Oluf Borbye Pedersen
Visiting professor, Clinical Professor
Pedersen Group
Blegdamsvej 3B, Mærsk Tårnet, 8. sal
2200 København N.
Department of Clinical Medicine
Blegdamsvej 3
2200 København N.
Member of:
Internal medicine: infection medicine
Internal Medicine: Endocrinology
- Published
'Omics'-driven discoveries in prevention and treatment of type 2 diabetes
Gjesing, A. M. P. & Pedersen, Oluf Borbye, 2012, In: European Journal of Clinical Investigation. Supplement. 42, 6, p. 579-88 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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(1)H-MRS measured ectopic fat in liver and muscle is associated with the metabolic syndrome in Danish girls but not in boys with overweight and obesity
Nissen, A., Fonvig, C. E., Chabanova, E., Bøjsøe, C., Trier, C., Pedersen, Oluf Borbye, Hansen, Torben, Thomsen, Henrik S. & Holm, Jens-Christian, Dec 2016, In: Obesity Science & Practice. 2, 4, p. 376-384 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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14-fold increased prevalence of rare glucokinase gene variant carriers in unselected Danish patients with newly diagnosed type 2 diabetes
Gjesing, A. P., Engelbrechtsen, L., Cathrine B. Thuesen, A., Have, C. T., Hollensted, M., Grarup, N., Linneberg, A., Steen Nielsen, J., Christensen, L. B., Thomsen, R. W., Johansson, K. E., Cagiada, M., Gersing, S., Hartmann-Petersen, R., Lindorff-Larsen, K., Vaag, A., Sørensen, H. T., Brandslund, I., Beck-Nielsen, H., Pedersen, O. & 2 others, , 2022, In: Diabetes Research and Clinical Practice. 194, 9 p., 110159.Research output: Contribution to journal › Journal article › Research › peer-review
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TCF7L2 rs7903146-macronutrient interaction in obese individuals' responses to a 10-wk randomized hypoenergetic diet
Grau, K., Cauchi, S., Holst, C., Astrup, A., Martinez, J. A., Saris, W. H. M., Blaak, E. E., Oppert, J., Arner, P., Rössner, S., Macdonald, I. A., Klimcakova, E., Langin, D., Pedersen, Oluf Borbye, Froguel, P. & Sørensen, Thorkild I.A., 2010, In: American Journal of Clinical Nutrition. 91, 2, p. 472-479 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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FTO genetic variants, dietary intake and body mass index: insights from 177 330 individuals
Qi, Q., Oskari Kilpeläinen, T., Downer, M. K., Tanaka, T., Smith, C. E., Sluijs, I., Sonestedt, E., Chu, A. Y., Renström, F., Lin, X., Angquist, L. H., Huang, J., Liu, Z., Li, Y., Asif Ali, M., Xu, M., Ahluwalia, T. V. S., Boer, J. M. A., Chen, P., Daimon, M. & 89 others, , 7 Aug 2014, In: Human Molecular Genetics. 23, 25, p. 6961-6972 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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FUT2–ABO epistasis increases the risk of early childhood asthma and Streptococcus pneumoniae respiratory illnesses
Ahluwalia, T. S., Eliasen, A. U., Sevelsted, A., Pedersen, C-E. T., Stokholm, J., Chawes, B., Bork-Jensen, J., Grarup, N., Pedersen, O., Hansen, T., Linneberg, A., Sharma, A., Weiss, S. T., Evans, M. D., Jackson, D. J., Morin, A., Krogfelt, K. A., Schjørring, S., Mortensen, P. B., Hougaard, D. M. & 13 others, , 2020, In: Nature Communications. 11, 12 p., 6398.Research output: Contribution to journal › Journal article › Research › peer-review
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In vivo and ex vivo inflammatory markers of common metabolic phenotypes in humans
Mærkedahl, R. B., Frøkiær, Hanne, Stenbæk, M. G., Nielsen, C. B., Lind, M. V., Lundtoft, C., Bohr, M. B., Ibrügger, S., Metzdorff, S. B., drb459, drb459, Pedersen, Oluf Borbye & Lauritzen, Lotte, 2018, In: Metabolic Syndrome and Related Disorders. 16, 1, p. 29-39 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study
Schmidt, A. F., Swerdlow, D. I., Holmes, M. V., Patel, R. S., Fairhurst-Hunter, Z., Lyall, D. M., Hartwig, F. P., Horta, B. L., Hyppönen, E., Power, C., Moldovan, M., van Iperen, E., Hovingh, G. K., Demuth, I., Norman, K., Steinhagen-Thiessen, E., Demuth, J., Bertram, L., Liu, T., Coassin, S. & 31 others, , Feb 2017, In: The Lancet Diabetes & Endocrinology. 5, 2, p. 97–105Research output: Contribution to journal › Journal article › Research › peer-review
