TY - JOUR

T1 - Five-Year Randomized Study Demonstrates Blood Pressure Increases in Young Women With Turner Syndrome Regardless of Estradiol Dose

AU - Brun, Sara

AU - Cleemann, Line

AU - Holm, Kirsten

AU - Salskov, Gitte

AU - Erlandsen, Mogens

AU - Berglund, Agnethe

AU - Andersen, Niels H

AU - Gravholt, Claus H

PY - 2019/1

Y1 - 2019/1

N2 - We evaluated the development in blood pressure (BP) and heart rate in young women with Turner syndrome (TS) and investigated potential influencing cofactors. Twenty TS women (mean±SD, 22.9±2.3 years of age) were investigated in a 5-year prospective setting. Data were derived from a randomized controlled clinical trial investigating 2 different doses of estradiol treatment (2 mg 17β-estradiol per day and placebo or 2+2 mg 17β-estradiol per day). A control group of 12 healthy age-matched young women (mean±SD, 23.11±2.2 years of age) was examined at the end of the study. BP and lipids were monitored yearly. At the end of the study, TS (n=15) and controls were examined by 24-hour ambulatory BP monitoring. Systolic and diastolic BPs increased regardless of estradiol dose ( P=0.005 and P=0.009) in TS patients, whereas heart rate decreased ( P=0.05). Neither body mass index, height, weight, nor lipids contributed significant to the changes. There was no difference in BP, heart rate, or lipids because of treatment. At the end of the study, diastolic BP and heart rate were significantly higher in TS during day, night, and over 24 hours. Systolic BP increased insignificantly. Lipids did not change during the study period, but body mass index determined individual levels. In conclusion, systolic and diastolic BPs increase significantly in late adolescence and early adulthood in TS. It remains an enigma why BP increases early in life in TS. Clinical Trial Registration- URL: http://www.clinicaltrials.gov . Unique identifier: NCT00134745.

AB - We evaluated the development in blood pressure (BP) and heart rate in young women with Turner syndrome (TS) and investigated potential influencing cofactors. Twenty TS women (mean±SD, 22.9±2.3 years of age) were investigated in a 5-year prospective setting. Data were derived from a randomized controlled clinical trial investigating 2 different doses of estradiol treatment (2 mg 17β-estradiol per day and placebo or 2+2 mg 17β-estradiol per day). A control group of 12 healthy age-matched young women (mean±SD, 23.11±2.2 years of age) was examined at the end of the study. BP and lipids were monitored yearly. At the end of the study, TS (n=15) and controls were examined by 24-hour ambulatory BP monitoring. Systolic and diastolic BPs increased regardless of estradiol dose ( P=0.005 and P=0.009) in TS patients, whereas heart rate decreased ( P=0.05). Neither body mass index, height, weight, nor lipids contributed significant to the changes. There was no difference in BP, heart rate, or lipids because of treatment. At the end of the study, diastolic BP and heart rate were significantly higher in TS during day, night, and over 24 hours. Systolic BP increased insignificantly. Lipids did not change during the study period, but body mass index determined individual levels. In conclusion, systolic and diastolic BPs increase significantly in late adolescence and early adulthood in TS. It remains an enigma why BP increases early in life in TS. Clinical Trial Registration- URL: http://www.clinicaltrials.gov . Unique identifier: NCT00134745.

KW - Adolescent

KW - Adult

KW - Blood Pressure/drug effects

KW - Blood Pressure Monitoring, Ambulatory/methods

KW - Dose-Response Relationship, Drug

KW - Drug Monitoring/methods

KW - Estradiol/administration & dosage

KW - Estrogens/administration & dosage

KW - Female

KW - Heart Rate/drug effects

KW - Humans

KW - Treatment Outcome

KW - Turner Syndrome/diagnosis

U2 - 10.1161/HYPERTENSIONAHA.118.11742

DO - 10.1161/HYPERTENSIONAHA.118.11742

M3 - Journal article

C2 - 30571546

VL - 73

SP - 242

EP - 248

JO - Hypertension

JF - Hypertension

SN - 0194-911X

IS - 1

ER -