Oluf Borbye Pedersen

Author's reply to Kahn's comment

Møller, G., Ritz, C., Kjølbæk, Louise, Vuholm, S., Korndal, S. K., Larsen, T. M., Pedersen, Oluf Borbye, Saris, W. H., Astrup, A., Lauritzen, Lotte, Kristensen, M. B. & Lind, M. V., 2021, In: Nutrition, Metabolism & Cardiovascular Diseases. 31, 6, p. 1940-1941 2 p.

Research output: Contribution to journal › Comment/debate › Research

Conjugated C-6 hydroxylated bile acids in serum relate to human metabolic health and gut Clostridia species

Petersen, A. Ø., Julienne, H., Hyötyläinen, T., Sen, P., Fan, Yong, Pedersen, H. K., Jäntti, S., Hansen, T. H., Nielsen, T., Jørgensen, T., Hansen, Torben, Myers, P. N., Nielsen, H. B., Ehrlich, S. D., Orešič, M. & Pedersen, Oluf Borbye, 2021, In: Scientific Reports. 11, 1, 11 p., 13252.

Research output: Contribution to journal › Journal article › Research › peer-review

Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes

Goodrich, J. K., Singer-Berk, M., Son, R., Sveden, A., Wood, J., England, E., Cole, J. B., Weisburd, B., Watts, N., Caulkins, L., Dornbos, P., Koesterer, R., Zappala, Z., Zhang, H., Maloney, K. A., Dahl, A., Aguilar-Salinas, C. A., Atzmon, G., Barajas-Olmos, F., Barzilai, N. & 31 others, Blangero, J., Boerwinkle, E., Bonnycastle, L. L., Bottinger, E., Bowden, D. W., Centeno-Cruz, F., Chambers, J. C., Chami, N., Chan, E., Chan, J., Cheng, C. Y., Cho, Y. S., Contreras-Cubas, C., Córdova, E., Correa, A., DeFronzo, R. A., Duggirala, R., Dupuis, J., Garay-Sevilla, M. E., García-Ortiz, H., Gieger, C., Glaser, B., González-Villalpando, C., Gonzalez, M. E., Grarup, Niels, Groop, L., Gross, M., Hansen, Torben, Linneberg, Allan René, Pedersen, Oluf Borbye & AMP-T2D-GENES Consortia, A. C., 2021, In: Nature Communications. 12, 15 p., 3505.

Research output: Contribution to journal › Journal article › Research › peer-review

FGL1 as a modulator of plasma D-dimer levels: exome-wide marker analysis of plasma tPA, PAI-1 and D-dimer

Thibord, F., Song, C., Pattee, J., Rodriguez, B. A. T., Chen, M-H., O'Donnell, C. J., Kleber, M. E., Delgado, G. E., Guo, X., Yao, J., Taylor, K. D., Ozel, A. B., Brody, J. A., McKnight, B., Gyorgy, B., Simonsick, E., Leonard, H. L., Carrasquilla, G. D., Guindo-Martinez, M., Silveira, A. & 30 others, Temprano-Sagrera, G., Yanek, L. R., Becker, D. M., Mathias, R. A., Becker, L. C., Raffield, L. M., Kilpeläinen, Tuomas O., Grarup, Niels, Pedersen, Oluf Borbye, Hansen, Torben, Linneberg, Allan René, Hamsten, A., Watkins, H., Sabater-Lleal, M., Nalls, M. A., Trégouët, D., Morange, P., Psaty, B. M., Tracy, R. P., Smith, N. L., Desch, K. C., Cushman, M., Rotter, J. I., de Vries, P. S., Pankratz, N. D., Folsom, A. R., Morrison, A. C., März, W., Tang, W. & Johnson, A. D., 2021, In: Journal of Thrombosis and Haemostasis. 19, 8, p. 2019-2028

Research output: Contribution to journal › Journal article › Research › peer-review

Fasting plasma GLP-1 associates with overweight/obesity and cardiometabolic risk factors in children and adolescents

Stinson, Sara, Jonsson, Anna Elisabet, Lund, M. A. V., Frithioff-Bøjsøe, C., Holm, L. A., Pedersen, Oluf Borbye, Ängquist, Lars, Sørensen, Thorkild I.A., Holst, Jens Juul, Christiansen, M., Holm, Jens-Christian, Hartmann, Bolette & Hansen, Torben, 2021, In: Journal of Clinical Endocrinology and Metabolism. 106, 6, p. 1718-1727

Research output: Contribution to journal › Journal article › Research › peer-review

Genetic markers of abdominal obesity and weight loss after gastric bypass surgery

Aasbrenn, M., Svendstrup, M., Schnurr, T. M., Hansen, D. L., Worm, Dorte, Balslev-Harder, M., Grarup, Niels, Burgdorf, Kristoffer Sølvsten, drb459, drb459, Pedersen, Oluf Borbye, Ängquist, Lars, Fenger, M., Sørensen, Thorkild I.A., Madsbad, Sten & Hansen, Torben, 2021, In: PLoS ONE. 16, 5, 11 p., 0252525.

Research output: Contribution to journal › Journal article › Research › peer-review

Genome-Wide Association Analysis of Pancreatic Beta-Cell Glucose Sensitivity

Deshmukh, H. A., Madsen, A. L., Viñuela, A., Have, C. T., Grarup, N., Tura, A., Mahajan, A., Heggie, A. J., Koivula, R. W., De Masi, F., Tsirigos, K. K., Linneberg, A., Drivsholm, T., Pedersen, O., Sørensen, T. I. A., Astrup, A., Gjesing, A. A. P., Pavo, I., Wood, A. R., Ruetten, H. & 14 others, Jones, A. G., Koopman, A. D. M., Cederberg, H., Rutters, F., Ridderstrale, M., Laakso, M., McCarthy, M. I., Frayling, T. M., Ferrannini, E., Franks, P. W., Pearson, E. R., Mari, A., Hansen, T. & Walker, M., 2021, In: Journal of Clinical Endocrinology and Metabolism. 106, 1, p. 80-90 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Genome-wide association study of circulating levels of glucagon during an oral glucose tolerance test

Jonsson, Anna Elisabet, Stinson, Sara, Torekov, Signe Sørensen, Clausen, Tine Dalsgaard, Færch, K., Kelstrup, Louise, Grarup, Niels, Mathiesen, Elisabeth, Damm, Peter, Witte, D. R., Jørgensen, M. E., Pedersen, Oluf Borbye, Holst, Jens Juul & Hansen, Torben, 2021, In: BMC Medical Genomics. 14, 7 p., 3.

