Niels Erik Skakkebæk

Niels Erik Skakkebæk

Affiliate Professor

Member of:

  • Paediatrics


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  1. Published

    Anogenital distance as a phenotypic signature through infancy

    Priskorn, L., Petersen, Jørgen Holm, Jørgensen, N., Kyhl, H. B., Andersen, M. S., Main, Katharina Maria, Andersson, A., Skakkebæk, Niels Erik & Jensen, T. K., 2018, In: Pediatric Research. 83, 3, p. 573-579 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Familial resemblance in markers of testicular function in fathers and their young sons: a cross-sectional study

    Priskorn, L., Joensen, Ulla Nordström, Petersen, Jørgen Holm, Jensen, T. K., Skakkebæk, Niels Erik & Jørgensen, N., 2021, In: Human reproduction (Oxford, England). 36, 3, p. 543-550 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Adverse trends in male reproductive health and decreasing fertility rates

    Priskorn, L., Holmboe, S., Jørgensen, N., Andersson, A., Almstrup, Kristian, Toppari, J. & Skakkebæk, Niels Erik, 2012, In: Animal Reproduction Science. 31, 2, p. 760-771 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Is Sedentary Lifestyle Associated With Testicular Function? A Cross-Sectional Study of 1,210 Men

    Priskorn, L., Jensen, T. K., Bang, A. K., Nordkap, L., Joensen, Ulla Nordström, Lassen, T. H., Olesen, I. A., Swan, S. H., Skakkebæk, Niels Erik & Jørgensen, N., 15 Aug 2016, In: American Journal of Epidemiology. 184, 4, p. 284-294 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    High maternal age at first and subsequent child births in Denmark in the mid-1800s-Letter to the editor

    Priskorn, L., Dahl, C. L., Pihl, A. S., Skakkebæk, Niels Erik & Juul, Anders, Oct 2019, In: European Journal of Obstetrics & Gynecology and Reproductive Biology. 241, p. 137-138 2 p.

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  6. Published

    Increasing trends in childlessness in recent birth cohorts - a registry-based study of the total Danish male population born from 1945 to 1980

    Priskorn, L., Holmboe, S., Jacobsen, R., Jensen, T. K., Lassen, T. H. & Skakkebæk, Niels Erik, 2012, In: International Journal of Andrology. 35, 3, p. 449-55 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Semen quality of young men in Switzerland: a nationwide cross-sectional population-based study

    Rahban, R., Priskorn, L., Senn, A., Stettler, E., Galli, F., Vargas, J., Van den Bergh, M., Fusconi, A., Garlantezec, R., Jensen, T. K., Multigner, L., Skakkebæk, Niels Erik, Germond, M., Jørgensen, N., Nef, S. & The NICER Working Group, T. N. W. G., 2019, In: Andrology. 7, 6, p. 818-826

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    The antidepressant Sertraline inhibits CatSper Ca2+channels in human sperm

    Rahban, R., Rehfeld, Anders Aagaard, Schiffer, C., Brenker, C., Egeberg Palme, D. L., Wang, T., Lorenz, J., Almstrup, Kristian, Skakkebæk, Niels Erik, Strünker, T. & Nef, S., 2021, In: Human Reproduction. 36, 10, p. 2638-2648

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Increasing international efforts to understand and conquer testicular germ cell cancer

    Rajpert-De Meyts, E., Daugaard, G., Almstrup, Kristian, Jørgensen, A., Rørth, M., Jørgensen, N., von der Maase, H. & Skakkebæk, Niels Erik, Jan 2015, In: Andrology. 3, 1, p. 1-3 3 p.

