Inge Marie Svane

Inge Marie Svane

Clinical Professor

Member of:

  • Clinical Oncology


  1. 2017
  2. Published

    Mutational and putative neoantigen load predict clinical benefit of adoptive T cell therapy in melanoma

    Lauss, M., dqp123, dqp123, Harbst, K., Andersen, R., Mitra, S., Rosengren, F., Salim, M., Vallon-Christersson, J., Törngren, T., Kvist, A., Ringnér, M., Svane, Inge Marie & Jönsson, G., 2017, In: Nature Communications. 8, 11 p., 1738.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    PD-1+ Polyfunctional T Cells Dominate the Periphery after Tumor-Infiltrating Lymphocyte Therapy for Cancer

    dqp123, dqp123, Kjeldsen, J. W., Andersen, R., Westergaard, M. C. W., Bianchi, V., Legut, M., Attaf, M., Szomolay, B., Ott, S., Dolton, G., Lyngaa, R., Hadrup, S. R., Sewell, A. K. & Svane, Inge Marie, 2017, In: Clinical Cancer Research. 23, 19, p. 5779-5788

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    PD-L1 expression and survival among melanoma patients treated with standard immunotherapy or chemotherapy

    Steiniche, T., Vestergaard Danielsen, A., Wang, Z., Feng, Y., Switten Nielsen, P., Bastholt, L., Schmidt, H., Svane, Inge Marie, Dolled-Filhart, M., Emancipator, K., Weiner, R., Busch-Sørensen, M. & Zhou, W., 2017, In: Journal of the European Academy of Dermatology and Venereology. 31, 7, p. e319-e321

    Research output: Contribution to journalComment/debateResearch

  5. Published

    Predictors of responses to immune checkpoint blockade in advanced melanoma

    Jacquelot, N., Roberti, M. P., Enot, D. P., Rusakiewicz, S., Ternès, N., Jegou, S., Woods, D. M., Sodré, A. L., Hansen, M., Meirow, Y., Sade-Feldman, M., Burra, A., Kwek, S. S., Flament, C., Messaoudene, M., Duong, C. P. M., Chen, L., Kwon, B. S., Anderson, A. C., Kuchroo, V. K. & 30 others, Weide, B., Aubin, F., Borg, C., Dalle, S., Beatrix, O., Ayyoub, M., Balme, B., Tomasic, G., Di Giacomo, A. M., Maio, M., Schadendorf, D., Melero, I., Dréno, B., Khammari, A., Dummer, R., Levesque, M., Koguchi, Y., Fong, L., Lotem, M., Baniyash, M., Schmidt, H., Svane, Inge Marie, Kroemer, G., Marabelle, A., Michiels, S., Cavalcanti, A., Smyth, M. J., Weber, J. S., Eggermont, A. M. & Zitvogel, L., 2017, In: Nature Communications. 8, 13 p., 592.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Survival of metastatic melanoma patients after dendritic cell vaccination correlates with expression of leukocyte phosphatidylethanolamine-binding protein 1/Raf kinase inhibitory protein

    Buschow, S. I., Ramazzotti, M., Reinieren-Beeren, I. M. J., Heinzerling, L. M., Westdorp, H., Stefanini, I., Beltrame, L., Hato, S. V., Ellebaek, E., Gross, S., Nguyen, V. A., Weinlich, G., Ragoussis, J., Baban, D., Schuler-Thurner, B., Svane, I. M., Romani, N., Austyn, J. M., De Vries, I. J. M., Schuler, G. & 2 others, Cavalieri, D. & Figdor, C. G., 2017, In: OncoTarget. 8, 40, p. 67439-67456 18 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    The JAK2V617F mutation is a target for specific T cells in the JAK2V617F-positive myeloproliferative neoplasms

    Holmström, M. O., Hjortso, M. D., Ahmad, S. M., Met, Özcan, Martinenaite, E., Riley, C., Straten, P., Svane, Inge Marie, Hasselbalch, Hans Carl & Andersen, Mads Hald, 2017, In: Leukemia. 31, p. 495-498

    Research output: Contribution to journalLetterResearchpeer-review

  8. Published

    The majority of patients with metastatic melanoma are not represented in pivotal phase III immunotherapy trials

    dqp123, dqp123, Kimper-Karl, M. L., Høyer, K. L., Bastholt, L., Schmidt, H. & Svane, Inge Marie, 2017, In: European Journal of Cancer. 74, p. 89-95

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. 2016
  10. Published

    Isolated asymptomatic masseter muscle metastasis as first sign of metastatic disease in a patient with known melanoma

    Gjorup, C. A., Hendel, Helle Westergren, Svane, Inge Marie & Hølmich, Lisbet Rosenkrantz, 1 Dec 2016, In: J P R A S Open. 10, p. 1-4 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    The CALR exon 9 mutations are shared neoantigens in patients with CALR mutant chronic myeloproliferative neoplasms

    Holmström, M. O., Riley, C. H., Svane, Inge Marie, Hasselbalch, H. C. & Andersen, Mads Hald, Dec 2016, In: Leukemia. 30, 12, p. 2413-2416 14 p.

