Niels Erik Skakkebæk
Affiliate Professor
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Serum inhibin-b in fertile men is strongly correlated with low but not high sperm counts: a coordinated study of 1,797 European and US men
Jørgensen, N., Liu, F., Andersson, A., Vierula, M., Irvine, D. S., Auger, J., Brazil, C. K., Drobnis, E. Z., Jensen, T. K., Jouannet, P., Overstreet, J. W., Redmon, J. B., Sparks, A., Toppari, J., Wang, C., Skakkebæk, Niels Erik & Swan, S. H., 1 Nov 2010, In: Fertility and Sterility. 94, 6, p. 2128-34 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Compensated reduction in Leydig cell function is associated with lower semen quality variables: A study of 8182 European young men
Jørgensen, N., Joensen, Ulla Nordström, Toppari, J., Punab, M., Erenpreiss, J., Zilaitiene, B., Paasch, U., Salzbrunn, A., Fernandez, M. F., Virtanen, H. E., Matulevicius, V., Olea, N., Jensen, T. K., Petersen, Jørgen Holm, Skakkebæk, Niels Erik & Andersson, A. M., 1 May 2016, In: Human Reproduction. 31, 5, p. 947-957 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Human semen quality in the new millennium: a prospective cross-sectional population-based study of 4867 men
Jørgensen, N., Joensen, Ulla Nordström, Jensen, T., Jensen, M., Almstrup, Kristian, Olesen, I., Juul, A., Andersson, A., Carlsen, E., Petersen, Jørgen Holm, Toppari, J. & Skakkebæk, Niels Erik, 2012, In: B M J Open. 2, 4, e000990.Research output: Contribution to journal › Journal article › Research › peer-review
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Recent adverse trends in semen quality and testis cancer incidence among Finnish men
Jørgensen, N., Vierula, M., Jacobsen, R., Pukkala, E., Perheentupa, A., Virtanen, H. E., Skakkebæk, Niels Erik & Toppari, J., 1 Aug 2011, In: International Journal of Andrology. 34, 4 Pt 2, p. e37-48Research output: Contribution to journal › Journal article › Research › peer-review
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Testicular dysgenesis syndrome comprises some but not all cases of hypospadias and impaired spermatogenesis
Jørgensen, N., Rajpert-De Meyts, E., Main, Katharina Maria & Skakkebæk, Niels Erik, 1 Apr 2010, In: International Journal of Andrology. 33, 2, p. 298-303 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Does breast feeding influence liver biochemistry?
Jørgensen, M. H., Ott, P., Juul, Anders, Skakkebæk, Niels Erik & Michaelsen, K. F., 2003, In: Journal of Pediatric Gastroenterology and Nutrition. 37, 5, p. 559-65 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Continuation of growth hormone therapy versus placebo in transition-phase patients with growth hormone deficiency: impact on body composition, insulin sensitivity, and thyroid function
Jørgensen, J., Nørrelund, H., Vahl, N., Juul, Anders, Skakkebæk, Niels Erik & Christiansen, J. S., 2002, In: Journal of Pediatric Endocrinology and Metabolism. 15 Suppl 5, p. 1355-60 6 p.Research output: Contribution to journal › Journal article › Research
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Adult Growth Hormone Deficiency
Jørgensen, J., Müller, J., Wolthers, T., Vahn, N., Juul, Anders & Skakkebæk, Niels Erik, 1994, In: Hormone Research. 42, p. 235-241 6 p.Research output: Contribution to journal › Review › Research
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Growth hormone (GH)-deficiency in adults: clinical features and effects of GH substitution.
Jørgensen, J., Møller, J., Wolthers, T., Vahn, N., Juul, Anders, Skakkebæk, Niels Erik & Christiansen, J., 1994, In: The journal of pediatric endocrinology. p. 283-293 10 p.Research output: Contribution to journal › Journal article › Research
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Impact of growth hormone administration on other hormonal axes.
Jørgensen, J., Ovesen, P., Juul, Anders, Hansen, T., Skakkebæk, Niels Erik & Christiansen, J., 1999, In: Hormone Research. 51, p. 121-126 5 p.Research output: Contribution to journal › Review › Research
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Nodal Signaling Regulates Germ Cell Development and Establishment of Seminiferous Cords in the Human Fetal Testis
Jørgensen, A., Macdonald, J., Nielsen, J. E., Kilcoyne, K. R., Perlman, S., Lundvall, L., Langhoff Thuesen, L., Hare, Kristine Juul, Frederiksen, H., Andersson, A., Skakkebæk, Niels Erik, Juul, Anders, Sharpe, R. M., Rajpert-De Meyts, E. & Mitchell, R. T., 13 Nov 2018, In: Cell Reports. 25, 7, p. 1924-1937.e4Research output: Contribution to journal › Journal article › Research › peer-review
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Pathogenesis of germ cell neoplasia in testicular dysgenesis and disorders of sex development
Jørgensen, A., Lindhardt Johansen, M., Juul, Anders, Skakkebæk, Niels Erik, Main, Katharina Maria & Rajpert-De Meyts, E., Sep 2015, In: Seminars in Cell and Developmental Biology. 45, p. 124-37 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Testosteronbehandling af ældre mænd: den såkaldte andropause eksisterer ikke.
