Oluf Borbye Pedersen
Visiting professor, Clinical Professor
Pedersen Group
Blegdamsvej 3B, Mærsk Tårnet, 8. sal
2200 København N.
Department of Clinical Medicine
Blegdamsvej 3
2200 København N.
Member of:
Internal medicine: infection medicine
Internal Medicine: Endocrinology
- 1991
- Published
Effects of hyperinsulinemia and hyperglycemia on insulin receptor function and glycogen synthase activation in skeletal muscle of normal man
Bak, J. F., Møller, N., Schmitz, O., Richter, Erik A. & Pedersen, Oluf Borbye, 1991, In: Metabolism. 40, 8, p. 830-835 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Impaired expression of glycogen synthase mRNA in skeletal muscle of NIDDM patients
drb459, drb459, Bjørbaek, C., Andersen, P. H., Bak, J. F. & Pedersen, Oluf Borbye, Dec 1991, In: Diabetes. 40, 12, p. 1740-5 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1993
- Published
The effect of intensive insulin therapy on the insulin-regulatable glucose transporter (GLUT4) expression in skeletal muscle in type 1 diabetes
Andersen, P. H., drb459, drb459, Lund, S., Vedel, P., Junker, S., Kahn, B. B. & Pedersen, Oluf Borbye, Oct 1993, In: Diabetic Medicine. 10, 8, p. 699-706 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Aminoacid polymorphisms of insulin receptor substrate-1 in non-insulin-dependent diabetes mellitus
Almind, K., Bjørbaek, C., drb459, drb459, Hansen, Torben, Echwald, S. M. & Pedersen, Oluf Borbye, 2 Oct 1993, In: Lancet. 342, 8875, p. 828-32 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Expression of insulin receptor spliced variants and their functional correlates in muscle from patients with non-insulin-dependent diabetes mellitus
Hansen, Torben, Bjørbaek, C., drb459, drb459, Grønskov, K., Bak, J. F. & Pedersen, Oluf Borbye, Dec 1993, In: The Journal of clinical endocrinology and metabolism. 77, 6, p. 1500-5 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1994
- Published
Expression of glycogen synthase and phosphofructokinase in muscle from type 1 (insulin-dependent) diabetic patients before and after intensive insulin treatment
drb459, drb459, Andersen, P. H., Lund, S., Vedel, P. & Pedersen, Oluf Borbye, Jan 1994, In: Diabetologia. 37, 1, p. 82-90 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genetic variants in promoters and coding regions of the muscle glycogen synthase and the insulin-responsive GLUT4 genes in NIDDM
Bjørbaek, C., Echwald, S. M., Hubricht, P., drb459, drb459, Hansen, Torben, Zierath, Juleen R & Pedersen, Oluf Borbye, Aug 1994, In: Diabetes. 43, 8, p. 976-83 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Sequence of the human glycogen-associated regulatory subunit of type 1 protein phosphatase and analysis of its coding region and mRNA level in muscle from patients with NIDDM
Chen, Y. H., Hansen, L., Chen, M., Bjørbaek, C., drb459, drb459, Hansen, Teis Schjals, Cohen, P., Pedersen, Oluf Borbye & drb459, drb459, Oct 1994, In: Diabetes. 43, 10, p. 1234-41 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1995
Severe insulin-resistant diabetes mellitus in patients with congenital muscle fiber type disproportion myopathy
drb459, drb459, Klein, H. H., Hansen, T., Müller, J., Skovby, F., Bjørbaek, C., Røder, M. E. & Pedersen, Oluf Borbye, 1995, In: The Journal of Clinical Investigation. 95, 4, p. 1925-1932 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Sulfonylurea therapy improves glucose disposal without changing skeletal muscle GLUT4 levels in noninsulin-dependent diabetes mellitus subjects: a longitudinal study
drb459, drb459, Weinreb, J. E., Rosen, A. S., Bjørbaek, C., Hansen, L., Pedersen, Oluf Borbye & Kahn, B. B., Jan 1995, In: The Journal of clinical endocrinology and metabolism. 80, 1, p. 270-5 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of four amino acid substitutions in hexokinase II and studies of relationships to NIDDM, glucose effectiveness, and insulin sensitivity
Echwald, S. M., Bjørbaek, C., Hansen, Torben, Clausen, J. O., drb459, drb459, Zierath, Juleen R, Printz, R. L., Granner, D. K. & Pedersen, Oluf Borbye, Mar 1995, In: Diabetes. 44, 3, p. 347-53 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Unchanged gene expression of glycogen synthase in muscle from patients with NIDDM following sulphonylurea-induced improvement of glycaemic control
drb459, drb459, Lund, S., Bjørbaek, C. & Pedersen, Oluf Borbye, Oct 1995, In: Diabetologia. 38, 10, p. 1230-8 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Elevation of serum insulin concentration during euglycemic hyperinsulinemic clamp studies leads to similar activation of insulin receptor kinase in skeletal muscle of subjects with and without NIDDM
Klein, H. H., drb459, drb459, Kotzke, G. & Pedersen, Oluf Borbye, Nov 1995, In: Diabetes. 44, 11, p. 1310-7 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1996
