Oluf Borbye Pedersen
Visiting professor, Clinical Professor
Pedersen Group
Blegdamsvej 3B, Mærsk Tårnet, 8. sal
2200 København N.
Department of Clinical Medicine
Blegdamsvej 3
2200 København N.
Member of:
Internal medicine: infection medicine
Internal Medicine: Endocrinology
- 2008
- Published
High prevalence of type 2 diabetes and pre-diabetes in adult offspring of women with gestational diabetes mellitus or type 1 diabetes: the role of intrauterine hyperglycemia
Clausen, Tine Dalsgaard, Mathiesen, E. R., Hansen, T., Pedersen, Oluf Borbye, Jensen, D. M., Lauenborg, J., Damm, Peter, Clausen, T. D., Mathiesen, Elisabeth, Hansen, T., Pedersen, O., Jensen, D., Lauenborg, J. & Damm, Peter, 1 Feb 2008, In: Diabetes Care. 31, 2, p. 340-6 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A candidate type 2 diabetes polymorphism near the HHEX locus affects acute glucose-stimulated insulin release in European populations: results from the EUGENE2 study
Staiger, H., Stancáková, A., Zilinskaite, J., Vänttinen, M., Hansen, T., Marini, M. A., Hammarstedt, A., Jansson, P., Sesti, G., Smith, U., Pedersen, Oluf Borbye, Laakso, M., Stefan, N., Fritsche, A. & Häring, H., 2008, In: Diabetes. 57, 2, p. 514-7 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
AHSG tag single nucleotide polymorphisms associate with type 2 diabetes and dyslipidemia: studies of metabolic traits in 7,683 white Danish subjects
Andersen, G., Burgdorf, K. S., Sparsø, T., Borch-Johnsen, K., Jørgensen, T., Hansen, T. & Pedersen, Oluf Borbye, 2008, In: Diabetes. 57, 5, p. 1427-32 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Association of the beta3-adrenergic receptor Trp64Arg polymorphism with common metabolic traits: studies of 7605 middle-aged white people
Gjesing, A. P., Andersen, G., Borch-Johnsen, K., Jørgensen, T., Hansen, Torben & Pedersen, Oluf Borbye, 2008, In: Molecular Genetics and Metabolism. 94, 1, p. 90-7 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Association of variants in the sterol regulatory element-binding factor 1 (SREBF1) gene with type 2 diabetes, glycemia, and insulin resistance: A study of 15,734 Danish subjects
Grarup, Niels, Stender-Petersen, K. L., Andersson, E. A., Jorgensen, T., Borch-Johnsen, K., Sandbaek, A., Lauritzen, T., Schmitz, O., Hansen, Torben & Pedersen, Oluf Borbye, 2008, In: Diabetes.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Association of variants in the sterol regulatory element-binding factor 1 (SREBF1) gene with type 2 diabetes, glycemia, and insulin resistance: a study of 15,734 Danish subjects
Grarup, N., Stender-Petersen, K. L., Andersson, E. A., Jørgensen, T., Borch-Johnsen, K., Sandbæk, A., Lauritzen, T., Schmitz, O., Hansen, T. & Pedersen, Oluf Borbye, 2008, In: Diabetes. 57, 4, p. 1136-42 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Association testing of novel type 2 diabetes risk alleles in the JAZF1, CDC123/CAMK1D, TSPAN8, THADA, ADAMTS9, and NOTCH2 loci with insulin release, insulin sensitivity, and obesity in a population-based sample of 4,516 glucose-tolerant middle-aged Danes.
Grarup, Niels, Andersen, G., Krarup, N. T., Albrechtsen, Anders, Schmitz, O., Jørgensen, T., Borch-Johnsen, K., Hansen, Torben & Pedersen, Oluf Borbye, 2008, In: Diabetes. 57, 9, p. 2534-40 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Autosomal inheritance of diabetes in two families characterized by obesity and a novel H241Q mutation in NEUROD1
Gonsorcíková, L., Pruhová, S., Cinek, O., Ek, J., Pelikánová, T., Jørgensen, T., Eiberg, Hans Rudolf Lytchoff, Pedersen, Oluf Borbye, Hansen, T. & Lebl, J., 2008, In: Pediatric Diabetes. 9, 4 Pt 2, p. 367-72 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Common nonsynonymous variants in PCSK1 confer risk of obesity.
