Standard
New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs. / Sturm, Dominik; Orr, Brent A; Toprak, Umut H; Hovestadt, Volker; Jones, David T W; Capper, David; Sill, Martin; Buchhalter, Ivo; Northcott, Paul A; Leis, Irina; Ryzhova, Marina; Koelsche, Christian; Pfaff, Elke; Allen, Sariah J; Balasubramanian, Gnanaprakash; Worst, Barbara C; Pajtler, Kristian W; Brabetz, Sebastian; Johann, Pascal David; Sahm, Felix; Reimand, Jüri; Mackay, Alan sim; Carvalho, Diana M; Remke, Marc; Phillips, Joanna J; Perry, Arie; Cowdrey, Cynthia; Drissi, Rachid; Fouladi, Maryam; Giangaspero, Felice; Łastowska, Maria; Grajkowska, Wiesława; Scheurlen, Wolfram; Pietsch, Torsten; Hagel, Christian; Gojo, Johannes; Lötsch, Daniela; Berger, Walter; Slavc, Irene; Haberler, Christine; Jouvet, Anne; Holm, Stefan; Hofer, Silvia; Prinz, Marco; Keohane, Catherine; Fried, Iris; Mawrin, Christian; Scheie, David; Mobley, Bret C; Schniederjan, Matthew J; Santi, Mariarita; Buccoliero, Anna M; Dahiya, Sonika; Kramm, Christof M; von Bueren, André O; von Hoff, Katja; Rutkowski, Stefan; Herold-Mende, Christel; Frühwald, Michael C; Milde, Till; Hasselblatt, Martin; Wesseling, Pieter; Rössler, Jochen; Schüller, Ulrich; Ebinger, Martin; Schittenhelm, Jens; Frank, Stephan; Grobholz, Rainer; Vajtai, Istvan; Hans, Volkmar; Schneppenheim, Reinhard; Zitterbart, Karel; Collins, V Peter; Aronica, Eleonora; Varlet, Pascale; Puget, Stephanie; Dufour, Christelle; Grill, Jacques; Figarella-Branger, Dominique; Wolter, Marietta; Schuhmann, Martin U; Shalaby, Tarek; Grotzer, Michael; van Meter, Timothy; Monoranu, Camelia-Maria; Felsberg, Jörg; Reifenberger, Guido; Snuderl, Matija; Forrester, Lynn Ann; Koster, Jan; Versteeg, Rogier; Volckmann, Richard; van Sluis, Peter; Wolf, Stephan; Mikkelsen, Tom; Gajjar, Amar; Aldape, Kenneth; Moore, Andrew S.; Taylor, Michael D; Jones, Chris; Jabado, Nada; Karajannis, Matthias A; Eils, Roland; Schlesner, Matthias; Lichter, Peter; von Deimling, Andreas; Pfister, Stefan M; Ellison, David W; Korshunov, Andrey; Kool, Marcel.
In:
Cell, Vol. 164, No. 5, 2016, p. 1060-72.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Sturm, D, Orr, BA, Toprak, UH, Hovestadt, V, Jones, DTW, Capper, D, Sill, M, Buchhalter, I, Northcott, PA, Leis, I, Ryzhova, M, Koelsche, C, Pfaff, E, Allen, SJ, Balasubramanian, G, Worst, BC, Pajtler, KW, Brabetz, S, Johann, PD, Sahm, F, Reimand, J, Mackay, AS, Carvalho, DM, Remke, M, Phillips, JJ, Perry, A, Cowdrey, C, Drissi, R, Fouladi, M, Giangaspero, F, Łastowska, M, Grajkowska, W, Scheurlen, W, Pietsch, T, Hagel, C, Gojo, J, Lötsch, D, Berger, W, Slavc, I, Haberler, C, Jouvet, A, Holm, S, Hofer, S, Prinz, M, Keohane, C, Fried, I, Mawrin, C
, Scheie, D, Mobley, BC, Schniederjan, MJ, Santi, M, Buccoliero, AM, Dahiya, S, Kramm, CM, von Bueren, AO, von Hoff, K, Rutkowski, S, Herold-Mende, C, Frühwald, MC, Milde, T, Hasselblatt, M, Wesseling, P, Rössler, J, Schüller, U, Ebinger, M, Schittenhelm, J, Frank, S, Grobholz, R, Vajtai, I, Hans, V, Schneppenheim, R, Zitterbart, K, Collins, VP, Aronica, E, Varlet, P, Puget, S, Dufour, C, Grill, J, Figarella-Branger, D, Wolter, M, Schuhmann, MU, Shalaby, T, Grotzer, M, van Meter, T, Monoranu, C-M, Felsberg, J, Reifenberger, G, Snuderl, M, Forrester, LA, Koster, J, Versteeg, R, Volckmann, R, van Sluis, P, Wolf, S, Mikkelsen, T, Gajjar, A, Aldape, K, Moore, AS, Taylor, MD, Jones, C, Jabado, N, Karajannis, MA, Eils, R, Schlesner, M, Lichter, P, von Deimling, A, Pfister, SM, Ellison, DW, Korshunov, A & Kool, M 2016, '
New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs',
Cell, vol. 164, no. 5, pp. 1060-72.