Juul, Anders & Skakkebæk, Niels Erik, 2002, In: Ugeskrift for Laeger. 164, 42, p. 4941-2 2 p.Research output: Contribution to journal › Review › Research
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Possible fetal determinants of male infertility
Juul, Anders, Almstrup, Kristian, Andersson, A., Jensen, T. K., Jørgensen, N., Main, K. M., Rajpert-De Meyts, E., Toppari, J. & Skakkebæk, Niels Erik, Sep 2014, In: Nature Reviews Endocrinology. 10, 9, p. 553-562 10 p.Research output: Contribution to journal › Review › Research › peer-review
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Androgens and the ageing male
Juul, Anders & Skakkebæk, Niels Erik, 2002, In: Human Reproduction Update. 8, 5, p. 423-33 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Diagnosis of GH deficiency and use of GH in children with growth disorders. A report from the Drugs and Therapeutics Committee of European Society for paediatric Endocrinology
Juul, Anders, Bernasconi, S., Chatelain, P., Hindsmarsh, P., Hochberg, Z., Hokke-Koelega, A., De Muinck Keizer-Schrama, S., Kiess, W., Oberfield, S., Strasburger, C., Volta, C., Westphal, O. & Skakkebæk, Niels Erik, 1999, In: Hormone Research. 51, p. 284-299 15 p.Research output: Contribution to journal › Review › Research
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Development: disorders of sex development-the tip of the iceberg?
Juul, Anders, Main, Katharina Maria & Skakkebæk, Niels Erik, 1 Jan 2011, In: Nature Reviews Endocrinology. 7, 9, p. 504-5 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Age at voice break in Danish boys: effects of pre-pubertal body mass index and secular trend
Juul, Anders, Magnusdottir, S., Scheike, T., Prytz, S. & Skakkebæk, Niels Erik, 1 Dec 2007, In: International Journal of Andrology. 30, 6, p. 537-42 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Klinefelter syndrome: the forgotten syndrome: basic and clinical questions posed to an international group of scientists
Juul, Anders, Aksglaede, L., Bay, K., Grigor, K. M. & Skakkebæk, Niels Erik, 1 Jun 2011, In: Acta Paediatrica. 100, 6, p. 791-2 2 p.Research output: Contribution to journal › Conference article › Research
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Væksthormon - virker på andet end væksten.
Juul, Anders & Skakkebæk, Niels Erik, 1997, Medicinsk Årbog 1997. p. 9-15 6 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
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Metabolic effects of GH: a rationale for continued GH treatment of GH-deficient adults after cessation of linear growth.
Juul, Anders, Jørgensen, J., Christiansen, J., Müller, J. & Skakkebæk, Niels Erik, 1995, In: Hormone Research. p. 64-72 8 p.Research output: Contribution to journal › Review › Research
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Growth hormone treatment in GH-deficient adults; therapeutic and diagnostic aspects.
Juul, Anders, Jørgensen, J., müller, J. & Skakkebæk, Niels Erik, 1994, In: Clinical Pediatric Endocrinology. p. 63-71 8 p.Research output: Contribution to journal › Review › Research
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Why Do Normal Children Have Acromegalic Levels of IGF-I During Puberty?
Juul, Anders & Skakkebæk, Niels Erik, 2019, In: The Journal of clinical endocrinology and metabolism. 104, 7, p. 2770-2776Research output: Contribution to journal › Journal article › Research › peer-review
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The Human Eccrine Sweat Gland: A possible GRowth hormone target organ ?
Juul, Anders, Nielsen, B., Hjortskov, N., Main, Katharina Maria & Skakkebæk, Niels Erik, 1997, The Clinical Pharmacology of Sports and Exercise.. p. 223 7 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
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GH-deficiency, sweating and thermoregulations
Juul, Anders, Main, Katharina Maria, Hjortskov, N., Jepsen, L., Nielsen, B., Halkjær-Kristensen, J. & Skakkebæk, Niels Erik, 1996, Growth Hormone in adults; Physiological and clinical aspects. p. 246 5 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
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Consequences of stopping Growth hormone (GH) therapy in young GH-deficient patients with childhood-onset disease
Juul, Anders, Vahl, N., Jørgensen, J., Christiansen, J. & Skakkebæk, Niels Erik, 1998, In: Growth Hormone & I G F Research. p. 15-19 4 p.Research output: Contribution to journal › Review › Research
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Disorders of sexual differentiation-the tip of the iceberg?
