Niels Erik Skakkebæk

Niels Erik Skakkebæk

Affiliate Professor

Member of:

  • Paediatrics


  1. 2004
  2. Published

    Association of in utero exposure to maternal smoking with reduced semen quality and testis size in adulthood: a cross-sectional study of 1,770 young men from the general population in five European countries

    Jensen, T. K., Jørgensen, N., Punab, M., Haugen, T. B., Suominen, J., Zilaitiene, B., Horte, A., Andersen, A., Carlsen, E., Magnus, Ø., Matulevicius, V., Nermoen, I., Vierula, M., Keiding, N., Toppari, J. & Skakkebæk, Niels Erik, 2004, In: American Journal of Epidemiology. 159, 1, p. 49-58 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Do environmental factors play a role in the aetiology of carcinoma in situ testis and the testicular dysgenesis syndrome?

    Sonne, Si Brask, Hoei-Hansen, C. E., Fisher, J. S., Leffers, H., Rajpert-de Meyts, E. & Skakkebæk, Niels Erik, 2004, In: Verhandlungen der Deutschen Gesellschaft fur Pathologie. 88, p. 144-51 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Transcription factor AP-2gamma is a developmentally regulated marker of testicular carcinoma in situ and germ cell tumors

    Hoei-Hansen, C. E., Nielsen, J. E., Almstrup, K., Sonne, Si Brask, Graem, N., Skakkebæk, Niels Erik, Leffers, H. & Rajpert-De Meyts, E., 2004, In: Clinical Cancer Research. 10, 24, p. 8521-30 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Transcription factor AP-2γ is a developmentally regulated marker of testicular carcinoma in situ and germ cell tumors

    Høi-Hansen, Christina Engel, Nielsen, J. E., Almstrup, Kristian, Sonne, Si Brask, Graem, N., Skakkebæk, Niels Erik, Leffers, H. & Rajpert-De Meyts, E., 2004, In: Clinical Cancer Research.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. 2003
  7. Published

    Increased risk of carcinoma in situ in patients with testicular germ cell cancer with ultrasonic microlithiasis in the contralateral testicle

    Holm, M., Hoei-Hansen, C. E., Rajpert-De Meyts, E. & Skakkebæk, Niels Erik, 1 Oct 2003, In: Journal of Urology. 170, 4 Pt 1, p. 1163-7 5 p.

    Research output: Contribution to journalJournal articleResearch

  8. Published

    Histological evidence of testicular dysgenesis in contralateral biopsies from 218 patients with testicular germ cell cancer

    Hoei-Hansen, C. E., Holm, M., Rajpert-De Meyts, E. & Skakkebæk, Niels Erik, 1 Jul 2003, In: Journal of Pathology. 200, 3, p. 370-4 5 p.

    Research output: Contribution to journalJournal articleResearch

  9. Published

    Leydig cell micronodules are a common finding in testicular biopsies from men with impaired spermatogenesis and are associated with decreased testosterone/LH ratio

    Holm, M., Rajpert-De Meyts, E., Andersson, A. & Skakkebæk, Niels Erik, 1 Mar 2003, In: Journal of Pathology. 199, 3, p. 378-86 9 p.

    Research output: Contribution to journalJournal articleResearch

  10. Published

    Association between testicular dysgenesis syndrome (TDS) and testicular neoplasia: evidence from 20 adult patients with signs of maldevelopment of the testis

    Skakkebæk, Niels Erik, Holm, M., Hoei-Hansen, C., Jørgensen, N. & Rajpert-De Meyts, E., 1 Jan 2003, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 111, 1, p. 1-9; discussion 9-11

    Research output: Contribution to journalJournal articleResearch

  11. Published

    Increase in maternal placental growth hormone during pregnancy and disappearance during parturition in normal and growth hormone-deficient pregnancies

    Lønberg, U., Damm, Peter, Andersson, A., Main, Katharina Maria, Chellakooty, M., Lauenborg, J., Skakkebæk, Niels Erik & Juul, Anders, 1 Jan 2003, In: American Journal of Obstetrics and Gynecology. 188, 1, p. 247-51 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Does breast feeding influence liver biochemistry?