https://doi.org/10.1016/j.cell.2016.01.015APA
Sturm, D., Orr, B. A., Toprak, U. H., Hovestadt, V., Jones, D. T. W., Capper, D., Sill, M., Buchhalter, I., Northcott, P. A., Leis, I., Ryzhova, M., Koelsche, C., Pfaff, E., Allen, S. J., Balasubramanian, G., Worst, B. C., Pajtler, K. W., Brabetz, S., Johann, P. D., ... Kool, M. (2016).
New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs.
Cell,
164(5), 1060-72.
https://doi.org/10.1016/j.cell.2016.01.015Vancouver
Sturm D, Orr BA, Toprak UH, Hovestadt V, Jones DTW, Capper D et al.
New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs.
Cell. 2016;164(5):1060-72.
https://doi.org/10.1016/j.cell.2016.01.015Author
Sturm, Dominik ; Orr, Brent A ; Toprak, Umut H ; Hovestadt, Volker ; Jones, David T W ; Capper, David ; Sill, Martin ; Buchhalter, Ivo ; Northcott, Paul A ; Leis, Irina ; Ryzhova, Marina ; Koelsche, Christian ; Pfaff, Elke ; Allen, Sariah J ; Balasubramanian, Gnanaprakash ; Worst, Barbara C ; Pajtler, Kristian W ; Brabetz, Sebastian ; Johann, Pascal David ; Sahm, Felix ; Reimand, Jüri ; Mackay, Alan sim ; Carvalho, Diana M ; Remke, Marc ; Phillips, Joanna J ; Perry, Arie ; Cowdrey, Cynthia ; Drissi, Rachid ; Fouladi, Maryam ; Giangaspero, Felice ; Łastowska, Maria ; Grajkowska, Wiesława ; Scheurlen, Wolfram ; Pietsch, Torsten ; Hagel, Christian ; Gojo, Johannes ; Lötsch, Daniela ; Berger, Walter ; Slavc, Irene ; Haberler, Christine ; Jouvet, Anne ; Holm, Stefan ; Hofer, Silvia ; Prinz, Marco ; Keohane, Catherine ; Fried, Iris ; Mawrin, Christian ; Scheie, David ; Mobley, Bret C ; Schniederjan, Matthew J ; Santi, Mariarita ; Buccoliero, Anna M ; Dahiya, Sonika ; Kramm, Christof M ; von Bueren, André O ; von Hoff, Katja ; Rutkowski, Stefan ; Herold-Mende, Christel ; Frühwald, Michael C ; Milde, Till ; Hasselblatt, Martin ; Wesseling, Pieter ; Rössler, Jochen ; Schüller, Ulrich ; Ebinger, Martin ; Schittenhelm, Jens ; Frank, Stephan ; Grobholz, Rainer ; Vajtai, Istvan ; Hans, Volkmar ; Schneppenheim, Reinhard ; Zitterbart, Karel ; Collins, V Peter ; Aronica, Eleonora ; Varlet, Pascale ; Puget, Stephanie ; Dufour, Christelle ; Grill, Jacques ; Figarella-Branger, Dominique ; Wolter, Marietta ; Schuhmann, Martin U ; Shalaby, Tarek ; Grotzer, Michael ; van Meter, Timothy ; Monoranu, Camelia-Maria ; Felsberg, Jörg ; Reifenberger, Guido ; Snuderl, Matija ; Forrester, Lynn Ann ; Koster, Jan ; Versteeg, Rogier ; Volckmann, Richard ; van Sluis, Peter ; Wolf, Stephan ; Mikkelsen, Tom ; Gajjar, Amar ; Aldape, Kenneth ; Moore, Andrew S. ; Taylor, Michael D ; Jones, Chris ; Jabado, Nada ; Karajannis, Matthias A ; Eils, Roland ; Schlesner, Matthias ; Lichter, Peter ; von Deimling, Andreas ; Pfister, Stefan M ; Ellison, David W ; Korshunov, Andrey ; Kool, Marcel. / New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs. In: Cell. 2016 ; Vol. 164, No. 5. pp. 1060-72.
