Niels Erik Skakkebæk

Niels Erik Skakkebæk

Affiliate Professor

Member of:

  • Paediatrics


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  1. Published

    The Association of Reproductive Hormone Levels and All-Cause, Cancer, and Cardiovascular Disease Mortality in Men

    Agergaard Holmboe, S., Vradi, E., Jensen, T. K., Linneberg, Allan René, Husemoen, L. L. N., Scheike, Thomas, Skakkebæk, Niels Erik, Juul, Anders & Andersson, A., Dec 2015, In: Journal of Clinical Endocrinology and Metabolism. 100, 12, p. 4472-4480 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Low semen volume in 47 adolescents and adults with 47,XXY Klinefelter or 46,XX male syndrome

    Aksglaede, L., Jørgensen, N., Skakkebæk, Niels Erik & Juul, Anders, 2008, In: International Journal of Andrology. 32, 4, p. 376-84 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Changes in anti-Müllerian hormone (AMH) throughout the life span: a population-based study of 1027 healthy males from birth (cord blood) to the age of 69 years

    Aksglaede, L., Sørensen, K., Boas, M., Mouritsen, A., Hagen, C. P., Jensen, R. B., Petersen, J. H., Linneberg, Allan René, Andersson, A., Main, Katharina Maria, Skakkebæk, Niels Erik & Juul, Anders, 2010, In: Journal of Clinical Endocrinology and Metabolism. 95, 12, p. 5357-64 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    47,XXY Klinefelter syndrome: clinical characteristics and age-specific recommendations for medical management

    Aksglaede, L., Link, K., Giwercman, A., Jørgensen, N., Skakkebæk, Niels Erik & Juul, Anders, 2013, In: American Journal of Medical Genetics. Part C: Seminars in Medical Genetics. 163, 1, p. 55-63 9 p.

    Research output: Contribution to journal › Journal article › Research

  5. Published

    Primary testicular failure in Klinefelter's syndrome: the use of bivariate luteinizing hormone-testosterone reference charts

    Aksglaede, L., Andersson, A., Jørgensen, N., Jensen, T. K., Carlsen, E., McLachlan, R. I., Skakkebæk, Niels Erik, Petersen, Jørgen Holm & Juul, Anders, 1 Feb 2007, In: Clinical Endocrinology. 66, 2, p. 276-81 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Serum concentrations of Anti-Müllerian Hormone (AMH) in 95 patients with Klinefelter syndrome with or without cryptorchidism

    Aksglaede, L., Christiansen, P., Sørensen, K., Boas, M., Linneberg, Allan René, Main, Katharina Maria, Andersson, A., Skakkebæk, Niels Erik & Juul, Anders, 2011, In: Acta Paediatrica. 100, 6, p. 839-845 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Abnormal sex chromosome constitution and longitudinal growth: serum levels of insulin-like growth factor (IGF)-I, IGF binding protein-3, luteinizing hormone, and testosterone in 109 males with 47,XXY, 47,XYY, or sex-determining region of the Y chromosome (SRY)-positive 46,XX karyotypes

    Aksglaede, L., Skakkebæk, Niels Erik & Juul, Anders, 2008, In: Journal of Clinical Endocrinology and Metabolism. 93, 1, p. 169-176 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    High normal testosterone levels in infants with non-mosaic Klinefelter's syndrome

    Aksglaede, L., Petersen, Jørgen Holm, Main, Katharina Maria, Skakkebæk, Niels Erik & Juul, Anders, 2007, In: European Journal of Endocrinology. 157, 3, p. 345-50 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    The sensitivity of the child to sex steroids: possible impact of exogenous estrogens

    Aksglaede, L., Juul, Anders, Leffers, H., Skakkebæk, Niels Erik & Andersson, A., 2006, In: Human Reproduction Update. 12, 4, p. 341-9 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Recent decline in age at breast development: the Copenhagen Puberty Study

    Aksglaede, L., Sørensen, K., Petersen, Jørgen Holm, Skakkebæk, Niels Erik & Juul, Anders, 2009, In: Pediatrics Electronic Pages. 123, 5, p. e932-9

