Thomas Werge

Thomas Werge

Clinical Professor

Member of:

  • Psychiatry


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  1. Published

    Polymorphisms in SREBF1 and SREBF2, two antipsychotic-activated transcription factors controlling cellular lipogenesis, are associated with schizophrenia in German and Scandinavian samples

    Le Hellard, S., Mühleisen, T. W., Djurovic, S., Fernø, J., Ouriaghi, Z., Mattheisen, M., Vasilescu, C., Raeder, M. B., Hansen, T. F., Strohmaier, J., Georgi, A., Brockschmidt, F. F., Melle, I., Nenadic, I., Sauer, H., Rietschel, M., Nöthen, M. M., Werge, T., Andreassen, O. A., Cichon, S. & 1 others, Steen, V. M., 1 May 2010, In: Molecular Psychiatry. 15, 5, p. 463-72 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders

    Weiner, D. J., Wigdor, E. M., Ripke, S., Walters, R. K., Kosmicki, J. A., Grove, J., Samocha, K. E., Goldstein, J. I., Okbay, A., Bybjerg-Grauholm, J., Werge, T., Hougaard, D. M., Taylor, J., Skuse, D., Devlin, B., Anney, R., Sanders, S. J., Bishop, S., Mortensen, P. B., Børglum, A. D. & 32 others, Smith, G. D., Daly, M. J., Robinson, E. B., Bækvad-Hansen, M., Dumont, A., Hansen, C., Hansen, T. F., Howrigan, D., Mattheisen, M., Moran, J., Mors, O., Nordentoft, Merete, Nørgaard-Pedersen, B., Poterba, T., Poulsen, J., Stevens, C., Anttila, V., Holmans, P., Huang, H., Klei, L., Lee, P. H., Medland, S. E., Neale, B., Weiss, L. A., Zwaigenbaum, L., Yu, T. W., Wittemeyer, K., Willsey, A. J., Wijsman, E. M., Wassink, T. H., Psychiatric Genomics Consortium Autism Group, P. G. C. A. G. & iPSYCH-Broad Autism Group, I. A. G., Jul 2017, In: Nature Genetics. 49, 7, p. 978-985 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Polygenic risk score, psychosocial environment and the risk of attention-deficit/hyperactivity disorder

    Østergaard, S. D., Trabjerg, B. B., Als, T. D., Climent, C. A., Privé, F., Vilhjálmsson, B. J., Bækvad-Hansen, M., Bybjerg-Grauholm, J., Hougaard, D. M., Nordentoft, Merete, Werge, Thomas, Demontis, D., Mortensen, P. B., Børglum, A. D., Mors, O. & Agerbo, E., 2020, In: Translational Psychiatry. 10, 1, 335.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Polygenic risk and progression to bipolar or psychotic disorders among individuals diagnosed with unipolar depression in early life

    Musliner, K. L., Krebs, M. D., Albiñana, C., Vilhjalmsson, B., Agerbo, E., Zandi, P. P., Hougaard, D. M., Nordentoft, Merete, Børglum, A. D., Werge, Thomas, Mortensen, P. B. & Østergaard, S. D., 2020, In: American Journal of Psychiatry. 177, 10, p. 936-943 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Polygenic profiles define aspects of clinical heterogeneity in attention deficit hyperactivity disorder

    LaBianca, S., Brikell, I., Helenius, D., Loughnan, R., Mefford, J., Palmer, C. E., Walker, R., Gådin, J. R., Krebs, M., Appadurai, V., Vaez, M., Agerbo, E., Pedersen, M. G., Børglum, A. D., Hougaard, D. M., Mors, O., Nordentoft, M., Mortensen, P. B., Kendler, K. S., Jernigan, T. L. & 7 others, Geschwind, D. H., Ingason, A., Dahl, A. W., Zaitlen, N., Dalsgaard, S., Werge, Thomas & Schork, A. J., 2024, In: Nature Genetics. 56, 2, p. 234-244 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Polygenic prediction of school performance in individuals with and without psychiatric disorders