    Jørgensen, M. H., Ott, P., Juul, Anders, Skakkebæk, Niels Erik & Michaelsen, K. F., 2003, In: Journal of Pediatric Gastroenterology and Nutrition. 37, 5, p. 559-65 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Endocrine function in patients treated for carcinoma in situ in the testis with irradiation

    Petersen, P. M., Daugaard, G., Rørth, M. & Skakkebæk, Niels Erik, 2003, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 111, 1, p. 93-8; discussion 98-9

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Germ cell differentiation-dependent and stage-specific expression of LANCL1 in rodent testis

    Nielsen, J. E., Hansen, M. A., Jørgensen, M., Tanaka, M., Almstrup, Kristian, Skakkebæk, Niels Erik & Leffers, H., 2003, In: European Journal of Histochemistry. 47, 3, p. 215-222 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Inhibin A, inhibin B, follicle-stimulating hormone, luteinizing hormone, estradiol, and sex hormone-binding globulin levels in 473 healthy infant girls

    Chellakooty, M., Schmidt, I. M., Haavisto, A. M., Boisen, K. A., Damgaard, I. N., Mau, C., Petersen, Jørgen Holm, Juul, Anders, Skakkebæk, Niels Erik & Main, Katharina Maria, 2003, In: Journal of Clinical Endocrinology and Metabolism. 88, 8, p. 3515-20 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Intrauterine growth retardation and consequences for endocrine and cardiovascular diseases in adult life: does insulin-like growth factor-I play a role?

    Jensen, R. B. B., Chellakooty, M., Vielwerth, S., Vaag, Allan, Larsen, T. K., Greisen, Gorm, Skakkebæk, Niels Erik, Scheike, T. H. & Juul, Anders, 2003, In: Hormone Research. 60 Suppl 3, p. 136-48 13 p.

    Research output: Contribution to journalJournal articleResearch

  17. Published

    The timing of normal puberty and the age limits of sexual precocity: variations around the world, secular trends, and changes after migration

    Parent, A., Teilmann, Grete Katrine, Juul, Anders, Skakkebæk, Niels Erik, Toppari, J. & Bourguignon, J., 2003, In: Endocrine Reviews. 24, 5, p. 668-93 26 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. 2002
  19. Published

    An audit of the insulin-tolerance test in 255 patients with pituitary disease

    Lange, M., Svendsen, Ole Lander, Skakkebæk, Niels Erik, Müller, J., Juul, Anders, Schmiegelow, M. & Feldt-Rasmussen, Ulla, 2002, In: European Journal of Endocrinology. 147, 1, p. 41-7 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Androgens and the ageing male

    Juul, Anders & Skakkebæk, Niels Erik, 2002, In: Human Reproduction Update. 8, 5, p. 423-33 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Continuation of growth hormone therapy versus placebo in transition-phase patients with growth hormone deficiency: impact on body composition, insulin sensitivity, and thyroid function

    Jørgensen, J., Nørrelund, H., Vahl, N., Juul, Anders, Skakkebæk, Niels Erik & Christiansen, J. S., 2002, In: Journal of Pediatric Endocrinology and Metabolism. 15 Suppl 5, p. 1355-60 6 p.

    Research output: Contribution to journalJournal articleResearch

  22. Published

    Longitudinal study of serum placental GH in 455 normal pregnancies: correlation to gestational age, fetal gender, and weight

    Chellakooty, M., Skibsted, L., Skouby, Sven O., Andersson, A., Petersen, J. H., Main, Katharina Maria, Skakkebæk, Niels Erik & Juul, Anders, 2002, In: Journal of Clinical Endocrinology and Metabolism. 87, 6, p. 2734-9 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Poor semen quality may contribute to recent decline in fertility rates

    Jensen, T. K., Carlsen, E., Jørgensen, N., Berthelsen, J. G., Keiding, N., Christensen, K., Petersen, Jørgen Holm, Knudsen, L. B. & Skakkebæk, Niels Erik, 2002, In: Human Reproduction. 17, 6, p. 1437-40 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Putative effects of endocrine disrupters on pubertal development in the human

    Teilmann, Grete Katrine, Juul, Anders, Skakkebæk, Niels Erik & Toppari, J., 2002, In: Best Practice & Research: Clinical Endocrinology & Metabolism. 16, 1, p. 105-21 17 p.