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Clinical and biological parameters in 166 boys, adolescents and adults with nonmosaic Klinefelter syndrome: a Copenhagen experience

    Aksglaede, L., Skakkebæk, Niels Erik, Almstrup, Kristian & Juul, Anders, 1 Jun 2011, In: Acta Paediatrica. 100, 6, p. 793-806 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Recent decline in age at breast development: the Copenhagen Puberty Study

    Aksglaede, L., Sørensen, K., Petersen, J. H., Skakkebæk, Niels Erik & Juul, Anders, 2009, In: Pediatrics. 123, 5, p. e932-9

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Natural history of seminiferous tubule degeneration in Klinefelter syndrome

    Aksglaede, L., Wikström, A. M., Rajpert-De Meyts, E., Dunkel, L., Skakkebæk, Niels Erik & Juul, Anders, 2006, In: Human Reproduction Update. 12, 1, p. 39-48 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Changes in Anti-Mullerian Hormone (AMH) throughout the Life Span: A Population-Based Study of 1027 Healthy Males from Birth (Cord Blood) to the Age of 69 Years

    Aksglæde, L., Sørensen, K., Boas, M., Mouritsen, Annette Korsholm, Hagen, C. P., Jensen, R. B., Petersen, J. H., Linneberg, Allan René, Andersson, A. M., Main, Katharina Maria, Skakkebæk, Niels Erik & Juul, Anders, 2010, In: Journal of Clinical Endocrinology and Metabolism. 95, 12, p. 5357-5364 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Changes in Anti-Müllerian Hormone (AMH) throughout the Life Span: A Population-Based Study of 1027 Healthy Males from Birth (Cord Blood) to the Age of 69 Years

    Aksglæde, L., Sørensen, K., Boas, M., Mouritsen, A. K. M., Hagen, C., Jensen, R., Petersen, Jørgen Holm, Linneberg, Allan René, Andersson, A., Main, Katharina Maria, Skakkebæk, Niels Erik & Juul, Anders, 2010, In: Journal of Clinical Endocrinology and Metabolism. 95, 12, p. 5357-5364 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Sex chromosome aneuploidy and anthropometry

    Aksglæde, L., Skakkebæk, Niels Erik & Juul, Anders, 2011, Handbook of Anthropometry: Physical measures of human form in health and disease. Springer

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

  17. Published

    Perinatal origin of testicular germ cell cancer: Possible involvement of developmental reprogramming

    Almstrup, H. K., Rajpert-De Meyts, E. & Skakkebæk, Niels Erik, 2012, Perinatal Programming: The State of the Art. Plagemann, A. (ed.). De Gruyter, p. 219-228 9 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  18. Published

    Carcinoma in situ testis displays permissive chromatin modifications similar to immature foetal germ cells

    Almstrup, Kristian, Nielsen, J. E., Mlynarska, O., Jansen, M. T., Jørgensen, A., Skakkebæk, Niels Erik & Rajpert-De Meyts, E., 12 Oct 2010, In: British Journal of Cancer. 103, 8, p. 1269-76 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Screening of subfertile men for testicular carcinoma in situ by an automated image analysis-based cytological test of the ejaculate

    Almstrup, Kristian, Lippert, M., Mogensen, H. O., Nielsen, J. E., Hansen, J. D., Daugaard, G., Jørgensen, N., Foged, N., Skakkebæk, Niels Erik & Rajpert-De Meyts, E., 1 Aug 2011, In: International Journal of Andrology. 34, 4 Pt 2, p. e21-30; discussion e30-1

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Genome-wide gene expression profiling of testicular carcinoma in situ progression into overt tumours

    Almstrup, Kristian, Høi-Hansen, Christina Engel, Nielsen, J. E., Wirkner, U., Ansorge, W., Skakkebæk, Niels Erik, Rajpert-De Meyts, E. & Leffers, H., 23 May 2005, In: British Journal of Cancer. 92, 10, p. 1934-1941 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    From embryonic stem cells to testicular germ cell cancer-- should we be concerned?