- Published
Impaired insulin-stimulated nonoxidative glucose metabolism in glucose-tolerant women with previous gestational diabetes
Damm, Peter, drb459, drb459, Kühl, C. E. & Pedersen, Oluf Borbye, Feb 1996, In: American Journal of Obstetrics and Gynecology. 174, 2, p. 722-9 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Studies of insulin resistance in congenital generalized lipodystrophy
Søvik, O., drb459, drb459, Trygstad, O. & Pedersen, Oluf Borbye, Jun 1996, In: Acta Paediatrica. Supplement. 413, p. 29-37 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1997
- Published
Identification of a common amino acid polymorphism in the p85alpha regulatory subunit of phosphatidylinositol 3-kinase: effects on glucose disappearance constant, glucose effectiveness, and the insulin sensitivity index
Hansen, Torben, Andersen, C. B., Echwald, S. M., Urhammer, S. A., Clausen, J. O., drb459, drb459, Owens, D., Hansen, L. & Pedersen, Oluf Borbye, Mar 1997, In: Diabetes. 46, 3, p. 494-501 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Short- and long-term metabolic effects of recombinant human IGF-I treatment in patients with severe insulin resistance and diabetes mellitus
Vestergaard, H., Rossen, M., Urhammer, S. A., Müller, J. & Pedersen, Oluf Borbye, May 1997, In: European Journal of Endocrinology. 136, 5, p. 475-82 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Chromosomal mapping and mutational analysis of the coding region of the glycogen synthase kinase-3alpha and beta isoforms in patients with NIDDM
Hansen, L., Arden, K. C., Rasmussen, S. B., Viars, C. S., drb459, drb459, Hansen, Teis Schjals, Møller, A. M., Woodgett, J. R. & Pedersen, Oluf Borbye, Aug 1997, In: Diabetologia. 40, 8, p. 940-6 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Expression of protein-tyrosine phosphatases in the major insulin target tissues
Norris, K., Norris, F., Kono, D. H., drb459, drb459, Pedersen, Oluf Borbye, Theofilopoulos, A. N. & Møller, N. P., 6 Oct 1997, In: FEBS Letters. 415, 3, p. 243-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1998
- Published
The effect of two frequent amino acid variants of the hepatocyte nuclear factor-1α gene on estimates of the pancreatic β-cell function in Caucasian glucosetolerant first-degree relatives of type 2 diabetic patients
Urhammer, Søren Asger, Møller, Ann, Nyholm, B., Ekstrøm, Claus Thorn, Eiberg, Hans Rudolf Lytchoff, Clausen, J. O., Hansen, Torben, Pedersen, Oluf Borbye & Schmitz, O., 20 Nov 1998, In: Journal of Clinical Endocrinology and Metabolism. 83, 11, p. 3992-3995 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Ala/Va198 polymorphism of the hepatocyte nuclear factor-1α gene contributes to the interindividual variation in serum C-peptide response during an oral glucose tolerance test: Evidence from studies of 231 glucose- tolerant first degree relatives of type 2 diabetic probands
Urhammer, Søren Asger, Hansen, Torben, Ekstrøm, Claus Thorn, Eiberg, Hans Rudolf Lytchoff & Pedersen, Oluf Borbye, 1 Dec 1998, In: Journal of Clinical Endocrinology and Metabolism. 83, 12, p. 4506-4509 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1999
- Published
Alternative splicing of exon 17 and a missense mutation in exon 20 of the insulin receptor gene in two brothers with a novel syndrome of insulin resistance (congenital fiber-type disproportion myopathy)
Vorwerk, P., Christoffersen, C. T., Müller, J., drb459, drb459, Pedersen, Oluf Borbye, De Meyts, P. & drb459, drb459, 1999, In: Hormone Research. 52, 5, p. 211-20 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Intermediate Expansions of a GAA Repeat in the Frataxin Gene are not associated with Type 2 Diabetes or Altered Glucose-Induced ¿-cell function in Danish Caucasians
Dalgaard, L. T., Hansen, T., Urhammer, S. A., Clausen, J. O., Eiberg, Hans Rudolf Lytchoff & Pedersen, Oluf Borbye, 1999, In: Diabetes. 48, p. 914-917Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Implications of compound heterozygous insulin receptor mutations in congenital muscle fibre type disproportion myopathy for the receptor kinase activation
Klein, H. H., Müller, R., drb459, drb459 & Pedersen, Oluf Borbye, Feb 1999, In: Diabetologia. 42, 2, p. 245-9 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mutational analysis of the coding regions of the genes encoding protein kinase B-alpha and -beta, phosphoinositide-dependent protein kinase-1, phosphatase targeting to glycogen, protein phosphatase inhibitor-1, and glycogenin: lessons from a search for genetic variability of the insulin-stimulated glycogen synthesis pathway of skeletal muscle in NIDDM patients
