D-amino acid oxidase activator gene (DAOA) variation affects cerebrospinal fluid homovanillic acid concentrations in healthy Caucasians

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

D-amino acid oxidase activator gene (DAOA) variation affects cerebrospinal fluid homovanillic acid concentrations in healthy Caucasians. / Andreou, Dimitrios; Saetre, Peter; Werge, Thomas; Andreassen, Ole A; Agartz, Ingrid; Sedvall, Göran C; Hall, Håkan; Terenius, Lars; Jönsson, Erik G.

In: European Archives of Psychiatry and Clinical Neuroscience, Vol. 262, No. 7, 2012, p. 549-56.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Andreou, D, Saetre, P, Werge, T, Andreassen, OA, Agartz, I, Sedvall, GC, Hall, H, Terenius, L & Jönsson, EG 2012, 'D-amino acid oxidase activator gene (DAOA) variation affects cerebrospinal fluid homovanillic acid concentrations in healthy Caucasians', European Archives of Psychiatry and Clinical Neuroscience, vol. 262, no. 7, pp. 549-56. https://doi.org/10.1007/s00406-012-0313-z

APA

Andreou, D., Saetre, P., Werge, T., Andreassen, O. A., Agartz, I., Sedvall, G. C., Hall, H., Terenius, L., & Jönsson, E. G. (2012). D-amino acid oxidase activator gene (DAOA) variation affects cerebrospinal fluid homovanillic acid concentrations in healthy Caucasians. European Archives of Psychiatry and Clinical Neuroscience, 262(7), 549-56. https://doi.org/10.1007/s00406-012-0313-z

Vancouver

Andreou D, Saetre P, Werge T, Andreassen OA, Agartz I, Sedvall GC et al. D-amino acid oxidase activator gene (DAOA) variation affects cerebrospinal fluid homovanillic acid concentrations in healthy Caucasians. European Archives of Psychiatry and Clinical Neuroscience. 2012;262(7):549-56. https://doi.org/10.1007/s00406-012-0313-z

Author

Andreou, Dimitrios ; Saetre, Peter ; Werge, Thomas ; Andreassen, Ole A ; Agartz, Ingrid ; Sedvall, Göran C ; Hall, Håkan ; Terenius, Lars ; Jönsson, Erik G. / D-amino acid oxidase activator gene (DAOA) variation affects cerebrospinal fluid homovanillic acid concentrations in healthy Caucasians. In: European Archives of Psychiatry and Clinical Neuroscience. 2012 ; Vol. 262, No. 7. pp. 549-56.

Bibtex

@article{0a986e0a4af7444cb0ccd52d320fa44d,
title = "D-amino acid oxidase activator gene (DAOA) variation affects cerebrospinal fluid homovanillic acid concentrations in healthy Caucasians",
abstract = "The D-amino acid oxidase activator (DAOA) protein regulates the function of D-amino oxidase (DAO), an enzyme that catalyzes the oxidative deamination of D-3,4-dihydroxyphenylalanine (D-DOPA) and D-serine. D-DOPA is converted to L-3,4-DOPA, a precursor of dopamine, whereas D-serine participates in glutamatergic transmission. We hypothesized that DAOA polymorphisms are associated with dopamine, serotonin and noradrenaline turnover in the human brain. Four single-nucleotide polymorphisms, previously reported to be associated with schizophrenia, were genotyped. Cerebrospinal fluid (CSF) samples were drawn by lumbar puncture, and the concentrations of the major dopamine metabolite homovanillic acid (HVA), the major serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) and the major noradrenaline metabolite 3-methoxy-4-hydroxyphenylglycol (MHPG) were measured. Two of the investigated polymorphisms, rs3918342 and rs1421292, were significantly associated with CSF HVA concentrations. Rs3918342 was found to be nominally associated with CSF 5-HIAA concentrations. None of the polymorphisms were significantly associated with MHPG concentrations. Our results indicate that DAOA gene variation affects dopamine turnover in healthy individuals, suggesting that disturbed dopamine turnover is a possible mechanism behind the observed associations between genetic variation in DAOA and behavioral phenotypes in humans.",
author = "Dimitrios Andreou and Peter Saetre and Thomas Werge and Andreassen, {Ole A} and Ingrid Agartz and Sedvall, {G{\"o}ran C} and H{\aa}kan Hall and Lars Terenius and J{\"o}nsson, {Erik G}",
year = "2012",
doi = "10.1007/s00406-012-0313-z",
language = "English",
volume = "262",
pages = "549--56",
journal = "European Archives of Psychiatry and Clinical Neuroscience",
issn = "0940-1334",
publisher = "Springer Medizin",
number = "7",