    Almstrup, Kristian, Sonne, Si Brask, Hoei-Hansen, C. E., Ottesen, A. M., Nielsen, J. E., Skakkebæk, Niels Erik, Leffers, H. & Rajpert-De Meyts, E., 2006, In: International Journal of Andrology. 29, 1, p. 211-8 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Analysis of cell-type-specific gene expression during mouse spermatogenesis

    Almstrup, Kristian, Nielsen, J. E., Hansen, M. A., Tanaka, M., Skakkebæk, Niels Erik & Leffers, H., Jun 2004, In: Biology of Reproduction. 70, 6, p. 1751-1761 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Improved gene expression signature of testicular carcinoma in situ

    Almstrup, Kristian, Leffers, H., Lothe, R. A., Skakkebæk, Niels Erik, Sonne, Si Brask, Nielsen, J. E., Rajpert-De Meyts, E. & Skotheim, R. I., 2007, In: International Journal of Andrology. 30, 4, p. 292-303

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Perinatal origin of testicular germ cell cancer: Possible involvement of developmental reprogramming

    Almstrup, Kristian, Meyts, E. R. D. & Skakkebæk, Niels Erik, 30 Nov 2011, Perinatal Programming: The State of the Art. Walter de Gruyter GmbH and Co. KG, p. 219-228 10 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  25. Published

    Embryonic stem cell-like features of testicular carcinoma in situ revealed by genome-wide gene expression profiling

    Almstrup, Kristian, Høi-Hansen, Christina Engel, Wirkner, U., Blake, J., Schwager, C., Ansorge, W., Nielsen, J. E., Skakkebæk, Niels Erik, Rajpert-De Meyts, E. & Leffers, H., 15 Jul 2004, In: Cancer Research. 64, 14, p. 4736-4743 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Genomic and gene expression signature of the pre-invasive testicular carcinoma in situ

    Almstrup, Kristian, Ottesen, A. M., Sonne, Si Brask, Hoei-Hansen, C. E., Leffers, H., Rajpert-De Meyts, E. & Skakkebæk, Niels Erik, 2005, In: Cell and Tissue Research. 322, 1, p. 159-65 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Paraoxonase 1 polymorphism and prenatal pesticide exposure associated with adverse cardiovascular risk profiles at school age

    Andersen, H. R., Veje, C. W., Dalgård, C., Christiansen, L. T., Main, Katharina Maria, Nellemann, C. L., Murata, K., Jensen, T. K., Skakkebæk, Niels Erik & Grandjean, P., 2012, In: P L o S One. 7, 5, p. e36830

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Serum inhibin B in healthy pubertal and adolescent boys: relation to age, stage of puberty, and follicle-stimulating hormone, luteinizing hormone, testosterone, and estradiol levels

    Andersson, A. M., Juul, Anders, Petersen, J. H., Müller, J., Groome, N. P. & Skakkebæk, Niels Erik, 1997, In: Journal of Clinical Endocrinology and Metabolism. 82, 12, p. 3976-81 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Endocrine disrupters: we need research, biomonitoring and action

    Andersson, A., Bay, K., Frederiksen, H. & Skakkebæk, Niels Erik, Jul 2016, In: Andrology. 4, 4, p. 556-60 5 p.

    Research output: Contribution to journal › Editorial › Research › peer-review

  30. Published

    Adverse trends in male reproductive health: we may have reached a crucial 'tipping point'

    Andersson, A., Jørgensen, N., Main, Katharina Maria, Toppari, J., Rajpert-De Meyts, E., Leffers, H., Juul, Anders, Jensen, T. K. & Skakkebæk, Niels Erik, 2008, In: International Journal of Andrology. 31, 2, p. 74-80 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Proceedings of the 5th Copenhagen Workshop on endocrine disrupters: ubiquitous endocrine disrupters and possible human health effects. Preface

    Andersson, A., Bay, K., Grigor, K. M., Toppari, J. & Skakkebæk, Niels Erik, 1 Apr 2010, In: International Journal of Andrology. 33, 2, p. 251 1 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Special issue on the impact of endocrine disrupters on reproductive health

    Andersson, A., Bay, K., Grigor, K. M., Meyts, E. R. & Skakkebæk, Niels Erik, 2012, In: International Journal of Andrology. 35, 3, p. 215

