Niels Erik Skakkebæk

Niels Erik Skakkebæk

Affiliate Professor

Member of:

  • Paediatrics


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  1. Published

    Association of in utero exposure to maternal smoking with reduced semen quality and testis size in adulthood: a cross-sectional study of 1,770 young men from the general population in five European countries

    Jensen, T. K., Jørgensen, N., Punab, M., Haugen, T. B., Suominen, J., Zilaitiene, B., Horte, A., Andersen, A., Carlsen, E., Magnus, Ø., Matulevicius, V., Nermoen, I., Vierula, M., Keiding, N., Toppari, J. & Skakkebæk, Niels Erik, 2004, In: American Journal of Epidemiology. 159, 1, p. 49-58 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Distinguishing between hidden testes and anorchia: The role of endocrine evaluation in infancy and childhood

    Jespersen, K., Ljubicic, M. L., Johannsen, T. H., Christiansen, P., Skakkebæk, Niels Erik & Juul, Anders, 2020, In: European Journal of Endocrinology. 183, 1, p. 107-117 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Exposure to phenols, parabens and UV filters: Associations with loss-of-function mutations in the filaggrin gene in men from the general population

    Joensen, U. N., Jørgensen, N., Thyssen, Jacob Pontoppidan, Petersen, Jørgen Holm, Szecsi, P. B., Stender, S., Andersson, A. M., Skakkebæk, Niels Erik & Frederiksen, H., 2017, In: Environment International. 105, p. 105-111

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Testicular dysgenesis syndrome and carcinoma in situ of the testes

    Joensen, Ulla Nordström, Jorgensen, N. & Skakkebæk, Niels Erik, Aug 2007, In: Nature Clinical Practice Urology. 4, 8, p. 402-403 2 p.

    Research output: Contribution to journal › Review › Research › peer-review

  5. Published

    Erratum: PFOS (perfluorooctanesulfonate) in serum is negatively associated with testosterone levels, but not with semen quality, in healthy men (Human Reproduction (2013) 28 (599-608))

    Joensen, Ulla Nordström, Veyrand, B., Antignac, J. P., Jensen, Martin Blomberg, Petersen, Jørgen Holm, Marchand, P., Skakkebæk, Niels Erik, Andersson, A. M., Le Bizec, B. & Jorgensen, N., 2014, In: Human Reproduction. 29, 7, p. 1600 1 p.

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  6. Published

    Is there a problem with male reproduction?

    Joensen, Ulla Nordström, Skakkebæk, Niels Erik & Jørgensen, N., 2009, In: Nature Clinical Practice Endocrinology & Metabolism. 5, 3, p. 144-5 1 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    PFOS (perfluorooctanesulfonate) in serum is negatively associated with testosterone levels, but not with semen quality, in healthy men

    Joensen, Ulla Nordström, Veyrand, B., Antignac, J. P., Jensen, Martin Blomberg, Petersen, Jørgen Holm, Marchand, P., Skakkebæk, Niels Erik, Andersson, A. M., Le Bizec, B. & Jørgensen, N., Mar 2013, In: Human Reproduction. 28, 3, p. 599-608 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Do perfluoroalkyl compounds impair human semen quality?

    Joensen, Ulla Nordström, Bossi, R., Leffers, H., Jensen, A. A., Skakkebæk, Niels Erik & Jørgensen, N., 2009, In: Environmental Health Perspectives. 117, 6, p. 923-7 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Associations of Filaggrin Gene Loss-of-Function Variants with Urinary Phthalate Metabolites and Testicular Function in Young Danish Men

    Joensen, U. N., Jørgensen, N., Meldgaard, M., Frederiksen, H., Andersson, A., Menné, T., Johansen, Jeanne Duus, Carlsen, B. C., Stender, S., Szecsi, P. B., Skakkebæk, Niels Erik, De Meyts, E. R. & Thyssen, Jacob Pontoppidan, Apr 2014, In: Environmental Health Perspectives. 122, 4, p. 345-350 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Serum concentrations of free and total insulin-like growth factor-I, IGF binding proteins -1 and -3 and IGFBP-3 protease activity in boys with normal or precocious puberty

    Juul, Anders, Flyvbjerg, A., Frystyk, J., Müller, J. & Skakkebæk, Niels Erik, 1996, In: Clinical Endocrinology. 44, 5, p. 515-23 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Impaired thermoregulation in adults with growth hormone deficiency during heat exposure and exercise

    Juul, Anders, Behrenscheer, A., Tims, T., Nielsen, B., Halkjaer-Kristensen, J. & Skakkebæk, Niels Erik, 1993, In: Clinical Endocrinology. 38, 3, p. 237-244 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Prediction of the outcome of growth hormone provocative testing in short children by measurement of serum levels of insulin-like growth factor I and insulin-like growth factor binding protein 3