Hansen, L., Fjordvang, H., Rasmussen, S. K., drb459, drb459, Echwald, S. M., Hansen, Teis Schjals, Alessi, D., Shenolikar, S., Saltiel, A. R., Barbetti, F. & Pedersen, Oluf Borbye, Feb 1999, In: Diabetes. 48, 2, p. 403-7 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Search for variants of the gene-promoter and the potential phosphotyrosine encoding sequence of the insulin receptor substrate-2 gene: Evaluation of their relation with alterations in insulin secretion and insulin sensitivity
Almind, K., Frederiksen, S. K., Bernal, D., Hansen, Torben, Ambye, L., Urhammer, Søren Asger, Ekstrøm, Claus Thorn, Berglund, L., Reneland, R., Lithell, H., White, M. F., Van Obberghen, E. & Pedersen, Oluf Borbye, 11 Oct 1999, In: Diabetologia. 42, 10, p. 1244-1249 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2000
- Published
The K121Q variant of the human PC-1 gene is not associated with insulin resistance or type 2 diabetes among Danish Caucasians
Rasmussen, S. K., Urhammer, Søren Asger, Pizzuti, A., Echwald, S. M., Ekstrøm, Claus Thorn, Hansen, L., Hansen, Torben, Borch-Johnsen, K., Frittitta, L., Trischitta, V. & Pedersen, Oluf Borbye, 2000, In: Diabetes. 49, 9, p. 1608-1611 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Studies of the variability of the genes encoding the insulin-like growth factor I receptor and its ligand in relation to type 2 diabetes mellitus
Rasmussen, S. K., Lautier, C., Hansen, L., Echwald, S. M., Hansen, Torben, Ekstrøm, Claus Thorn, Urhammer, Søren Asger, Borch-Johnsen, K., Grigorescu, F., Smith, R. J. & Pedersen, Oluf Borbye, 1 Dec 2000, In: Journal of Clinical Endocrinology and Metabolism. 85, 4, p. 1606-1610 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2001
- Published
A prevalent polymorphism in the putative promotor of the UCP3 gene and its relationship to body mass index in the Danish population
Dalgaard, L. T., Sørensen, Thorkild I.A., Drivsholm, T. B., Borch-Johnsen, K., Andersen, T., Hansen, T. & Pedersen, Oluf Borbye, 2001, In: Journal of Clinical Endocrinology and Metabolism. 86, p. 1398-1402Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The association between the val/ala-55 polymorphism of the uncoupling protein 2 gene and exercise efficiency
Buemann, B., Schierning, B., Toubro, S., Bibby, B. M., Sørensen, Thorkild I.A., Dalgaard, L., Pedersen, Oluf Borbye & Astrup, A., 2001, In: International Journal of Obesity. 25, p. 467-471 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Studies of variability in the PTEN gene among Danish caucasian patients with Type II diabetes mellitus
Hansen, L., Jensen, J. N., Ekstrøm, Claus Thorn, drb459, drb459, Hansen, Teis Schjals, Pedersen, Oluf Borbye & drb459, drb459, Feb 2001, In: Diabetologia. 44, 2, p. 237-240 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Serum leptin levels in pregnant women with type 1 diabetes mellitus
Lauszus, F., Schmitz, O., drb459, drb459, Klebe, J. G., Pedersen, Oluf Borbye & drb459, drb459, Jul 2001, In: Acta Obstetricia et Gynecologica Scandinavica. 80, 7, p. 596-601 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rosiglitazone treatment of patients with extreme insulin resistance and diabetes mellitus due to insulin receptor mutations has no effects on glucose and lipid metabolism
drb459, drb459, Lund, S., Pedersen, Oluf Borbye & drb459, drb459, Nov 2001, In: Journal of Internal Medicine. 250, 5, p. 406-14 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2002
- Published
Fat mass measured by DXA varies with scan velocity
Black, E., Petersen, L., Kreutzer, M., Toubro, S., Sørensen, Thorkild I.A., Pedersen, Oluf Borbye & Astrup, A., 2002, In: Obesity. 10, 2, p. 69-77 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genetic evidence that HNF-1alpha-dependent transcriptional control of HNF-4alpha is essential for human pancreatic beta cell function
Hansen, S. K., Párrizas, M., Jensen, M. L., Pruhova, S., Ek, J., Boj, S. F., Johansen, A., Maestro, M. A., Rivera, F., Eiberg, Hans Rudolf Lytchoff, Andel, M., Lebl, J., Pedersen, Oluf Borbye, Ferrer, J. & Hansen, Torben, 2002, In: Journal of Clinical Investigation. 110, 6, p. 827-33 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Jagten på de genetiske determinanter for de formodede polygene former for type 2-diabetes. Status og perspektivering
Pedersen, Oluf Borbye, Hansen, Torben, Hansen, L., Echwald, S. M. & Urhammer, S. A., 2002, In: Ugeskrift for Laeger. 164, 16, p. 2163-6 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Long-term AICAR administration reduces metabolic disturbances and lowers blood pressure in rats displaying features of the insulin resistance syndrome
Buhl, E. S., Jessen, N., Pold, R., Ledet, T., Flyvbjerg, A., Pedersen, Steen, Pedersen, Oluf Borbye, Schmitz, O. & Lund, S., 2002, In: Diabetes. 51, 7, p. 2199-206 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Maturity-onset diabetes of the young--MODY. Molekylaergenetiske, patofysiologiske og kliniske karakteristika