    Research output: Contribution to journal › Editorial › Research › peer-review

  10. Published

    Changes in the profile of simple mucin-type O-glycans and polypeptide GalNAc-transferases in human testis and testicular neoplasms are associated with germ cell maturation and tumour differentiation

    Rajpert-De Meyts, E., Poll, S. N., Goukasian, I., Jeanneau, C., Herlihy, A. S., Bennett, Eric Paul, Skakkebæk, Niels Erik, Clausen, Henrik, Giwercman, A. & Mandel, Ulla, 2007, In: Virchows Archiv. 451, 4, p. 805-14 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Goodbye International Journal of Andrology, welcome Andrology!

    Rajpert-De Meyts, E., Eliasson, R., Comhaire, F. H., Skakkebæk, Niels Erik, Sharpe, R. M. & Toppari, J., 2022, In: Andrology. 10, S2, p. 133-138

    Research output: Contribution to journal › Editorial › Research › peer-review

  12. Published

    Prolonged expression of the c-kit receptor in germ cells of intersex fetal testes

    Rajpert-De Meyts, E., Jørgensen, N., Müller, J. & Skakkebæk, Niels Erik, 1 Feb 1996, In: Journal of Pathology. 178, 2, p. 166-9 4 p.

    Research output: Contribution to journal › Journal article › Research

  13. Published

    The testis in childhood between birth and puberty

    Rajpert-De Meyts, E., Almstrup, H. K. & Skakkebæk, Niels Erik, 2012, Atlas on the Human Testis: Normal Morphology and Pathology. p. 69-75 6 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  14. Published

    Goodbye International Journal of Andrology, welcome Andrology!

    Rajpert-De Meyts, E., Eliasson, R., Comhaire, F. H., Skakkebæk, Niels Erik, Sharpe, R. M. & Toppari, J., 2012, In: International Journal of Andrology. 36, 6, p. 769-774 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Pathogenesis of testicular carcinoma in situ and germ cell cancer: still more questions than answers

    Rajpert-De Meyts, E. & Skakkebæk, Niels Erik, 1 Aug 2011, In: International Journal of Andrology. 34, 4 Pt 2, p. e2-6

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Optimised detection of germ cell neoplasia in situ in contralateral biopsy reduces the risk of second testis cancer

    Rajpert-De Meyts, E., Jørgensen, N., Petersen, Jørgen Holm, Almstrup, Kristian, Aksglaede, L., Lauritsen, J., Rørth, M., Daugaard, G. & Skakkebæk, Niels Erik, 2022, In: BJU International. 130, 5, p. 646-654 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Proceedings of the 7th Copenhagen Workshop on Testicular Carcinoma in situ and Germ Cell Cancer, 13-15 October 2010

    Rajpert-De Meyts, E., Grigor, K. M. & Skakkebæk, Niels Erik, 1 Aug 2011, In: International Journal of Andrology. 34, 4 Pt 2, p. e1

    Research output: Contribution to journal › Journal article › Research

  18. Published

    Testicular Dysgenesis Syndrom and Carcinoma In Situ Testis

    Rajpert-De Meyts, E., Almstrup, H. K. & Skakkebæk, Niels Erik, 2012, Atlas on the Human Testis. Jezek, D. (ed.). p. 159-178 19 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  19. Published

    Testicular cancer: New inroads into early diagnosis

    Rajpert-De Meyts, E., Znaor, A. & Skakkebæk, Niels Erik, 2020, World Cancer Report: Cancer Research for Cancer Prevention. Wild, C. P., Weiderpass, E. & Stewart, B. W. (eds.). IARC Press, p. 430-438 (World Cancer Reports).

