Congenital Heart Disease and Fertility: A Danish Nationwide Cohort Study Including Both Men and Women
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Congenital Heart Disease and Fertility : A Danish Nationwide Cohort Study Including Both Men and Women. / Udholm, Louise F.; Arendt, Linn H.; Knudsen, Ulla B.; Ramlau-Hansen, Cecilia H.; Hjortdal, Vibeke E.
In: Journal of the American Heart Association, Vol. 12, No. 2, 2023, p. e027409.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Congenital Heart Disease and Fertility
T2 - A Danish Nationwide Cohort Study Including Both Men and Women
AU - Udholm, Louise F.
AU - Arendt, Linn H.
AU - Knudsen, Ulla B.
AU - Ramlau-Hansen, Cecilia H.
AU - Hjortdal, Vibeke E.
PY - 2023
Y1 - 2023
N2 - Background Despite an increasing number of patients with congenital heart disease (CHD) reaching reproductive age, the fertility of these patients remains undescribed. Therefore, the aim of the study was to evaluate the fertility in men and women with CHD by estimating the risk of infertility and comparing the birth rates, proportions of individuals becoming parents or remaining childless, and the number of children per parent with unaffected individuals. Methods and Results The study population consisted of individuals born between 1977 and 2000. Information on CHD, infertility, and live born children were obtained from the Danish health registries. Hazard ratios for infertility were analyzed using a Cox regression model. Differences of proportions and birth rates were calculated and compared between groups. Among 1 385 895 individuals, a total of 8679 (0.6%) were diagnosed with CHD. Men and women with simple or moderate CHD had no increased risk of infertility when compared with the reference population. Estimates for complex CHD groups were too imprecise for evaluation. Individuals with CHD were more often childless with consequently lower birth rates compared with unaffected individuals. However, those becoming parents had the same number of children as the reference population. Conclusions Men and women with simple or moderate CHD had the same risk of infertility as the reference population. Despite patients with CHD more often being childless, those becoming parents had the same number of children as parents without CHD. The current findings increase the knowledge regarding fertility in the CHD population.
AB - Background Despite an increasing number of patients with congenital heart disease (CHD) reaching reproductive age, the fertility of these patients remains undescribed. Therefore, the aim of the study was to evaluate the fertility in men and women with CHD by estimating the risk of infertility and comparing the birth rates, proportions of individuals becoming parents or remaining childless, and the number of children per parent with unaffected individuals. Methods and Results The study population consisted of individuals born between 1977 and 2000. Information on CHD, infertility, and live born children were obtained from the Danish health registries. Hazard ratios for infertility were analyzed using a Cox regression model. Differences of proportions and birth rates were calculated and compared between groups. Among 1 385 895 individuals, a total of 8679 (0.6%) were diagnosed with CHD. Men and women with simple or moderate CHD had no increased risk of infertility when compared with the reference population. Estimates for complex CHD groups were too imprecise for evaluation. Individuals with CHD were more often childless with consequently lower birth rates compared with unaffected individuals. However, those becoming parents had the same number of children as the reference population. Conclusions Men and women with simple or moderate CHD had the same risk of infertility as the reference population. Despite patients with CHD more often being childless, those becoming parents had the same number of children as parents without CHD. The current findings increase the knowledge regarding fertility in the CHD population.
KW - congenital heart disease
KW - fertility
KW - infertility
KW - live births
KW - reproductive health
U2 - 10.1161/JAHA.122.027409
DO - 10.1161/JAHA.122.027409
M3 - Journal article
C2 - 36648105
AN - SCOPUS:85146331763
VL - 12
SP - e027409
JO - Journal of the American Heart Association
JF - Journal of the American Heart Association
SN - 2047-9980
IS - 2
ER -
ID: 335295446