    Research output: Contribution to journalJournal articleResearch

  25. Published

    Serum inhibin B, FSH, LH and testosterone levels before and after human chorionic gonadotropin stimulation in prepubertal boys with cryptorchidism

    Christiansen, P., Andersson, A., Skakkebæk, Niels Erik & Juul, Anders, 2002, In: European Journal of Endocrinology. 147, 1, p. 95-101 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Testosteronbehandling af ældre mænd: den såkaldte andropause eksisterer ikke.

    Juul, Anders & Skakkebæk, Niels Erik, 2002, In: Ugeskrift for Laeger. 164, 42, p. 4941-2 2 p.

    Research output: Contribution to journalReviewResearch

  27. Published

    Time to pregnancy and semen parameters: a cross-sectional study among fertile couples from four European cities

    Slama, R., Eustache, F., Ducot, B., Jensen, T. K., Jørgensen, N., Horte, A., Irvine, S., Suominen, J., Andersen, A. G., Auger, J., Vierula, M., Toppari, J., Andersen, A. N., Keiding, N., Skakkebæk, Niels Erik, Spira, A. & Jouannet, P., 2002, In: Human Reproduction. 17, 2, p. 503-515 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. 2001
  29. Published

    Regional differences in waiting time to pregnancy among fertile couples from four European cities

    Kold-Jensen, T., Slama, R., Ducot, B., Suominen, J., Cawood, E. H. H., Andersen, A. G., Eustache, F., Irvine, S., Auger, S., Jouannet, P., Vierula, M., Jørgensen, N., Toppari, J., Skakkebæk, Niels Erik, Keiding, N. & Spira, A., 1 Dec 2001, In: Human Reproduction. 16, 12, p. 2697-2704 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Cardiovascular risk factors in men: The role of gonadal steroids and sex hormone-binding globulin

    Gyllenborg, J., Rasmussen, S. L., Borch-Johnsen, K., Heitmann, B. L., Skakkebæk, Niels Erik & Juul, Anders, 2001, In: Metabolism. 50, 8, p. 882-8 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Skin morphological changes in growth hormone deficiency and acromegaly

    Lange, M. W., Thulesen, J., Feldt-Rasmussen, Ulla, Skakkebæk, Niels Erik, Vahl, N., Jørgensen, J. O., Christiansen, J. S., Poulsen, Steen Seier, Sneppen, S. B. & Juul, Anders, 2001, In: European Journal of Endocrinology. 145, 2, p. 147-153 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    The growth hormone (GH)-insulin-like growth factor axis during testosterone replacement therapy in GH-treated hypopituitary males

    Fisker, S., Nørrelund, H., Juul, Anders, Skakkebæk, Niels Erik, Christiansen, J. S. & Jørgensen, J. O., 2001, In: Growth Hormone & I G F Research. 11, 2, p. 104-9 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Total and free insulin-like growth factor I, insulin-like growth factor binding protein 3 and acid-labile subunit reflect clinical activity in acromegaly

    Sneppen, S. B., Lange, M. W., Pedersen, L. M., Kristensen L, L. Ø., Main, Katharina Maria, Juul, Anders, Skakkebæk, Niels Erik & Feldt-Rasmussen, Ulla, 2001, In: Growth Hormone & I G F Research. 11, 6, p. 384-91 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. 2000
  35. Published

    Carcinoma in situ in the testis

    Rørth, M., Rajpert-De Meyts, E., Andersson, L., Dieckmann, Peter, Fosså, S. D., Grigor, K. M., Hendry, W. F., Herr, H. W., Looijenga, L. H., Oosterhuis, J. W. & Skakkebæk, Niels Erik, 2000, In: Scandinavian Journal of Urology and Nephrology, Supplementum. 205, p. 166-86 20 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Continuation of growth hormone (GH) therapy in GH-deficient patients during transition from childhood to adulthood: impact on insulin sensitivity and substrate metabolism

