Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and age at onset of schizophrenia: No consistent evidence for an association in the nordic population

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and age at onset of schizophrenia : No consistent evidence for an association in the nordic population. / Saetre, Peter; Grove, Jakob; Børglum, Anders; Mors, Ole; Werge, Thomas; Andreassen, Ole A; Vares, Maria; Agartz, Ingrid; Terenius, Lars; Jönsson, Erik G.

In: American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, Vol. 159B, No. 8, 12.2012, p. 981-6.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Saetre, P, Grove, J, Børglum, A, Mors, O, Werge, T, Andreassen, OA, Vares, M, Agartz, I, Terenius, L & Jönsson, EG 2012, 'Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and age at onset of schizophrenia: No consistent evidence for an association in the nordic population', American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, vol. 159B, no. 8, pp. 981-6. https://doi.org/10.1002/ajmg.b.32104

APA

Saetre, P., Grove, J., Børglum, A., Mors, O., Werge, T., Andreassen, O. A., Vares, M., Agartz, I., Terenius, L., & Jönsson, E. G. (2012). Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and age at onset of schizophrenia: No consistent evidence for an association in the nordic population. American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, 159B(8), 981-6. https://doi.org/10.1002/ajmg.b.32104

Vancouver

Saetre P, Grove J, Børglum A, Mors O, Werge T, Andreassen OA et al. Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and age at onset of schizophrenia: No consistent evidence for an association in the nordic population. American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics. 2012 Dec;159B(8):981-6. https://doi.org/10.1002/ajmg.b.32104

Author

Saetre, Peter ; Grove, Jakob ; Børglum, Anders ; Mors, Ole ; Werge, Thomas ; Andreassen, Ole A ; Vares, Maria ; Agartz, Ingrid ; Terenius, Lars ; Jönsson, Erik G. / Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and age at onset of schizophrenia : No consistent evidence for an association in the nordic population. In: American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics. 2012 ; Vol. 159B, No. 8. pp. 981-6.

Bibtex

@article{2a08066005a241e996fa6e19688dbeba,
title = "Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and age at onset of schizophrenia: No consistent evidence for an association in the nordic population",
abstract = "Methylenetetrahydrofolate reductase (MTHFR) is an enzyme involved in metabolic pathways of importance for nucleotide synthesis and methylation of DNA, membranes, proteins and lipids. The MTHFR gene includes a common polymorphism (rs1801133 or C677T), which is associated with enzyme activity. The T-allele of the C677T polymorphism has been associated with earlier age at onset of schizophrenia in a Scandinavian population, although no association was found in replication attempts in other populations. Extending the study to five Nordic samples consisting of 2,198 patients with schizophrenia, including the original Scandinavian samples, there was no significant association between MTHFR C677T polymorphism and age at onset in schizophrenia. The present results do not suggest that the investigated MTHFR polymorphism has any significant influence on age at onset of schizophrenia in the Nordic population. {\textcopyright} 2012 Wiley Periodicals, Inc.",
author = "Peter Saetre and Jakob Grove and Anders B{\o}rglum and Ole Mors and Thomas Werge and Andreassen, {Ole A} and Maria Vares and Ingrid Agartz and Lars Terenius and J{\"o}nsson, {Erik G}",
note = "Copyright {\textcopyright} 2012 Wiley Periodicals, Inc.",
year = "2012",
month = dec,
doi = "10.1002/ajmg.b.32104",
language = "English",
volume = "159B",
pages = "981--6",
journal = "American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics",
issn = "1552-4841",
publisher = "JohnWiley & Sons, Inc.",
number = "8",

}

RIS

TY - JOUR

T1 - Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and age at onset of schizophrenia

T2 - No consistent evidence for an association in the nordic population

AU - Saetre, Peter

AU - Grove, Jakob

AU - Børglum, Anders

AU - Mors, Ole

AU - Werge, Thomas

AU - Andreassen, Ole A

AU - Vares, Maria

AU - Agartz, Ingrid

AU - Terenius, Lars

AU - Jönsson, Erik G

N1 - Copyright © 2012 Wiley Periodicals, Inc.

PY - 2012/12

Y1 - 2012/12

N2 - Methylenetetrahydrofolate reductase (MTHFR) is an enzyme involved in metabolic pathways of importance for nucleotide synthesis and methylation of DNA, membranes, proteins and lipids. The MTHFR gene includes a common polymorphism (rs1801133 or C677T), which is associated with enzyme activity. The T-allele of the C677T polymorphism has been associated with earlier age at onset of schizophrenia in a Scandinavian population, although no association was found in replication attempts in other populations. Extending the study to five Nordic samples consisting of 2,198 patients with schizophrenia, including the original Scandinavian samples, there was no significant association between MTHFR C677T polymorphism and age at onset in schizophrenia. The present results do not suggest that the investigated MTHFR polymorphism has any significant influence on age at onset of schizophrenia in the Nordic population. © 2012 Wiley Periodicals, Inc.

AB - Methylenetetrahydrofolate reductase (MTHFR) is an enzyme involved in metabolic pathways of importance for nucleotide synthesis and methylation of DNA, membranes, proteins and lipids. The MTHFR gene includes a common polymorphism (rs1801133 or C677T), which is associated with enzyme activity. The T-allele of the C677T polymorphism has been associated with earlier age at onset of schizophrenia in a Scandinavian population, although no association was found in replication attempts in other populations. Extending the study to five Nordic samples consisting of 2,198 patients with schizophrenia, including the original Scandinavian samples, there was no significant association between MTHFR C677T polymorphism and age at onset in schizophrenia. The present results do not suggest that the investigated MTHFR polymorphism has any significant influence on age at onset of schizophrenia in the Nordic population. © 2012 Wiley Periodicals, Inc.

U2 - 10.1002/ajmg.b.32104

DO - 10.1002/ajmg.b.32104

M3 - Journal article

C2 - 23076983

VL - 159B

SP - 981

EP - 986

JO - American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics

JF - American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics

SN - 1552-4841

IS - 8

ER -

ID: 48611451