Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

Research output: Contribution to journal › Journal article › Research › peer-review

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Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank. / Coleman, Jonathan R.I.; Peyrot, Wouter J.; Purves, Kirstin L.; Davis, Katrina A.S.; Rayner, Christopher; Choi, Shing Wan; Hübel, Christopher; Gaspar, Héléna A.; Kan, Carol; Van der Auwera, Sandra; Adams, Mark James; Lyall, Donald M.; Choi, Karmel W.; Wray, Naomi R.; Ripke, Stephan; Mattheisen, Manuel; Trzaskowski, Maciej; Byrne, Enda M.; Abdellaoui, Abdel; Adams, Mark J.; Agerbo, Esben; Air, Tracy M.; Andlauer, Till F.M.; Bacanu, Silviu Alin; Bækvad-Hansen, Marie; Beekman, Aartjan T.F.; Bigdeli, Tim B.; Binder, Elisabeth B.; Bryois, Julien; Buttenschøn, Henriette N.; Bybjerg-Grauholm, Jonas; Cai, Na; Castelao, Enrique; Christensen, Jane Hvarregaard; Clarke, Toni Kim; Coleman, Jonathan R.I.; Colodro-Conde, Lucía; Couvy-Duchesne, Baptiste; Craddock, Nick; Crawford, Gregory E.; Davies, Gail; Deary, Ian J.; Degenhardt, Franziska; Derks, Eske M.; Hansen, Christine Søholm; Hansen, Thomas F.; Pedersen, Carsten Bøcker; Pedersen, Marianne Giørtz; Nordentoft, Merete; Werge, Thomas; on the behalf of Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium.

In: Molecular Psychiatry, Vol. 25, 05.2020, p. 1430-1446.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Coleman, JRI, Peyrot, WJ, Purves, KL, Davis, KAS, Rayner, C, Choi, SW, Hübel, C, Gaspar, HA, Kan, C, Van der Auwera, S, Adams, MJ, Lyall, DM, Choi, KW, Wray, NR, Ripke, S, Mattheisen, M, Trzaskowski, M, Byrne, EM, Abdellaoui, A, Adams, MJ, Agerbo, E, Air, TM, Andlauer, TFM, Bacanu, SA, Bækvad-Hansen, M, Beekman, ATF, Bigdeli, TB, Binder, EB, Bryois, J, Buttenschøn, HN, Bybjerg-Grauholm, J, Cai, N, Castelao, E, Christensen, JH, Clarke, TK, Coleman, JRI, Colodro-Conde, L, Couvy-Duchesne, B, Craddock, N, Crawford, GE, Davies, G, Deary, IJ, Degenhardt, F, Derks, EM, Hansen, CS, Hansen, TF, Pedersen, CB, Pedersen, MG, Nordentoft, M, Werge, T & on the behalf of Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium 2020, 'Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank', Molecular Psychiatry, vol. 25, pp. 1430-1446. https://doi.org/10.1038/s41380-019-0546-6

APA

Coleman, J. R. I., Peyrot, W. J., Purves, K. L., Davis, K. A. S., Rayner, C., Choi, S. W., Hübel, C., Gaspar, H. A., Kan, C., Van der Auwera, S., Adams, M. J., Lyall, D. M., Choi, K. W., Wray, N. R., Ripke, S., Mattheisen, M., Trzaskowski, M., Byrne, E. M., Abdellaoui, A., ... on the behalf of Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (2020). Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank. Molecular Psychiatry, 25, 1430-1446. https://doi.org/10.1038/s41380-019-0546-6

Vancouver

Coleman JRI, Peyrot WJ, Purves KL, Davis KAS, Rayner C, Choi SW et al. Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank. Molecular Psychiatry. 2020 May;25:1430-1446. https://doi.org/10.1038/s41380-019-0546-6