Research output: Contribution to journal › Journal article › Research › peer-review

Gut microbiota in human metabolic health and disease

Fan, Yong & Pedersen, Oluf Borbye, 2021, In: Nature Reviews. Microbiology. 19, p. 55-71 17 p.

Research output: Contribution to journal › Review › Research › peer-review

Human and preclinical studies of the host-gut microbiome co-metabolite hippurate as a marker and mediator of metabolic health

Brial, F., Chilloux, J., Nielsen, T., Vieira-Silva, S., Falony, G., Andrikopoulos, P., Olanipekun, M., Hoyles, L., Djouadi, F., Neves, A. L., Rodriguez-Martinez, A., Mouawad, G. I., Pons, N., Forslund, S., Le-chatelier, E., Le Lay, A., Nicholson, J., Hansen, T., Hyotylainen, T., Clement, K. & 7 others, Oresic, M., Bork, P., Ehrlich, S. D., Raes, J., Pedersen, Oluf Borbye, Gauguier, D. & Dumas, M., 2021, In: Gut. 70, 11, p. 2105-2114 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Large-scale association analyses identify host factors influencing human gut microbiome composition

Kurilshikov, A., Medina-Gomez, C., Bacigalupe, R., Radjabzadeh, D., Wang, J., Demirkan, A., Le Roy, C. I., Raygoza Garay, J. A., Finnicum, C. T., Liu, X., Zhernakova, D. V., Bonder, M. J., Hansen, T. H., Frost, F., Rühlemann, M. C., Turpin, W., Moon, J. Y., Kim, H. N., Lüll, K., Barkan, E. & 84 others, Shah, S. A., Fornage, M., Szopinska-Tokov, J., Wallen, Z. D., Borisevich, D., Agreus, L., Andreasson, A., Bang, C., Bedrani, L., Bell, J. T., Bisgaard, H., Boehnke, M., Boomsma, D. I., Burk, R. D., Claringbould, A., Croitoru, K., Davies, G. E., van Duijn, C. M., Duijts, L., Falony, G., Fu, J., van der Graaf, A., Hansen, Torben, Homuth, G., Hughes, D. A., Ijzerman, R. G., Jackson, M. A., Jaddoe, V. W. V., Joossens, M., Jørgensen, T., Keszthelyi, D., Knight, R., Laakso, M., Laudes, M., Launer, L. J., Lieb, W., Lusis, A. J., Masclee, A. A. M., Moll, H. A., Mujagic, Z., Qibin, Q., Rothschild, D., Shin, H., Sørensen, Søren Johannes, Steves, C. J., Thorsen, Jonathan Jan Ilve, Timpson, N. J., Tito, R. Y., Vieira-Silva, S., Völker, U., Völzke, H., Võsa, U., Wade, K. H., Walter, S., Watanabe, K., Weiss, S., Weiss, F. U., Weissbrod, O., Westra, H. J., Willemsen, G., Payami, H., Jonkers, D. M. A. E., Arias Vasquez, A., de Geus, E. J. C., Meyer, K. A., Stokholm, Jakob, Segal, E., Org, E., Wijmenga, C., Kim, H. L., Kaplan, R. C., Spector, T. D., Uitterlinden, A. G., Rivadeneira, F., Franke, A., Lerch, M. M., Franke, L., Sanna, S., D’Amato, M., Pedersen, Oluf Borbye, Paterson, A. D., Kraaij, R., Raes, J. & Zhernakova, A., 2021, In: Nature Genetics. 53, p. 156-165 19 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis

Sveidahl Johansen, O., Ma, T., Hansen, J. B., Markussen, L. K., Schreiber, R., Reverte-Salisa, L., Dong, H., Christensen, D. P., Sun, W., Gnad, T., Karavaeva, I., Nielsen, T. S., Kooijman, S., Cero, C., Dmytriyeva, O., Shen, Y., Razzoli, M., O'Brien, S. L., Kuipers, E. N., Nielsen, C. H. & 31 others, Orchard, W., Willemsen, N., Jespersen, N. Z., Lundh, M., Sustarsic, E. G., Hallgren, C. M., Frost, M., McGonigle, S., Isidor, Marie Sophie, Broholm, C., Pedersen, Oluf Borbye, Hansen, Jacob B., Grarup, Niels, Hansen, Torben, Kjær, Andreas, Granneman, J. G., Babu, M. M., Calebiro, D., Nielsen, S., Rydén, M., Soccio, R., Rensen, P. C. N., Treebak, Jonas Thue, Schwartz, Thue W., Emanuelli, Brice, Bartolomucci, A., Pfeifer, A., Zechner, R., Schéele, Camilla Charlotte Nielsen, Mandrup, S. & Gerhart-Hines, Z., 2021, In: Cell. 184, 13, p. 3502-3518 + 50 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Non-linear interaction between physical activity and polygenic risk score of body mass index in Danish and Russian populations

Borisevich, D., Schnurr, T. M., pjx571, pjx571, Rakitko, A., Ängquist, Lars, Ilinsky, V., Aadahl, Mette, Grarup, Niels, Pedersen, Oluf Borbye, Sørensen, Thorkild I.A. & Hansen, Torben, 2021, In: PLoS ONE. 16, 10, 16 p., e0258748.