    Juul, Anders & Skakkebæk, Niels Erik, 1997, In: Journal of Pediatrics. 130, 2, p. 197-204 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Growth hormone deficiency and hyperthermia during exercise: a controlled study of sixteen GH-deficient patients

    Juul, Anders, Hjortskov, N., Jepsen, L., Nielsen, B., Halkjaer-Kristensen, J., Vahl, N., Jørgensen, J. O., Christiansen, J. S. & Skakkebæk, Niels Erik, 1995, In: Journal of Clinical Endocrinology and Metabolism. 80, 11, p. 3335-40 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Serum levels of insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) in healthy infants, children, and adolescents: the relation to IGF-I, IGF-II, IGFBP-1, IGFBP-2, age, sex, body mass index, and pubertal maturation

    Juul, Anders, Dalgaard, P., Blum, W. F., Bang, P., Hall, K. P., Michaelsen, K. F., Müller, J. & Skakkebæk, Niels Erik, 1995, In: Journal of Clinical Endocrinology and Metabolism. 80, 8, p. 2534-42 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Serum insulin-like growth factor-I in 1030 healthy children, adolescents, and adults: relation to age, sex, stage of puberty, testicular size, and body mass index

    Juul, Anders, Bang, P., Hertel, N., Main, Katharina Maria, Dalgaard, P., Jørgensen, K., Müller, J., Hall, K. P. & Skakkebæk, Niels Erik, 1994, In: Journal of Clinical Endocrinology and Metabolism. 78, 3, p. 744-52 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Growth hormone (GH) provocative retesting of 108 young adults with childhood-onset GH deficiency and the diagnostic value of insulin-like growth factor I (IGF-I) and IGF-binding protein-3

    Juul, Anders, Kastrup, K. W., Pedersen, S. A. & Skakkebæk, Niels Erik, 1997, In: Journal of Clinical Endocrinology and Metabolism. 82, 4, p. 1195-201 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Growth hormone deficiency and hyperthermia

    Juul, Anders & Skakkebæk, Niels Erik, 1991, In: Lancet. 338, 8771, p. 887

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Effects of growth hormone replacement therapy on IGF-related parameters and on the pituitary-gonadal axis in GH-deficient males. A double-blind, placebo-controlled crossover study

    Juul, Anders, Andersson, A. M., Pedersen, S. A., Jørgensen, J. O., Christiansen, J. S., Groome, N. P. & Skakkebæk, Niels Erik, 1998, In: Hormone Research. 49, 6, p. 269-78 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Pubertal development in Danish children: comparison of recent European and US data

    Juul, Anders, Teilmann, Grete Katrine, Scheike, T. H., Hertel, N., Holm, Kirsten, Laursen, E., Main, Katharina Maria & Skakkebæk, Niels Erik, 2006, In: International Journal of Andrology. 29, 1, p. 247-55; discussion 286-90

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Preserved fertility in a non-mosaic Klinefelter patient with a mutation in the fibroblast growth factor receptor 3 gene: case report

    Juul, Anders, Aksglaede, L., Lund, Allan Meldgaard, Duno, M., Skakkebæk, Niels Erik & Rajpert-De Meyts, E., 2007, In: Human Reproduction. 22, 7, p. 1907-11 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    The ratio between serum levels of insulin-like growth factor (IGF)-I and the IGF binding proteins (IGFBP-1, 2 and 3) decreases with age in healthy adults and is increased in acromegalic patients

    Juul, Anders, Main, Katharina Maria, Blum, W. F., Lindholm, J., Ranke, M. B. & Skakkebæk, Niels Erik, 1994, In: Clinical Endocrinology. 41, 1, p. 85-93 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Prostate specific antigen in boys with precocious puberty before and during gonadal suppression by GnRH agonist treatment

    Juul, Anders, Müller, J. & Skakkebæk, Niels Erik, 1997, In: European Journal of Endocrinology. 136, 4, p. 401-5 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Serum levels of growth hormone binding protein in children with normal and precocious puberty: relation to age, gender, body composition and gonadal steroids

    Juul, Anders, Fisker, S., Scheike, T. H., Hertel, T. K., Müller, J., Orskov, H. & Skakkebæk, Niels Erik, 2000, In: Clinical Endocrinology. 52, 2, p. 165-72 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    The acid-labile subunit of human ternary insulin-like growth factor binding protein complex in serum: hepatosplanchnic release, diurnal variation, circulating concentrations in healthy subjects, and diagnostic use in patients with growth hormone deficiency