}

RIS

TY - JOUR

T1 - D-amino acid oxidase activator gene (DAOA) variation affects cerebrospinal fluid homovanillic acid concentrations in healthy Caucasians

AU - Andreou, Dimitrios

AU - Saetre, Peter

AU - Werge, Thomas

AU - Andreassen, Ole A

AU - Agartz, Ingrid

AU - Sedvall, Göran C

AU - Hall, Håkan

AU - Terenius, Lars

AU - Jönsson, Erik G

PY - 2012

Y1 - 2012

N2 - The D-amino acid oxidase activator (DAOA) protein regulates the function of D-amino oxidase (DAO), an enzyme that catalyzes the oxidative deamination of D-3,4-dihydroxyphenylalanine (D-DOPA) and D-serine. D-DOPA is converted to L-3,4-DOPA, a precursor of dopamine, whereas D-serine participates in glutamatergic transmission. We hypothesized that DAOA polymorphisms are associated with dopamine, serotonin and noradrenaline turnover in the human brain. Four single-nucleotide polymorphisms, previously reported to be associated with schizophrenia, were genotyped. Cerebrospinal fluid (CSF) samples were drawn by lumbar puncture, and the concentrations of the major dopamine metabolite homovanillic acid (HVA), the major serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) and the major noradrenaline metabolite 3-methoxy-4-hydroxyphenylglycol (MHPG) were measured. Two of the investigated polymorphisms, rs3918342 and rs1421292, were significantly associated with CSF HVA concentrations. Rs3918342 was found to be nominally associated with CSF 5-HIAA concentrations. None of the polymorphisms were significantly associated with MHPG concentrations. Our results indicate that DAOA gene variation affects dopamine turnover in healthy individuals, suggesting that disturbed dopamine turnover is a possible mechanism behind the observed associations between genetic variation in DAOA and behavioral phenotypes in humans.

AB - The D-amino acid oxidase activator (DAOA) protein regulates the function of D-amino oxidase (DAO), an enzyme that catalyzes the oxidative deamination of D-3,4-dihydroxyphenylalanine (D-DOPA) and D-serine. D-DOPA is converted to L-3,4-DOPA, a precursor of dopamine, whereas D-serine participates in glutamatergic transmission. We hypothesized that DAOA polymorphisms are associated with dopamine, serotonin and noradrenaline turnover in the human brain. Four single-nucleotide polymorphisms, previously reported to be associated with schizophrenia, were genotyped. Cerebrospinal fluid (CSF) samples were drawn by lumbar puncture, and the concentrations of the major dopamine metabolite homovanillic acid (HVA), the major serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) and the major noradrenaline metabolite 3-methoxy-4-hydroxyphenylglycol (MHPG) were measured. Two of the investigated polymorphisms, rs3918342 and rs1421292, were significantly associated with CSF HVA concentrations. Rs3918342 was found to be nominally associated with CSF 5-HIAA concentrations. None of the polymorphisms were significantly associated with MHPG concentrations. Our results indicate that DAOA gene variation affects dopamine turnover in healthy individuals, suggesting that disturbed dopamine turnover is a possible mechanism behind the observed associations between genetic variation in DAOA and behavioral phenotypes in humans.

U2 - 10.1007/s00406-012-0313-z

DO - 10.1007/s00406-012-0313-z

M3 - Journal article

C2 - 22454242

VL - 262

SP - 549

EP - 556

JO - European Archives of Psychiatry and Clinical Neuroscience

JF - European Archives of Psychiatry and Clinical Neuroscience

SN - 0940-1334

IS - 7

ER -

ID: 48611219