Juul, Anders, Main, Katharina Maria & Skakkebæk, Niels Erik, 2011, In: Nature Reviews Endocrinology. 7, p. 504-5 1 p.Research output: Contribution to journal › Letter › Research
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Vækst og Regeration
Juul, Anders, Korndrup, J. & Skakkebæk, Niels Erik, 1999, Medicinsk Kompendium. 15 ed. p. 140-148 8 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
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Growth hormone (GH), exercise performance, muscle strength and sweat production in healthy subjects and adults with GH deficiency
Juul, Anders, Main, Katharina Maria & Skakkebæk, Niels Erik, 2000, Growth Hormone in adults; Physiological and clinical aspects. 2 ed. p. 281-300 19 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
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Serum concentrations of free and total insulin-like growth factor-I, IGF binding proteins -1 and -3 and IGFBP-3 protease activity in boys with normal or precocious puberty
Juul, Anders, Flyvbjerg, A., Frystyk, J., Müller, J. & Skakkebæk, Niels Erik, 1996, In: Clinical Endocrinology. 44, 5, p. 515-23 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Impaired thermoregulation in adults with growth hormone deficiency during heat exposure and exercise
Juul, Anders, Behrenscheer, A., Tims, T., Nielsen, B., Halkjaer-Kristensen, J. & Skakkebæk, Niels Erik, 1993, In: Clinical Endocrinology. 38, 3, p. 237-244 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Prediction of the outcome of growth hormone provocative testing in short children by measurement of serum levels of insulin-like growth factor I and insulin-like growth factor binding protein 3
Juul, Anders & Skakkebæk, Niels Erik, 1997, In: Journal of Pediatrics. 130, 2, p. 197-204 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Growth hormone deficiency and hyperthermia during exercise: a controlled study of sixteen GH-deficient patients
Juul, Anders, Hjortskov, N., Jepsen, L., Nielsen, B., Halkjaer-Kristensen, J., Vahl, N., Jørgensen, J. O., Christiansen, J. S. & Skakkebæk, Niels Erik, 1995, In: Journal of Clinical Endocrinology and Metabolism. 80, 11, p. 3335-40 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Serum levels of insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) in healthy infants, children, and adolescents: the relation to IGF-I, IGF-II, IGFBP-1, IGFBP-2, age, sex, body mass index, and pubertal maturation
Juul, Anders, Dalgaard, P., Blum, W. F., Bang, P., Hall, K. P., Michaelsen, K. F., Müller, J. & Skakkebæk, Niels Erik, 1995, In: Journal of Clinical Endocrinology and Metabolism. 80, 8, p. 2534-42 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Serum insulin-like growth factor-I in 1030 healthy children, adolescents, and adults: relation to age, sex, stage of puberty, testicular size, and body mass index
Juul, Anders, Bang, P., Hertel, N., Main, Katharina Maria, Dalgaard, P., Jørgensen, K., Müller, J., Hall, K. P. & Skakkebæk, Niels Erik, 1994, In: Journal of Clinical Endocrinology and Metabolism. 78, 3, p. 744-52 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Growth hormone (GH) provocative retesting of 108 young adults with childhood-onset GH deficiency and the diagnostic value of insulin-like growth factor I (IGF-I) and IGF-binding protein-3
Juul, Anders, Kastrup, K. W., Pedersen, S. A. & Skakkebæk, Niels Erik, 1997, In: Journal of Clinical Endocrinology and Metabolism. 82, 4, p. 1195-201 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Growth hormone deficiency and hyperthermia
Juul, Anders & Skakkebæk, Niels Erik, 1991, In: Lancet. 338, 8771, p. 887Research output: Contribution to journal › Journal article › Research › peer-review
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Effects of growth hormone replacement therapy on IGF-related parameters and on the pituitary-gonadal axis in GH-deficient males. A double-blind, placebo-controlled crossover study
Juul, Anders, Andersson, A. M., Pedersen, S. A., Jørgensen, J. O., Christiansen, J. S., Groome, N. P. & Skakkebæk, Niels Erik, 1998, In: Hormone Research. 49, 6, p. 269-78 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Pubertal development in Danish children: comparison of recent European and US data
Juul, Anders, Teilmann, Grete Katrine, Scheike, T. H., Hertel, N., Holm, Kirsten, Laursen, E., Main, Katharina Maria & Skakkebæk, Niels Erik, 2006, In: International Journal of Andrology. 29, 1, p. 247-55; discussion 286-90Research output: Contribution to journal › Journal article › Research › peer-review
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Preserved fertility in a non-mosaic Klinefelter patient with a mutation in the fibroblast growth factor receptor 3 gene: case report