Benzinou, M., Creemers, J. W. M., Choquet, H., Lobbens, S., Dina, C., Durand, E., Guerardel, A., Boutin, P., Jouret, B., Heude, B., Balkau, B., Tichet, J., Marre, M., Potoczna, N., Horber, F., Le Stunff, C., Czernichow, S., Sandbæk, A., Lauritzen, T., Borch-Johnsen, K. & 12 others, , 2008, In: Nature Genetics. 40, 8, p. 943-5 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cost-effectiveness of intensified versus conventional multifactorial intervention in type 2 diabetes: results and projections from the Steno-2 study
Gaede, P., Valentine, W. J., Palmer, A. J., Tucker, D. M. D., Lammert, M., Parving, H. & Pedersen, Oluf Borbye, 2008, In: Diabetes Care. 31, 8, p. 1510-5 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effect of a multifactorial intervention on mortality in type 2 diabetes
Gaede, P., Lund-Andersen, H., Parving, H. & Pedersen, Oluf Borbye, 2008, In: New England Journal of Medicine. 358, 6, p. 580-91 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Endocannabinoid receptor 1 gene variations increase risk for obesity and modulate body mass index in European populations
Benzinou, M., Chèvre, J., Ward, K. J., Lecoeur, C., Dina, C., Lobbens, S., Durand, E., Delplanque, J., Horber, F. F., Heude, B., Balkau, B., Borch-Johnsen, K., Jørgensen, T., Hansen, T., Pedersen, Oluf Borbye, Meyre, D. & Froguel, P., 2008, In: Human Molecular Genetics. 17, 13, p. 1916-21 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
FTO gene associated fatness in relation to body fat distribution and metabolic traits throughout a broad range of fatness
Kring, S. I. I., Holst, C., Zimmermann, E., Jess, T., Berentzen, T., Toubro, S., Hansen, Torben, Astrup, A., Pedersen, Oluf Borbye & Sørensen, Thorkild I.A., 2008, In: PLoS ONE. 3, 8, p. e2958 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genetic analysis of Kruppel-like zinc finger 11 variants in 5864 Danish individuals: potential effect on insulin resistance and modified signal transducer and activator of transcription-3 binding by promoter variant -1659G>C
Gutiérrez-Aguilar, R., Froguel, P., Hamid, Y. H., Benmezroua, Y., Jørgensen, T., Borch-Johnsen, K., Hansen, T., Pedersen, Oluf Borbye & Neve, B., 2008, In: Journal of Clinical Endocrinology and Metabolism. 93, 8, p. 3128-35 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genetikken ved ikkeautoimmun diabetes. Dansk Endokrinologisk Selskab
Hansen, T., Pedersen, Oluf Borbye & Dansk Endokrinologisk Selskab, D. E. S., 2008, In: Ugeskrift for læger. 170, 12, p. 1021Research output: Contribution to journal › Review › Research
- Published
Genotype-phenotype associations in obesity dependent on definition of the obesity phenotype
Kring, S. I. I., Larsen, L. H., Holst, C., Toubro, S., Hansen, Torben, Astrup, A., Pedersen, Oluf Borbye & Sørensen, Thorkild I.A., 2008, In: Obesity Facts. 1, 3, p. 138-145 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Impact of TCF7L2 rs7903146 on insulin secretion and action in young and elderly Danish twins.