Bibtex
@article{24ab858bde334e7bb672130b1d104b03,
title = "New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs",
abstract = "Primitive neuroectodermal tumors of the central nervous system (CNS-PNETs) are highly aggressive, poorly differentiated embryonal tumors occurring predominantly in young children but also affecting adolescents and adults. Herein, we demonstrate that a significant proportion of institutionally diagnosed CNS-PNETs display molecular profiles indistinguishable from those of various other well-defined CNS tumor entities, facilitating diagnosis and appropriate therapy for patients with these tumors. From the remaining fraction of CNS-PNETs, we identify four new CNS tumor entities, each associated with a recurrent genetic alteration and distinct histopathological and clinical features. These new molecular entities, designated {"}CNS neuroblastoma with FOXR2 activation (CNS NB-FOXR2),{"} {"}CNS Ewing sarcoma family tumor with CIC alteration (CNS EFT-CIC),{"} {"}CNS high-grade neuroepithelial tumor with MN1 alteration (CNS HGNET-MN1),{"} and {"}CNS high-grade neuroepithelial tumor with BCOR alteration (CNS HGNET-BCOR),{"} will enable meaningful clinical trials and the development of therapeutic strategies for patients affected by poorly differentiated CNS tumors.",
keywords = "Amino Acid Sequence, Central Nervous System Neoplasms, Child, DNA Methylation, Forkhead Transcription Factors, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Humans, Molecular Sequence Data, Neuroectodermal Tumors, Proto-Oncogene Proteins, Repressor Proteins, Signal Transduction, Tumor Suppressor Proteins, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't",
author = "Dominik Sturm and Orr, {Brent A} and Toprak, {Umut H} and Volker Hovestadt and Jones, {David T W} and David Capper and Martin Sill and Ivo Buchhalter and Northcott, {Paul A} and Irina Leis and Marina Ryzhova and Christian Koelsche and Elke Pfaff and Allen, {Sariah J} and Gnanaprakash Balasubramanian and Worst, {Barbara C} and Pajtler, {Kristian W} and Sebastian Brabetz and Johann, {Pascal David} and Felix Sahm and J{\"u}ri Reimand and Mackay, {Alan sim} and Carvalho, {Diana M} and Marc Remke and Phillips, {Joanna J} and Arie Perry and Cynthia Cowdrey and Rachid Drissi and Maryam Fouladi and Felice Giangaspero and Maria {\L}astowska and Wies{\l}awa Grajkowska and Wolfram Scheurlen and Torsten Pietsch and Christian Hagel and Johannes Gojo and Daniela L{\"o}tsch and Walter Berger and Irene Slavc and Christine Haberler and Anne Jouvet and Stefan Holm and Silvia Hofer and Marco Prinz and Catherine Keohane and Iris Fried and Christian Mawrin and David Scheie and Mobley, {Bret C} and Schniederjan, {Matthew J} and Mariarita Santi and Buccoliero, {Anna M} and Sonika Dahiya and Kramm, {Christof M} and {von Bueren}, {Andr{\'e} O} and {von Hoff}, Katja and Stefan Rutkowski and Christel Herold-Mende and Fr{\"u}hwald, {Michael C} and Till Milde and Martin Hasselblatt and Pieter Wesseling and Jochen R{\"o}ssler and Ulrich Sch{\"u}ller and Martin Ebinger and Jens Schittenhelm and Stephan Frank and Rainer Grobholz and Istvan Vajtai and Volkmar Hans and Reinhard Schneppenheim and Karel Zitterbart and Collins, {V Peter} and Eleonora