    Juul, Anders, Møller, S., Mosfeldt-Laursen, E., Rasmussen, M. H., Scheike, T. H., Pedersen, S. A., Kastrup, K. W., Yu, H., Mistry, J., Rasmussen, S., Müller, J., Henriksen, J. & Skakkebæk, Niels Erik, 1998, In: Journal of Clinical Endocrinology and Metabolism. 83, 12, p. 4408-15 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Growth hormone (GH) treatment increases serum insulin-like growth factor binding protein-3, bone isoenzyme alkaline phosphatase and forearm bone mineral content in young adults with GH deficiency of childhood onset

    Juul, Anders, Pedersen, S. A., Sørensen, S., Winkler, K., Jørgensen, J. O., Christiansen, J. S. & Skakkebæk, Niels Erik, 1994, In: European Journal of Endocrinology. 131, 1, p. 41-9 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Serum insulin-like growth factor I (IGF-I) and IGF-binding protein 3 levels are increased in central precocious puberty: effects of two different treatment regimens with gonadotropin-releasing hormone agonists, without or in combination with an antiandrogen (cyproterone acetate)

    Juul, Anders, Scheike, T. H., Nielsen, C. T., Krabbe, S., Müller, J. & Skakkebæk, Niels Erik, 1995, In: Journal of Clinical Endocrinology and Metabolism. 80, 10, p. 3059-67 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Changes in serum concentrations of growth hormone, insulin, insulin-like growth factor and insulin-like growth factor-binding proteins 1 and 3 and urinary growth hormone excretion during the menstrual cycle

    Juul, Anders, Scheike, T. H., Pedersen, Anette Tønnes, Main, Katharina Maria, Andersson, A. M., Pedersen, L. M. & Skakkebæk, Niels Erik, 1997, In: Human Reproduction. 12, 10, p. 2123-8 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Free insulin-like growth factor I serum levels in 1430 healthy children and adults, and its diagnostic value in patients suspected of growth hormone deficiency

    Juul, Anders, Holm, Kirsten, Kastrup, K. W., Pedersen, S. A., Michaelsen, K. F., Scheike, T. H., Rasmussen, S., Müller, J. & Skakkebæk, Niels Erik, 1997, In: Journal of Clinical Endocrinology and Metabolism. 82, 8, p. 2497-502 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Testosteronbehandling af ældre mænd: den såkaldte andropause eksisterer ikke.

    Juul, Anders & Skakkebæk, Niels Erik, 2002, In: Ugeskrift for Laeger. 164, 42, p. 4941-2 2 p.

    Research output: Contribution to journal › Review › Research

  30. Published

    Possible fetal determinants of male infertility

    Juul, Anders, Almstrup, Kristian, Andersson, A., Jensen, T. K., Jørgensen, N., Main, K. M., Rajpert-De Meyts, E., Toppari, J. & Skakkebæk, Niels Erik, Sep 2014, In: Nature Reviews Endocrinology. 10, 9, p. 553-562 10 p.

    Research output: Contribution to journal › Review › Research › peer-review

  31. Published

    Androgens and the ageing male

    Juul, Anders & Skakkebæk, Niels Erik, 2002, In: Human Reproduction Update. 8, 5, p. 423-33 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Diagnosis of GH deficiency and use of GH in children with growth disorders. A report from the Drugs and Therapeutics Committee of European Society for paediatric Endocrinology

    Juul, Anders, Bernasconi, S., Chatelain, P., Hindsmarsh, P., Hochberg, Z., Hokke-Koelega, A., De Muinck Keizer-Schrama, S., Kiess, W., Oberfield, S., Strasburger, C., Volta, C., Westphal, O. & Skakkebæk, Niels Erik, 1999, In: Hormone Research. 51, p. 284-299 15 p.

    Research output: Contribution to journal › Review › Research

  33. Published

    Development: disorders of sex development-the tip of the iceberg?

    Juul, Anders, Main, Katharina Maria & Skakkebæk, Niels Erik, 1 Jan 2011, In: Nature Reviews Endocrinology. 7, 9, p. 504-5 2 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Age at voice break in Danish boys: effects of pre-pubertal body mass index and secular trend

    Juul, Anders, Magnusdottir, S., Scheike, T., Prytz, S. & Skakkebæk, Niels Erik, 1 Dec 2007, In: International Journal of Andrology. 30, 6, p. 537-42 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Klinefelter syndrome: the forgotten syndrome: basic and clinical questions posed to an international group of scientists

    Juul, Anders, Aksglaede, L., Bay, K., Grigor, K. M. & Skakkebæk, Niels Erik, 1 Jun 2011, In: Acta Paediatrica. 100, 6, p. 791-2 2 p.

    Research output: Contribution to journal › Conference article › Research

  36. Published

    Væksthormon - virker på andet end væksten.

    Juul, Anders & Skakkebæk, Niels Erik, 1997, Medicinsk Årbog 1997. p. 9-15 6 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

  37. Published

    Metabolic effects of GH: a rationale for continued GH treatment of GH-deficient adults after cessation of linear growth.