    Research output: Contribution to journalLetterResearchpeer-review

  12. Published

    The Danish Melanoma Database

    Hølmich, Lisbet Rosenkrantz, Klausen, S., Spaun, E., Schmidt, G., Gad, D., Svane, Inge Marie, Schmidt, H., Lorentzen, H. F. & Ibfelt, E. H., 25 Oct 2016, In: Clinical Epidemiology. 8, p. 543-548 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Large-scale detection of antigen-specific T cells using peptide-MHC-I multimers labeled with DNA barcodes

    Bentzen, A. K., Marquard, A. M., Lyngaa, R., Saini, S. K., Ramskov, S., Donia, M., Such, L., Furness, A. J. S., McGranahan, N., Rosenthal, R., thor Straten, E. P., Szallasi, Z., Svane, Inge Marie, Swanton, C., Quezada, S. A., Jakobsen, S. N., Eklund, A. C. & Hadrup, S. R., Oct 2016, In: Nature Biotechnology. 34, 10, p. 1037-1045 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Therapeutic Vaccination against A Modified Minimal Survivin Epitope Induces Functional CD4 T Cells That Recognize Survivin-Expressing Cells

    Nitschke, N. J., Bjoern, J., Met, Özcan, Svane, Inge Marie & Andersen, M. H., 1 Sep 2016, In: Scandinavian Journal of Immunology. 84, 3, p. 191-193 3 p.

    Research output: Contribution to journalComment/debateResearchpeer-review

  15. Published

    mRNA-transfected dendritic cell vaccine in combination with metronomic cyclophosphamide as treatment for patients with advanced malignant melanoma

    Borch, T. H., Engell-Noerregaard, L., Iversen, T. Z., Ellebaek, E., Met, Özcan, Hansen, M., Andersen, Mads Hald, thor Straten, E. P. & Svane, Inge Marie, 1 Sep 2016, In: OncoImmunology. 5, 9, 12 p., e1207842.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Autocrine CCL19 blocks dendritic cell migration toward weak gradients of CCL21

    Hansen, M., Met, Özcan, Larsen, N. B., Rosenkilde, Mette, Andersen, Mads Hald, Svane, Inge Marie & Hjortø, Gertrud Malene, Sep 2016, In: Cytotherapy. 18, 9, p. 1187-1196

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    PD-L1 peptide co-stimulation increases immunogenicity of a dendritic cell-based cancer vaccine

    Munir Ahmad, S., Martinenaite, E., Hansen, M., Junker, N., Borch, T. H., Met, Özcan, Donia, M., Svane, Inge Marie & Andersen, Mads Hald, 2 Aug 2016, In: OncoImmunology. 5, 8, e1202391.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Cabazitaxel as second-line or third-line therapy in patients with metastatic castration-resistant prostate cancer

    Kongsted, P., Svane, Inge Marie, Lindberg, H., Bisbjerg, R., Daugaard, G. & Sengeløv, L., Aug 2016, In: Anti-Cancer Drugs. 27, 7, p. 695-701 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Long-Lasting Complete Responses in Patients with Metastatic Melanoma after Adoptive Cell Therapy with Tumor-Infiltrating Lymphocytes and an Attenuated IL2 Regimen

    Andersen, R., Donia, M., Ellebæk, E., Borch, T. H., Kongsted, P., Iversen, T. Z., Hølmich, Lisbet Rosenkrantz, Hendel, Helle Westergren, Met, Özcan, Andersen, Mads Hald, Thor Straten, E. P. & Svane, Inge Marie, Aug 2016, In: Clinical Cancer Research. 22, 15, p. 3734-3745 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Safety, immune and clinical responses in metastatic melanoma patients vaccinated with a long peptide derived from indoleamine 2,3-dioxygenase in combination with ipilimumab

    Bjørn, J., Iversen, T. Z., Nitschke, N. J., Andersen, Mads Hald & Svane, Inge Marie, Aug 2016, In: Cytotherapy. 18, 8, p. 1043-1055 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Behandlingen af BRAF-muteret metastatisk melanom med BRAF/MEK-inhibitorer bedrer prognosen