Hansen, Torben, Urhammer, S. A. & Pedersen, Oluf Borbye, 2002, In: Ugeskrift for Laeger. 164, 15, p. 2017-22 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
PC-1 amino acid variant (K121Q) has no impact on progression of diabetic nephropathy in type 1 diabetic patients
Jacobsen, P., Grarup, Niels, Tarnow, L., Parving, H. & Pedersen, Oluf Borbye, 2002, In: Nephrology, Dialysis, Transplantation. 17, 8, p. 1408-12 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Variants within the calpain-10 gene on chromosome 2q37 (NIDDM1) and relationships to type 2 diabetes, insulin resistance, and impaired acute insulin secretion among Scandinavian Caucasians
Rasmussen, S. K., Urhammer, S. A., Berglund, L. E., Jensen, J. N., Hansen, L., Echwald, S. M., Borch-Johnsen, K., Horikawa, Y., Mashima, H., Lithell, H., Cox, N. J., Hansen, Torben, Bell, G. I. & Pedersen, Oluf Borbye, 2002, In: Diabetes. 51, 12, p. 3561-7 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of the Met326Ile variant of phosphatidylinositol 3-kinase p85alpha
Almind, K., Delahaye, L., Hansen, Torben, Van Obberghen, E., Pedersen, Oluf Borbye & Kahn, C. R., 19 Feb 2002, In: Proceedings of the National Academy of Sciences of the United States of America. 99, 4, p. 2124-8 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2003
- Published
A Gly482Ser missense mutation in the peroxisome proliferator-activated receptor gamma coactivator-1 is associated with altered lipid oxidation and early insulin secretion in Pima Indians
Muller, Y. L., Bogardus, C., Pedersen, Oluf Borbye & Baier, L., 2003, In: Diabetes. 52, 3, p. 895-8 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A genome-wide scan in families with maturity-onset diabetes of the young: evidence for further genetic heterogeneity
Frayling, T. M., Lindgren, C. M., Chevre, J. C., Menzel, S., Wishart, M., Benmezroua, Y., Brown, A., Evans, J. C., Rao, P. S., Dina, C., Lecoeur, C., Kanninen, T., Almgren, P., Bulman, M. P., Wang, Y., Mills, J., Wright-Pascoe, R., Mahtani, M. M., Prisco, F., Costa, A. & 9 others, , 2003, In: Diabetes. 52, 3, p. 872-81 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Evidence for an association between the Leu162Val polymorphism of the PPARalpha gene and decreased fasting serum triglyceride levels in glucose tolerant subjects
Nielsen, E. D., Hansen, L., Echwald, S. M., Drivsholm, Thomas, Borch-Johnsen, K., Ekstrøm, C. T., Hansen, Torben & Pedersen, Oluf Borbye, 2003, In: Pharmacogenetics and Genomics. 13, 7, p. 417-23 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Impact of low-dose acetylsalicylic acid on kidney function in type 2 diabetic patients with elevated urinary albumin excretion rate
Gaede, P., Hansen, H. P., Parving, H. & Pedersen, Oluf Borbye, 2003, In: Nephrology, Dialysis, Transplantation. 18, 3, p. 539-42 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Impact of two common polymorphisms in the PPARgamma gene on glucose tolerance and plasma insulin profiles in monozygotic and dizygotic twins: thrifty genotype, thrifty phenotype, or both?
Poulsen, P., Andersen, G., Fenger, M., Hansen, Torben, Echwald, S. M., Vølund, A., Beck-Nielsen, H., Pedersen, Oluf Borbye & Vaag, Allan, 2003, In: Diabetes. 52, 1, p. 194-8 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Insulin resistance and maximal oxygen uptake
Seibaek, M., drb459, drb459, Burchardt, H., Sloth, C., Torp-Pedersen, Christian, Nielsen, S. L., Hildebrandt, P. & Pedersen, Oluf Borbye, 2003, In: Clinical Cardiology. 26, 11, p. 515-20 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Intensified multifactorial intervention and cardiovascular outcome in type 2 diabetes: the Steno-2 study
Pedersen, Oluf Borbye & Gaede, P., 2003, In: Metabolism. 52, 8 Suppl 1, p. 19-23 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Leptin and bone mineral density: a cross-sectional study in obese and nonobese men
Morberg, C. M., Tetens, Inge , Black, E., Toubro, S., Sørensen, Thorkild I.A., Pedersen, Oluf Borbye & Astrup, A., 2003, In: Journal of Clinical Endocrinology and Metabolism. 88, 12, p. 5795-5800 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes
Gaede, P., Vedel, P., Larsen, N., Jensen, G. V. H., Parving, H. & Pedersen, Oluf Borbye, 2003, In: Briefings from the New England Journal of Medicine. 348, 5, p. 383-93 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Steno-2-studiet: intensiv multifaktoriel behandling reducerer forekomsten af kardiovaskulaer sygdom hos patienter med type 2-diabetes
Gaede, P. H., Jepsen, P. V., Larsen, J. N. B., Jensen, G. V., Parving, H. & Pedersen, Oluf Borbye, 2003, In: Ugeskrift for Laeger. 165, 26, p. 2658-61 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The E23K variant of Kir6.2 associates with impaired post-OGTT serum insulin response and increased risk of type 2 diabetes