    Juul, Anders, Jørgensen, J., Christiansen, J., Müller, J. & Skakkebæk, Niels Erik, 1995, In: Hormone Research. p. 64-72 8 p.

    Research output: Contribution to journal › Review › Research

  38. Published

    Growth hormone treatment in GH-deficient adults; therapeutic and diagnostic aspects.

    Juul, Anders, Jørgensen, J., müller, J. & Skakkebæk, Niels Erik, 1994, In: Clinical Pediatric Endocrinology. p. 63-71 8 p.

    Research output: Contribution to journal › Review › Research

  39. Published

    Why Do Normal Children Have Acromegalic Levels of IGF-I During Puberty?

    Juul, Anders & Skakkebæk, Niels Erik, 2019, In: The Journal of clinical endocrinology and metabolism. 104, 7, p. 2770-2776

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    The Human Eccrine Sweat Gland: A possible GRowth hormone target organ ?

    Juul, Anders, Nielsen, B., Hjortskov, N., Main, Katharina Maria & Skakkebæk, Niels Erik, 1997, The Clinical Pharmacology of Sports and Exercise.. p. 223 7 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

  41. Published

    GH-deficiency, sweating and thermoregulations

    Juul, Anders, Main, Katharina Maria, Hjortskov, N., Jepsen, L., Nielsen, B., Halkjær-Kristensen, J. & Skakkebæk, Niels Erik, 1996, Growth Hormone in adults; Physiological and clinical aspects. p. 246 5 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

  42. Published

    Consequences of stopping Growth hormone (GH) therapy in young GH-deficient patients with childhood-onset disease

    Juul, Anders, Vahl, N., Jørgensen, J., Christiansen, J. & Skakkebæk, Niels Erik, 1998, In: Growth Hormone & I G F Research. p. 15-19 4 p.

    Research output: Contribution to journal › Review › Research

  43. Published

    Disorders of sexual differentiation-the tip of the iceberg?

    Juul, Anders, Main, Katharina Maria & Skakkebæk, Niels Erik, 2011, In: Nature Reviews Endocrinology. 7, p. 504-5 1 p.

    Research output: Contribution to journal › Letter › Research

  44. Published

    Vækst og Regeration

    Juul, Anders, Korndrup, J. & Skakkebæk, Niels Erik, 1999, Medicinsk Kompendium. 15 ed. p. 140-148 8 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

  45. Published

    Growth hormone (GH), exercise performance, muscle strength and sweat production in healthy subjects and adults with GH deficiency

    Juul, Anders, Main, Katharina Maria & Skakkebæk, Niels Erik, 2000, Growth Hormone in adults; Physiological and clinical aspects. 2 ed. p. 281-300 19 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

  46. Published

    Nodal Signaling Regulates Germ Cell Development and Establishment of Seminiferous Cords in the Human Fetal Testis

    Jørgensen, A., Macdonald, J., Nielsen, J. E., Kilcoyne, K. R., Perlman, S., Lundvall, L., Langhoff Thuesen, L., Hare, Kristine Juul, Frederiksen, H., Andersson, A., Skakkebæk, Niels Erik, Juul, Anders, Sharpe, R. M., Rajpert-De Meyts, E. & Mitchell, R. T., 13 Nov 2018, In: Cell Reports. 25, 7, p. 1924-1937.e4

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Pathogenesis of germ cell neoplasia in testicular dysgenesis and disorders of sex development

    Jørgensen, A., Lindhardt Johansen, M., Juul, Anders, Skakkebæk, Niels Erik, Main, Katharina Maria & Rajpert-De Meyts, E., Sep 2015, In: Seminars in Cell and Developmental Biology. 45, p. 124-37 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Adult Growth Hormone Deficiency

    Jørgensen, J., Müller, J., Wolthers, T., Vahn, N., Juul, Anders & Skakkebæk, Niels Erik, 1994, In: Hormone Research. 42, p. 235-241 6 p.

    Research output: Contribution to journal › Review › Research

  49. Published

    Growth hormone (GH)-deficiency in adults: clinical features and effects of GH substitution.

    Jørgensen, J., Møller, J., Wolthers, T., Vahn, N., Juul, Anders, Skakkebæk, Niels Erik & Christiansen, J., 1994, In: The journal of pediatric endocrinology. p. 283-293 10 p.

    Research output: Contribution to journal › Journal article › Research

  50. Published

    Impact of growth hormone administration on other hormonal axes.

    Jørgensen, J., Ovesen, P., Juul, Anders, Hansen, T., Skakkebæk, Niels Erik & Christiansen, J., 1999, In: Hormone Research. 51, p. 121-126 5 p.

    Research output: Contribution to journal › Review › Research

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