Research output: Contribution to journal › Journal article › Research › peer-review

Obesity treatment effect in Danish children and adolescents carrying Melanocortin-4 Receptor mutations

Trier, C., Hollensted, M., Schnurr, T. M., Lund, Morten Asp Vonsild, Nielsen, T. R. H., Rui, G., Andersson, E. A., Svendstrup, M., Bille, D. S., Gjesing, A. P., Fonvig, Cilius Esmann, Frithioff-Bojsoe, C., Balslev-Harder, M., Quan, S., Gamborg, Michael Orland, Pedersen, Oluf Borbye, Ängquist, Lars, Holm, Jens-Christian & Hansen, Torben, 2021, In: International Journal of Obesity. 45, p. 66-76 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Ocular Surface Microbiota in Contact Lens Users and Contact-Lens-Associated Bacterial Keratitis

Andersson, J., Vogt, J. K., Dalgaard, M. D., Pedersen, Oluf Borbye, Holmgaard, Kim & Heegaard, Steffen, 2021, In: Vision (Switzerland). 5, 2, 12 p., 27.

Research output: Contribution to journal › Journal article › Research › peer-review

Ocular surface microbiota in patients with aqueous tear-deficient dry eye

Andersson, J., Vogt, J. K., Dalgaard, M. D., Pedersen, Oluf Borbye, Holmgaard, Kim & Heegaard, Steffen, 2021, In: Ocular Surface. 19, p. 210-217

Research output: Contribution to journal › Journal article › Research › peer-review

Physical activity attenuates postprandial hyperglycaemia in homozygous TBC1D4 loss-of-function mutation carriers

Schnurr, T. M., Jørsboe, E., Chadt, A., Dahl-Petersen, I. K., Kristensen, Jonas Møller, Wojtaszewski, Jørgen F P, Springer, C., Bjerregaard, P., Brage, S., Pedersen, Oluf Borbye, Moltke, Ida, Grarup, Niels, Al-Hasani, H., Albrechtsen, Anders, Jørgensen, M. E. & Hansen, Torben, 2021, In: Diabetologia. 64, p. 1795-1804

Research output: Contribution to journal › Journal article › Research › peer-review

Plasma trimethylamine N-oxide and its metabolic precursors and risk of mortality, cardiovascular and renal disease in individuals with type 2-diabetes and albuminuria

Winther, S. A., Øllgaard, J. C., Hansen, T. W., Von Scholten, B. J., Reinhard, H., Ahluwalia, Tarun Veer Singh, Wang, Z., Gæde, P., Parving, H. H., Hazen, S., Pedersen, Oluf Borbye & Rossing, Peter, 2021, In: PLoS ONE. 16, 3, 14 p., e0244402.

Research output: Contribution to journal › Journal article › Research › peer-review

Processes Underlying Glycemic Deterioration in Type 2 Diabetes: An IMI DIRECT Study

Bizzotto, R., Jennison, C., Jones, A. G., Kurbasic, A., Tura, A., Kennedy, G., Bell, J. D., Thomas, E. L., Frost, G., Eriksen, R., Koivula, R. W., Brage, S., Kaye, J., Hattersley, A. T., Heggie, A., McEvoy, D., 't Hart, L. M., Beulens, J. W., Elders, P., Musholt, P. B. & 28 others, Ridderstrale, M., Hansen, T. H., Allin, K. H., Hansen, Torben, drb459, drb459, Lundgaard, Agnete Troen, Thomsen, Henrik S., De Masi, F., Tsirigos, Konstantinos, Brunak, Søren, Vinuela, A., Mahajan, A., McDonald, T. J., Kokkola, T., Forgie, I. M., Giordano, G. N., Pavo, I., Ruetten, H., Dermitzakis, E., McCarthy, M. I., Pedersen, Oluf Borbye, Schwenk, J. M., Adamski, J., Franks, P. W., Walker, M., Pearson, E. R., Mari, A. & IMI-DIRECT consortium, I. C., 2021, In: Diabetes Care. 44, 2, p. 511-518 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Profiles of glucose metabolism in different prediabetes phenotypes, classified by fasting glycemia, 2-hour OGTT, glycated hemoglobin, and 1-hour OGTT: An IMI DIRECT study

Tura, A., Grespan, E., Göbl, C. S., Koivula, R. W., Franks, P. W., Pearson, E. R., Walker, M., Forgie, I. M., Giordano, G. N., Pavo, I., Ruetten, H., Dermitzakis, E. T., McCarthy, M. I., Pedersen, O., Schwenk, J. M., Adamski, J., De Masi, F., Tsirigos, K. D., Brunak, S., Viñuela, A. & 17 others, Mahajan, A., McDonald, T. J., Kokkola, T., Vangipurapu, J., Cederberg, H., Laakso, M., Rutters, F., Elders, P. J. M., Koopman, A. D. M., Beulens, J. W., Ridderstråle, M., Hansen, T. H., Allin, K. H., Hansen, Torben, drb459, drb459, Mari, A. & IMI-DIRECT consortium, I. C., 2021, In: Diabetes. 70, 6, db210227.

Research output: Contribution to journal › Journal article › Research › peer-review

Protein intake, metabolic status and the gut microbiota in different ethnicities: Results from two independent cohorts

Bel Lassen, P., Attaye, I., Adriouch, S., Nicolaou, M., Aron-Wisnewsky, J., Nielsen, T., Chakaroun, R., Le Chatelier, E., Forslund, S., Belda, E., Bork, P., Bäckhed, F., Stumvoll, M., Pedersen, O., Herrema, H., Groen, A. K., Pinto-Sietsma, S. J., Zwinderman, A. H., Nieuwdorp, M., Clement, K. & 1 others, MetaCardis Consortium, M. C., 2021, In: Nutrients. 13, 9, 3159.