    Rajagopal, V. M., Trajberg, B. B., Grove, J., Horsdal, H. T., Petersen, L., Bulik, C. M., Bybjerg-Grauholm, J., Baekvad-Hansen, M., Hougaard, D. M., Mors, O., Nordentoft, Merete, Werge, Thomas, Mortensen, P. B., Agerbo, E., Borglum, A. D., Demontis, D. & iPSYCH-Broad Consortium, I. C., 2020, In: Behavior Genetics. 50, 6, p. 476-477 2 p.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  7. Published

    Polygenic liability, stressful life events and risk for secondary-treated depression in early life: a nationwide register-based case-cohort study

    Musliner, K. L., Andersen, K. K., Agerbo, E., Albiñana, C., Vilhjalmsson, B. J., Rajagopal, V. M., Bybjerg-Grauholm, J., Bækved-Hansen, M., Pedersen, C. B., Pedersen, M. G., Munk-Olsen, T., Benros, M. E., Als, T. D., Grove, J., Werge, T., Børglum, A. D., Hougaard, D. M., Mors, O., Nordentoft, M., Mortensen, P. B. & 2 others, Suppli, N. P. & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, M. D. D. W. G. O. T. P. G. C., 2023, In: Psychological Medicine. 53, p. 217–226 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Polygenic Heterogeneity Across Obsessive-Compulsive Disorder Subgroups Defined by a Comorbid Diagnosis

    Strom, N. I., Grove, J., Meier, S. M., Bækvad-Hansen, M., Becker Nissen, J., Damm Als, T., Halvorsen, M., Nordentoft, Merete, Mortensen, P. B., Hougaard, D. M., Werge, Thomas, Mors, O., Børglum, A. D., Crowley, J. J., Bybjerg-Grauholm, J. & Mattheisen, M., 2021, In: Frontiers in Genetics. 12, 711624.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Accepted/In press

    Polygenic Analyses Show Important Differences Between Major Depressive Disorder Symptoms Measured Using Various Instruments

    Huang, L., Tang, S., Rietkerk, J., Appadurai, V., Krebs, M. D., Schork, A. J., Werge, Thomas, Zuber, V., Kendler, K. & Cai, N., 2024, (Accepted/In press) In: Biological Psychiatry. 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Pleiotropy between language impairment and broader behavioral disorders—an investigation of both common and rare genetic variants

    Nudel, R., Appadurai, V., Buil, A., Nordentoft, Merete & Werge, Thomas, 2021, In: Journal of Neurodevelopmental Disorders. 13, 15 p., 54.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Phenotype integration improves power and preserves specificity in biobank-based genetic studies of major depressive disorder

    Dahl, A., Thompson, M., An, U., Krebs, M., Appadurai, V., Border, R., Bacanu, S., Werge, Thomas, Flint, J., Schork, A. J., Sankararaman, S., Kendler, K. S. & Cai, N., 2023, In: Nature Genetics. 55, 12, p. 2082-2093

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Pharmacogenetic genotype and phenotype frequencies in a large Danish population-based case-cohort sample

    Lunenburg, C. A. T. C., Thirstrup, J. P., Bybjerg-Grauholm, J., Bækvad-Hansen, M., Hougaard, D. M., Nordentoft, Merete, Werge, Thomas, Børglum, A. D., Mors, O., Mortensen, P. B. & Gasse, C., 2021, In: Translational Psychiatry. 11, 1, 294.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Persistent gating deficit and increased sensitivity to NMDA receptor antagonism after puberty in a new mouse model of the human 22q11.2 microdeletion syndrome: A study in male mice

    Didriksen, M., Fejgin, K., Nilsson, S. R. O., Birknow, M. R., Grayton, H. M., Larsen, P. H., Lauridsen, J. B., Nielsen, V., Celada, P., Santana, N., Kallunki, P., Christensen, K. V., Werge, Thomas, Stensbøl, T. B., Egebjerg, J., Gastambide, F., Artigas, F., Bastlund, J. F. & Nielsen, J., 2017, In: Journal of Psychiatry and Neuroscience. 42, 1, p. 48-58 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Parental Origin of Interstitial Duplications at 15q11.2-q13.3 in Schizophrenia and Neurodevelopmental Disorders