Aronica and Pascale Varlet and Stephanie Puget and Christelle Dufour and Jacques Grill and Dominique Figarella-Branger and Marietta Wolter and Schuhmann, {Martin U} and Tarek Shalaby and Michael Grotzer and {van Meter}, Timothy and Camelia-Maria Monoranu and J{\"o}rg Felsberg and Guido Reifenberger and Matija Snuderl and Forrester, {Lynn Ann} and Jan Koster and Rogier Versteeg and Richard Volckmann and {van Sluis}, Peter and Stephan Wolf and Tom Mikkelsen and Amar Gajjar and Kenneth Aldape and Moore, {Andrew S.} and Taylor, {Michael D} and Chris Jones and Nada Jabado and Karajannis, {Matthias A} and Roland Eils and Matthias Schlesner and Peter Lichter and {von Deimling}, Andreas and Pfister, {Stefan M} and Ellison, {David W} and Andrey Korshunov and Marcel Kool",
note = "Copyright {\textcopyright} 2016 Elsevier Inc. All rights reserved.",
year = "2016",
doi = "10.1016/j.cell.2016.01.015",
language = "English",
volume = "164",
pages = "1060--72",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "5",
}
RIS
TY - JOUR
T1 - New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs
AU - Sturm, Dominik
AU - Orr, Brent A
AU - Toprak, Umut H
AU - Hovestadt, Volker
AU - Jones, David T W
AU - Capper, David
AU - Sill, Martin
AU - Buchhalter, Ivo
AU - Northcott, Paul A
AU - Leis, Irina
AU - Ryzhova, Marina
AU - Koelsche, Christian
AU - Pfaff, Elke
AU - Allen, Sariah J
AU - Balasubramanian, Gnanaprakash
AU - Worst, Barbara C
AU - Pajtler, Kristian W
AU - Brabetz, Sebastian
AU - Johann, Pascal David
AU - Sahm, Felix
AU - Reimand, Jüri
AU - Mackay, Alan sim
AU - Carvalho, Diana M
AU - Remke, Marc
AU - Phillips, Joanna J
AU - Perry, Arie
AU - Cowdrey, Cynthia
AU - Drissi, Rachid
AU - Fouladi, Maryam
AU - Giangaspero, Felice
AU - Łastowska, Maria
AU - Grajkowska, Wiesława
AU - Scheurlen, Wolfram
AU - Pietsch, Torsten
AU - Hagel, Christian
AU - Gojo, Johannes
AU - Lötsch, Daniela
AU - Berger, Walter
AU - Slavc, Irene
AU - Haberler, Christine
AU - Jouvet, Anne
AU - Holm, Stefan
AU - Hofer, Silvia
AU - Prinz, Marco
AU - Keohane, Catherine
AU - Fried, Iris
AU - Mawrin, Christian
AU - Scheie, David
AU - Mobley, Bret C
AU - Schniederjan, Matthew J
AU - Santi, Mariarita
AU - Buccoliero, Anna M
AU - Dahiya, Sonika
AU - Kramm, Christof M
AU - von Bueren, André O
AU - von Hoff, Katja
AU - Rutkowski, Stefan
AU - Herold-Mende, Christel
AU - Frühwald, Michael C
AU - Milde, Till
AU - Hasselblatt, Martin
AU - Wesseling, Pieter
AU - Rössler, Jochen
AU - Schüller, Ulrich
AU - Ebinger, Martin
AU - Schittenhelm, Jens
AU - Frank, Stephan
AU - Grobholz, Rainer
AU - Vajtai, Istvan
AU - Hans, Volkmar
AU - Schneppenheim, Reinhard
AU - Zitterbart, Karel
AU - Collins, V Peter
AU - Aronica, Eleonora
AU - Varlet, Pascale
AU - Puget, Stephanie
AU - Dufour, Christelle
AU - Grill, Jacques
AU - Figarella-Branger, Dominique
AU - Wolter, Marietta
AU - Schuhmann, Martin U
AU - Shalaby, Tarek
AU - Grotzer, Michael
AU - van Meter, Timothy
AU - Monoranu, Camelia-Maria
AU - Felsberg, Jörg
AU - Reifenberger, Guido
AU - Snuderl, Matija
AU - Forrester, Lynn Ann
AU - Koster, Jan
AU - Versteeg, Rogier
AU - Volckmann, Richard
AU - van Sluis, Peter
AU - Wolf, Stephan
AU - Mikkelsen, Tom
AU - Gajjar, Amar
AU - Aldape, Kenneth
AU - Moore, Andrew S.