    Research output: Chapter in Book/Report/Conference proceeding › Report chapter › Research › peer-review

  20. Published

    Cryptorchidism, hypospadias, testicular tumours and testicular dysgenesis syndrome

    Rajpert-De Meyts, E., Main, Katharina Maria, Toppari, J. & Skakkebæk, Niels Erik, 2010, Endocrinology.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  21. Published

    Origin of testicular germ cell neoplasia: The role of sex chromosomes

    Rajpert-De Meyts, E., Ottesen, A. M., Høi-Hansen, Christina Engel, Sonne, Si Brask, Leffers, H. & Skakkebæk, Niels Erik, 1 Jan 2007, The Y Chromosome and Male Germ Cell Biology in Health and Diseases. World Scientific Publishing Co., p. 289-308 20 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  22. Published

    Histopathological Evaluation of Testicular Biopsy

    Rajpert-de Meyts, E., Grigor, K. M. & Skakkebæk, Niels Erik, 2017, Endocrinology of the Testis and Male Reproduction. SimoniIlpo, M. & Huhtaniemi, I. (eds.). p. 1-20 (Endocrinology of the Testis and Male Reproduction).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  23. Published

    Massive weight loss restores 24-hour growth hormone release profiles and serum insulin-like growth factor-I levels in obese subjects

    Rasmussen, M. H., Hvidberg, A., Juul, Anders, Main, Katharina Maria, Gotfredsen, A., Skakkebæk, Niels Erik, Hilsted, J. & Skakkebae, N. E., 1995, In: Journal of Clinical Endocrinology and Metabolism. 80, 4, p. 1407-15 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Lack of stimulation of 24-hour growth hormone release by hypocaloric diet in obesity

    Rasmussen, M. H., Juul, Anders, Kjems, L. L., Skakkebæk, Niels Erik & Hilsted, J., 1995, In: Journal of Clinical Endocrinology and Metabolism. 80, 3, p. 796-801 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Prenatal and adult exposures to smoking are associated with adverse effects on reproductive hormones, semen quality, final height and body mass index

    Ravnborg, T. L., Jensen, T. K., Andersson, A., Toppari, J., Skakkebæk, Niels Erik & Jørgensen, N., 18 Feb 2011, In: Human Reproduction. 26, 5, p. 1000-1011 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Human sperm cells can form paracetamol metabolite AM404 that directly interferes with sperm calcium signalling and function through a CatSper-dependent mechanism

    Rehfeld, Anders Aagaard, Frederiksen, H., Rasmussen, R. H., David, A., Chaker, J., Nielsen, B. S., Nielsen, J. E., Juul, Anders, Skakkebæk, Niels Erik & Kristensen, D. M., 2022, In: Human reproduction (Oxford, England). 37, 5, p. 922-935 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Chemical UV Filters Mimic the Effect of Progesterone on Ca(2+) Signaling in Human Sperm Cells

    Rehfeld, Anders Aagaard, Dissing, Steen & Skakkebæk, Niels Erik, Nov 2016, In: Endocrinology. 157, 11, p. 4297-4308 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Bisphenol A Diglycidyl Ether (BADGE) and Bisphenol Analogs, but Not Bisphenol A (BPA), Activate the CatSper Ca2+ Channel in Human Sperm

    Rehfeld, Anders Aagaard, Andersson, A. M. & Skakkebæk, Niels Erik, 2020, In: Frontiers in Endocrinology. 11, 11 p., 324.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Medium-throughput Screening Assays for Assessment of Effects on Ca2+-Signaling and Acrosome Reaction in Human Sperm

    Rehfeld, Anders Aagaard, Palme, D. L. E., Almstrup, Kristian, Juul, Anders & Skakkebæk, Niels Erik, 2019, In: Journal of Visualized Experiments. 145, p. e59212

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    EDC IMPACT: Chemical UV filters can affect human sperm function in a progesterone-like manner

    Rehfeld, Anders Aagaard, Egeberg, D., Almstrup, Kristian, Petersen, Jørgen Holm, Dissing, Steen & Skakkebæk, Niels Erik, 2018, In: Endocrine Connections. 7, 1, p. 16-25

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Medium-throughput Screening Assays for Assessment of Effects on Ca2+-Signaling and Acrosome Reaction in Human Sperm