Research output: Contribution to journal › Journal article › Research › peer-review

Sagittal abdominal diameter and waist circumference appear to be equally good as identifiers of cardiometabolic risk

Møller, G., Ritz, C., Kjølbæk, Louise, Vuholm, S., Korndal, S. K., Larsen, T. M., Pedersen, Oluf Borbye, Saris, W. H., Astrup, A., Lauritzen, Lotte, Kristensen, M. B. & Lind, M. V., 2021, In: Nutrition, Metabolism & Cardiovascular Diseases. 31, 2, p. 518-527 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Superficial fungal infections and patients with hidradenitis suppurativa: a study under the Danish Blood Donor Study

Lindso Andersen, P., Andersen, Rune Kjærsgaard, Jemec, Gregor, Ullum, H., Erikstrup, C., Nielsen, K. R., Bruun, M. T., Hjalgrim, Henrik, Sørensen, E., Burgdorf, K. S., Dinh, K. M., Banasik, Karina, Hansen, T., Saunte, Ditte Marie & Pedersen, Oluf Borbye, 2021, In: Clinical and Experimental Dermatology. 46, 3, p. 571-573 3 p.

Research output: Contribution to journal › Letter › Research › peer-review

The power of genetic diversity in genome-wide association studies of lipids

Graham, S. E., Clarke, S. L., Wu, K-H. H., Kanoni, S., Zajac, G. J. M., Ramdas, S., Surakka, I., Ntalla, I., Vedantam, S., Winkler, T. W., Locke, A. E., Marouli, E., Hwang, M. Y., Han, S., Narita, A., Choudhury, A., Bentley, A. R., Ekoru, K., Verma, A., Trivedi, B. & 504 others, Martin, H. C., Hunt, K. A., Hui, Q., Klarin, D., Zhu, X., Thorleifsson, G., Helgadottir, A., Gudbjartsson, D. F., Holm, H., Olafsson, I., Akiyama, M., Sakaue, S., Terao, C., Kanai, M., Zhou, W., Brumpton, B. M., Rasheed, H., Ruotsalainen, S. E., Havulinna, A. S., Veturi, Y., Feng, Q., Rosenthal, E. A., Lingren, T., Pacheco, J. A., Pendergrass, S. A., Haessler, J., Giulianini, F., Bradford, Y., Miller, J. E., Campbell, A., Lin, K., Millwood, I. Y., Hindy, G., Rasheed, A., Faul, J. D., Zhao, W., Weir, D. R., Turman, C., Huang, H., Graff, M., Mahajan, A., Brown, M. R., Zhang, W., Yu, K., Schmidt, E. M., Pandit, A., Gustafsson, S., Yin, X., Luan, J., Zhao, J., Matsuda, F., Jang, H., Yoon, K., Medina-Gomez, C., Pitsillides, A., Hottenga, J. J., Willemsen, G., Wood, A. R., Ji, Y., Gao, Z., Haworth, S., Mitchell, R. E., Chai, J. F., Aadahl, Mette, Yao, J., Manichaikul, A., Warren, H. R., Ramirez, J., Bork-Jensen, J., Karhus, L. L., Goel, A., Sabater-Lleal, M., Noordam, R., Sidore, C., Fiorillo, E., McDaid, A. F., Marques-Vidal, P., Wielscher, M., Trompet, S., Sattar, N., Møllehave, Line Tang, Thuesen, B. H., Munz, M., Zeng, L., Huang, J., Yang, B., Poveda, A., Kurbasic, A., Lamina, C., Forer, L., Scholz, M., Galesloot, T. E., Bradfield, J. P., Daw, E. W., Zmuda, J. M., Mitchell, J. S., Fuchsberger, C., Christensen, H., Brody, J. A., Feitosa, M. F., Wojczynski, M. K., Preuss, M., Mangino, M., Christofidou, P., Verweij, N., Benjamins, J. W., Engmann, J., Kember, R. L., Slieker, R. C., Lo, K. S., Zilhao, N. R., Phuong Le, Kleber, M. E., Delgado, G. E., Huo, S., Ikeda, D. D., Iha, H., Yang, J., Liu, J., Leonard, H. L., Marten, J., Schmidt, B., Arendt, M., Smyth, L. J., Canadas-Garre, M., Wang, C., Nakatochi, M., Wong, A., Hutri-Kahonen, N., Sim, X., Xia, R., Huerta-Chagoya, A., Fernandez-Lopez, J. C., Lyssenko, V., Ahmed, M., Jackson, A. U., Irvin, M. R., Oldmeadow, C., Kim, H., Ryu, S., Timmers, P. R. H. J., Arbeeva, L., Dorajoo, R., Lange, L. A., Chai, X., Prasad, G., Lores-Motta, L., Pauper, M., Long, J., Li, X., Theusch, E., Takeuchi, F., Spracklen, C. N., Loukola, A., Bollepalli, S., Warner, S. C., Wang, Y. X., Wei, W. B., Nutile, T., Ruggiero, D., Sung, Y. J., Hung, Y., Chen, S., Liu, F., Yang, J., Kentistou, K. A., Gorski, M., Brumat, M., Meidtner, K., Bielak, L. F., Smith, J. A., Hebbar, P., Farmaki, A., Hofer, E., Lin, M., Xue, C., Zhang, J., Concas, M. P., Vaccargiu, S., van der Most, P. J., Pitkanen, N., Cade, B. E., Lee, J., van Der Laan, S. W., Chitrala, K. N., Weiss, S., Zimmermann, M. E., Lee, J. Y., Choi, H. S., Nethander, M., Freitag-Wolf, S., Southam, L., Rayner, N. W., Wang, C. A., Lin, S., Wang, J., Couture, C., Lyytikainen, L., Nikus, K., Cuellar-Partida, G., Vestergaard, H., Hildalgo, B., Giannakopoulou, O., Cai, Q., Obura, M. O., van Setten, J., Li, X., Schwander, K., Terzikhan, N., Shin, J. H., Jackson, R. D., Reiner, A. P., Martin, L. W., Chen, Z., Li, L., Highland, H. M., Young, K. L., Kawaguchi, T., Thiery, J., Bis, J. C., Nadkarni, G. N., Launer, L. J., Li, H., Nalls, M. A., Raitakari, O. T., Ichihara, S., Wild, S. H., Nelson, C. P., Campbell, H., Jager, S., Nabika, T., Al-Mulla, F., Niinikoski, H., Braund, P. S., Kolcic, I., Kovacs, P., Giardoglou, T., Katsuya, T., Bhatti, F., de Kleijn, D., de Borst, G. J., Kim, E. K., Adams, H. H. H., Ikram, M. A., Zhu, X., Asselbergs, F. W., Kraaijeveld, A. O., Beulens, J. W. J., Shu, X., Rallidis, L. S., Pedersen, Oluf Borbye, Hansen, Torben, Mitchell, P., Hewitt, A. W., Kahonen, M., Perusse, L., Bouchard, C., Tonjes, A., Chen, Y. I., Pennell, C. E., Mori, T. A., Lieb, W., Franke, A., Ohlsson, C., Mellstrom, D., Cho, Y. S., Lee, H., Yuan, J., Koh, W., Rhee, S. Y., Woo, J., Heid, I. M., Stark, K. J., Volzke, H., Homuth, G., Evans, M. K., Zonderman, A. B., Polasek, O., Pasterkamp, G., Hoefer, I. E., Redline, S., Pahkala, K., Oldehinkel, A. J., Snieder, H., Biino, G., Schmidt, R., Schmidt, H., Chen, Y. E., Bandinelli, S., Dedoussis, G., Thanaraj, T. A., Kardia, S. L. R., Kato, N., Schulze, M. B., Girotto, G., Jung, B., Boger, C. A., Joshi, P. K., Bennett, D. A., De Jager, P. L., Lu, X., Mamakou, V., Brown, M., Caulfield, M. J., Munroe, P. B., Guo, X., Ciullo, M., Jonas, J. B., Samani, N. J., Kaprio, J., Pajukanta, P., Adair, L. S., Bechayda, S. A., de Silva, H. J., Wickremasinghe, A. R., Krauss, R. M., Wu, J., Zheng, W., den Hollander, A. I., Bharadwaj, D., Correa, A., Wilson, J. G., Lind, L., Heng, C., Nelson, A. E., Golightly, Y. M., Wilson, J. F., Penninx, B., Kim, H., Attia, J., Scott, R. J., Rao, D. C., Arnett, D. K., Walker, M., Koistinen, H. A., Chandak, G. R., Yajnik, C. S., Mercader, J. M., Tusie-Luna, T., Aguilar-Salinas, C. A., Villalpando, C. G., Orozco, L., Fornage, M., Tai, E. S., van Dam, R. M., Lehtimaki, T., Chaturvedi, N., Yokota, M., Liu, J., Reilly, D. F., McKnight, A. J., Kee, F., Jockel, K., McCarthy, M. I., Palmer, C. N. A., Vitart, V., Hayward, C., Simonsick, E., van Duijn, C. M., Lu, F., Qu, J., Hishigaki, H., Lin, X., Marz, W., Parra, E. J., Cruz, M., Gudnason, V., Tardif, J., Lettre, G., 't Hart, L. M., Elders, P. J. M., Damrauer, S. M., Kumari, M., Kivimaki, M., van der Harst, P., Spector, T. D., Loos, R. J. F., Province, M. A., Psaty, B. M., Brandslund, I., Pramstaller, P. P., Christensen, K., Ripatti, S., Widen, E., Hakonarson, H., Grant, S. F. A., Kiemeney, L. A. L. M., de Graaf, J., Loeffler, M., Kronenberg, F., Gu, D., Erdmann, J., Schunkert, H., Franks, P. W., Linneberg, Allan René, Jukema, J. W., Khera, A. 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Research output: Contribution to journal › Journal article › Research › peer-review

