Oluf Borbye Pedersen
Visiting professor, Clinical Professor
Pedersen Group
Blegdamsvej 3B, Mærsk Tårnet, 8. sal
2200 København N.
Department of Clinical Medicine
Blegdamsvej 3
2200 København N.
Member of:
Internal medicine: infection medicine
Internal Medicine: Endocrinology
- 1991
- Published
Effects of hyperinsulinemia and hyperglycemia on insulin receptor function and glycogen synthase activation in skeletal muscle of normal man
Bak, J. F., Møller, N., Schmitz, O., Richter, Erik A. & Pedersen, Oluf Borbye, 1991, In: Metabolism. 40, 8, p. 830-835 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Impaired expression of glycogen synthase mRNA in skeletal muscle of NIDDM patients
drb459, drb459, Bjørbaek, C., Andersen, P. H., Bak, J. F. & Pedersen, Oluf Borbye, Dec 1991, In: Diabetes. 40, 12, p. 1740-5 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1993
- Published
The effect of intensive insulin therapy on the insulin-regulatable glucose transporter (GLUT4) expression in skeletal muscle in type 1 diabetes
Andersen, P. H., drb459, drb459, Lund, S., Vedel, P., Junker, S., Kahn, B. B. & Pedersen, Oluf Borbye, Oct 1993, In: Diabetic Medicine. 10, 8, p. 699-706 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Aminoacid polymorphisms of insulin receptor substrate-1 in non-insulin-dependent diabetes mellitus
Almind, K., Bjørbaek, C., drb459, drb459, Hansen, Torben, Echwald, S. M. & Pedersen, Oluf Borbye, 2 Oct 1993, In: Lancet. 342, 8875, p. 828-32 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Expression of insulin receptor spliced variants and their functional correlates in muscle from patients with non-insulin-dependent diabetes mellitus
Hansen, Torben, Bjørbaek, C., drb459, drb459, Grønskov, K., Bak, J. F. & Pedersen, Oluf Borbye, Dec 1993, In: The Journal of clinical endocrinology and metabolism. 77, 6, p. 1500-5 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1994
- Published
Expression of glycogen synthase and phosphofructokinase in muscle from type 1 (insulin-dependent) diabetic patients before and after intensive insulin treatment
drb459, drb459, Andersen, P. H., Lund, S., Vedel, P. & Pedersen, Oluf Borbye, Jan 1994, In: Diabetologia. 37, 1, p. 82-90 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genetic variants in promoters and coding regions of the muscle glycogen synthase and the insulin-responsive GLUT4 genes in NIDDM
Bjørbaek, C., Echwald, S. M., Hubricht, P., drb459, drb459, Hansen, Torben, Zierath, Juleen R & Pedersen, Oluf Borbye, Aug 1994, In: Diabetes. 43, 8, p. 976-83 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Sequence of the human glycogen-associated regulatory subunit of type 1 protein phosphatase and analysis of its coding region and mRNA level in muscle from patients with NIDDM
Chen, Y. H., Hansen, L., Chen, M., Bjørbaek, C., drb459, drb459, Hansen, Teis Schjals, Cohen, P., Pedersen, Oluf Borbye & drb459, drb459, Oct 1994, In: Diabetes. 43, 10, p. 1234-41 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1995
Severe insulin-resistant diabetes mellitus in patients with congenital muscle fiber type disproportion myopathy
drb459, drb459, Klein, H. H., Hansen, T., Müller, J., Skovby, F., Bjørbaek, C., Røder, M. E. & Pedersen, Oluf Borbye, 1995, In: The Journal of Clinical Investigation. 95, 4, p. 1925-1932 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Sulfonylurea therapy improves glucose disposal without changing skeletal muscle GLUT4 levels in noninsulin-dependent diabetes mellitus subjects: a longitudinal study
drb459, drb459, Weinreb, J. E., Rosen, A. S., Bjørbaek, C., Hansen, L., Pedersen, Oluf Borbye & Kahn, B. B., Jan 1995, In: The Journal of clinical endocrinology and metabolism. 80, 1, p. 270-5 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of four amino acid substitutions in hexokinase II and studies of relationships to NIDDM, glucose effectiveness, and insulin sensitivity