Author

Coleman, Jonathan R.I. ; Peyrot, Wouter J. ; Purves, Kirstin L. ; Davis, Katrina A.S. ; Rayner, Christopher ; Choi, Shing Wan ; Hübel, Christopher ; Gaspar, Héléna A. ; Kan, Carol ; Van der Auwera, Sandra ; Adams, Mark James ; Lyall, Donald M. ; Choi, Karmel W. ; Wray, Naomi R. ; Ripke, Stephan ; Mattheisen, Manuel ; Trzaskowski, Maciej ; Byrne, Enda M. ; Abdellaoui, Abdel ; Adams, Mark J. ; Agerbo, Esben ; Air, Tracy M. ; Andlauer, Till F.M. ; Bacanu, Silviu Alin ; Bækvad-Hansen, Marie ; Beekman, Aartjan T.F. ; Bigdeli, Tim B. ; Binder, Elisabeth B. ; Bryois, Julien ; Buttenschøn, Henriette N. ; Bybjerg-Grauholm, Jonas ; Cai, Na ; Castelao, Enrique ; Christensen, Jane Hvarregaard ; Clarke, Toni Kim ; Coleman, Jonathan R.I. ; Colodro-Conde, Lucía ; Couvy-Duchesne, Baptiste ; Craddock, Nick ; Crawford, Gregory E. ; Davies, Gail ; Deary, Ian J. ; Degenhardt, Franziska ; Derks, Eske M. ; Hansen, Christine Søholm ; Hansen, Thomas F. ; Pedersen, Carsten Bøcker ; Pedersen, Marianne Giørtz ; Nordentoft, Merete ; Werge, Thomas ; on the behalf of Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium. / Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank. In: Molecular Psychiatry. 2020 ; Vol. 25. pp. 1430-1446.

Bibtex

@article{ce61337f12d94d2d9bcd92be7dbd40da,
title = "Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank",
abstract = "Depression is more frequent among individuals exposed to traumatic events. Both trauma exposure and depression are heritable. However, the relationship between these traits, including the role of genetic risk factors, is complex and poorly understood. When modelling trauma exposure as an environmental influence on depression, both gene-environment correlations and gene-environment interactions have been observed. The UK Biobank concurrently assessed Major Depressive Disorder (MDD) and self-reported lifetime exposure to traumatic events in 126,522 genotyped individuals of European ancestry. We contrasted genetic influences on MDD stratified by reported trauma exposure (final sample size range: 24,094–92,957). The SNP-based heritability of MDD with reported trauma exposure (24%) was greater than MDD without reported trauma exposure (12%). Simulations showed that this is not confounded by the strong, positive genetic correlation observed between MDD and reported trauma exposure. We also observed that the genetic correlation between MDD and waist circumference was only significant in individuals reporting trauma exposure (rg = 0.24, p = 1.8 × 10−7 versus rg = −0.05, p = 0.39 in individuals not reporting trauma exposure, difference p = 2.3 × 10−4). Our results suggest that the genetic contribution to MDD is greater when reported trauma is present, and that a complex relationship exists between reported trauma exposure, body composition, and MDD.",
author = "Coleman, {Jonathan R.I.} and Peyrot, {Wouter J.} and Purves, {Kirstin L.} and Davis, {Katrina A.S.} and Christopher Rayner and Choi, {Shing Wan} and Christopher H{\"u}bel and Gaspar, {H{\'e}l{\'e}na A.} and Carol Kan and {Van der Auwera}, Sandra and Adams, {Mark James} and Lyall, {Donald M.} and Choi, {Karmel W.} and Wray, {Naomi R.} and Stephan Ripke and Manuel Mattheisen and Maciej Trzaskowski and Byrne, {Enda M.} and Abdel Abdellaoui and Adams, {Mark J.} and Esben Agerbo and Air, {Tracy M.} and Andlauer, {Till F.M.} and Bacanu, {Silviu Alin} and Marie B{\ae}kvad-Hansen and Beekman, {Aartjan T.F.} and Bigdeli, {Tim B.} and Binder, {Elisabeth B.} and Julien Bryois and Buttensch{\o}n, {Henriette N.} and Jonas Bybjerg-Grauholm and Na Cai and Enrique Castelao and Christensen, {Jane Hvarregaard} and Clarke, {Toni Kim} and Coleman, {Jonathan R.I.} and Luc{\'i}a Colodro-Conde and Baptiste Couvy-Duchesne and Nick Craddock and Crawford, {Gregory E.} and Gail Davies and Deary, {Ian J.} and Franziska Degenhardt and Derks, {Eske M.} and Hansen, {Christine S{\o}holm} and Hansen, {Thomas F.} and Pedersen, {Carsten B{\o}cker} and Pedersen, {Marianne Gi{\o}rtz} and Merete Nordentoft and Thomas Werge and {on the behalf of Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium}",
year = "2020",
month = may,
doi = "10.1038/s41380-019-0546-6",
language = "English",
volume = "25",
pages = "1430--1446",
journal = "Molecular Psychiatry",
issn = "1359-4184",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

AU - Coleman, Jonathan R.I.

AU - Peyrot, Wouter J.

AU - Purves, Kirstin L.

AU - Davis, Katrina A.S.