The trans-ancestral genomic architecture of glycemic traits

Chen, J., Spracklen, C. N., Marenne, G., Varshney, A., Corbin, L. J., Luan, J., Willems, S. M., Wu, Y., Zhang, X., Horikoshi, M., Boutin, T. S., Magi, R., Waage, J., Li-Gao, R., Chan, K. H. K., Yao, J., Anasanti, M. D., Chu, A. Y., Claringbould, A., Heikkinen, J. & 31 others, Hong, J., Hottenga, J., Huo, S., Kaakinen, M. A., Louie, T., Maerz, W., Moreno-Macias, H., Ndungu, A., Nelson, S. C., Nolte, I. M., North, K. E., Appel, E. V. R., Liu, J., Sparso, T., Zhao, J., Astrup, A., Jørgensen, M. E., Linneberg, Allan René, Vestergaard, H., Bisgaard, H., Bønnelykke, Klaus, Grarup, Niels, Hansen, Torben, Kovacs, P., Lind, L., Loos, R. J. F., Njølstad, I., Pedersen, Oluf Borbye, Schwarz, Peter, Sørensen, Thorkild I.A. & Meta-Analysis of Glucose and Insulin-Related Trait Consortium (MAGIC), M. O. G. A. I. T. C. (., 2021, In: Nature Genetics. 53, 6, p. 840-860 41 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Trans-ethnic gut microbial signatures of prediabetic subjects from India and Denmark

Pinna, N. K., Anjana, R. M., Saxena, S., Dutta, A., Gnanaprakash, V., Rameshkumar, G., Aswath, S., Raghavan, S., Rani, C. S. S., Radha, V., Balasubramanyam, M., Pant, A., Nielsen, T., Jørgensen, T., Færch, K., Kashani, A., Silva, M. C. A., Vestergaard, H., Hansen, T. H., Hansen, T. & 6 others, Arumugam, Mani, Nair, G. B., Das, B., Pedersen, Oluf Borbye, Mohan, V. & Mande, S. S., 2021, In: Genome Medicine. 13, 20 p., 36.

