Integreret diagnostik af hjernetumorer baseret på histologiske og molekylære karakteristika
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Integreret diagnostik af hjernetumorer baseret på histologiske og molekylære karakteristika. / Petersen, Jeanette K; Scheie, David; Boldt, Henning B; Ulhøi, Benedicte P; Ettrup, Marianne S; Kristensen, Bjarne W.
In: Ugeskrift for Laeger, Vol. 181, V07180509, 2019.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Integreret diagnostik af hjernetumorer baseret på histologiske og molekylære karakteristika
AU - Petersen, Jeanette K
AU - Scheie, David
AU - Boldt, Henning B
AU - Ulhøi, Benedicte P
AU - Ettrup, Marianne S
AU - Kristensen, Bjarne W
PY - 2019
Y1 - 2019
N2 - Diagnostics of tumours of the central nervous system has for decades been based entirely on microscopy. A con-siderable degree of diagnostic interobserver variability has been observed due to imprecise histological criteria. In the revised WHO classification for central nervous system tumours from 2016, several diagnoses are now defined by both histological and molecular features and constitute "integrated diagnoses". The development based on new technologies like next-generation sequencing and DNA methylation profiling is discussed in this review as well as its implication for daily diagnostics and the patient.
AB - Diagnostics of tumours of the central nervous system has for decades been based entirely on microscopy. A con-siderable degree of diagnostic interobserver variability has been observed due to imprecise histological criteria. In the revised WHO classification for central nervous system tumours from 2016, several diagnoses are now defined by both histological and molecular features and constitute "integrated diagnoses". The development based on new technologies like next-generation sequencing and DNA methylation profiling is discussed in this review as well as its implication for daily diagnostics and the patient.
KW - Brain Neoplasms/diagnosis
KW - Central Nervous System Neoplasms/diagnosis
KW - Glioma/diagnosis
KW - Humans
M3 - Tidsskriftartikel
C2 - 30729918
VL - 181
JO - Ugeskrift for Laeger
JF - Ugeskrift for Laeger
SN - 0041-5782
M1 - V07180509
ER -
ID: 241123730