    Research output: Contribution to journal › Journal article › Research

  33. Published

    Secular decline in male testosterone and sex hormone binding globulin serum levels in Danish population surveys

    Andersson, A., Jensen, T. K., Juul, Anders, Petersen, Jørgen Holm, Jørgensen, T. & Skakkebæk, Niels Erik, 1 Dec 2007, In: Journal of Clinical Endocrinology and Metabolism. 92, 12, p. 4696-705 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Country-specific chemical signatures of persistent organic pollutants (POPs) in breast milk of French, Danish and Finnish women

    Antignac, J. P., Main, Katharina Maria, Virtanen, H. E., Boquien, C. Y., Marchand, P., Venisseau, A., Guiffard, I., Bichon, E., Wohlfahrt-Veje, C., Legrand, S., Boscher, C., Skakkebæk, Niels Erik, Toppari, J. & Le Bizec, B., Nov 2016, In: Environmental Pollution. 218, p. 728-738 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Bone mineral density is preserved in men with idiopathic infertility

    Antonio, L., Priskorn, L., Nordkap, L., Bang, A. K., Jensen, T. K., Skakkebæk, Niels Erik, Petersen, Jørgen Holm, Vanderschueren, D. & Jørgensen, N., 2020, In: Andrology. 8, 2, p. 315-322 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Assumed non-persistent environmental chemicals in human adipose tissue; matrix stability and correlation with levels measured in urine and serum

    Artacho-Cordón, F., Arrebola, J. P., Nielsen, O., Hernández, P., Skakkebæk, Niels Erik, Fernández, M. F., Andersson, A. M., Olea, N. & Frederiksen, H., Jul 2017, In: Environmental Research. 156, p. 120-127 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Proposed Key Characteristics of Male Reproductive Toxicants as an Approach for Organizing and Evaluating Mechanistic Evidence in Human Health Hazard Assessments

    Arzuaga, X., Smith, M. T., Gibbons, C. F., Skakkebæk, Niels Erik, Yost, E. E., Beverly, B. E. J., Hotchkiss, A. K., Hauser, R., Pagani, R. L., Schrader, S. M., Zeise, L. & Prins, G. S., 2019, In: Environmental Health Perspectives. 127, 6, p. 1-12 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Semen quality, reproductive hormones and fertility of men operated for hypospadias

    Asklund, C., Jensen, T. K., Main, Katharina Maria, Sobotka, T., Skakkebæk, Niels Erik & Jørgensen, N., 1 Feb 2010, In: International Journal of Andrology. 33, 1, p. 80-7 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Variations in repeated serum concentrations of UV filters, phthalates, phenols and parabens during pregnancy

    Assens, M., Frederiksen, H., Petersen, Jørgen Holm, Larsen, T., Skakkebæk, Niels Erik, Juul, Anders, Andersson, A. & Main, Katharina Maria, 2019, In: Environment International. 123, p. 318-324 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Is the FSHR 2039A>G variant associated with susceptibility to testicular germ cell cancer?

    Bang, A. K., Busch, A. S., Almstrup, Kristian, Gromoll, J., Kliesch, S., Rajpert-De Meyts, E., Skakkebæk, Niels Erik, Juul, Anders, Tüttelmann, F. & Jørgensen, N., 2018, In: Andrology. 6, 1, p. 176-183 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Reply to ‘Paracetamol use in pregnancy — caution over causal inference from available data’; ‘Handle with care — interpretation, synthesis and dissemination of data on paracetamol in pregnancy’

    Bauer, A. Z., Swan, S. H., Kriebel, D., Liew, Z., Taylor, H. S., Bornehag, C., M. Andrade, A., Olsen, J., Jensen, Rigmor Højland, Mitchell, R. T., Skakkebæk, Niels Erik & Kristensen, D. M., 2022, In: Nature Reviews Endocrinology. 18, 3, p. 192 1 p.