Wegner, L., Hussain, M. S., Pilgaard, K., Hansen, T., Pedersen, Oluf Borbye, Vaag, Allan & Poulsen, I. P., 2008, In: Journal of Clinical Endocrinology and Metabolism. 93, 10, p. 4013-9 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Impact of metformin versus repaglinide on non-glycaemic cardiovascular risk markers related to inflammation and endothelial dysfunction in non-obese patients with type 2 diabetes
Lund, S. S., Tarnow, L., Stehouwer, C. D. A., Schalkwijk, C. G., Teerlink, T., Gram, J., Winther, K., Frandsen, M., Smidt, U. M., Pedersen, Oluf Borbye, Parving, H. & Vaag, Allan, 2008, In: European Journal of Endocrinology. 158, 5, p. 631-41 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Impact of metformin versus the prandial insulin secretagogue, repaglinide, on fasting and postprandial glucose and lipid responses in non-obese patients with type 2 diabetes
Lund, S. S., Tarnow, L., Frandsen, M., Smidt, U. M., Pedersen, Oluf Borbye, Parving, H. & Vaag, Allan, 2008, In: European Journal of Endocrinology. 158, 1, p. 35-46 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Impact of polymorphisms in WFS1 on prediabetic phenotypes in a population-based sample of middle-aged people with normal and abnormal glucose regulation
Sparsø, T., Andersen, G., Albrechtsen, Anders, Jørgensen, T., Borch-Johnsen, K., Sandbaek, A., Lauritzen, T., Wasson, J., Permutt, M. A., Glaser, B., Madsbad, Sten, Pedersen, Oluf Borbye & Hansen, Torben, 2008, In: Diabetologia. 51, 9, p. 1646-52 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Impact on weight dynamics and general growth of the common FTO rs9939609: a longitudinal Danish cohort study
Jess, T., Zimmermann, E., Kring, S. I. I., Berentzen, T., Holst, C., Toubro, S., Astrup, A., Hansen, Torben, Pedersen, O., Sørensen, Thorkild I.A. & Pedersen, Oluf Borbye, 2008, In: International Journal of Obesity. 32, 9, p. 1388-94 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Impaired fasting glycaemia vs impaired glucose tolerance: similar impairment of pancreatic alpha and beta cell function but differential roles of incretin hormones and insulin action
Faerch, K., Vaag, Allan, Holst, Jens Juul, Glümer, C., Pedersen, Oluf Borbye & Borch-Johnsen, K., 2008, In: Diabetologia. 51, 5, p. 853-61 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Increased recovery rates of phosphocreatine (PCr) and inorganic phosphate (Pi) after isometric contraction in oxidative muscle fibres and elevated hepatic insulin resistance in carriers of the fat mass and obesity-associated FTO genotypes
Grunnet, Louise Groth, Brøns, C., Jacobsen, S., Nielsen, E., Astrup, A., Hansen, T., Pedersen, Oluf Borbye, Poulsen, P., Quistorff, B. & Vaag, A., 2008, In: Diabetes. 57, Suppl. 1, p. A329 1 p.Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Insulin sensitivity, insulin release and glucagon-like peptide-1 levels in persons with impaired fasting glucose and/or impaired glucose tolerance in the EUGENE2 study
Laakso, M., Zilinskaite, J., Hansen, Torben, Boesgaard, T. W., Vänttinen, M., Stancáková, A., Jansson, P., Pellmé, F., Kuulasmaa, T., Hribal, M. L., Sesti, G., Stefan, N., Fritsche, A., Häring, H., Pedersen, Oluf Borbye, Smith, U., EUGENE2 Consortium, E. C. & Holst, Jens Juul, 2008, In: Diabetologia. 51, 3, p. 502-11 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Lack of association between PKLR rs3020781 and NOS1AP rs7538490 and type 2 diabetes, overweight, obesity and related metabolic phenotypes in a Danish large-scale study: case-control studies and analyses of quantitative traits
Andreasen, C. H., Mogensen, M. S., Borch-Johnsen, K., Sandbæk, A., Lauritzen, T., Almind, K., Pedersen, Oluf Borbye, Hansen, L., Jørgensen, T. & Hansen, Torben, 2008, In: BMC Medical Genetics. 9, p. 118Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Lack of association of fatness-related FTO gene variants with energy expenditure or physical activity
Berentzen, T., Kring, S. I. I., Holst, C., Zimmermann, E., Jess, T., Hansen, T., Pedersen, Oluf Borbye, Toubro, S., Astrup, A. & Sørensen, Thorkild I.A., 2008, In: Journal of Clinical Endocrinology and Metabolism. 93, 7, p. 2904-2908 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation
Andreasen, C. H., Stender-Petersen, K. L., Mogensen, M. S., Torekov, Signe Sørensen, Wegner, L., Andersen, G., Nielsen, A. L., Albrechtsen, Anders, Borch-Johnsen, K., Rasmussen, S. S., Clausen, J. O., Sandbaek, A., Lauritzen, T., Hansen, L., Jørgensen, T., Pedersen, Oluf Borbye & Hansen, T., 2008, In: Diabetes. 57, 1, p. 95-101 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Many sequence variants affecting diversity of adult human height