Research output: Contribution to journal › Journal article › Research › peer-review

Trans-ethnic gut microbiota signatures of type 2 diabetes in Denmark and India

Alvarez-Silva, C., Kashani, A., Hansen, T. H., Pinna, N. K., Anjana, R. M., Dutta, A., Saxena, S., Støy, J., Kampmann, U., Nielsen, T., Jørgensen, T., Gnanaprakash, V., Gnanavadivel, R., Sukumaran, A., Rani, C. S. S., Færch, K., Radha, V., Balasubramanyam, M., Nair, G. B., Das, B. & 6 others, drb459, drb459, Hansen, Torben, Mande, S. S., Mohan, V., Arumugam, Mani & Pedersen, Oluf Borbye, 2021, In: Genome Medicine. 13, 37.

Research output: Contribution to journal › Journal article › Research › peer-review

Voices: Insulin and beyond

Roth, J., Ashcroft, F. M., Wollheim, C. B., Kieffer, T. J., Cherrington, A. D., Bergman, R. N., Taylor, R., Najjar, S. M., Pedersen, Oluf Borbye, Ellingsgaard, H., Holst, Jens Juul, Nauck, M. A., Kadowaki, T., Czech, M. P., Corvera, S., Saltiel, A. R., Corkey, B. E. & Atkinson, M. A., 2021, In: Cell Metabolism. 33, 4, p. 692-699 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Dietary metabolite profiling brings new insight into the relationship between nutrition and metabolic risk: An IMI DIRECT study

Eriksen, R., Perez, I. G., Posma, J. M., Haid, M., Sharma, S., Prehn, C., Thomas, L. E., Koivula, R. W., Bizzotto, R., Prehn, C., Mari, A., Giordano, G. N., Pavo, I., Schwenk, J. M., De Masi, F., Tsirigos, K. D., Brunak, S., Viñuela, A., Mahajan, A., McDonald, T. J. & 18 others, Kokkola, T., Rutter, F., Teare, H., Hansen, T. H., Fernandez, J., Jones, A., Jennison, C., Walker, M., McCarthy, M. I., Pedersen, Oluf Borbye, Ruetten, H., Forgie, I., Bell, J. D., Pearson, E. R., Franks, P. W., Adamski, J., Holmes, E. & Frost, G., Aug 2020, In: EBioMedicine. 58, p. 102932

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FUT2–ABO epistasis increases the risk of early childhood asthma and Streptococcus pneumoniae respiratory illnesses

Ahluwalia, T. S., Eliasen, A. U., Sevelsted, A., Pedersen, C-E. T., Stokholm, J., Chawes, B., Bork-Jensen, J., Grarup, N., Pedersen, O., Hansen, T., Linneberg, A., Sharma, A., Weiss, S. T., Evans, M. D., Jackson, D. J., Morin, A., Krogfelt, K. A., Schjørring, S., Mortensen, P. B., Hougaard, D. M. & 13 others, Bybjerg-Grauholm, J., Bækvad-Hansen, M., Mors, O., Nordentoft, Merete, Børglum, A. D., Werge, Thomas, Agerbo, E., Gern, J. E., Lemanske, R. F., Ober, C., Pedersen, A. G., Bisgaard, H. & Bønnelykke, Klaus, 2020, In: Nature Communications. 11, 12 p., 6398.

Research output: Contribution to journal › Journal article › Research › peer-review

A mutation map for human glycoside hydrolase genes

Hansen, Lars, Husein, D. M., Gericke, B., Hansen, Torben, Pedersen, Oluf Borbye, Tambe, M. A., Freeze, H. H., Naim, H. Y., Henrissat, B., Wandall, Hans H., Clausen, Henrik & Bennett, Eric Paul, 2020, In: Glycobiology. 30, 8, p. 500-515 16 p.

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A reference map of potential determinants for the human serum metabolome

Bar, N., Korem, T., Weissbrod, O., Zeevi, D., Rothschild, D., Leviatan, S., Kosower, N., Lotan-Pompan, M., Weinberger, A., Le Roy, C. I., Menni, C., Visconti, A., Falchi, M., Spector, T. D., Adamski, J., Franks, P. W., Pedersen, Oluf Borbye, Segal, E. & IMI-DIRECT consortium, I. C., 2020, In: Nature. 588, p. 135-140 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Aberrant gut microbiota alters host metabolome and impacts renal failure in humans and rodents

Wang, X., Yang, S., Li, S., Zhao, L., Hao, Y., Qin, J., Zhang, L., Zhang, C., Bian, W., Zuo, L. I., Gao, X., Zhu, B., Lei, X., Gu, Z., Cui, W., Xu, X., Li, Z., Zhu, B., Li, Y., Chen, S. & 24 others, Guo, H., Zhang, H., Sun, Jing, Zhang, M., Hui, Y., Zhang, X., Liu, X., Sun, B., Wang, L., Qiu, Q., Zhang, Y., Li, X., Liu, W., Xue, R., Wu, H., Shao, D., Li, J., Zhou, Y., Li, S., Yang, R., Pedersen, Oluf Borbye, Yu, Z., Ehrlich, S. D. & Ren, F., 2020, In: Gut. 69, 12, p. 2131-2142 319766.

Research output: Contribution to journal › Journal article › Research › peer-review

Authors' reply to Sert's comment on low-grade inflammation independently associates with cardiometabolic risk in children with overweight/obesity

Lund, M. A. V., Thostrup, A. H., Frithioff-Bojsoe, C., Lausten-Thomsen, U., Hedley, P. L., Pedersen, Oluf Borbye, Christiansen, M., Hansen, Torben & Holm, Jens-Christian, 2020, In: Nutrition, Metabolism & Cardiovascular Diseases. 30, 12, p. 2422-2424

Research output: Contribution to journal › Letter › Research › peer-review

Comparative Studies of the Gut Microbiota in the Offspring of Mothers With and Without Gestational Diabetes

Crusell, Mie Korslund Wiinblad, Hansen, T. H., Nielsen, T., Allin, K. H., Rühlemann, M. C., Damm, Peter, Vestergaard, H., Rørbye, Christina, Jørgensen, Niklas Rye, Christiansen, O. B., Heinsen, F. A., Franke, A., Hansen, Torben, Lauenborg, J. & Pedersen, Oluf Borbye, 2020, In: Frontiers in Cellular and Infection Microbiology. 10, 14 p., 536282.

