The Patent Ductus Arteriosus in Extremely Preterm Neonates Is More than a Hemodynamic Challenge: New Molecular Insights
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Complications to preterm birth are numerous, including the presence of a patent ductus arteriosus (PDA). The biological understanding of the PDA is sparse and treatment remains controversial. Herein, we speculate whether the PDA is more than a cardiovascular imbalance, and may be a marker in response to immature core molecular and physiological processes driven by biological systems, such as inflammation. To achieve a new biological understanding of the PDA, we performed echocardiography and collected plasma samples on day 3 of life in 53 consecutively born neonates with a gestational age at birth below 28 completed weeks. The proteome of these samples was analyzed by mass spectrometry (nanoLC-MS/MS) and immunoassay of 17 cytokines and chemokines. We found differences in 21 proteins and 8 cytokines between neonates with a large PDA (>1.5 mm) compared to neonates without a PDA. Amongst others, we found increased levels of angiotensinogen, periostin, pro-inflammatory associations, including interleukin (IL)-1β and IL-8, and anti-inflammatory associations, including IL-1RA and IL-10. Levels of complement factors C8 and carboxypeptidases were decreased. Our findings associate the PDA with the renin-angiotensin-aldosterone system and immune- and complement systems, indicating that PDA goes beyond the persistence of a fetal circulatory connection of the great vessels.
Original language | English |
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Article number | 1179 |
Journal | Biomolecules |
Volume | 12 |
Issue number | 9 |
Number of pages | 16 |
ISSN | 2218-273X |
DOIs | |
Publication status | Published - 2022 |
Bibliographical note
Funding Information:
The work was supported financially by Arvid Nilssons Foundation (A.S.); Grosserer L.F. Foghts Foundation (A.S.); Aarhus University Hospital (A.S.); Novo Nordisk Foundation, grant no. NFF17SA0030576 (V.E.H.); and The John and Birthe Meyer Foundation (J.P.). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
- angiotensinogen, inflammation, patent ductus arteriosus, periostin, preterm neonate, proteomics
Research areas
ID: 327676182