    Isles, A. R., Ingason, A., Lowther, C., Walters, J. T. R., Gawlick, M., Stöber, G., Rees, E., Martin, J., Little, R. B., Potter, H., Georgieva, L., Pizzo, L., Ozaki, N., Aleksic, B., Kushima, I., Ikeda, M., Iwata, N., Levinson, D. F., Gejman, P. V., Shi, J. & 20 others, Sanders, A. R., Duan, J., Willis, J., Sisodiya, S. M., Costain, G., Werge, Thomas, Degenhardt, F., Giegling, I., Rujescu, D., Hreidarsson, S. J., Saemundsen, E., Ahn, J. W., Ogilvie, C. M., Girirajan, S. D., Stefansson, H., Stefansson, K., O'Donovan, M. C., Owen, M. J., Bassett, A. & Kirov, G., May 2016, In: P L o S Genetics. 12, 5, e1005993.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    PCM1 is necessary for focal ciliary integrity and is a candidate for severe schizophrenia

    Monroe, T. O., Garrett, M. E., Kousi, M., Rodriguiz, R. M., Moon, S., Bai, Y., Brodar, S. C., Soldano, K. L., Savage, J., Hansen, T. F., Muzny, D. M., Gibbs, R. A., Barak, L., Sullivan, P. F., Ashley-Koch, A. E., Sawa, A., Wetsel, W. C., Werge, Thomas & Katsanis, N., 2020, In: Nature Communications. 11, 1, 14 p., 5903.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Novel variant of CYP2D6*6 is undetected by a commonly used genotyping procedure

    Rasmussen, H. B. & Werge, Thomas, 2011, In: Pharmacological Reports. 63, 5, p. 1264-6 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Nomenclature for alleles of the human carboxylesterase 1 gene

    INDICES Consortium, I. C., 1 Jan 2017, In: Pharmacogenetics and Genomics. 27, 2, p. 78-80 3 p.

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  18. Published

    No significant association of the 5' end of neuregulin 1 and schizophrenia in a large Danish sample

    Ingason, A., Søeby, K., Timm, S., Wang, August Gabriel, Jakobsen, K. D., Fink-Jensen, Anders, Hemmingsen, R. P. A., Berg Rasmussen, H. & Werge, Thomas, 2006, In: Schizophrenia Research. 83, 1, p. 1-5 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    No interactions between genetic polymorphisms and stressful life events on outcome of antidepressant treatment

    Bukh, Jens Otto Drachmann, Bock, C., Vinberg, Maj, Werge, Thomas, Gether, Ulrik, Kessing, Lars Vedel, Bukh, J. D., Bock, C., Vinberg, Maj, Werge, Thomas, Gether, U. & Kessing, Lars Vedel, 2009, In: European Neuropsychopharmacology.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    No influence of the polymorphisms CYP2C19 and CYP2D6 on the efficacy of cyclophosphamide, thalidomide, and bortezomib in patients with Multiple Myeloma

    Vangsted, A. J., Søeby, K., Klausen, T. W., Abildgaard, N., Andersen, N. F., Gimsing, P., Gregersen, H., Vogel, U., Werge, Thomas & Rasmussen, Henrik Berg, 4 Aug 2010, In: B M C Cancer. 10, p. 404 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    No evidence of associations between genetic liability for schizophrenia and development of cannabis use disorder

    Hjorthøj, Carsten, Uddin, M. J., Wimberley, T., Dalsgaard, S., Hougaard, D. M., Borglum, A., Werge, Thomas & Nordentoft, Merete, 2021, In: Psychological Medicine. 51, 3, p. 479-484 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    No association of polymorphisms in human endogenous retrovirus K18 and CD48 with schizophrenia

    Nyegaard, M., Demontis, D., Thestrup, B. B., Hedemand, A., Sørensen, K. M., Hansen, T., Werge, Thomas, Hougaard, D. M., Yolken, R. H., Mortensen, P. B., Mors, O. & Børglum, A., Jun 2012, In: Psychiatric Genetics. 22, 3, p. 146-8 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    No association between DGKH and bipolar disorder in a Scandinavian case-control sample