Juul, Anders, Aksglaede, L., Lund, Allan Meldgaard, Duno, M., Skakkebæk, Niels Erik & Rajpert-De Meyts, E., 2007, In: Human Reproduction. 22, 7, p. 1907-11 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The ratio between serum levels of insulin-like growth factor (IGF)-I and the IGF binding proteins (IGFBP-1, 2 and 3) decreases with age in healthy adults and is increased in acromegalic patients
Juul, Anders, Main, Katharina Maria, Blum, W. F., Lindholm, J., Ranke, M. B. & Skakkebæk, Niels Erik, 1994, In: Clinical Endocrinology. 41, 1, p. 85-93 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Prostate specific antigen in boys with precocious puberty before and during gonadal suppression by GnRH agonist treatment
Juul, Anders, Müller, J. & Skakkebæk, Niels Erik, 1997, In: European Journal of Endocrinology. 136, 4, p. 401-5 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Serum levels of growth hormone binding protein in children with normal and precocious puberty: relation to age, gender, body composition and gonadal steroids
Juul, Anders, Fisker, S., Scheike, T. H., Hertel, T. K., Müller, J., Orskov, H. & Skakkebæk, Niels Erik, 2000, In: Clinical Endocrinology. 52, 2, p. 165-72 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The acid-labile subunit of human ternary insulin-like growth factor binding protein complex in serum: hepatosplanchnic release, diurnal variation, circulating concentrations in healthy subjects, and diagnostic use in patients with growth hormone deficiency
Juul, Anders, Møller, S., Mosfeldt-Laursen, E., Rasmussen, M. H., Scheike, T. H., Pedersen, S. A., Kastrup, K. W., Yu, H., Mistry, J., Rasmussen, S., Müller, J., Henriksen, J. & Skakkebæk, Niels Erik, 1998, In: Journal of Clinical Endocrinology and Metabolism. 83, 12, p. 4408-15 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Growth hormone (GH) treatment increases serum insulin-like growth factor binding protein-3, bone isoenzyme alkaline phosphatase and forearm bone mineral content in young adults with GH deficiency of childhood onset
Juul, Anders, Pedersen, S. A., Sørensen, S., Winkler, K., Jørgensen, J. O., Christiansen, J. S. & Skakkebæk, Niels Erik, 1994, In: European Journal of Endocrinology. 131, 1, p. 41-9 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Serum insulin-like growth factor I (IGF-I) and IGF-binding protein 3 levels are increased in central precocious puberty: effects of two different treatment regimens with gonadotropin-releasing hormone agonists, without or in combination with an antiandrogen (cyproterone acetate)
Juul, Anders, Scheike, T. H., Nielsen, C. T., Krabbe, S., Müller, J. & Skakkebæk, Niels Erik, 1995, In: Journal of Clinical Endocrinology and Metabolism. 80, 10, p. 3059-67 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Changes in serum concentrations of growth hormone, insulin, insulin-like growth factor and insulin-like growth factor-binding proteins 1 and 3 and urinary growth hormone excretion during the menstrual cycle
Juul, Anders, Scheike, T. H., Pedersen, Anette Tønnes, Main, Katharina Maria, Andersson, A. M., Pedersen, L. M. & Skakkebæk, Niels Erik, 1997, In: Human Reproduction. 12, 10, p. 2123-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Free insulin-like growth factor I serum levels in 1430 healthy children and adults, and its diagnostic value in patients suspected of growth hormone deficiency
Juul, Anders, Holm, Kirsten, Kastrup, K. W., Pedersen, S. A., Michaelsen, K. F., Scheike, T. H., Rasmussen, S., Müller, J. & Skakkebæk, Niels Erik, 1997, In: Journal of Clinical Endocrinology and Metabolism. 82, 8, p. 2497-502 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Is there a problem with male reproduction?
Joensen, Ulla Nordström, Skakkebæk, Niels Erik & Jørgensen, N., 2009, In: Nature Clinical Practice Endocrinology & Metabolism. 5, 3, p. 144-5 1 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Associations of Filaggrin Gene Loss-of-Function Variants with Urinary Phthalate Metabolites and Testicular Function in Young Danish Men
Joensen, U. N., Jørgensen, N., Meldgaard, M., Frederiksen, H., Andersson, A., Menné, T., Johansen, Jeanne Duus, Carlsen, B. C., Stender, S., Szecsi, P. B., Skakkebæk, Niels Erik, De Meyts, E. R. & Thyssen, Jacob Pontoppidan, Apr 2014, In: Environmental Health Perspectives. 122, 4, p. 345-350 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 35319116
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EDC IMPACT: Chemical UV filters can affect human sperm function in a progesterone-like manner
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Prenatal exposure to antifungal medication may change anogenital distance in male offspring: a preliminary study
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Variations in repeated serum concentrations of UV filters, phthalates, phenols and parabens during pregnancy
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