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1H-MRS Measured Ectopic Fat in Liver and Muscle in Danish Lean and Obese Children and Adolescents
Fonvig, C. E., Chabanova, E., Andersson, E. A., Ohrt, J. D., Pedersen, Oluf Borbye, Hansen, Torben, Thomsen, Henrik S. & Holm, Jens-Christian, 2015, In: PLOS ONE. 10, 8, 15 p., e0135018.Research output: Contribution to journal › Journal article › Research › peer-review
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A -30G>A polymorphism of the beta-cell-specific glucokinase promoter associates with hyperglycemia in the general population of whites
Rose, C. S., Ek, J., Urhammer, S. A., Glümer, C., Borch-Johnsen, K., Jørgensen, T., Pedersen, Oluf Borbye & Hansen, Torben, 2005, In: Diabetes. 54, 10, p. 3026-31 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A Genome-Wide Association Study of IVGTT-Based Measures of First Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants
Wood, A. R., Jonsson, A., Jackson, A. U., Wang, T-N., van Leewen, N., Palmer, N. D., Kobes, S., Deelen, J., Boquete-Vilarino, L., Paananen, J., Stančáková, A., Boomsma, D. I., de Geus, E. J., Eekhoff, E. M., Fritsche, A., Kramer, M., Nijpels, G., Simonis-Bik, A. M. C., van Haeften, T. W., Mahajan, A. & 31 others, , 2017, In: Diabetes. 66, 8, p. 2296-2309Research output: Contribution to journal › Journal article › Research › peer-review
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A Gly482Ser missense mutation in the peroxisome proliferator-activated receptor gamma coactivator-1 is associated with altered lipid oxidation and early insulin secretion in Pima Indians
Muller, Y. L., Bogardus, C., Pedersen, Oluf Borbye & Baier, L., 2003, In: Diabetes. 52, 3, p. 895-8 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A Human Variant of Glucose-Regulated Protein 94 That Inefficiently Supports IGF Production
Marzec, Michal Tomasz, Hawkes, C. P., Eletto, D., Boyle, S., Rosenfeld, R. G., Hwa, V., Wit, J. M., van Duyvenvoorde, H. A., Oostdijk, W., Losekoot, M., Pedersen, Oluf Borbye, Yeap, B. B., Flicker, L., Barzilai, N., Atzmon, G., Grimberg, A. & Argon, Y., May 2016, In: Endocrinology. 157, 5, p. 1914-1928 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A Low-Frequency Inactivating Akt2 Variant Enriched in the Finnish Population is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk
Manning, A., Highland, H. M., Gasser, J., Sim, X., Tukiainen, T., Fontanillas, P., Grarup, N., Rivas, M. A., Mahajan, A., Locke, A. E., Cingolani, P., Pers, T. H., Viñuela, A., Brown, A. A., Wu, Y., Flannick, J., Fuchsberger, C., Gamazon, E. R., Gaulton, K. J., Im, H. K. & 243 others, , Dec 2017, In: Diabetes. 66, p. 2019-2032 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A Splice Region Variant in LDLR Lowers Non-high Density Lipoprotein Cholesterol and Protects against Coronary Artery Disease
Gretarsdottir, S., Helgason, H., Helgadottir, A., Sigurdsson, A., Thorleifsson, G., Magnusdottir, A., Oddsson, A., Steinthorsdottir, V., Rafnar, T., de Graaf, J., Daneshpour, M. S., Hedayati, M., Azizi, F., Grarup, N., Jørgensen, T., Vestergaard, H., Hansen, T., Eyjolfsson, G., Sigurdardottir, O., Olafsson, I. & 8 others, , Sep 2015, In: P L o S Genetics. 11, 9, 20 p., e1005379.Research output: Contribution to journal › Journal article › Research › peer-review
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A candidate type 2 diabetes polymorphism near the HHEX locus affects acute glucose-stimulated insulin release in European populations: results from the EUGENE2 study
Staiger, H., Stancáková, A., Zilinskaite, J., Vänttinen, M., Hansen, T., Marini, M. A., Hammarstedt, A., Jansson, P., Sesti, G., Smith, U., Pedersen, Oluf Borbye, Laakso, M., Stefan, N., Fritsche, A. & Häring, H., 2008, In: Diabetes. 57, 2, p. 514-7 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A combined analysis of 48 type 2 diabetes genetic risk variants shows no discriminative value to predict time to first prescription of a glucose lowering drug in Danish patients with screen detected type 2 diabetes.