    Boyles, T. B., Svane, Inge Marie, Bastholt, L. & Schmidt, H., 2016, In: Ugeskrift for Laeger. 178, 4 p., V02160126.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    CCL22-specific T Cells: Modulating the immunosuppressive tumor microenvironment

    Martinenaite, E., Munir Ahmad, S., Hansen, M., Met, Özcan, Westergaard, M. W., Larsen, S. K., Klausen, T. W., Donia, M., Svane, Inge Marie & Andersen, Mads Hald, 2016, In: OncoImmunology. 5, 11, 10 p., e1238541.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Immuncheckpointantistoffer øger overlevelsen for patienter med metastatisk melanom

    Fløe, L. E., Svane, Inge Marie, Bastholt, L. & Schmidt, H., 2016, In: Ugeskrift for Laeger. 178, 4 p., V01160070.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Immune monitoring using mRNA-transfected dendritic cells

    Borch, T. H., Svane, Inge Marie & Met, Özcan, 2016, Synthetic mRNA: Production, Introduction Into Cells, and Physiological Consequences. Humana Press, Vol. 1428. p. 245-259 15 p. (Methods in Molecular Biology, Vol. 1428).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  25. Published

    Immunological correlates of treatment and response in stage IV malignant melanoma patients treated with Ipilimumab

    Bjoern, J., Juul Nitschke, N., Zeeberg Iversen, T., Schmidt, H., Fode, K. & Svane, Inge Marie, 2016, In: OncoImmunology. 5, 4, 10 p., e1100788.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Interferon-α induces marked alterations in circulating regulatory T cells, NK cell subsets, and dendritic cells in patients with JAK2V617F-positive essential thrombocythemia and polycythemia vera

    Riley, C. H., Brimnes, M. K., Hansen, M., Jensen, M. K., Hasselbalch, Hans Carl, Kjaer, L., Straten, P. T. & Svane, Inge Marie, 2016, In: European Journal of Haematology. 97, 1, p. 83-92 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Large-scale mRNA transfection of dendritic cells by electroporation in continuous flow systems

    Selmeczi, D., Hansen, T. S., Met, Özcan, Svane, Inge Marie & Larsen, N. B., 2016, Methods in Molecular Biology. Humana Press, Vol. 1428. p. 151-161 11 p. (Methods in Molecular Biology, Vol. 1428).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  28. Published

    Peptide vaccination against multiple myeloma using peptides derived from anti-apoptotic proteins: a phase I trial

    Jørgensen, N. G., Ahmad, S. M., Abildgaard, N., Straten, P. T., Svane, Inge Marie, Andersen, Mads Hald & Knudsen, L. M., 2016, In: Stem Cell Investigation. 3, 5 p., 95.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Predictors of Chemotherapy-Induced Toxicity and Treatment Outcomes in Elderly Versus Younger Patients With Metastatic Castration-Resistant Prostate Cancer

    Kongsted, P., Svane, Inge Marie, Lindberg, H. & Sengeløv, L., 2016, In: Clinical Genitourinary Cancer. 14, 6, p. e559-e568

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    The controversial role of TNF in melanoma

    Donia, M., Kjeldsen, J. W. & Svane, Inge Marie, 2016, In: OncoImmunology. 5, 4, 2 p., e1107699.

    Research output: Contribution to journalComment/debateResearchpeer-review

  31. Published

    Transfection of tumor-infiltrating T cells with mRNA encoding CXCR2

    Idorn, M., thor Straten, E. P., Svane, Inge Marie & Met, Özcan, 2016, Synthetic mRNA: Production, Introduction Into Cells, and Physiological Consequences. Rhoads, R. E. (ed.). Springer, Vol. 1428. p. 261-276 16 p. (Methods in Molecular Biology, Vol. 1428).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  32. 2015
  33. Published

    Tumor-infiltrating lymphocytes for the treatment of metastatic cancer

    Geukes Foppen, M. H., Donia, M., Svane, Inge Marie & Haanen, J. B. A. G., Dec 2015, In: Molecular Oncology. 9, 10, p. 1918-35 18 p.

    Research output: Contribution to journalReviewResearchpeer-review

  34. Published

    Low-dose prednisolone in first-line docetaxel for patients with metastatic castration-resistant prostate cancer: is there a clinical benefit?