Nielsen, E. D., Hansen, L., Carstensen, Bendix, Echwald, S. M., Drivsholm, Thomas, Glümer, C., Thorsteinsson, B., Borch-Johnsen, K., Hansen, Torben & Pedersen, Oluf Borbye, 2003, In: Diabetes. 52, 2, p. 573-7 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2004
- Published
A common polymorphism in the promoter of the IGF-I gene associates with increased fasting serum triglyceride levels in glucose-tolerant subjects
Nielsen, E. D., Hansen, L., Lajer, M., Andersen, K. L., Echwald, S. M., Urhammer, S. A., Hansen, Torben & Pedersen, Oluf Borbye, 2004, In: Clinical Biochemistry. 37, 8, p. 660-5 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A novel syndrome of autosomal-dominant hyperinsulinemic hypoglycemia linked to a mutation in the human insulin receptor gene
Højlund, K., Hansen, Torben, Lajer, M., Henriksen, J. E., Levin, K., Lindholm, J., Pedersen, Oluf Borbye & Beck-Nielsen, H., 2004, In: Diabetes. 53, 6, p. 1592-8 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Expression profiling of insulin action in human myotubes: induction of inflammatory and pro-angiogenic pathways in relationship with glycogen synthesis and type 2 diabetes
Hansen, L., Gaster, M., Oakeley, E. J., Brusgaard, K., Damsgaard Nielsen, E., Beck-Nielsen, H., Pedersen, Oluf Borbye & Hemmings, B. A., 2004, In: Biochemical and Biophysical Research Communications. 323, 2, p. 685-95 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Grey-box modelling of pharmacokinetic/pharmacodynamic systems
Tornøe, C. W., Jacobsen, Judith Lone, Pedersen, Oluf Borbye, Hansen, Torben & Madsen, H. T., 2004, In: Journal of Pharmacokinetics and Pharmacodynamics. 31, 5, p. 401-17 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Handlingsplan om diabetes
Pedersen, Oluf Borbye, 2004, In: Ugeskrift for Laeger. 166, 12, p. 1099Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Increasing incidence of diabetes after gestational diabetes: a long-term follow-up in a Danish population
Lauenborg, J., Hansen, Torben, Jensen, D. M., drb459, drb459, Mølsted-Pedersen, L., Hornnes, P., Locht, H., Pedersen, Oluf Borbye & Damm, Peter, 2004, In: Diabetes Care. 27, 5, p. 1194-9 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Intensive integrated therapy of type 2 diabetes: implications for long-term prognosis
Gaede, P. & Pedersen, Oluf Borbye, 2004, In: Diabetes. 53 Suppl 3, p. S39-47Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Maturity-onset diabetes of the young with end-stage nephropathy: a new indication for simultaneous pancreas and kidney transplantation?
Saudek, F., Pruhová, S., Boucek, P., Lebl, J., Adamec, M., Ek, J., Pedersen, Oluf Borbye & Hansen, Torben, 2004, In: Transplantation. 77, 8, p. 1298-301 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mutation analysis of NR0B2 among 1545 Danish men identifies a novel c.278G>A (p.G93D) variant with reduced functional activity
Echwald, S. M., Andersen, K. L., Sørensen, Thorkild I.A., Larsen, L. H., Andersen, T., Tonooka, N., Tomura, H., Takeda, J. & Pedersen, Oluf Borbye, 2004, In: Human Mutation. 24, 5, p. 381-387 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Remission to normoalbuminuria during multifactorial treatment preserves kidney function in patients with type 2 diabetes and microalbuminuria
Gaede, P., Tarnow, L., Vedel, P., Parving, H. & Pedersen, Oluf Borbye, 2004, In: Nephrology, Dialysis, Transplantation. 19, 11, p. 2784-8 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Target intervention against multiple-risk markers to reduce cardiovascular disease in patients with type 2 diabetes
Gaede, P. & Pedersen, Oluf Borbye, 2004, In: Annals of Medicine. 36, 5, p. 355-66 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Variation in the interleukin-6 receptor gene associates with type 2 diabetes in Danish whites
Hamid, Y. H., Urhammer, S. A., Jensen, D. P., Glümer, C., Borch-Johnsen, K., Jørgensen, T., Hansen, Torben & Pedersen, Oluf Borbye, 2004, In: Diabetes. 53, 12, p. 3342-5 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Studies of the Ala/Val98 polymorphism of the hepatocyte nuclear factor-1alpha gene and the relationship to beta-cell function during an OGTT in glucose-tolerant women with and without previous gestational diabetes mellitus
Lauenborg, J., Damm, Peter, Ek, J., Glümer, C., Jørgensen, Tina, Borch-Johnsen, K., Vestergaard, H., Hornnes, P., Pedersen, Oluf Borbye & Hansen, Torben, Dec 2004, In: Diabetic Medicine. 21, 12, p. 1310-5 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2005
- Published
A -30G>A polymorphism of the beta-cell-specific glucokinase promoter associates with hyperglycemia in the general population of whites
