nielsen, J. E., Almstrup, K., Sonne, Si Brask, Graem, N., Skakkebæk, Niels Erik, Leffers, H. & Rajpert-De Meyts, E., 2004, In: Clinical Cancer Research. 10, 24, p. 8521-30 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Transcription factor AP-2γ is a developmentally regulated marker of testicular carcinoma in situ and germ cell tumors

    Høi-Hansen, Christina Engel, Nielsen, J. E., Almstrup, Kristian, Sonne, Si Brask, Graem, N., Skakkebæk, Niels Erik, Leffers, H. & Rajpert-De Meyts, E., 2004, In: Clinical Cancer Research.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Transcriptome analysis of the adult human Klinefelter testis and cellularity-matched controls reveals disturbed differentiation of Sertoli- and Leydig cells

    Winge, S. B., Dalgaard, M. D., Belling, K. G., Jensen, J. M., Nielsen, J. E., Aksglaede, L., Schierup, M. H., Brunak, Søren, Skakkebæk, Niels Erik, Juul, Anders, Rajpert-De Meyts, E. & Almstrup, Kristian, 2018, In: Cell Death & Disease. 9, 6, 14 p., 586.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Translational repression of E2F1 mRNA in carcinoma in situ and normal testis correlates with expression of the miR-17-92 cluster

    Novotny, G. W., Sonne, Si Brask, Nielsen, J. E., Jonstrup, S. P., Hansen, M. A., Skakkebæk, Niels Erik, Rajpert-De Meyts, E., Kjems, J. & Leffers, H., 2007, In: Cell Death and Differentiation. 14, 4, p. 879-82 3 p.

    Research output: Contribution to journal › Letter › Research

  37. Published

    Trends in rates of natural conceptions among Danish women born during 1960-1984

    Lassen, T. H., Sobotka, T., Jensen, T. K., Jacobsen, R. S., Erb, K. & Skakkebæk, Niels Erik, 2012, In: Human Reproduction. 27, 9, p. 2815-22 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    UV filters analyzed by isotope diluted TurboFlow-LC-MS/MS in urine from Danish children and adolescents

    Frederiksen, H., Nielsen, O., Skakkebæk, Niels Erik, Juul, Anders & Andersson, A., Mar 2017, In: International Journal of Hygiene and Environmental Health. 220, 2, Part A, p. 244-253 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    UV filters in matched seminal fluid-, urine-, and serum samples from young men

    Frederiksen, H., Krause, M., Jørgensen, N., Rehfeld, Anders Aagaard, Skakkebæk, Niels Erik & Andersson, A., 2021, In: Journal of Exposure Science and Environmental Epidemiology. 31, p. 345–355

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Urinary bisphenol A levels in young Urinary Bisphenol A Levels in Young Men: Association with Reproductive Hormones and Semen Quality

    Lassen, T. H., Frederiksen, H., Jensen, T. K., Petersen, Jørgen Holm, Joensen, U. N., Main, Katharina Maria, Skakkebæk, Niels Erik, Juul, Anders, Jørgensen, N. & Andersson, A., 2014, In: Environmental Health Perspectives. 122, 5, p. 478-484 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Urinary excretion of phthalate metabolites in 129 healthy Danish children and adolescents: Estimation of daily phthalate intake

    Frederiksen, H., Aksglaede, L., Sørensen, K., Skakkebæk, Niels Erik, Juul, Anders & Andersson, A., 1 Jul 2011, In: Environmental Research. 111, 5, p. 656-63 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Urinary excretion of phthalates and paraben after repeated whole-body topical application in humans

    Janjua, N. R., Frederiksen, H., Skakkebæk, Niels Erik, Wulf, H. C. & Andersson, A., 1 Apr 2008, In: International Journal of Andrology. 31, 2, p. 118-30 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Urinary phthalate excretion in 555 healthy Danish boys with and without pubertal gynaecomastia

    Mieritz, M. G., Frederiksen, H., Sørensen, K., Aksglaede, L., Mouritsen, A., Hagen, C. P., Skakkebæk, Niels Erik, Andersson, A. & Juul, Anders, 2012, In: International Journal of Andrology. 35, 3, p. 227-35 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Urinary phthalates from 168 girls and boys measured twice a year during a 5-year period

    Mouritsen, Annette Korsholm, Frederiksen, H., Sørensen, K., Aksglæde, L., Hagen, C., Skakkebæk, Niels Erik, Main, Katharina Maria, Andersson, A. M. & Juul, Anders, 2013, In: Journal of Clinical Endocrinology and Metabolism. 98, 9, p. 3755-3764 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Use of e-cigarettes associated with lower sperm counts in a cross-sectional study of young men from the general population

    Holmboe, S. A., Priskorn, L., Jensen, T. K., Skakkebæk, Niels Erik, Andersson, A. & Jørgensen, N., Jul 2020, In: Human Reproduction. 35, 7, p. 1693-1701

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Use of stored serum in the study of time trends and geographical differences in exposure of pregnant women to phthalates

    Henriksen, L. S., Mathiesen, B. K., Assens, M., Krause, M., Skakkebæk, Niels Erik, Juul, Anders, Andersson, A. M., Hart, R. J., Newnham, J. P., Keelan, J. A., Pennell, C., Main, Katharina Maria & Frederiksen, H., 2020, In: Environmental Research. 184, 109231.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Validation of image cytometry for sperm concentration measurement: Comparison with manual counting of 4010 human semen samples

    Egeberg Palme, D. L., Johannsen, T. H., Petersen, Jørgen Holm, Skakkebæk, Niels Erik, Juul, Anders, Jørgensen, N. & Almstrup, Kristian, 2017, In: Clinica Chimica Acta. 468, p. 114-119 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Variant PNLDC1, Defective piRNA Processing, and Azoospermia

    Nagirnaja, L., Mørup, N., Nielsen, J. E., Stakaitis, R., Golubickaite, I., Oud, M. S., Winge, S. B., Carvalho, F., Aston, K. I., Khani, F., Van Der Heijden, G. W., Marques, C. J., Skakkebæk, Niels Erik, Rajpert–de Meyts, E., Schlegel, P. N., Jørgensen, N., Veltman, J. A., Lopes, A. M., Conrad, D. F. & Almstrup, Kristian, 19 Aug 2021, In: New England Journal of Medicine. 385, 8, p. 707-719 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Variations in repeated serum concentrations of UV filters, phthalates, phenols and parabens during pregnancy

    Assens, M., Frederiksen, H., Petersen, Jørgen Holm, Larsen, T., Skakkebæk, Niels Erik, Juul, Anders, Andersson, A. & Main, Katharina Maria, 2019, In: Environment International. 123, p. 318-324 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Varicocele Is Associated with Impaired Semen Quality and Reproductive Hormone Levels: A Study of 7035 Healthy Young Men from Six European Countries

    Damsgaard, J., Joensen, U. N., Carlsen, E., Erenpreiss, J., Jensen, M. B., Matulevicius, V., Zilaitiene, B., Olesen, I. A., Perheentupa, A., Punab, M., Salzbrunn, A., Toppari, J., Virtanen, H. E., Juul, Anders, Skakkebæk, Niels Erik & Jørgensen, N., Dec 2016, In: European Urology. 70, 6, p. 1019-1029 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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ID: 35319116