    Tesli, M., Kähler, A., Andreassen, B., Werge, T., Mors, O., Mellerup, E., Koefoed, P., Melle, I., Morken, G., Wirgenes, K., Andreassen, O., Djurovic, S., Tesli, M., Kähler, A. K., Andreassen, B. K., Werge, T., Mors, O., Mellerup, E., Koefoed, P., Melle, I. & 4 others, Morken, G., Wirgenes, K. V., Andreassen, O. A. & Djurovic, S., 2009, In: Psychiatric Genetics. 19, 5, p. 269-72 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication Study

    Johnson, E. C., Bjelland, D. W., Howrigan, D. P., Abdellaoui, A., Breen, G., Borglum, A. D., Cichon, S., Degenhardt, F., Forstner, A. J., Frank, J., Genovese, G., Heilmann-Heimbach, S., Herms, S., Hoffman, P., Maier, W., Mattheisen, M., Morris, D. W., Mowry, B. J., Müller-Mhysok, B., Neale, B. M. & 297 others, Nenadic, I., Nöthen, M. M., O’Dushlaine, C., Rietschel, M., Ruderfer, D. M., Rujescu, D., Schulze, T. G., Simonson, M. A., Stahl, E. A., Strohmaier, J., Witt, S. H., Ripke, S., Neale, B. M., Corvin, A., Walters, J. T. R., Farh, K., Holmans, P. A., Lee, P. H., Bulik-Sullivan, B., Collier, D. A., Huang, H., Pers, Tune H, Agartz, I., Agerbo, E., Albus, M., Alexander, M., Amin, F., Bacanu, S., Begemann, M., Belliveau, R. A., Bene, J., Bergen, S. E., Bevilacqua, E., Bigdeli, T. B., Black, D. W., Bruggeman, R., Buccola, N. G., Buckner, R. L., Byerley, W. F., Cahn, W., Cai, G., Campion, D., Cantor, R. M., Carr, V. J., Carrera, N., Catts, S. V., Chambert, K. D., Chan, R. C. K., Chen, R. Y. L., Chen, E. Y. H., Cheng, W., Cheung, E. F. C., Chong, S. A., Robert Cloninger, C., Cohen, D., Cohen, N., Cormican, P., Craddock, N., Crowley, J. J., Curtis, D., Davidson, M., Davis, K. L., Del-Favero, J., Demontis, D., Dikeos, D., Dinan, T., Djurovic, S., Donohoe, G., Drapeau, E., Duan, J., Dudbridge, F., Durmishi, N., Eichhammer, P., Eriksson, J., Escott-Price, V., Essioux, L., Fanous, A. H., Farrell, M. S., Franke, L., Freedman, R., Freimer, N. B., Friedl, M., Friedman, J. I., Fromer, M., Georgieva, L., Giegling, I., Giusti-Rodríguez, P., Godard, S., Goldstein, J. I., Golimbet, V., Gopal, S., Gratten, J., de Haan, L., Hammer, C., Hamshere, M. L., Hansen, M., Hansen, T., Haroutunian, V., Hartmann, A. M., Henskens, F. A., Hirschhorn, J. N., Hoffmann, P., Hofman, A., Hollegaard, M. V., Hougaard, D. M., Ikeda, M., Joa, I., Julià, A., Kahn, R. S., Kalaydjieva, L., Karachanak-Yankova, S., Karjalainen, J., Kavanagh, D., Kennedy, J. L., Khrunin, A., Kim, Y., Klovins, J., Knowles, J. A., Konte, B., Kucinskas, V., Kucinskiene, Z. A., Kuzelova-Ptackova, H., Kähler, A. K., Laurent, C., Chee Keong, J. L., Hong