Negative symptoms in First-Episode Schizophrenia related to morphometric alterations in orbitofrontal and superior temporal cortex: the OPTiMiSE study
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Negative symptoms in First-Episode Schizophrenia related to morphometric alterations in orbitofrontal and superior temporal cortex : the OPTiMiSE study. / Demjaha, Arsime; Galderisi, Silvana; Glenthoj, Birthe; Arango, Celso; Mucci, Armida; Lawrence, Andrew; O'Daly, Owen; Kempton, Matthew; Ciufolini, Simone; Baandrup, Lone; Ebdrup, Bjorn H.; Rodriguez-Jimenez, Roberto; Diaz-Marsa, Maria; Martinez Diaz-Caneja, Covadonga; van Rossum, Inge Winter; Kahn, Rene; Dazzan, Paola; McGuire, Philip.
In: Psychological Medicine, Vol. 53, No. 8, 2023, p. 3471-3479.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Negative symptoms in First-Episode Schizophrenia related to morphometric alterations in orbitofrontal and superior temporal cortex
T2 - the OPTiMiSE study
AU - Demjaha, Arsime
AU - Galderisi, Silvana
AU - Glenthoj, Birthe
AU - Arango, Celso
AU - Mucci, Armida
AU - Lawrence, Andrew
AU - O'Daly, Owen
AU - Kempton, Matthew
AU - Ciufolini, Simone
AU - Baandrup, Lone
AU - Ebdrup, Bjorn H.
AU - Rodriguez-Jimenez, Roberto
AU - Diaz-Marsa, Maria
AU - Martinez Diaz-Caneja, Covadonga
AU - van Rossum, Inge Winter
AU - Kahn, Rene
AU - Dazzan, Paola
AU - McGuire, Philip
PY - 2023
Y1 - 2023
N2 - Background Negative symptoms are one of the most incapacitating features of Schizophrenia but their pathophysiology remains unclear. They have been linked to alterations in grey matter in several brain regions, but findings have been inconsistent. This may reflect the investigation of relatively small patient samples, and the confounding effects of chronic illness and exposure to antipsychotic medication. We sought to address these issues by investigating concurrently grey matter volumes (GMV) and cortical thickness (CTh) in a large sample of antipsychotic-naive or minimally treated patients with First-Episode Schizophrenia (FES). Methods T1-weighted structural MRI brain scans were acquired from 180 antipsychotic-naive or minimally treated patients recruited as part of the OPTiMiSE study. The sample was stratified into subgroups with (N = 88) or without (N = 92) Prominent Negative Symptoms (PMN), based on PANSS ratings at presentation. Regional GMV and CTh in the two groups were compared using Voxel-Based Morphometry (VBM) and FreeSurfer (FS). Between-group differences were corrected for multiple comparisons via Family-Wise Error (FWE) and Monte Carlo z-field simulation respectively at p < 0.05 (2-tailed). Results The presence of PMN symptoms was associated with larger left inferior orbitofrontal volume (p = 0.03) and greater CTh in the left lateral orbitofrontal gyrus (p = 0.007), but reduced CTh in the left superior temporal gyrus (p = 0.009). Conclusions The findings highlight the role of orbitofrontal and temporal cortices in the pathogenesis of negative symptoms of Schizophrenia. As they were evident in generally untreated FEP patients, the results are unlikely to be related to effects of previous treatment or illness chronicity.
AB - Background Negative symptoms are one of the most incapacitating features of Schizophrenia but their pathophysiology remains unclear. They have been linked to alterations in grey matter in several brain regions, but findings have been inconsistent. This may reflect the investigation of relatively small patient samples, and the confounding effects of chronic illness and exposure to antipsychotic medication. We sought to address these issues by investigating concurrently grey matter volumes (GMV) and cortical thickness (CTh) in a large sample of antipsychotic-naive or minimally treated patients with First-Episode Schizophrenia (FES). Methods T1-weighted structural MRI brain scans were acquired from 180 antipsychotic-naive or minimally treated patients recruited as part of the OPTiMiSE study. The sample was stratified into subgroups with (N = 88) or without (N = 92) Prominent Negative Symptoms (PMN), based on PANSS ratings at presentation. Regional GMV and CTh in the two groups were compared using Voxel-Based Morphometry (VBM) and FreeSurfer (FS). Between-group differences were corrected for multiple comparisons via Family-Wise Error (FWE) and Monte Carlo z-field simulation respectively at p < 0.05 (2-tailed). Results The presence of PMN symptoms was associated with larger left inferior orbitofrontal volume (p = 0.03) and greater CTh in the left lateral orbitofrontal gyrus (p = 0.007), but reduced CTh in the left superior temporal gyrus (p = 0.009). Conclusions The findings highlight the role of orbitofrontal and temporal cortices in the pathogenesis of negative symptoms of Schizophrenia. As they were evident in generally untreated FEP patients, the results are unlikely to be related to effects of previous treatment or illness chronicity.
KW - Cortical thickness
KW - first-episode psychosis
KW - FreeSurfer
KW - negative symptoms
KW - voxel-based morphometry
KW - GRAY-MATTER ABNORMALITIES
KW - CORTICAL THICKNESS
KW - ANTIPSYCHOTIC TREATMENT
KW - PSYCHOSIS PATIENTS
KW - PREFRONTAL CORTEX
KW - SYNDROME SCALE
KW - BRAIN CHANGES
KW - SURFACE-AREA
KW - LOBE REGIONS
KW - VOLUME
U2 - 10.1017/S0033291722000010
DO - 10.1017/S0033291722000010
M3 - Journal article
C2 - 35197142
VL - 53
SP - 3471
EP - 3479
JO - Psychological Medicine
JF - Psychological Medicine
SN - 0033-2917
IS - 8
ER -
ID: 316147202