AU - Taylor, Michael D
AU - Jones, Chris
AU - Jabado, Nada
AU - Karajannis, Matthias A
AU - Eils, Roland
AU - Schlesner, Matthias
AU - Lichter, Peter
AU - von Deimling, Andreas
AU - Pfister, Stefan M
AU - Ellison, David W
AU - Korshunov, Andrey
AU - Kool, Marcel
N1 - Copyright © 2016 Elsevier Inc. All rights reserved.
PY - 2016
Y1 - 2016
N2 - Primitive neuroectodermal tumors of the central nervous system (CNS-PNETs) are highly aggressive, poorly differentiated embryonal tumors occurring predominantly in young children but also affecting adolescents and adults. Herein, we demonstrate that a significant proportion of institutionally diagnosed CNS-PNETs display molecular profiles indistinguishable from those of various other well-defined CNS tumor entities, facilitating diagnosis and appropriate therapy for patients with these tumors. From the remaining fraction of CNS-PNETs, we identify four new CNS tumor entities, each associated with a recurrent genetic alteration and distinct histopathological and clinical features. These new molecular entities, designated "CNS neuroblastoma with FOXR2 activation (CNS NB-FOXR2)," "CNS Ewing sarcoma family tumor with CIC alteration (CNS EFT-CIC)," "CNS high-grade neuroepithelial tumor with MN1 alteration (CNS HGNET-MN1)," and "CNS high-grade neuroepithelial tumor with BCOR alteration (CNS HGNET-BCOR)," will enable meaningful clinical trials and the development of therapeutic strategies for patients affected by poorly differentiated CNS tumors.
AB - Primitive neuroectodermal tumors of the central nervous system (CNS-PNETs) are highly aggressive, poorly differentiated embryonal tumors occurring predominantly in young children but also affecting adolescents and adults. Herein, we demonstrate that a significant proportion of institutionally diagnosed CNS-PNETs display molecular profiles indistinguishable from those of various other well-defined CNS tumor entities, facilitating diagnosis and appropriate therapy for patients with these tumors. From the remaining fraction of CNS-PNETs, we identify four new CNS tumor entities, each associated with a recurrent genetic alteration and distinct histopathological and clinical features. These new molecular entities, designated "CNS neuroblastoma with FOXR2 activation (CNS NB-FOXR2)," "CNS Ewing sarcoma family tumor with CIC alteration (CNS EFT-CIC)," "CNS high-grade neuroepithelial tumor with MN1 alteration (CNS HGNET-MN1)," and "CNS high-grade neuroepithelial tumor with BCOR alteration (CNS HGNET-BCOR)," will enable meaningful clinical trials and the development of therapeutic strategies for patients affected by poorly differentiated CNS tumors.
KW - Amino Acid Sequence
KW - Central Nervous System Neoplasms
KW - Child
KW - DNA Methylation
KW - Forkhead Transcription Factors
KW - Gene Expression Profiling
KW - Gene Expression Regulation, Neoplastic
KW - Humans
KW - Molecular Sequence Data
KW - Neuroectodermal Tumors
KW - Proto-Oncogene Proteins
KW - Repressor Proteins
KW - Signal Transduction
KW - Tumor Suppressor Proteins
KW - Journal Article
KW - Research Support, N.I.H., Extramural
KW - Research Support, Non-U.S. Gov't
U2 - 10.1016/j.cell.2016.01.015
DO - 10.1016/j.cell.2016.01.015
M3 - Journal article
C2 - 26919435
VL - 164
SP - 1060
EP - 1072
JO - Cell
JF - Cell
SN - 0092-8674
IS - 5
ER -
