Labial adhesions are well-known in prepubertal girls. We present a seven year-old girl treated with estrogen gel due to labial adhesion resulting in precocious pseudopuberty. Endocrine tests and bone age were normal. Symptoms regressed upon cessation of treatment. Labial adhesions often resolve spontaneously in early puberty. Precocious pseudopuberty is a well-known side effect to estrogen gel used in excess which should only be initiated in prepubertal girls with great caution and after careful consideration.