Echwald, S. M., Bjørbaek, C., Hansen, Torben, Clausen, J. O., drb459, drb459, Zierath, Juleen R, Printz, R. L., Granner, D. K. & Pedersen, Oluf Borbye, Mar 1995, In: Diabetes. 44, 3, p. 347-53 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Unchanged gene expression of glycogen synthase in muscle from patients with NIDDM following sulphonylurea-induced improvement of glycaemic control
drb459, drb459, Lund, S., Bjørbaek, C. & Pedersen, Oluf Borbye, Oct 1995, In: Diabetologia. 38, 10, p. 1230-8 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Elevation of serum insulin concentration during euglycemic hyperinsulinemic clamp studies leads to similar activation of insulin receptor kinase in skeletal muscle of subjects with and without NIDDM
Klein, H. H., drb459, drb459, Kotzke, G. & Pedersen, Oluf Borbye, Nov 1995, In: Diabetes. 44, 11, p. 1310-7 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1996
- Published
Impaired insulin-stimulated nonoxidative glucose metabolism in glucose-tolerant women with previous gestational diabetes
Damm, Peter, drb459, drb459, Kühl, C. E. & Pedersen, Oluf Borbye, Feb 1996, In: American Journal of Obstetrics and Gynecology. 174, 2, p. 722-9 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Studies of insulin resistance in congenital generalized lipodystrophy
Søvik, O., drb459, drb459, Trygstad, O. & Pedersen, Oluf Borbye, Jun 1996, In: Acta Paediatrica. Supplement. 413, p. 29-37 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1997
- Published
Identification of a common amino acid polymorphism in the p85alpha regulatory subunit of phosphatidylinositol 3-kinase: effects on glucose disappearance constant, glucose effectiveness, and the insulin sensitivity index
Hansen, Torben, Andersen, C. B., Echwald, S. M., Urhammer, S. A., Clausen, J. O., drb459, drb459, Owens, D., Hansen, L. & Pedersen, Oluf Borbye, Mar 1997, In: Diabetes. 46, 3, p. 494-501 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Short- and long-term metabolic effects of recombinant human IGF-I treatment in patients with severe insulin resistance and diabetes mellitus
Vestergaard, H., Rossen, M., Urhammer, S. A., Müller, J. & Pedersen, Oluf Borbye, May 1997, In: European Journal of Endocrinology. 136, 5, p. 475-82 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Chromosomal mapping and mutational analysis of the coding region of the glycogen synthase kinase-3alpha and beta isoforms in patients with NIDDM
Hansen, L., Arden, K. C., Rasmussen, S. B., Viars, C. S., drb459, drb459, Hansen, Teis Schjals, Møller, A. M., Woodgett, J. R. & Pedersen, Oluf Borbye, Aug 1997, In: Diabetologia. 40, 8, p. 940-6 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Expression of protein-tyrosine phosphatases in the major insulin target tissues
Norris, K., Norris, F., Kono, D. H., drb459, drb459, Pedersen, Oluf Borbye, Theofilopoulos, A. N. & Møller, N. P., 6 Oct 1997, In: FEBS Letters. 415, 3, p. 243-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1998
- Published
The effect of two frequent amino acid variants of the hepatocyte nuclear factor-1α gene on estimates of the pancreatic β-cell function in Caucasian glucosetolerant first-degree relatives of type 2 diabetic patients
Urhammer, Søren Asger, Møller, Ann, Nyholm, B., Ekstrøm, Claus Thorn, Eiberg, Hans Rudolf Lytchoff, Clausen, J. O., Hansen, Torben, Pedersen, Oluf Borbye & Schmitz, O., 20 Nov 1998, In: Journal of Clinical Endocrinology and Metabolism. 83, 11, p. 3992-3995 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Ala/Va198 polymorphism of the hepatocyte nuclear factor-1α gene contributes to the interindividual variation in serum C-peptide response during an oral glucose tolerance test: Evidence from studies of 231 glucose- tolerant first degree relatives of type 2 diabetic probands