AU - Rayner, Christopher

AU - Choi, Shing Wan

AU - Hübel, Christopher

AU - Gaspar, Héléna A.

AU - Kan, Carol

AU - Van der Auwera, Sandra

AU - Adams, Mark James

AU - Lyall, Donald M.

AU - Choi, Karmel W.

AU - Wray, Naomi R.

AU - Ripke, Stephan

AU - Mattheisen, Manuel

AU - Trzaskowski, Maciej

AU - Byrne, Enda M.

AU - Abdellaoui, Abdel

AU - Adams, Mark J.

AU - Agerbo, Esben

AU - Air, Tracy M.

AU - Andlauer, Till F.M.

AU - Bacanu, Silviu Alin

AU - Bækvad-Hansen, Marie

AU - Beekman, Aartjan T.F.

AU - Bigdeli, Tim B.

AU - Binder, Elisabeth B.

AU - Bryois, Julien

AU - Buttenschøn, Henriette N.

AU - Bybjerg-Grauholm, Jonas

AU - Cai, Na

AU - Castelao, Enrique

AU - Christensen, Jane Hvarregaard

AU - Clarke, Toni Kim

AU - Coleman, Jonathan R.I.

AU - Colodro-Conde, Lucía

AU - Couvy-Duchesne, Baptiste

AU - Craddock, Nick

AU - Crawford, Gregory E.

AU - Davies, Gail

AU - Deary, Ian J.

AU - Degenhardt, Franziska

AU - Derks, Eske M.

AU - Hansen, Christine Søholm

AU - Hansen, Thomas F.

AU - Pedersen, Carsten Bøcker

AU - Pedersen, Marianne Giørtz

AU - Nordentoft, Merete

AU - Werge, Thomas

AU - on the behalf of Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium

PY - 2020/5

Y1 - 2020/5

N2 - Depression is more frequent among individuals exposed to traumatic events. Both trauma exposure and depression are heritable. However, the relationship between these traits, including the role of genetic risk factors, is complex and poorly understood. When modelling trauma exposure as an environmental influence on depression, both gene-environment correlations and gene-environment interactions have been observed. The UK Biobank concurrently assessed Major Depressive Disorder (MDD) and self-reported lifetime exposure to traumatic events in 126,522 genotyped individuals of European ancestry. We contrasted genetic influences on MDD stratified by reported trauma exposure (final sample size range: 24,094–92,957). The SNP-based heritability of MDD with reported trauma exposure (24%) was greater than MDD without reported trauma exposure (12%). Simulations showed that this is not confounded by the strong, positive genetic correlation observed between MDD and reported trauma exposure. We also observed that the genetic correlation between MDD and waist circumference was only significant in individuals reporting trauma exposure (rg = 0.24, p = 1.8 × 10−7 versus rg = −0.05, p = 0.39 in individuals not reporting trauma exposure, difference p = 2.3 × 10−4). Our results suggest that the genetic contribution to MDD is greater when reported trauma is present, and that a complex relationship exists between reported trauma exposure, body composition, and MDD.

AB - Depression is more frequent among individuals exposed to traumatic events. Both trauma exposure and depression are heritable. However, the relationship between these traits, including the role of genetic risk factors, is complex and poorly understood. When modelling trauma exposure as an environmental influence on depression, both gene-environment correlations and gene-environment interactions have been observed. The UK Biobank concurrently assessed Major Depressive Disorder (MDD) and self-reported lifetime exposure to traumatic events in 126,522 genotyped individuals of European ancestry. We contrasted genetic influences on MDD stratified by reported trauma exposure (final sample size range: 24,094–92,957). The SNP-based heritability of MDD with reported trauma exposure (24%) was greater than MDD without reported trauma exposure (12%). Simulations showed that this is not confounded by the strong, positive genetic correlation observed between MDD and reported trauma exposure. We also observed that the genetic correlation between MDD and waist circumference was only significant in individuals reporting trauma exposure (rg = 0.24, p = 1.8 × 10−7 versus rg = −0.05, p = 0.39 in individuals not reporting trauma exposure, difference p = 2.3 × 10−4). Our results suggest that the genetic contribution to MDD is greater when reported trauma is present, and that a complex relationship exists between reported trauma exposure, body composition, and MDD.

U2 - 10.1038/s41380-019-0546-6

DO - 10.1038/s41380-019-0546-6

M3 - Journal article

C2 - 31969693

AN - SCOPUS:85078355026

VL - 25

SP - 1430

EP - 1446

JO - Molecular Psychiatry

JF - Molecular Psychiatry

SN - 1359-4184

ER -

ID: 244367395