Rose, C. S., Ek, J., Urhammer, S. A., Glümer, C., Borch-Johnsen, K., Jørgensen, T., Pedersen, Oluf Borbye & Hansen, Torben, 2005, In: Diabetes. 54, 10, p. 3026-31 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A prevalent amino acid polymorphism at codon 98 (Ala98Val) of the hepatocyte nuclear factor-1alpha is associated with maturity-onset diabetes of the young and younger age at onset of type 2 diabetes in Asian Indians
Anuradha, S., Radha, V., Deepa, R., Hansen, Torben, Carstensen, Bendix, Pedersen, Oluf Borbye & Mohan, V., 2005, In: Diabetes Care. 28, 10, p. 2430-5 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Evidence of an association between the Arg72 allele of the peptide YY and increased risk of type 2 diabetes
Torekov, Signe Sørensen, Larsen, L. H., Glümer, C., Borch-Johnsen, K., Jørgensen, T., Holst, Jens Juul, Madsen, O. D., Hansen, Torben & Pedersen, Oluf Borbye, 2005, In: Diabetes. 54, 7, p. 2261-5 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Evidence that the mitochondrial leucyl tRNA synthetase (LARS2) gene represents a novel type 2 diabetes susceptibility gene
hart, L. M., Hansen, Torben, Rietveld, I., Dekker, J. M., Nijpels, G., Janssen, G. M. C., Arp, P. A., Uitterlinden, A. G., Jørgensen, T., Borch-Johnsen, K., Pols, H. A. P., Pedersen, Oluf Borbye, van Duijn, C. M., Heine, R. J. & Maassen, J. A., 2005, In: Diabetes. 54, 6, p. 1892-5 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genetics of type 2 diabetes mellitus: status and perspectives
Hansen, L. & Pedersen, Oluf Borbye, 2005, In: Diabetes, Obesity and Metabolism. 7, 2, p. 122-35 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mutation analysis of the MCHR1 gene in human obesity
Wermter, A-K., Reichwald, K., Büch, T., Geller, F., Platzer, C., Huse, K., Hess, C., Remschmidt, H., Gudermann, T., Preibisch, G., Siegfried, W., Goldschmidt, H-P., Li, W-D., Price, R. A., Biebermann, H., Krude, H., Vollmert, C., Wichmann, H-E., Illig, T., Sørensen, T. I. A. & 11 others, , 2005, In: European Journal of Endocrinology. 152, 6, p. 851-62 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mutation analysis of the preproghrelin gene: no association with obesity and type 2 diabetes
Larsen, L. H., Gjesing, A. P., Sørensen, Thorkild I.A., Hamid, Y. H., Echwald, S. M., Toubro, S., Black, E., Astrup, A., Hansen, Torben & Pedersen, Oluf Borbye, 2005, In: Clinical Biochemistry. 38, 5, p. 420-424 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Prevalence of mutations and functional analyses of melanocortin 4 receptor variants identified among 750 men with juvenile-onset obesity
Larsen, L. H., Echwald, S. M., Sørensen, Thorkild I.A., Andersen, T., Wulff, B. S. & Pedersen, Oluf Borbye, 2005, In: The Journal of Clinical Endocrinology & Metabolism. 90, 1, p. 219-224 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Role of transcription factor KLF11 and its diabetes-associated gene variants in pancreatic beta cell function
Neve, B., Fernandez-Zapico, M. E., Ashkenazi-Katalan, V., Dina, C., Hamid, Y. H., Joly, E., Vaillant, E., Benmezroua, Y., Durand, E., Bakaher, N., Delannoy, V., Vaxillaire, M., Cook, T., Dallinga-Thie, G. M., Jansen, H., Charles, M-A., Clément, K., Galan, P., Hercberg, S., Helbecque, N. & 7 others, , 2005, In: Proceedings of the National Academy of Sciences of the United States of America. 102, 13, p. 4807-12 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Studies of variations of the cyclin-dependent kinase inhibitor 1C and the cyclin-dependent kinase 4 genes in relation to type 2 diabetes mellitus and related quantitative traits
Nielsen, E. D., Hansen, L., Stissing, T., Yanagisawa, K., Borch-Johnsen, K., Poulsen, P., Vaag, Allan, Hansen, Torben & Pedersen, Oluf Borbye, 2005, In: Journal of Molecular Medicine. 83, 5, p. 353-61 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The N363S polymorphism of the glucocorticoid receptor and metabolic syndrome factors in men
Buemann, B., Black, E., Holst, C., Toubro, S., Echwald, S., Pedersen, Oluf Borbye, Astrup, A. & Sørensen, Thorkild I.A., 2005, In: Obesity Research. 13, 5, p. 862-867 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The functional Thr130Ile and Val255Met polymorphisms of the hepatocyte nuclear factor-4alpha (HNF4A): gene associations with type 2 diabetes or altered beta-cell function among Danes
Ek, J., Rose, C. S., Jensen, D. P., Glümer, C., Borch-Johnsen, K., Jørgensen, T., Pedersen, Oluf Borbye & Hansen, Torben, 2005, In: Journal of Clinical Endocrinology and Metabolism. 90, 5, p. 3054-9 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The prevalence of the metabolic syndrome in a danish population of women with previous gestational diabetes mellitus is three-fold higher than in the general population