Research output: Contribution to journal › Journal article › Research › peer-review

Data integration for prediction of weight loss in randomized controlled dietary trials

Nielsen, R. L., Helenius, M., Garcia, S. L., Roager, H. M., Aytan-Aktug, D., Hansen, L. B. S., Lind, M. V., Vogt, J. K., Dalgaard, M. D., Bahl, M. I., Jensen, C. B., Muktupavela, R., Warinner, C., Aaskov, V., Gøbel, R., Kristensen, M. B., Frøkiær, H., Sparholt, M. H., Christensen, A. F., Vestergaard, H. & 8 others, Hansen, Torben, Kristiansen, Karsten, Brix, Susanne, Petersen, T. N., Lauritzen, Lotte, Licht, T. R., Pedersen, Oluf Borbye & Gupta, R., 2020, In: Scientific Reports. 10, 15 p., 20103.

Research output: Contribution to journal › Journal article › Research › peer-review

Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals

Surendran, P., Feofanova, E. V., Lahrouchi, N., Ntalla, I., Karthikeyan, S., Cook, J., Chen, L., Mifsud, B., Yao, C., Kraja, A. T., Cartwright, J. H., Hellwege, J. N., Giri, A., Tragante, V., Thorleifsson, G., Liu, D. J., Prins, B. P., Stewart, I. D., Cabrera, C. P., Eales, J. M. & 34 others, Akbarov, A., Auer, P. L., Bielak, L. F., Bis, J. C., Braithwaite, V. S., Brody, J. A., Daw, E. W., Warren, H. R., Drenos, F., Nielsen, S. F., Faul, J. D., Fauman, E. B., Fava, C., Varga, T. V., Zhao, J. H., Bork-Jensen, J., Grarup, Niels, Hansen, Torben, Have, C. T., Jørgensen, M. E., Karpe, F., Linneberg, Allan René, Pedersen, Oluf Borbye, Rasmussen, K. L., Sun, Y. V., Witte, D. R., Lind, L., Loos, Ruth, Nordestgaard, Børge, LifeLines Cohort Study, L. C. S., EPIC-CVD, E., EPIC-InterAct, E., Understanding Society Scientific Group, U. S. S. G. & Million Veteran Program, M. V. P., 2020, In: Nature Genetics. 52, 12, p. 1314-1332 19 p.

Research output: Contribution to journal › Journal article › Research › peer-review

GLP-1 Receptor Agonist Treatment in Morbid Obesity and Type 2 Diabetes Due to Pathogenic Homozygous Melanocortin-4 Receptor Mutation: A Case Report

Iepsen, E. W., Have, C. T., Veedfald, Simon, Madsbad, Sten, Holst, Jens Juul, Grarup, Niels, Pedersen, Oluf Borbye, Brandslund, I., Holm, Jens-Christian, Hansen, Torben & Torekov, Signe Sørensen, 2020, In: Cell Reports Medicine. 1, 1, 8 p., 100006.

Research output: Contribution to journal › Journal article › Research › peer-review

Gestational diabetes and the human salivary microbiota: a longitudinal study during pregnancy and postpartum

Crusell, M. K. W., Brink, L. R., Nielsen, T., Allin, K. H., Hansen, Torben, Damm, Peter, Lauenborg, J., Hansen, T. H. & Pedersen, Oluf Borbye, 2020, In: BMC Pregnancy and Childbirth. 20, 12 p., 69.

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Gut microbiota profile and selected plasma metabolites in type 1 diabetes without and with stratification by albuminuria

Winther, S. A., Henriksen, P., Vogt, J. K., Hansen, T. H., Ahonen, L., Suvitaival, T., Zobel, E. H., Frimodt-Møller, M., Hansen, T. W., Hansen, Torben, Parving, H., Legido-Quigley, C., Rossing, Peter & Pedersen, Oluf Borbye, 2020, In: Diabetologia. 63, p. 2713-2724 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology

Molinaro, A., Bel Lassen, P., Henricsson, M., Wu, H., Adriouch, S., Belda, E., Chakaroun, R., Nielsen, T., Bergh, P-O., Rouault, C., Andre, S., Marquet, F., Andreelli, F., Salem, J-E., Assmann, K., Bastard, J-P., Forslund, S., Le Chatelier, E., Falony, G., Pons, N. & 26 others, Prifti, E., Quinquis, B., Roume, H., Vieira-Silva, S., Hansen, T. H., Pedersen, H. K., Lewinter, C., Sønderskov, N. B., Køber, Lars Valeur, Vestergaard, H., Hansen, Torben, Zucker, J., Galan, P., Dumas, M., Raes, J., Oppert, J., Letunic, I., Nielsen, J., Bork, P., Ehrlich, S. D., Stumvoll, M., Pedersen, Oluf Borbye, Aron-Wisneswky, J., Clement, K., Baeckhed, F. & MetaCardis Consortium, M. C., 2020, In: Nature Communications. 11, 1, 10 p., 5881.

Research output: Contribution to journal › Journal article › Research › peer-review

Leptin, adiponectin, and their ratio as markers of insulin resistance and cardiometabolic risk in childhood obesity

Frithioff-Bojsoe, C., Lund, Morten Asp Vonsild, Lausten-Thomsen, U., Hedley, P. L., Pedersen, Oluf Borbye, Christiansen, M., Baker, J. L., Hansen, Torben & Holm, Jens-Christian, 2020, In: Pediatric Diabetes. 21, 2, p. 194-202

Research output: Contribution to journal › Journal article › Research › peer-review

Low-grade inflammation independently associates with cardiometabolic risk in children with overweight/obesity

Lund, M. A., Thostrup, A. H., Frithioff-Bojsoe, C., Lausten-Thomsen, U., Hedley, P. L., Pedersen, Oluf Borbye, Christiansen, M., Hansen, Torben & Holm, Jens-Christian, 2020, In: Nutrition, Metabolism & Cardiovascular Diseases. 30, 9, p. 1544-1553

Research output: Contribution to journal › Journal article › Research › peer-review

Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits

Vogelezang, S., Bradfield, J. P., Ahluwalia, Tarun Veer Singh, Curtin, J. A., Grarup, Niels, Schnurr, T. M., Hansen, Torben, Michaelsen, Kim F., Pedersen, Oluf Borbye, Stokholm, Jakob, Lind, M. V., Frithioff-Bøjsøe, C., Holm, Jens-Christian, Felix, J. F. & Early Growth Genetics Consortium, E. G. G. C., 2020, In: P L o S Genetics. 16, 10, 26 p., e1008718.