Urhammer, Søren Asger, Hansen, Torben, Ekstrøm, Claus Thorn, Eiberg, Hans Rudolf Lytchoff & Pedersen, Oluf Borbye, 1 Dec 1998, In: Journal of Clinical Endocrinology and Metabolism. 83, 12, p. 4506-4509 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1999
- Published
Alternative splicing of exon 17 and a missense mutation in exon 20 of the insulin receptor gene in two brothers with a novel syndrome of insulin resistance (congenital fiber-type disproportion myopathy)
Vorwerk, P., Christoffersen, C. T., Müller, J., drb459, drb459, Pedersen, Oluf Borbye, De Meyts, P. & drb459, drb459, 1999, In: Hormone Research. 52, 5, p. 211-20 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Intermediate Expansions of a GAA Repeat in the Frataxin Gene are not associated with Type 2 Diabetes or Altered Glucose-Induced ¿-cell function in Danish Caucasians
Dalgaard, L. T., Hansen, T., Urhammer, S. A., Clausen, J. O., Eiberg, Hans Rudolf Lytchoff & Pedersen, Oluf Borbye, 1999, In: Diabetes. 48, p. 914-917Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Implications of compound heterozygous insulin receptor mutations in congenital muscle fibre type disproportion myopathy for the receptor kinase activation
Klein, H. H., Müller, R., drb459, drb459 & Pedersen, Oluf Borbye, Feb 1999, In: Diabetologia. 42, 2, p. 245-9 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mutational analysis of the coding regions of the genes encoding protein kinase B-alpha and -beta, phosphoinositide-dependent protein kinase-1, phosphatase targeting to glycogen, protein phosphatase inhibitor-1, and glycogenin: lessons from a search for genetic variability of the insulin-stimulated glycogen synthesis pathway of skeletal muscle in NIDDM patients
Hansen, L., Fjordvang, H., Rasmussen, S. K., drb459, drb459, Echwald, S. M., Hansen, Teis Schjals, Alessi, D., Shenolikar, S., Saltiel, A. R., Barbetti, F. & Pedersen, Oluf Borbye, Feb 1999, In: Diabetes. 48, 2, p. 403-7 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Search for variants of the gene-promoter and the potential phosphotyrosine encoding sequence of the insulin receptor substrate-2 gene: Evaluation of their relation with alterations in insulin secretion and insulin sensitivity
Almind, K., Frederiksen, S. K., Bernal, D., Hansen, Torben, Ambye, L., Urhammer, Søren Asger, Ekstrøm, Claus Thorn, Berglund, L., Reneland, R., Lithell, H., White, M. F., Van Obberghen, E. & Pedersen, Oluf Borbye, 11 Oct 1999, In: Diabetologia. 42, 10, p. 1244-1249 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2000
- Published
The K121Q variant of the human PC-1 gene is not associated with insulin resistance or type 2 diabetes among Danish Caucasians
Rasmussen, S. K., Urhammer, Søren Asger, Pizzuti, A., Echwald, S. M., Ekstrøm, Claus Thorn, Hansen, L., Hansen, Torben, Borch-Johnsen, K., Frittitta, L., Trischitta, V. & Pedersen, Oluf Borbye, 2000, In: Diabetes. 49, 9, p. 1608-1611 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Studies of the variability of the genes encoding the insulin-like growth factor I receptor and its ligand in relation to type 2 diabetes mellitus
Rasmussen, S. K., Lautier, C., Hansen, L., Echwald, S. M., Hansen, Torben, Ekstrøm, Claus Thorn, Urhammer, Søren Asger, Borch-Johnsen, K., Grigorescu, F., Smith, R. J. & Pedersen, Oluf Borbye, 1 Dec 2000, In: Journal of Clinical Endocrinology and Metabolism. 85, 4, p. 1606-1610 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2001
- Published
A prevalent polymorphism in the putative promotor of the UCP3 gene and its relationship to body mass index in the Danish population
Dalgaard, L. T., Sørensen, Thorkild I.A., Drivsholm, T. B., Borch-Johnsen, K., Andersen, T., Hansen, T. & Pedersen, Oluf Borbye, 2001, In: Journal of Clinical Endocrinology and Metabolism. 86, p. 1398-1402Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The association between the val/ala-55 polymorphism of the uncoupling protein 2 gene and exercise efficiency