    Rehfeld, A., Egeberg Palme, D. L., Almstrup, K., Juul, Anders & Skakkebæk, Niels Erik, 1 Mar 2019, In: Journal of visualized experiments : JoVE. 145, 9 p., e59212.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Bisphenol A Diglycidyl Ether (BADGE) and Progesterone Do Not Induce Ca2+ Signals in Boar Sperm Cells

    Rehfeld, Anders Aagaard, Mendoza, N., Ausejo, R. & Skakkebæk, Niels Erik, 2020, In: Frontiers in Physiology. 11, p. 785

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    An update on semen quality among young Finnish men and comparison with Danish data

    Rodprasert, W., Virtanen, H. E., Sadov, S., Perheentupa, A., Skakkebæk, Niels Erik, Jørgensen, N. & Toppari, J., 2019, In: Andrology. 7, 1, p. 15-23 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Reproductive Markers of Testicular Function and Size During Puberty in Boys With and Without a History of Cryptorchidism

    Rodprasert, W., Koskenniemi, J. J., Virtanen, H. E., Sadov, S., Perheentupa, A., Ollila, H., Albrethsen, J., Andersson, A., Juul, Anders, Skakkebæk, Niels Erik, Main, Katharina Maria & Toppari, J., 2022, In: The Journal of clinical endocrinology and metabolism. 107, 12, p. 3353-3361 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Sperm retrieval in adolescent males with Klinefelter syndrome: medical and ethical issues

    Rogol, A. D. & Skakkebæk, Niels Erik, Apr 2016, In: Translational Pediatrics. 5, 2, p. 104-106

    Research output: Contribution to journal › Comment/debate › Research

  36. Published

    Sperm Concentration, Testicular Volume and Age Predict Risk of Carcinoma In Situ in Contralateral Testis of Men with Testicular Germ Cell Cancer

    Rud, C. N., Daugaard, G., Rajpert-De Meyts, E., Skakkebæk, Niels Erik, Petersen, Jørgen Holm & Jørgensen, N., 2013, In: Journal of Urology. 190, 6, p. 2074-2080 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Contralateral biopsy in the management of testicular cancer: what we have learned and what we need to improve

    Rørth, M., Grigor, K. M., Jørgensen, N., Skakkebæk, Niels Erik & Rajpert-De Meyts, E., Jan 2015, In: Andrology. 3, 1, p. 99-101 3 p.

    Research output: Contribution to journal › Editorial › Research

  38. Published

    Carcinoma in situ in the testis

    Rørth, M., Rajpert-De Meyts, E., Andersson, L., Dieckmann, Peter, Fosså, S. D., Grigor, K. M., Hendry, W. F., Herr, H. W., Looijenga, L. H., Oosterhuis, J. W. & Skakkebæk, Niels Erik, 2000, In: Scandinavian Journal of Urology and Nephrology, Supplementum. 205, p. 166-86 20 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Testicular Growth During Puberty in Boys With and Without a History of Congenital Cryptorchidism

    Sadov, S., Koskenniemi, J. J., Virtanen, H. E., Perheentupa, A., Petersen, Jørgen Holm, Skakkebæk, Niels Erik, Main, Katharina Maria & Toppari, J., Jun 2016, In: The Journal of Clinical Endocrinology & Metabolism. 101, 6, p. 2570–2577 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Serum testosterone levels in three-month-old boys predict their semen quality as young adults

    Scheutz Henriksen, L., Petersen, Jørgen Holm, Skakkebæk, Niels Erik, Jørgensen, N., Virtanen, H. E., Priskorn, Lærke, Juul, Anders, Toppari, J. & Main, Katharina Maria, 2022, In: The Journal of clinical endocrinology and metabolism. 107, 7, p. 1965–1975 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Direct action of endocrine disrupting chemicals on human sperm