Research output: Contribution to journal › Journal article › Research › peer-review

Obesity, unfavourable lifestyle and genetic risk of type 2 diabetes: a case-cohort study

Schnurr, T. M., Jakupovic, Hermina, Carrasquilla, Germán D., Ängquist, Lars, Grarup, Niels, Sørensen, Thorkild I.A., Tjønneland, Anne, Overvad, K., Pedersen, Oluf Borbye, Hansen, Torben & Kilpeläinen, Tuomas O., 2020, In: Diabetologia. 63, 7, p. 1324-1332 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Post-load glucose subgroups and associated metabolic traits in individuals with type 2 diabetes: An IMI-DIRECT study

Obura, M., Beulens, J. W. J., Slieker, R., Koopman, A. D. M., Hoekstra, T., Nijpels, G., Elders, P., Koivula, R. W., Kurbasic, A., Laakso, M., Hansen, T. H., Ridderstråle, M., Hansen, T., Pavo, I., Forgie, I., Jablonka, B., Ruetten, H., Mari, A., McCarthy, M. I., Walker, M. & 19 others, Heggie, A., McDonald, T. J., Perry, M. H., De Masi, F., Brunak, Søren, Mahajan, A., Giordano, G. N., Kokkola, T., Dermitzakis, E., Viñuela, A., Pedersen, Oluf Borbye, Schwenk, J. M., Adamski, J., Teare, H. J. A., Pearson, E. R., Franks, P. W., Hart, L. M. T., Rutters, F. & for the IMI-DIRECT Consortium, F. T. I. C., 2020, In: PLoS ONE. 15, 11, 11 p., e0242360.

Research output: Contribution to journal › Journal article › Research › peer-review

Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts

Atabaki-Pasdar, N., Ohlsson, M., Viñuela, A., Frau, F., Pomares-Millan, H., Haid, M., Jones, A. G., Thomas, E. L., Koivula, R. W., Kurbasic, A., Mutie, P. M., Fitipaldi, H., Fernandez, J., Dawed, A. Y., Giordano, G. N., Forgie, I. M., McDonald, T. J., Rutters, F., Cederberg, H., Chabanova, E. & 30 others, Dale, M., Masi, F. D., Thomas, C. E., Allin, K. H., Hansen, T. H., Heggie, A., Hong, M., Elders, P. J. M., Kennedy, G., Kokkola, T., Pedersen, H. K., Mahajan, A., McEvoy, D., Pattou, F., Raverdy, V., Häussler, R. S., Sharma, S., Thomsen, Henrik S., Vangipurapu, J., Vestergaard, H., Adamski, J., Musholt, P. B., Brage, S., Brunak, Søren, Dermitzakis, E., Frost, G., Hansen, Torben, Laakso, M., Pedersen, Oluf Borbye & IMI-DIRECT consortium, I. C., 2020, In: PLoS Medicine. 17, 6, 27 p., e1003149.

Research output: Contribution to journal › Journal article › Research › peer-review

Role of fasting duration and weekday in incretin and glucose regulation

Clemmensen, K. K. B., Quist, J. S., Vistisen, D., Witte, D. R., Jonsson, Anna Elisabet, Pedersen, Oluf Borbye, Hansen, Torben, Holst, Jens Juul, Lauritzen, T., Jørgensen, M. E., Torekov, Signe Sørensen & Færch, K., 2020, In: Endocrine Connections. 9, 4, p. 279-288

Research output: Contribution to journal › Journal article › Research › peer-review

Skeletal muscle enhancer interactions identify genes controlling whole-body metabolism

Williams, K., Ingerslev, L. R., Bork-Jensen, J., Wohlwend, M., Hansen, Ann Normann, Small, Lewin Barkla, Ribel-Madsen, R., Astrup, A., Pedersen, Oluf Borbye, Auwerx, J., Workman, C. T., Grarup, Niels, Hansen, Torben & Barrès, Romain, 2020, In: Nature Communications. 11, 16 p., 2695.

Research output: Contribution to journal › Journal article › Research › peer-review

Statin therapy is associated with lower prevalence of gut microbiota dysbiosis

Vieira-Silva, S., Falony, G., Belda, E., Nielsen, T., Aron-Wisnewsky, J., Chakaroun, R., Forslund, S. K., Assmann, K., Valles-Colomer, M., Nguyen, T. T. D., Proost, S., Prifti, E., Tremaroli, V., Pons, N., Le Chatelier, E., Andreelli, F., Bastard, J-P., Coelho, L. P., Galleron, N., Hansen, T. H. & 28 others, Hulot, J., Lewinter, C., Pedersen, H. K., Quinquis, B., Rouault, C., Roume, H., Salem, J., Søndertoft, N. B., Touch, S., Dumas, M., Ehrlich, S. D., Galan, P., Gøtze, J. P., Hansen, Torben, Holst, Jens Juul, Køber, Lars Valeur, Letunic, I., Nielsen, J., Oppert, J., Stumvoll, M., Vestergaard, H., Zucker, J., Bork, P., Pedersen, Oluf Borbye, Bäckhed, F., Clément, K., Raes, J. & MetaCardis Consortium, M. C., 2020, In: Nature. 581, 7808, p. 310-315

Research output: Contribution to journal › Journal article › Research › peer-review