    Nørrelund, H., Vahl, N., Juul, Anders, Møller, N., Alberti, K. G., Skakkebæk, Niels Erik, Christiansen, J. S. & Jørgensen, J. O., 2000, In: Journal of Clinical Endocrinology and Metabolism. 85, 5, p. 1912-7 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Growth hormone (GH), exercise performance, muscle strength and sweat production in healthy subjects and adults with GH deficiency

    Juul, Anders, Main, Katharina Maria & Skakkebæk, Niels Erik, 2000, Growth Hormone in adults; Physiological and clinical aspects. 2 ed. p. 281-300 19 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  38. Published

    Hormonal changes during GnRH analogue therapy in children with central precocious puberty

    Müller, J., Juul, Anders, Andersson, A. M., Sehested, A. & Skakkebæk, Niels Erik, 2000, In: Journal of Pediatric Endocrinology and Metabolism. 13 Suppl 1, p. 739-46 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Serum inhibin A and inhibin B in healthy prepubertal, pubertal, and adolescent girls and adult women: relation to age, stage of puberty, menstrual cycle, follicle-stimulating hormone, luteinizing hormone, and estradiol levels

    Sehested, A., Juul, Anders, Andersson, A. M., Petersen, Jørgen Holm, Jensen, T. K., Müller, J. & Skakkebæk, Niels Erik, 2000, In: Journal of Clinical Endocrinology and Metabolism. 85, 4, p. 1634-40 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Serum levels of growth hormone binding protein in children with normal and precocious puberty: relation to age, gender, body composition and gonadal steroids

    Juul, Anders, Fisker, S., Scheike, T. H., Hertel, T. K., Müller, J., Orskov, H. & Skakkebæk, Niels Erik, 2000, In: Clinical Endocrinology. 52, 2, p. 165-72 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Sweat secretion rates in growth hormone disorders

    Sneppen, S. B., Main, Katharina Maria, Juul, Anders, Pedersen, L. M., Kristensen, L. O., Skakkebæk, Niels Erik & Feldt-Rasmussen, Ulla, 2000, In: Clinical Endocrinology. 53, 5, p. 601-8 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. 1999
  43. Published

    Diagnosis of GH deficiency and use of GH in children with growth disorders. A report from the Drugs and Therapeutics Committee of European Society for paediatric Endocrinology

    Juul, Anders, Bernasconi, S., Chatelain, P., Hindsmarsh, P., Hochberg, Z., Hokke-Koelega, A., De Muinck Keizer-Schrama, S., Kiess, W., Oberfield, S., Strasburger, C., Volta, C., Westphal, O. & Skakkebæk, Niels Erik, 1999, In: Hormone Research. 51, p. 284-299 15 p.

    Research output: Contribution to journalReviewResearch

  44. Published

    Impact of growth hormone administration on other hormonal axes.

    Jørgensen, J., Ovesen, P., Juul, Anders, Hansen, T., Skakkebæk, Niels Erik & Christiansen, J., 1999, In: Hormone Research. 51, p. 121-126 5 p.

    Research output: Contribution to journalReviewResearch

  45. Published

    Impaired testicular function in patients with carcinoma-in-situ of the testis

    Petersen, P. M., Giwercman, A., Hansen, S. W., Berthelsen, Jens, Daugaard, G., Rørth, M. & Skakkebæk, Niels Erik, 1999, In: Journal of Clinical Oncology. 17, 1, p. 173-9 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Vækst og Regeration

    Juul, Anders, Korndrup, J. & Skakkebæk, Niels Erik, 1999, Medicinsk Kompendium. 15 ed. p. 140-148 8 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  47. 1998
  48. Published

    Re: The relationship of sperm counts to birth rates: A population based study

    Keiding, N. & Skakkebæk, Niels Erik, Jun 1998, In: Journal of Urology. 159, 6, p. 2103-2103 1 p.

    Research output: Contribution to journalComment/debateResearch

  49. Published

    Selection Biases in Semen Study?

