Common Variants at VRK2 and TCF4 Conferring Risk of Schizophrenia
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Common Variants at VRK2 and TCF4 Conferring Risk of Schizophrenia. / Irish Schizophrenia Genomics Consortium; GROUP; Wellcome Trust Case Control Consortium.
In: Human Molecular Genetics, Vol. 20, No. 20, 26.07.2011, p. 4076-4081.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Common Variants at VRK2 and TCF4 Conferring Risk of Schizophrenia
AU - Steinberg, Stacy
AU - de Jong, Simone
AU - Irish Schizophrenia Genomics Consortium
AU - Andreassen, Ole A
AU - Werge, Thomas
AU - Børglum, Anders
AU - Mors, Ole
AU - Mortensen, Preben Bo
AU - Gustafsson, Omar
AU - Costas, Javier
AU - Pietiläinen, Olli P H
AU - Demontis, Ditte
AU - Papiol, Sergi
AU - Huttenlocher, Johanna
AU - Mattheisen, Manuel
AU - Breuer, René
AU - Vassos, Evangelos
AU - Giegling, Ina
AU - Fraser, Gillian
AU - Walker, Nicholas
AU - Tuulio-Henriksson, Annamari
AU - Suvisaari, Jaana
AU - Lönnqvist, Jouko
AU - Paunio, Tiina
AU - Agartz, Ingrid
AU - Melle, Ingrid
AU - Djurovic, Srdjan
AU - Strengman, Eric
AU - GROUP
AU - Jürgens, Gesche
AU - Glenthøj, Birte
AU - Terenius, Lars
AU - Hougaard, David M
AU - Orntoft, Torben
AU - Wiuf, Carsten Henrik
AU - Didriksen, Michael
AU - Hollegaard, Mads Vilhelm
AU - Nordentoft, Merete
AU - van Winkel, Ruud
AU - Kenis, Gunter
AU - Abramova, Lilia
AU - Kaleda, Vasily
AU - Arrojo, Manuel
AU - Sanjuán, Julio
AU - Arango, Celso
AU - Sperling, Swetlana
AU - Rossner, Moritz
AU - Ribolsi, Michele
AU - Magni, Valentina
AU - Siracusano, Alberto
AU - Christiansen, Claus
AU - Kiemeney, Lambertus A
AU - Wellcome Trust Case Control Consortium
PY - 2011/7/26
Y1 - 2011/7/26
N2 - Common sequence variants have recently joined rare structural polymorphisms as genetic factors with strong evidence for association with schizophrenia. Here we extend our previous genome-wide association (GWA) study and meta-analysis (totalling 7,946 cases and 19,036 controls) by examining an expanded set of variants using an enlarged follow-up sample (up to 10,260 cases and 23,500 controls). In addition to previously-reported alleles in the major histocompatibility complex (MHC) region, near neurogranin (NRGN) and in an intron of transcription factor 4 (TCF4), we find two novel variants showing genome-wide significant association: rs2312147[C], upstream of vaccinia-related kinase 2 (VRK2) (OR = 1.09, P = 1.9 x 10(-9)), and rs4309482[A], between coiled-coiled domain containing 68 (CCDC68) and TCF4, about 400 kb from the previously-described risk allele, but not accounted for by its association (OR = 1.09, P = 7.8 x 10(-9)).
AB - Common sequence variants have recently joined rare structural polymorphisms as genetic factors with strong evidence for association with schizophrenia. Here we extend our previous genome-wide association (GWA) study and meta-analysis (totalling 7,946 cases and 19,036 controls) by examining an expanded set of variants using an enlarged follow-up sample (up to 10,260 cases and 23,500 controls). In addition to previously-reported alleles in the major histocompatibility complex (MHC) region, near neurogranin (NRGN) and in an intron of transcription factor 4 (TCF4), we find two novel variants showing genome-wide significant association: rs2312147[C], upstream of vaccinia-related kinase 2 (VRK2) (OR = 1.09, P = 1.9 x 10(-9)), and rs4309482[A], between coiled-coiled domain containing 68 (CCDC68) and TCF4, about 400 kb from the previously-described risk allele, but not accounted for by its association (OR = 1.09, P = 7.8 x 10(-9)).
U2 - 10.1093/hmg/ddr325
DO - 10.1093/hmg/ddr325
M3 - Journal article
C2 - 21791550
VL - 20
SP - 4076
EP - 4081
JO - Human Molecular Genetics
JF - Human Molecular Genetics
SN - 0964-6906
IS - 20
ER -
ID: 34045619