    Schiffer, C., Müller, A., Egeberg, D. L., Alvarez, L., Brenker, C., Rehfeld, Anders Aagaard, Frederiksen, H., Wäschle, B., Kaupp, U. B., Balbach, M., Wachten, D., Skakkebæk, Niels Erik, Almstrup, Kristian & Strünker, T., Jul 2014, In: E M B O Reports. 15, 7, p. 758-65 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Testicular germ cell cancer incidence in an immigration perspective, Denmark, 1978 to 2003

    Schmiedel, S., Schüz, J., Skakkebæk, Niels Erik & Johansen, C., 1 Apr 2010, In: Journal of Urology. 183, 4, p. 1378-82 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Testicular seminoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

    Schmoll, H., Jordan, K., Huddart, R., Pes, M. P. L., Horwich, A., Fizazi, K., Kataja, V., Rajpert-De Meyts, E., Skakkebæk, Niels Erik, ESMO Guidelines Working Group, E. G. W. G. & von der Maase, H. R. R., 1 May 2010, In: Annals of Oncology. 21 Suppl 5, p. v140-6

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Testicular non-seminoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

    Schmoll, H., Jordan, K., Huddart, R., Pes, M. P. L., Horwich, A., Fizazi, K., Kataja, V., Rajpert-De Meyts, E., Skakkebæk, Niels Erik, ESMO Guidelines Working Group, E. G. W. G. & von der Maase, H. R. R., 1 May 2010, In: Annals of Oncology. 21 Suppl 5, p. v147-54

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Serum inhibin A and inhibin B in healthy prepubertal, pubertal, and adolescent girls and adult women: relation to age, stage of puberty, menstrual cycle, follicle-stimulating hormone, luteinizing hormone, and estradiol levels

    Sehested, A., Juul, Anders, Andersson, A. M., Petersen, Jørgen Holm, Jensen, T. K., Müller, J. & Skakkebæk, Niels Erik, 2000, In: Journal of Clinical Endocrinology and Metabolism. 85, 4, p. 1634-40 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Gene expression profiles of mouse spermatogenesis during recovery from irradiation

    Shah, F. J., Tanaka, M., Nielsen, J. E., Iwamoto, T., Kobayashi, S., Skakkebæk, Niels Erik, Leffers, H., Almstrup, K., Shah, F. J., Tanaka, M., Nielsen, J. E., Iwamoto, T., Kobayashi, S., Skakkebæk, Niels Erik, Leffers, H. & Almstrup, Kristian, 1 Jan 2009, In: Reproductive Biology and Endocrinology. 7, p. 130

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    In vitro bioassay investigations of the endocrine disrupting potential of steviol glycosides and their metabolite steviol, components of the natural sweetener Stevia

    Shannon, M., Rehfeld, Anders Aagaard, Frizzell, C., Livingstone, C., McGonagle, C., Skakkebæk, Niels Erik, Wielogórska, E. & Connolly, L., 15 May 2016, In: Molecular and Cellular Endocrinology. 427, p. 65-72

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Testicular dysgenesis syndrome: mechanistic insights and potential new downstream effects

    Sharpe, R. M. & Skakkebæk, Niels Erik, 2008, In: Fertility and Sterility. 89, 2 Suppl, p. e33-e38

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Concentrations of persistent organochlorine compounds in human milk and placenta are higher in Denmark than in Finland

    Shen, H., Main, K. M., Andersson, A. M., Damgaard, I. N., Virtanen, H. E., Toppari, J., Schramm, K. W. & Skakkebæk, Niels Erik, 2008, In: Human Reproduction. 23, 1, p. 201-210 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Testicular cancer trends as 'whistle blowers' of testicular developmental problems in populations

    Skakkebæk, Niels Erik, Rajpert-De Meyts, E., Jørgensen, N., Main, Katharina Maria, Leffers, H., Andersson, A., Juul, Anders, Jensen, T. K. & Toppari, J., 2007, In: International Journal of Andrology. 30, 4, p. 198-204; discussion 204-5

    Research output: Contribution to journal › Review › Research

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