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  42. Published

    Paracetamol use during pregnancy — a call for precautionary action

    Bauer, A. Z., Swan, S. H., Kriebel, D., Liew, Z., Taylor, H. S., Bornehag, C., Andrade, A. M., Olsen, J., Jensen, Rigmor Højland, Mitchell, R. T., Skakkebæk, Niels Erik, Jégou, B. & Kristensen, D. M., 2021, In: Nature Reviews Endocrinology. 17, p. 757–766 10 p.

    Research output: Contribution to journal › Review › Research › peer-review

  43. Published

    Reply to ‘Paracetamol use in pregnancy — neglecting context promotes misinterpretation’

    Bauer, A. Z., Swan, S. H., Kriebel, D., Liew, Z., Taylor, H. S., Bornehag, C., Andrade, A. M., Olsen, J., Jensen, Rigmor Højland, Mitchell, R. T., Skakkebæk, Niels Erik & Kristensen, D. M., 2022, In: Nature Reviews Endocrinology. 18, 1 p., 386.

    Research output: Contribution to journal › Letter › Research › peer-review

  44. Published

    Paracetamol Use During Pregnancy - A Call for Precautionary Action

    Bauer, A. Z., Swan, S. H., Kriebel, D., Liew, Z., Taylor, H. S., Bornehag, C., Andrade, A. M., Olsen, J., Jensen, Rigmor Højland, Mitchell, R. T., Skakkebæk, Niels Erik, Jégou, B. & Kristensen, D. M., 2022, In: Obstetrical and Gynecological Survey. 77, 3, p. 133-134 2 p.

    Research output: Contribution to journal › Review › Research › peer-review

  45. Published

    Testicular dysgenesis syndrome: possible role of endocrine disrupters

    Bay, K., Asklund, C., Skakkebæk, Niels Erik & Andersson, A., 1 Mar 2006, In: Best Practice & Research: Clinical Endocrinology & Metabolism. 20, 1, p. 77-90 14 p.

    Research output: Contribution to journal › Journal article › Research

  46. Published

    Testicular descent: INSL3, testosterone, genes and the intrauterine milieu

    Bay, K., Main, Katharina Maria, Toppari, J., Skakkebæk, Niels Erik & Medscape, M., 15 Mar 2011, In: Nature Reviews. Urology.

    Research output: Contribution to journal › Journal article › Research

  47. Published

    Insulin-like factor 3 levels in second-trimester amniotic fluid

    Bay, K., Cohen, A. S., Jørgensen, Finn Stener, Jørgensen, C., Lind, A. M., Skakkebæk, Niels Erik & Andersson, A., 1 Oct 2008, In: Journal of Clinical Endocrinology and Metabolism. 93, 10, p. 4048-51 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Insulin-like factor 3 levels in cord blood and serum from children: effects of age, postnatal hypothalamic-pituitary-gonadal axis activation, and cryptorchidism

    Bay, K., Virtanen, H. E., Hartung, S., Ivell, R., Main, Katharina Maria, Skakkebæk, Niels Erik, Andersson, A., Toppari, J. & Nordic Cryptorchidism Study Group, N. C. S. G., 1 Oct 2007, In: Journal of Clinical Endocrinology and Metabolism. 92, 10, p. 4020-7 8 p.

    Research output: Contribution to journal › Journal article › Research

  49. Published

    Cotinine concentrations in maternal serum and amniotic fluid during pregnancy and risk of testicular germ cell cancer in the offspring: A prospective nested case-control study

    Beck, A. L., Uldbjerg, C. S., Lim, Youn-Hee, Coull, B. A., Sørensen, K. M., Utko, M. M., Wilkowski, B., Rantakokko, P., Bengtsson, M., Lindh, C., Petersen, Jørgen Holm, Skakkebæk, Niels Erik, Hauser, R., Juul, Anders & Bräuner, E. V., 2023, In: International Journal of Cancer. 154, 1, p. 71-80 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Klinefelter syndrome comorbidities linked to increased X chromosome gene dosage and altered protein interactome activity

    Belling, K., Russo, F., Jensen, A. B., Dalgaard, M. D., Westergaard, David, Rajpert-De Meyts, E., Skakkebæk, Niels Erik, Juul, Anders & Brunak, Søren, 1 Apr 2017, In: Human Molecular Genetics. 26, 7, p. 1219-1229 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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ID: 35319116