Lee, S., Legge, S. E., Lerer, B., Li, M., Li, T., Liang, K., Lieberman, J., Limborska, S., Loughland, C. M., Lubinski, J., Lönnqvist, J., Macek, M., Magnusson, P. K. E., Maher, B. S., Mallet, J., Marsal, S., Mattingsdal, M., McCarley, R. W., McDonald, C., McIntosh, A. M., Meier, S. M., Meijer, C. J., Melegh, B., Melle, I., Mesholam-Gately, R. I., Metspalu, A., Michie, P. T., Milani, L., Milanova, V., Mokrab, Y., Morris, D. W., Mors, O., Murphy, K. C., Murray, R. M., Myin-Germeys, I., Müller-Myhsok, B., Nelis, M., Nertney, D. A., Nestadt, G., Nicodemus, K. K., Nikitina-Zake, L., Nisenbaum, L., Nordin, A., O'Callaghan, E., O'Dushlaine, C. T., Anthony O'Neill, F., Oh, S. Y., Olincy, A., Olsen, L., van Os, J., Pantelis, C., Papadimitriou, G. N., Papiol, S., Parkhomenko, E., Pato, M. T., Paunio, T., Pejovic-Milovancevic, M., Perkins, D. O., Pietiläinen, O., Pimm, J., Pocklington, A. J., Powell, J., Price, A. L., Pulver, A. E., Purcell, S. M., Quested, D., Rasmussen, Henrik Berg, Reichenberg, A., Reimers, M. A., Richards, A. L., Roffman, J. L., Roussos, P., Salomaa, V., Sanders, A. R., Schall, U., Schubert, C. R., Schwab, S. G., Scolnick, E. M., Scott, R. J., Seidman, L. J., Shi, J., Sigurdsson, E., Silagadze, T., Silverman, J. M., Sim, K., Slominsky, P., Smoller, J. W., So, H. C., Spencer, C. C. A., Stahl, E. A., Stefansson, H., Steinberg, S., Stogmann, E., Straub, R. E., Strengman, E., Scott Stroup, T., Subramaniam, M., Suvisaari, J., Svrakic, D. M., Szatkiewicz, J. P., Söderman, E., Thirumalai, S., Toncheva, D., Tosato, S., Veijola, J., Waddington, J., Walsh, D., Wang, D., Wang, Q., Webb, B. T., Weiser, M., Wildenauer, D. B., Williams, N. M., Watts-Williams, S. J., Wolen, A. R., Wong, E. H. M., Wormley, B. K., Xi, H. S., Zai, C. C., Zheng, X., Zimprich, F., Wray, N. R., Stefansson, K., Visscher, P. M., Adolfsson, R., Andreassen, O. A., Blackwood, D. H. R., Bramon, E., Buxbaum, J. D., Børglum, A. D., Darvasi, A., Domenici, E., Ehrenreich, H., Esko, T., Gejman, P. V., Gill, M., Gurling, H., Hultman, C. M., Iwata, N., Jablensky, A. V., Jönsson, E. G., Kendler, K. S., Kirov, G., Knight, J., Lencz, T., Levinson, D. F., Li, Q. S., Liu, J., Malhotra, A. K., McCarroll, S. A., McQuillin, A., Moran, J. L., Mortensen, P. B., Mowry, B. J., Nöthen, M. M., Ophoff, R. A., Owen, M. J., Palotie, A., Pato, C. N., Petryshen, T. L., Posthuma, D., Riley, B. P., Sham, P., Sklar, P., St Clair, D., Weinberger, D. R., Wendland, J. R., Werge, Thomas, Daly, M. J., O'Donovan, M. C., Sullivan, P. F. & Keller, M. C., Oct 2016, In: PLOS Genetics. 12, 10, 20 p., e1006343.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Neuropeptide Y genes and suicidal behaviour among schizophrenic patients

    Wang, August Gabriel, Koefoed, P., Jacoby, A. S., Woldbye, David Paul Drucker, Rasmussen, Henrik Berg, Timm, S., Dam, H., Jakobsen, K. D., Nordentoft, Merete, Jürgens, Gesche, Sorensen, H. J., Garsdal, O., Hvid, M. & Werge, Thomas, Jun 2013, In: Psychiatric Genetics. 23, 3, p. 139-40 2 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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ID: 34394780