Gudbjartsson, D. F., Walters, G. B., Thorleifsson, G., Stefansson, H., Halldorsson, B. V., Zusmanovich, P., Sulem, P., Thorlacius, S., Gylfason, A., Steinberg, S., Helgadottir, A., Ingason, A., Steinthorsdottir, V., Olafsdottir, E. J., Olafsdottir, G. H., Jonsson, T., Borch-Johnsen, K., Hansen, T., Andersen, G., Jørgensen, T. & 17 others, , 2008, In: Nature Genetics. 40, 5, p. 609-15 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
Zeggini, E., Scott, L. J., Saxena, R., Voight, B. F., Marchini, J. L., Hu, T., de Bakker, P. I. W., Abecasis, G. R., Almgren, P., Andersen, G., Ardlie, K., Boström, K. B., Bergman, R. N., Bonnycastle, L. L., Borch-Johnsen, K., Burtt, N. P., Chen, H., Chines, P. S., Daly, M. J., Deodhar, P. & 31 others, , 2008, In: Nature Genetics. 40, 5, p. 638-45 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Multifactorial intervention and mortallity in type 2 diabetes- Reply
Gaede, P., Parving, H. & Pedersen, Oluf Borbye, 2008, In: New England Journal of Medicine. p. 358: 2292-2293Research output: Contribution to journal › Comment/debate › Research
- Published
Non-replication of genome-wide based associations between common variants in INSIG2 and PFKP and obesity in studies of 18,014 Danes
Sandholt, C. H., Mogensen, M. S., Borch-Johnsen, K., Sandbaek, A., Lauritzen, T., Sørensen, Thorkild I.A., Hansen, L., Almind, K., Jørgensen, T., Pedersen, Oluf Borbye & Hansen, Torben, 2008, In: PLoS ONE. 3, 8, p. e2872 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Polymorphisms in AHI1 are not associated with type 2 diabetes or related phenotypes in Danes: non-replication of a genome-wide association result
Holmkvist, J., Anthonsen, S., Wegner, L., Andersen, G., Jørgensen, T., Borch-Johnsen, K., Sandbaek, A., Lauritzen, T., Pedersen, Oluf Borbye & Hansen, Torben, 2008, In: Diabetologia. 51, 4, p. 609-14 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations.
Unoki, H., Takahashi, A., Kawaguchi, T., Hara, K., Horikoshi, M., Andersen, G., Ng, D. P. K., Holmkvist, J., Borch-Johnsen, K., Jørgensen, T., Sandbæk, A., Lauritzen, T., Hansen, T., Nurbaya, S., Tsunoda, T., Kubo, M., Babazono, T., Hirose, H., Hayashi, M., Iwamoto, Y. & 10 others, , 2008, In: Nature Genetics. 40, 9, p. 1098-1102 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Seven mutations in the human insulin gene linked to permanent neonatal/infancy-onset diabetes mellitus
Colombo, C., Porzio, O., Liu, M., Massa, O., Vasta, M., Salardi, S., Beccaria, L., Monciotti, C., Toni, S., Pedersen, Oluf Borbye, Hansen, T., Federici, L., Pesavento, R., Cadario, F., Federici, G., Ghirri, P., Arvan, P., Iafusco, D., Barbetti, F. & Early Onset Diabetes Study Group of the Italian Society of Pediatric Endocrinology and Diabetes (SIEDP), E. O. D. S. G. O. T. I. S. O. P. E. A. D. (., 2008, In: Journal of Clinical Investigation. 118, 6, p. 2148-56 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose tolerance
Stancáková, A., Pihlajamäki, J., Kuusisto, J., Stefan, N., Fritsche, A., Häring, H., Andreozzi, F., Succurro, E., Sesti, G., Boesgaard, T. W., Hansen, T., Pedersen, Oluf Borbye, Jansson, P. A., Hammarstedt, A., Smith, U., Laakso, M. & EUGENE2 Consortium, E. C., 2008, In: Journal of Clinical Endocrinology and Metabolism. 93, 5, p. 1924-30 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The -250G>A promoter variant in hepatic lipase associates with elevated fasting serum high-density lipoprotein cholesterol modulated by interaction with physical activity in a study of 16,156 Danish subjects
Grarup, N., Andreasen, C. H., Lepola, Mette Andersen, Albrechtsen, Anders, Sandbaek, A., Lauritzen, T., Borch-Johnsen, K., Jørgensen, T., Schmitz, O., Hansen, T. & Pedersen, Oluf Borbye, 2008, In: Journal of Clinical Endocrinology and Metabolism. 93, 6, p. 2294-9 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Gly482Ser genotype at the PPARGC1A gene and elevated blood pressure: a meta-analysis involving 13,949 individuals
Vimaleswaran, K. S., Luan, J., Andersen, G., Muller, Y. L., Wheeler, E., Brito, E. C., O'Rahilly, S., Pedersen, Oluf Borbye, Baier, L. J., Knowler, W. C., Barroso, I., Wareham, N. J., Loos, R. J. F. & Franks, P. W., 2008, In: Journal of Applied Physiology. 105, 4, p. 1352-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The KCNMB1 Glu65Lys polymorphism associates with reduced systolic and diastolic blood pressure in the Inter99 study of 5729 Danes.