    Skakkebæk, Niels Erik, Giwercman, A., Jensen, T. K., Carlsen, E., Jørgensen, N. & Keiding, N., Jun 1998, In: Fertility & Sterility. 69, 6, p. 1158-1159 2 p.

    Research output: Contribution to journalComment/debateResearch

  50. Published

    Consequences of stopping Growth hormone (GH) therapy in young GH-deficient patients with childhood-onset disease

    Juul, Anders, Vahl, N., Jørgensen, J., Christiansen, J. & Skakkebæk, Niels Erik, 1998, In: Growth Hormone & I G F Research. p. 15-19 4 p.

    Research output: Contribution to journalReviewResearch

  51. Published

    Effects of growth hormone replacement therapy on IGF-related parameters and on the pituitary-gonadal axis in GH-deficient males. A double-blind, placebo-controlled crossover study

    Juul, Anders, Andersson, A. M., Pedersen, S. A., Jørgensen, J. O., Christiansen, J. S., Groome, N. P. & Skakkebæk, Niels Erik, 1998, In: Hormone Research. 49, 6, p. 269-78 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    The acid-labile subunit of human ternary insulin-like growth factor binding protein complex in serum: hepatosplanchnic release, diurnal variation, circulating concentrations in healthy subjects, and diagnostic use in patients with growth hormone deficiency

    Juul, Anders, Møller, S., Mosfeldt-Laursen, E., Rasmussen, M. H., Scheike, T. H., Pedersen, S. A., Kastrup, K. W., Yu, H., Mistry, J., Rasmussen, S., Müller, J., Henriksen, J. & Skakkebæk, Niels Erik, 1998, In: Journal of Clinical Endocrinology and Metabolism. 83, 12, p. 4408-15 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published

    Year of birth and sperm count in 10 Danish occupational studies

    Bonde, Jens Peter, Jensen, T. K., Larsen, S. B., Abell, A., Scheike, Thomas, Hjøllund, N. H. I., Kolstad, H. A., Ernst, E., Giwercman, A., Skakkebæk, Niels Erik, Keiding, N. & Olsen, J., 1998, In: Scandinavian Journal of Work, Environment & Health. 24, 5, p. 407-413 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. 1997
  55. Published

    Changes in serum concentrations of growth hormone, insulin, insulin-like growth factor and insulin-like growth factor-binding proteins 1 and 3 and urinary growth hormone excretion during the menstrual cycle

    Juul, Anders, Scheike, T. H., Pedersen, Anette Tønnes, Main, Katharina Maria, Andersson, A. M., Pedersen, L. M. & Skakkebæk, Niels Erik, 1997, In: Human Reproduction. 12, 10, p. 2123-8 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. Published

    Den prognostiske værdi af insulinlignende vækstfaktor i (IGF-I) og bindingsproteinet IGFBP-3 ved alkoholistisk leversygdom

    Møller, S., Becker, U., Juul, Anders, Skakkebæk, Niels Erik, Christensen, E. & EMALD-gruppen, E., 1997, In: Ugeskrift for Laeger. 159, 30, p. 4636-4640 4 p.

    Research output: Contribution to journalJournal articleResearch

  57. Published

    Free insulin-like growth factor I serum levels in 1430 healthy children and adults, and its diagnostic value in patients suspected of growth hormone deficiency

    Juul, Anders, Holm, Kirsten, Kastrup, K. W., Pedersen, S. A., Michaelsen, K. F., Scheike, T. H., Rasmussen, S., Müller, J. & Skakkebæk, Niels Erik, 1997, In: Journal of Clinical Endocrinology and Metabolism. 82, 8, p. 2497-502 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  58. Published

    Growth hormone (GH) provocative retesting of 108 young adults with childhood-onset GH deficiency and the diagnostic value of insulin-like growth factor I (IGF-I) and IGF-binding protein-3

    Juul, Anders, Kastrup, K. W., Pedersen, S. A. & Skakkebæk, Niels Erik, 1997, In: Journal of Clinical Endocrinology and Metabolism. 82, 4, p. 1195-201 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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