Hornbak, M., Allin, K. H., Jensen, M. L., Lau, C. J., Witte, D. R., Jørgensen, M. E., Sandbæk, A., Lauritzen, T., Andersson, Åsa, Pedersen, Oluf Borbye & Hansen, Torben, 2014, In: PloS One. 9, 8, 10 p., e104837.Research output: Contribution to journal › Journal article › Research › peer-review
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A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes
Moltke, I., Grarup, N., Jørgensen, M. E., Bjerregaard, P., Treebak, J. T., Fumagalli, M., Korneliussen, T. S., Andersen, M. A., Nielsen, T. S., Krarup, N. T., Gjesing, A. M. P., Zierath, J. R., Linneberg, A., Wu, X., Sun, G., Jin, X., Al-Aama, J., Wang, J., Borch-Johnsen, K., Pedersen, O. & 3 others, , 2014, In: Nature. 512, 7513, p. 190-193 4 p.Research output: Contribution to journal › Letter › Research › peer-review
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A common haplotype in the G-protein-coupled receptor gene GPR74 is associated with leanness and increased lipolysis
Dahlman, I., Dicker, A., Jiao, H., Kere, J., Blomqvist, L., van Harmelen, V., Hoffstedt, J., Borch-Johnsen, K., Jorgensen, T., Hansen, Torben, Pedersen, Oluf Borbye, Laakso, M. & Arner, P., 2007, In: American Journal of Human Genetics. 80, 6, p. 1115-24 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A common polymorphism in the promoter of the IGF-I gene associates with increased fasting serum triglyceride levels in glucose-tolerant subjects
Nielsen, E. D., Hansen, L., Lajer, M., Andersen, K. L., Echwald, S. M., Urhammer, S. A., Hansen, Torben & Pedersen, Oluf Borbye, 2004, In: Clinical Biochemistry. 37, 8, p. 660-5 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A computational framework to integrate high-throughput "-omics" datasets for the identification of potential mechanistic links
Pedersen, H. K., Forslund, S. K., Gudmundsdottir, V., Petersen, A. Ø., Hildebrand, F., Hyötyläinen, T., Nielsen, T., Hansen, Torben, Bork, P., Ehrlich, S. D., Brunak, Søren, Oresic, M., Pedersen, Oluf Borbye & Nielsen, H. B., 2018, In: Nature Protocols. 13, 12, p. 2781-2800 20 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A cost analysis of intensified vs conventional multifactorial therapy in individuals with type 2 diabetes: a post hoc analysis of the Steno-2 study
Gæde, J., Oellgaard, J., Ibsen, R., Gæde, P., Nortoft, E., Parving, H., Kjellberg, J. & Pedersen, Oluf Borbye, 2019, In: Diabetologia. 62, 1, p. 147-155Research output: Contribution to journal › Journal article › Research › peer-review
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A diet-induced gut microbiota component and related plasma metabolites are associated with depressive-like behaviour in rats
Abildgaard, A., Kern, T., Pedersen, Oluf Borbye, Hansen, Torben, Lund, S. & Wegener, G., 2021, In: European Neuropsychopharmacology. 43, p. 10-21Research output: Contribution to journal › Journal article › Research › peer-review
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A functional amino acid substitution in the glucose-dependent insulinotropic polypeptide receptor (GIPR) gene is associated with lower bone mineral density and increased fracture risk
Torekov, Signe Sørensen, Harsløf, T., Rejnmark, L., Eiken, P., Jensen, Jens-Erik Beck, Herman, A. P., Hansen, Torben, Pedersen, Oluf Borbye, Holst, Jens Juul & Langdahl, B. L., Apr 2014, In: The Journal of clinical endocrinology and metabolism. 99, 4, p. E729-33 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A genome-wide association search for type 2 diabetes genes in African Americans
Palmer, N. D., McDonough, C. W., Hicks, P. J., Roh, B. H., Wing, M. R., An, S. S., Hester, J. M., Cooke, J. N., Bostrom, M. A., Rudock, M. E., Talbert, M. E., Lewis, J. P., Ferrara, A., Lu, L., Ziegler, J. T., Sale, M. M., Divers, J., Shriner, D., Adeyemo, A., Rotimi, C. N. & 31 others, , 2012, In: P L o S One. 7, 1, p. e29202Research output: Contribution to journal › Journal article › Research › peer-review
ID: 919113
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Natural selection affects multiple aspects of genetic variation at putatively peutral sites across the human genome
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Genetic architecture of vitamin B12 and folate levels uncovered applying deeply sequenced large datasets
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Family and population-based studies of variation within the ghrelin receptor locus in relation to measures of obesity
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