Nielsen, T., Burgdorf, K. S., Grarup, Niels, Borch-Johnsen, K., Hansen, T., Jørgensen, T., Pedersen, Oluf Borbye & Andersen, G., 2008, In: Journal of Hypertension. 26, 11, p. 2142-6 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The PPAR gamma 2 Pro12Ala variant predicts ESRD and mortality in patients with type 1 diabetes and diabetic nephropathy
Jorsal, A., Tarnow, L., Lajer, M., Ek, J., Hansen, Torben, Pedersen, Oluf Borbye & Parving, H., 2008, In: Molecular Genetics and Metabolism. 94, 3, p. 347-51 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The common SLC30A8 Arg325Trp variant is associated with reduced first-phase insulin release in 846 non-diabetic offspring of type 2 diabetes patients--the EUGENE2 study
Boesgaard, T. W., Zilinskaite, J., Vänttinen, M., Laakso, M., Jansson, P., Hammarstedt, A., Smith, U., Stefan, N., Fritsche, A., Häring, H., Hribal, M., Sesti, G., Zobel, D. P., Pedersen, Oluf Borbye, Hansen, Torben & EUGENE 2 Consortium, E. 2. C., 2008, In: Diabetologia. 51, 5, p. 816-20 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm
Helgadottir, A., Thorleifsson, G., Magnusson, K. P., Grétarsdottir, S., Steinthorsdottir, V., Manolescu, A., Jones, G. T., Rinkel, G. J. E., Blankensteijn, J. D., Ronkainen, A., Jääskeläinen, J. E., Kyo, Y., Lenk, G. M., Sakalihasan, N., Kostulas, K., Gottsäter, A., Flex, A., Stefansson, H., Hansen, T., Andersen, G. & 48 others, , 2008, In: Nature Genetics. 40, 2, p. 217-24 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Variance of the SGK1 gene is associated with insulin secretion in different European populations: results from the TUEF, EUGENE2, and METSIM studies.
Friedrich, B., Weyrich, P., Stancáková, A., Wang, J., Kuusisto, J., Laakso, M., Sesti, G., Succurro, E., Smith, U., Hansen, Torben, Pedersen, Oluf Borbye, Machicao, F., Schäfer, S., Lang, F., Risler, T., Ullrich, S., Stefan, N., Fritsche, A. & Häring, H., 2008, In: PLoS ONE. 3, 11, p. e3506Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels
Chen, W-M., Erdos, M. R., Jackson, A. U., Saxena, R., Sanna, S., Silver, K. D., Timpson, N. J., Hansen, T., Orrù, M., Grazia Piras, M., Bonnycastle, L. L., Willer, C. J., Lyssenko, V., Shen, H., Kuusisto, J., Ebrahim, S., Sestu, N., Duren, W. L., Spada, M. C., Stringham, H. M. & 31 others, , 2008, In: Journal of Clinical Investigation. 118, 7, p. 2620-8 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 919113
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Natural selection affects multiple aspects of genetic variation at putatively peutral sites across the human genome
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Family and population-based studies of variation within the ghrelin receptor locus in relation to measures of obesity
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