Lauenborg, J., Mathiesen, Elisabeth, Hansen, Torben, Glümer, C., Jørgensen, T., Borch-Johnsen, K., Hornnes, P., Pedersen, Oluf Borbye & Damm, Peter, 2005, In: Journal of Clinical Endocrinology and Metabolism. 90, 7, p. 4004-10 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Variation of the McKusick-Kaufman gene and studies of relationships with common forms of obesity
Andersen, K. L., Echwald, S. M., Larsen, L. H., Hamid, Y. H., Glumer, C., Jørgensen, T., Borch-Johnsen, K., Andersen, T., Sørensen, Thorkild I.A., Hansen, Torben & Pedersen, Oluf Borbye, 2005, In: Journal of Clinical Endocrinology and Metabolism. 90, 1, p. 225-230 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
PGC-1alpha Gly482Ser polymorphism associates with hypertension among Danish whites
Andersen, G., Wegner, L., Jensen, D. P., Glümer, C., Tarnow, L., Drivsholm, Thomas, Poulsen, P., Hansen, S. K., Nielsen, E. D., Ek, J., Mouritzen, P., Vaag, A., Parving, H., Borch-Johnsen, K., Jørgensen, T., Hansen, Torben & Pedersen, Oluf Borbye, 1 Apr 2005, In: Hypertension. 45, 4, p. 565-70 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2006
- Published
A novel -192c/g Mutation in the Proximal P2 Promoter of the Hepatocyte Nuclear Factor-4α Gene (HNF4A) Associates With Late-onset Diabetes
Ek, J., Hansen, S. P., Lajer, M., Nicot, C., Boesgaard, T. W., Pruhova, S., Johansen, A., Albrechtsen, Anders, Yderstraede, K., Lauenborg, J., Parrizas, M., Boj, S. F., Jørgensen, T., Borch-Johnsen, K., Damm, Peter, Ferrer, J., Lebl, J., Pedersen, Oluf Borbye & Hansen, Torben, 2006, In: Diabetes. 55, 6, p. 1869-73 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Association between neuromedin U gene variants and overweight and obesity
Hainerová, I., Torekov, Signe Sørensen, Ek, J., Finková, M., Borch-Johnsen, K., Jørgensen, T., Madsen, O. D., Lebl, J., Hansen, Torben & Pedersen, Oluf Borbye, 2006, In: Journal of Clinical Endocrinology and Metabolism. 91, 12, p. 5057-63 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Association of the calpain-10 gene with type 2 diabetes in Europeans: results of pooled and meta-analyses
Tsuchiya, T., Schwarz, P. E. H., Bosque-Plata, L. D., Geoffrey Hayes, M., Dina, C., Froguel, P., Wayne Towers, G., Fischer, S., Temelkova-Kurktschiev, T., Rietzsch, H., Graessler, J., Vcelák, J., Palyzová, D., Selisko, T., Bendlová, B., Schulze, J., Julius, U., Hanefeld, M., Weedon, M. N., Evans, J. C. & 12 others, , 2006, In: Molecular Genetics and Metabolism. 89, 1-2, p. 174-84 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
EIF4A2 is a positional candidate gene at the 3q27 locus linked to type 2 diabetes in French families
Cheyssac, C., Dina, C., Leprêtre, F., Vasseur-Delannoy, V., Dechaume, A., Lobbens, S., Balkau, B., Ruiz, J., Charpentier, G., Pattou, F., Joly, E., Prentki, M., Hansen, Torben, Pedersen, Oluf Borbye, Vaxillaire, M. & Froguel, P., 2006, In: Diabetes. 55, 4, p. 1171-6 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Fedmens genetik
Echwald, S. M., Larsen, P. J., Pedersen, Oluf Borbye & Sørensen, Thorkild I.A., 2006, In: Ugeskrift for læger. 168, 2, p. 150-152 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genetic polymorphisms and weight loss in obesity: a randomised trial of hypo-energetic high- versus low-fat diets
Sørensen, T. I. A., Boutin, P., Taylor, M. A., Larsen, L. H., Verdich, C., Petersen, L., Holst, C., Echwald, S. M., Dina, C., Toubro, S., Petersen, M., Polak, J., Clément, K., Martinez, J. A., Langin, D., Oppert, J-M., Stich, V., Macdonald, I., Arner, P., Saris, W. H. M. & 3 others, , 2006, In: PLoS Clinical Trials. 12, 2, p. 1-14 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genotype-by-nutrient interactions assessed in European obese women: a case-only study
Santos, J. L., Boutin, P., Verdich, C., Holst, C., Larsen, L. H., Toubro, S., Dina, C., Saris, W. H. M., Blaak, E. E., Hoffstedt, J., Taylor, M. A., Polak, J., Clement, K., Langin, D., Astrup, A., Froguel, P., Pedersen, Oluf Borbye, Sørensen, Thorkild I.A., Martinez, J. A. & NUGENOB* consortium, N. C., 2006, In: European Journal of Nutrition. 45, 8, p. 454-462 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
IL6 gene promoter polymorphisms and type 2 diabetes: joint analysis of individual participants' data from 21 studies
Huth, C., Heid, I. M., Vollmert, C., Gieger, C., Grallert, H., Wolford, J. K., Langer, B., Thorand, B., Klopp, N., Hamid, Y. H., Pedersen, O., Hansen, T., Lyssenko, V., Groop, L., Meisinger, C., Döring, A., Löwel, H., Lieb, W., Hengstenberg, C., Rathmann, W. & 25 others, , 2006, In: Diabetes. 55, 10, p. 2915-21 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Lens fluorescence in relation to glucose tolerance and genetic predisposition to type 2 diabetes mellitus in a population-based study
Koefoed Theil, P., Kessel, Line, Hansen, Torben, Lund-Andersen, H., Pedersen, Oluf Borbye & Larsen, Michael, 2006, In: Current Eye Research. 31, 9, p. 733-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molekylaer patogenese ved monogen og polygen fedme