Buemann, B., Schierning, B., Toubro, S., Bibby, B. M., Sørensen, Thorkild I.A., Dalgaard, L., Pedersen, Oluf Borbye & Astrup, A., 2001, In: International Journal of Obesity. 25, p. 467-471 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Studies of variability in the PTEN gene among Danish caucasian patients with Type II diabetes mellitus
Hansen, L., Jensen, J. N., Ekstrøm, Claus Thorn, drb459, drb459, Hansen, Teis Schjals, Pedersen, Oluf Borbye & drb459, drb459, Feb 2001, In: Diabetologia. 44, 2, p. 237-240 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Serum leptin levels in pregnant women with type 1 diabetes mellitus
Lauszus, F., Schmitz, O., drb459, drb459, Klebe, J. G., Pedersen, Oluf Borbye & drb459, drb459, Jul 2001, In: Acta Obstetricia et Gynecologica Scandinavica. 80, 7, p. 596-601 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rosiglitazone treatment of patients with extreme insulin resistance and diabetes mellitus due to insulin receptor mutations has no effects on glucose and lipid metabolism
drb459, drb459, Lund, S., Pedersen, Oluf Borbye & drb459, drb459, Nov 2001, In: Journal of Internal Medicine. 250, 5, p. 406-14 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2002
- Published
Fat mass measured by DXA varies with scan velocity
Black, E., Petersen, L., Kreutzer, M., Toubro, S., Sørensen, Thorkild I.A., Pedersen, Oluf Borbye & Astrup, A., 2002, In: Obesity. 10, 2, p. 69-77 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genetic evidence that HNF-1alpha-dependent transcriptional control of HNF-4alpha is essential for human pancreatic beta cell function
Hansen, S. K., Párrizas, M., Jensen, M. L., Pruhova, S., Ek, J., Boj, S. F., Johansen, A., Maestro, M. A., Rivera, F., Eiberg, Hans Rudolf Lytchoff, Andel, M., Lebl, J., Pedersen, Oluf Borbye, Ferrer, J. & Hansen, Torben, 2002, In: Journal of Clinical Investigation. 110, 6, p. 827-33 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Jagten på de genetiske determinanter for de formodede polygene former for type 2-diabetes. Status og perspektivering
Pedersen, Oluf Borbye, Hansen, Torben, Hansen, L., Echwald, S. M. & Urhammer, S. A., 2002, In: Ugeskrift for Laeger. 164, 16, p. 2163-6 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Long-term AICAR administration reduces metabolic disturbances and lowers blood pressure in rats displaying features of the insulin resistance syndrome
Buhl, E. S., Jessen, N., Pold, R., Ledet, T., Flyvbjerg, A., Pedersen, Steen, Pedersen, Oluf Borbye, Schmitz, O. & Lund, S., 2002, In: Diabetes. 51, 7, p. 2199-206 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Maturity-onset diabetes of the young--MODY. Molekylaergenetiske, patofysiologiske og kliniske karakteristika
Hansen, Torben, Urhammer, S. A. & Pedersen, Oluf Borbye, 2002, In: Ugeskrift for Laeger. 164, 15, p. 2017-22 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
PC-1 amino acid variant (K121Q) has no impact on progression of diabetic nephropathy in type 1 diabetic patients
Jacobsen, P., Grarup, Niels, Tarnow, L., Parving, H. & Pedersen, Oluf Borbye, 2002, In: Nephrology, Dialysis, Transplantation. 17, 8, p. 1408-12 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Variants within the calpain-10 gene on chromosome 2q37 (NIDDM1) and relationships to type 2 diabetes, insulin resistance, and impaired acute insulin secretion among Scandinavian Caucasians
Rasmussen, S. K., Urhammer, S. A., Berglund, L. E., Jensen, J. N., Hansen, L., Echwald, S. M., Borch-Johnsen, K., Horikawa, Y., Mashima, H., Lithell, H., Cox, N. J., Hansen, Torben, Bell, G. I. & Pedersen, Oluf Borbye, 2002, In: Diabetes. 51, 12, p. 3561-7 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of the Met326Ile variant of phosphatidylinositol 3-kinase p85alpha
