DTNBP1, NRG1, DAOA, DAO and GRM3 polymorphisms and schizophrenia: an association study
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DTNBP1, NRG1, DAOA, DAO and GRM3 polymorphisms and schizophrenia: an association study. / Jönsson, Erik G; Saetre, Peter; Vares, Maria; Andreou, Dimitrios; Larsson, Kristina; Timm, Sally; Rasmussen, Henrik B; Djurovic, Srdjan; Melle, Ingrid; Andreassen, Ole A; Agartz, Ingrid; Werge, Thomas; Hall, Håkan; Terenius, Lars; Jönsson, Erik G; Saetre, Peter; Vares, Maria; Andreou, Dimitrios; Larsson, Kristina; Timm, Sally; Rasmussen, Henrik B; Djurovic, Srdjan; Melle, Ingrid; Andreassen, Ole A; Agartz, Ingrid; Werge, Thomas; Hall, Håkan; Terenius, Lars.
In: Neuropsychobiology, Vol. 59, No. 3, 2009, p. 142-50.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - DTNBP1, NRG1, DAOA, DAO and GRM3 polymorphisms and schizophrenia: an association study
AU - Jönsson, Erik G
AU - Saetre, Peter
AU - Vares, Maria
AU - Andreou, Dimitrios
AU - Larsson, Kristina
AU - Timm, Sally
AU - Rasmussen, Henrik B
AU - Djurovic, Srdjan
AU - Melle, Ingrid
AU - Andreassen, Ole A
AU - Agartz, Ingrid
AU - Werge, Thomas
AU - Hall, Håkan
AU - Terenius, Lars
AU - Jönsson, Erik G
AU - Saetre, Peter
AU - Vares, Maria
AU - Andreou, Dimitrios
AU - Larsson, Kristina
AU - Timm, Sally
AU - Rasmussen, Henrik B
AU - Djurovic, Srdjan
AU - Melle, Ingrid
AU - Andreassen, Ole A
AU - Agartz, Ingrid
AU - Werge, Thomas
AU - Hall, Håkan
AU - Terenius, Lars
N1 - Keywords: Adult; Alleles; Carrier Proteins; Case-Control Studies; D-Amino-Acid Oxidase; DNA Mutational Analysis; Female; Gene Frequency; Genome-Wide Association Study; Genotype; Haplotypes; Humans; Logistic Models; Male; Middle Aged; Nerve Tissue Proteins; Odds Ratio; Polymorphism, Single Nucleotide; Receptors, Metabotropic Glutamate; Schizophrenia
PY - 2009
Y1 - 2009
N2 - BACKGROUND: Several studies of the dystrobrevin-binding protein 1 gene (DTNBP1), neuregulin 1 (NRG1), D-amino-acid oxidase (DAO), DAO activator (DAOA, G72), and metabotropic glutamate receptor 3 (GRM3) genes have suggested an association between variants of these genes and schizophrenia. METHODS: In a replication attempt, single-nucleotide polymorphisms of the DTNBP1, NRG1, DAO, DAOA, and GRM3 genes were analyzed in three independent Scandinavian schizophrenia case-control samples. RESULTS: One DTNBP1 and three GRM3 single-nucleotide polymorphisms showed nominal significant associations to the disease. However, after correction for multiple testing, there were no statistically significant allele, genotype or haplotype case-control differences. CONCLUSIONS: The present Scandinavian results do not verify previous associations between the analyzed DTNBP1, NRG1, DAO, DAOA, and GRM3 gene polymorphisms and schizophrenia. Additional studies and meta-analyses are warranted to shed further light on these relationships.
AB - BACKGROUND: Several studies of the dystrobrevin-binding protein 1 gene (DTNBP1), neuregulin 1 (NRG1), D-amino-acid oxidase (DAO), DAO activator (DAOA, G72), and metabotropic glutamate receptor 3 (GRM3) genes have suggested an association between variants of these genes and schizophrenia. METHODS: In a replication attempt, single-nucleotide polymorphisms of the DTNBP1, NRG1, DAO, DAOA, and GRM3 genes were analyzed in three independent Scandinavian schizophrenia case-control samples. RESULTS: One DTNBP1 and three GRM3 single-nucleotide polymorphisms showed nominal significant associations to the disease. However, after correction for multiple testing, there were no statistically significant allele, genotype or haplotype case-control differences. CONCLUSIONS: The present Scandinavian results do not verify previous associations between the analyzed DTNBP1, NRG1, DAO, DAOA, and GRM3 gene polymorphisms and schizophrenia. Additional studies and meta-analyses are warranted to shed further light on these relationships.
U2 - 10.1159/000218076
DO - 10.1159/000218076
M3 - Journal article
C2 - 19439994
VL - 59
SP - 142
EP - 150
JO - Neuropsychobiology
JF - Neuropsychobiology
SN - 0302-282X
IS - 3
ER -
ID: 21337043