Larsen, P. J., Echwald, S. M., Sørensen, Thorkild I.A. & Pedersen, Oluf Borbye, 2006, In: Ugeskrift for Laeger. 168, 2, p. 152-5 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Monitoring kidney function in type 2 diabetic patients with incipient and overt diabetic nephropathy
Rossing, Peter, Rossing, K., Gaede, P., Pedersen, Oluf Borbye & Parving, H., 2006, In: Diabetes Care. 29, 5, p. 1024-30 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
PROactive study
Gaede, P., Parving, H. & Pedersen, Oluf Borbye, 2006, In: Lancet. 367, 9504, p. 23-4; author reply 26-7Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The HADHSC gene encoding short-chain L-3-hydroxyacyl-CoA dehydrogenase (SCHAD) and type 2 diabetes susceptibility: the DAMAGE study
van Hove, E. C., Hansen, Torben, Dekker, J. M., Reiling, E., Nijpels, G., Jørgensen, T., Borch-Johnsen, K., Hamid, Y. H., Heine, R. J., Pedersen, Oluf Borbye, Maassen, J. A. & hart, L. M., 2006, In: Diabetes. 55, 11, p. 3193-6 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Variants in the 5' region of the neuropeptide Y receptor Y2 gene (NPY2R) are associated with obesity in 5,971 white subjects
Torekov, Signe Sørensen, Larsen, L. H., Andersen, G., Albrechtsen, Anders, Glümer, C., Borch-Johnsen, K., Jørgensen, Tina, Hansen, Teis Schjals & Pedersen, Oluf Borbye, 2006, In: Diabetologia. 49, 11, p. 2653-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Variation in CAPN10 in relation to type 2 diabetes, obesity and quantitative metabolic traits: studies in 6018 whites
Jensen, D. P., Urhammer, S. A., Eiberg, Hans Rudolf Lytchoff, Borch-Johnsen, K., Jørgensen, T., Hansen, Torben & Pedersen, Oluf Borbye, 2006, In: Molecular Genetics and Metabolism. 89, 4, p. 360-7 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2007
- Published
A common haplotype in the G-protein-coupled receptor gene GPR74 is associated with leanness and increased lipolysis
Dahlman, I., Dicker, A., Jiao, H., Kere, J., Blomqvist, L., van Harmelen, V., Hoffstedt, J., Borch-Johnsen, K., Jorgensen, T., Hansen, Torben, Pedersen, Oluf Borbye, Laakso, M. & Arner, P., 2007, In: American Journal of Human Genetics. 80, 6, p. 1115-24 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A variant in CDKAL1 influences insulin response and risk of type 2 diabetes
Steinthorsdottir, V., Thorleifsson, G., Reynisdottir, I., Benediktsson, R., Jonsdottir, T., Walters, G. B., Styrkarsdottir, U., Gretarsdottir, S., Emilsson, V., Ghosh, S., Baker, A., Snorradottir, S., Bjarnason, H., Ng, M. C. Y., Hansen, T., Bagger, Y., Wilensky, R. L., Reilly, M. P., Adeyemo, A., Chen, Y. & 25 others, , 2007, In: Nature Genetics. 39, 6, p. 770-5 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Common variation in LMNA increases susceptibility to type 2 diabetes and associates with elevated fasting glycemia and estimates of body fat and height in the general population: studies of 7,495 Danish whites
Wegner, L., Andersen, G., Sparsø, T., Grarup, Niels, Glümer, C., Borch-Johnsen, K., Jørgensen, T., Hansen, Torben & Pedersen, Oluf Borbye, 2007, In: Diabetes. 56, 3, p. 694-8 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genetic analysis of the estrogen-related receptor alpha and studies of association with obesity and type 2 diabetes
Larsen, L. H., Rose, C. S., Sparsø, T., Overgaard, J., Torekov, Signe Sørensen, Grarup, Niels, Jensen, Dan Funck, Albrechtsen, Anders, Andersen, G., Ek, J., Glümer, C., Borch-Johnsen, K., Jørgensen, Tina, Hansen, Teis Schjals & Pedersen, Oluf Borbye, 2007, In: International Journal of Obesity. 31, 2, p. 365-70 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Polymorphisms in the 3' UTR in the neurocalcin delta gene affect mRNA stability, and confer susceptibility to diabetic nephropathy
Kamiyama, M., Kobayashi, M., Araki, S., Iida, A., Tsunoda, T., Kawai, K., Imanishi, M., Nomura, M., Babazono, T., Iwamoto, Y., Kashiwagi, A., Kaku, K., Kawamori, R., Ng, D. P. K., Hansen, Torben, Gaede, P., Pedersen, Oluf Borbye, Nakamura, Y. & Maeda, S., 2007, In: Human Genetics. 122, 3-4, p. 397-407 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 919113
Most downloads
-
5481
downloads
Natural selection affects multiple aspects of genetic variation at putatively peutral sites across the human genome
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
5236
downloads
Genetic architecture of vitamin B12 and folate levels uncovered applying deeply sequenced large datasets
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
4519
downloads
Family and population-based studies of variation within the ghrelin receptor locus in relation to measures of obesity
Research output: Contribution to journal › Journal article › Research › peer-review
Published