Almind, K., Delahaye, L., Hansen, Torben, Van Obberghen, E., Pedersen, Oluf Borbye & Kahn, C. R., 19 Feb 2002, In: Proceedings of the National Academy of Sciences of the United States of America. 99, 4, p. 2124-8 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2003
- Published
A Gly482Ser missense mutation in the peroxisome proliferator-activated receptor gamma coactivator-1 is associated with altered lipid oxidation and early insulin secretion in Pima Indians
Muller, Y. L., Bogardus, C., Pedersen, Oluf Borbye & Baier, L., 2003, In: Diabetes. 52, 3, p. 895-8 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A genome-wide scan in families with maturity-onset diabetes of the young: evidence for further genetic heterogeneity
Frayling, T. M., Lindgren, C. M., Chevre, J. C., Menzel, S., Wishart, M., Benmezroua, Y., Brown, A., Evans, J. C., Rao, P. S., Dina, C., Lecoeur, C., Kanninen, T., Almgren, P., Bulman, M. P., Wang, Y., Mills, J., Wright-Pascoe, R., Mahtani, M. M., Prisco, F., Costa, A. & 9 others, , 2003, In: Diabetes. 52, 3, p. 872-81 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Evidence for an association between the Leu162Val polymorphism of the PPARalpha gene and decreased fasting serum triglyceride levels in glucose tolerant subjects
Nielsen, E. D., Hansen, L., Echwald, S. M., Drivsholm, Thomas, Borch-Johnsen, K., Ekstrøm, C. T., Hansen, Torben & Pedersen, Oluf Borbye, 2003, In: Pharmacogenetics and Genomics. 13, 7, p. 417-23 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Impact of low-dose acetylsalicylic acid on kidney function in type 2 diabetic patients with elevated urinary albumin excretion rate
Gaede, P., Hansen, H. P., Parving, H. & Pedersen, Oluf Borbye, 2003, In: Nephrology, Dialysis, Transplantation. 18, 3, p. 539-42 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Impact of two common polymorphisms in the PPARgamma gene on glucose tolerance and plasma insulin profiles in monozygotic and dizygotic twins: thrifty genotype, thrifty phenotype, or both?
Poulsen, P., Andersen, G., Fenger, M., Hansen, Torben, Echwald, S. M., Vølund, A., Beck-Nielsen, H., Pedersen, Oluf Borbye & Vaag, Allan, 2003, In: Diabetes. 52, 1, p. 194-8 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Insulin resistance and maximal oxygen uptake
Seibaek, M., drb459, drb459, Burchardt, H., Sloth, C., Torp-Pedersen, Christian, Nielsen, S. L., Hildebrandt, P. & Pedersen, Oluf Borbye, 2003, In: Clinical Cardiology. 26, 11, p. 515-20 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Intensified multifactorial intervention and cardiovascular outcome in type 2 diabetes: the Steno-2 study
Pedersen, Oluf Borbye & Gaede, P., 2003, In: Metabolism. 52, 8 Suppl 1, p. 19-23 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Leptin and bone mineral density: a cross-sectional study in obese and nonobese men
Morberg, C. M., Tetens, Inge , Black, E., Toubro, S., Sørensen, Thorkild I.A., Pedersen, Oluf Borbye & Astrup, A., 2003, In: Journal of Clinical Endocrinology and Metabolism. 88, 12, p. 5795-5800 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes
Gaede, P., Vedel, P., Larsen, N., Jensen, G. V. H., Parving, H. & Pedersen, Oluf Borbye, 2003, In: Briefings from the New England Journal of Medicine. 348, 5, p. 383-93 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 919113
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Natural selection affects multiple aspects of genetic variation at putatively peutral sites across the human genome
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Genetic architecture of vitamin B12 and folate levels uncovered applying deeply sequenced large datasets
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Family and population-based studies of variation within the ghrelin receptor locus in relation to measures of obesity
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