Association between genetic polymorphisms in the human interleukin-7 receptor alpha-chain and inhalation allergy
Research output: Contribution to journal › Journal article › Research › peer-review
Thymic stromal-derived lymphopoietin (TSLP) and interleukin-7 share a common receptor chain, IL-7Ralpha. IL-7 is involved in T-cell homeostasis, and TSLP induces production of pro-allergic cytokines. The gene encoding the IL-7Ralpha chain is polymorphic, and investigation of inhalation allergic patients compared with controls showed significant association with two alleles at position +1237 and +2087.
| Original language | English |
|---|---|
| Journal | International Journal of Immunogenetics (Print Edition) |
| Volume | 34 |
| Issue number | 3 |
| Pages (from-to) | 149-51 |
| Number of pages | 3 |
| ISSN | 1744-3121 |
| DOIs | |
| Publication status | Published - 2007 |
- Adult, Case-Control Studies, Denmark, Female, Gene Frequency, Genetic Predisposition to Disease, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, Receptors, Interleukin-7, Respiratory Hypersensitivity
Research areas
ID: 43535286