Virtual reality-assisted cognitive behavioural therapy for outpatients with alcohol use disorder (CRAVR): A protocol for a randomised controlled trial
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Virtual reality-assisted cognitive behavioural therapy for outpatients with alcohol use disorder (CRAVR) : A protocol for a randomised controlled trial. / Thaysen-Petersen, Daniel; Hammerum, Sigurd Krogh; Vissing, Anne Cathrine; Arnfred, Benjamin Thorup; Nordahl, Rolf; Adjorlu, Ali; Nordentoft, Merete; Oestrich, Irene Henriette; Düring, Signe Wegmann; Fink-Jensen, Anders.
In: BMJ Open, Vol. 13, No. 3, e068658, 2023.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Virtual reality-assisted cognitive behavioural therapy for outpatients with alcohol use disorder (CRAVR)
T2 - A protocol for a randomised controlled trial
AU - Thaysen-Petersen, Daniel
AU - Hammerum, Sigurd Krogh
AU - Vissing, Anne Cathrine
AU - Arnfred, Benjamin Thorup
AU - Nordahl, Rolf
AU - Adjorlu, Ali
AU - Nordentoft, Merete
AU - Oestrich, Irene Henriette
AU - Düring, Signe Wegmann
AU - Fink-Jensen, Anders
N1 - Publisher Copyright: © Author(s) (or their employer(s)) 2023.
PY - 2023
Y1 - 2023
N2 - Introduction Alcohol use disorder (AUD) is a brain disorder linked to over 200 health conditions. Cognitive behavioural therapy (CBT) is considered the best practice in the treatment of AUD, but more than 60% of patients relapse within the first year after treatment. Psychotherapy combined with virtual reality (VR) has received increasing interest in the treatment of AUD. However, existing studies have primarily investigated the use of VR for cue reactivity. We therefore aimed to investigate the effect of VR-assisted CBT (VR-CBT). Methods and analysis This study is an assessor-blinded, randomised clinical trial being conducted at three outpatient clinics in Denmark. We will randomise 102 patients to 14 individual sessions of either manualised VR-CBT or CBT. The VR-CBT group will receive exposure to immersive high-risk VR situations from a pub, bar/party, restaurant, supermarket and at-home (30 videos) to activate high-risk-related beliefs and cravings for subsequent modification using CBT techniques. The treatment period is 6 months, and follow-up visits will be performed 3, 6, 9 and 12 months after inclusion. The primary outcome measure is the change in total alcohol consumption from baseline to 6 months after inclusion, measured with the Timeline Followback Method. Key secondary outcome measures include changes in the number of heavy drinking days, alcohol cravings, cognition, and symptoms of depression and anxiety. Ethics and dissemination Approval has been obtained by the research ethics committee in the Capital Region of Denmark (H-20082136) and the Danish Data Protection Agency (P-2021-217). All patients will receive both oral and written information about the trial and written informed consent will be obtained from each patient before inclusion. The study results will be disseminated in peer-reviewed publications and conference presentations. Trial registration number ClinicalTrial.gov, NCT05042180.
AB - Introduction Alcohol use disorder (AUD) is a brain disorder linked to over 200 health conditions. Cognitive behavioural therapy (CBT) is considered the best practice in the treatment of AUD, but more than 60% of patients relapse within the first year after treatment. Psychotherapy combined with virtual reality (VR) has received increasing interest in the treatment of AUD. However, existing studies have primarily investigated the use of VR for cue reactivity. We therefore aimed to investigate the effect of VR-assisted CBT (VR-CBT). Methods and analysis This study is an assessor-blinded, randomised clinical trial being conducted at three outpatient clinics in Denmark. We will randomise 102 patients to 14 individual sessions of either manualised VR-CBT or CBT. The VR-CBT group will receive exposure to immersive high-risk VR situations from a pub, bar/party, restaurant, supermarket and at-home (30 videos) to activate high-risk-related beliefs and cravings for subsequent modification using CBT techniques. The treatment period is 6 months, and follow-up visits will be performed 3, 6, 9 and 12 months after inclusion. The primary outcome measure is the change in total alcohol consumption from baseline to 6 months after inclusion, measured with the Timeline Followback Method. Key secondary outcome measures include changes in the number of heavy drinking days, alcohol cravings, cognition, and symptoms of depression and anxiety. Ethics and dissemination Approval has been obtained by the research ethics committee in the Capital Region of Denmark (H-20082136) and the Danish Data Protection Agency (P-2021-217). All patients will receive both oral and written information about the trial and written informed consent will be obtained from each patient before inclusion. The study results will be disseminated in peer-reviewed publications and conference presentations. Trial registration number ClinicalTrial.gov, NCT05042180.
KW - Protocols & guidelines
KW - PSYCHIATRY
KW - PUBLIC HEALTH
KW - Substance misuse
U2 - 10.1136/bmjopen-2022-068658
DO - 10.1136/bmjopen-2022-068658
M3 - Journal article
C2 - 36990475
AN - SCOPUS:85151195850
VL - 13
JO - BMJ Open
JF - BMJ Open
SN - 2044-6055
IS - 3
M1 - e068658
ER -
ID: 372872707