Novel variant of CYP2D6*6 is undetected by a commonly used genotyping procedure
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We report the identification of a novel and defective variant of the gene encoding cytochrome P450 2D6 (CYP2D6). This novel variant is a subtype of CYP2D6*6 that was undetected by a commercially available 5' exonuclease-based assay. Because the novel variant was found in only one of 609 individuals, it represents a rare subtype of CYP2D6*6 that may be restricted to a single family or a subpopulation. A procedure for the identification of the novel CYP2D6*6 variant using restriction enzyme treatment of amplified fragments was developed.
Original language | English |
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Journal | Pharmacological Reports |
Volume | 63 |
Issue number | 5 |
Pages (from-to) | 1264-6 |
Number of pages | 3 |
ISSN | 1734-1140 |
Publication status | Published - 2011 |
ID: 40205201