Extracorporeal cardiopulmonary resuscitation: a national study on the association between favourable neurological status and biomarkers of hypoperfusion, inflammation, and organ injury
Research output: Contribution to journal › Journal article › Research › peer-review
Aims In refractory out-of-hospital cardiac arrest (OHCA) with prolonged whole-body ischaemia, global tissue injury proceeds even after establishment of circulation with extracorporeal cardiopulmonary resuscitation (ECPR). We aimed to investigate the role of biomarkers reflecting hypoperfusion, inflammation, and organ injury in prognostication of patients with refractory OHCA managed with ECPR. Methods and results This nationwide retrospective study included 226 adults with refractory OHCA managed with ECPR in Denmark (2011-2020). Biomarkers the first days after ECPR-initiation were assessed. Odds ratio of favourable neurological status (Cerebral Performance Category 1-2) at hospital discharge was estimated by logistic regression analyses. Cut-off values were calculated using the Youden's index. Fifty-six patients (25%) survived to hospital discharge, 51 (91%) with a favourable neurological status. Factors independently associated with favourable neurological status were low flow time = 12.8 x 10(9)/L, admission lactate
Original language | English |
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Journal | European Heart Journal: Acute Cardiovascular Care |
Volume | 11 |
Issue number | 11 |
Pages (from-to) | 808-817 |
Number of pages | 10 |
ISSN | 2048-8726 |
DOIs | |
Publication status | Published - 2022 |
- Extracorporeal cardiopulmonary resuscitation, Out-of-hospital cardiac arrest, biomarkers, Neurological outcome, Inflammation, Hypoperfusion, Organ injury, HOSPITAL CARDIAC-ARREST, CREATINE KINASE-MB, CORONARY INTERVENTION, CONSENSUS STATEMENT, ELEVATION, SCORE
Research areas
ID: 346239492