    Kongsted, P., Svane, Inge Marie, Lindberg, H., Daugaard, G. & Sengeløv, L., Nov 2015, In: Urologic Oncology: Seminars and Original Investigations. 33, 11, p. 494.e15-20

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Design and validation of conditional ligands for HLA-B*08:01, HLA-B*15:01, HLA-B*35:01, and HLA-B*44:05

    Frøsig, T. M., Yap, J., Seremet, T., Lyngaa, R., Svane, Inge Marie, Thor Straten, P., Heemskerk, M. H. M., Grotenbreg, G. M. & Hadrup, S. R., Oct 2015, In: Cytometry. Part A. 87, 10, p. 967-75 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Aberrant Expression of MHC Class II in Melanoma Attracts Inflammatory Tumor-Specific CD4+ T- Cells, Which Dampen CD8+ T-cell Antitumor Reactivity

    Donia, M., Andersen, R., Kjeldsen, J. W., Fagone, P., Munir, S., Nicoletti, F., Andersen, Mads Hald, Thor Straten, P. & Svane, Inge Marie, 15 Sep 2015, In: Cancer Research. 75, 18, p. 3747-59 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    More tricks with tetramers: a practical guide to staining T cells with peptide-MHC multimers

    Dolton, G., Tungatt, K., Lloyd, A., Bianchi, V., Theaker, S. M., Trimby, A., Holland, C. J., Donia, M., Godkin, A. J., Cole, D. K., Straten, P. T., Peakman, M., Svane, Inge Marie & Sewell, A. K., Sep 2015, In: Immunology. 146, 1, p. 11-22 12 p.

    Research output: Contribution to journalReviewResearchpeer-review

  38. Published

    Reorienting the immune system in the treatment of cancer by using anti-PD-1 and anti-PD-L1 antibodies

    Borch, T. H., Donia, M., Andersen, Mads Hald & Svane, Inge Marie, Sep 2015, In: Drug Discovery Today. 20, 9, p. 1127-34 8 p.

    Research output: Contribution to journalReviewResearchpeer-review

  39. Published

    Broadening the repertoire of melanoma-associated T-cell epitopes

    Frøsig, T. M., Lyngaa, R., Met, Özcan, Larsen, S. K., Donia, M., Svane, Inge Marie, Thor Straten, P. & Hadrup, S. R., May 2015, In: Cancer immunology, immunotherapy : CII. 64, 5, p. 609-20 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Neuroprotective and anti-inflammatory mechanisms are activated early in optic neuritis

    Tsakiri, A., Ravanidis, S., Lagoudaki, R., Poulatsidou, K., Svane, Inge Marie, Fredriksen, Jette Lautrup & Grigoriadis, N., May 2015, In: Acta Neurologica Scandinavica. 131, 5, p. 305-12 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Confinement dependent chemotaxis in two-photon polymerized linear migration constructs with highly definable concentration gradients

    Hjortø, Gertrud Malene, Olsen, M. H., Svane, Inge Marie & Larsen, N. B., Apr 2015, In: Biomedical Microdevices. 17, 2, p. 1-10 10 p., 30.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, phase 3 trial

    Weber, J. S., D'Angelo, S. P., Minor, D., Hodi, F. S., Gutzmer, R., Neyns, B., Hoeller, C., Khushalani, N. I., Miller, W. H., Lao, C. D., Linette, G. P., Thomas, L., Lorigan, P., Grossmann, K. F., Hassel, J. C., Maio, M., Sznol, M., Ascierto, P. A., Mohr, P., Chmielowski, B. & 8 others, Bryce, A., Svane, Inge Marie, Grob, J., Krackhardt, A. M., Horak, C., Lambert, A., Yang, A. S. & Larkin, J., Apr 2015, In: Lancet Oncology. 16, 4, p. 375-84 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Expansion of circulating CD56bright natural killer cells in patients with JAK2-positive chronic myeloproliferative neoplasms during treatment with interferon-α

    Riley, C. H., Hansen, M., Brimnes, M. K., Hasselbalch, H. C., Bjerrum, O. W., Straten, P. T., Svane, Inge Marie & Jensen, M. K., Mar 2015, In: European Journal of Haematology. 94, 3, p. 227–234 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Antibody Stabilization of Peptide–MHC Multimers Reveals Functional T Cells Bearing Extremely Low-Affinity TCRs

    Tungatt, K., Bianchi, V., Crowther, M. D., Powell, W. E., Schauenburg, A. J., Trimby, A., Donia, M., Miles, J. J., Holland, C. J., Cole, D. K., Godkin, A. J., Peakman, M., Straten, P. T., Svane, Inge Marie, Sewell, A. K. & Dolton, G., Jan 2015, In: Journal of immunology (Baltimore, Md. : 1950). 194, 1, p. 463-474 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    The Targeting of Indoleamine 2,3 Dioxygenase -Mediated Immune Escape in Cancer

    Iversen, T. Z., Andersen, Mads Hald & Svane, Inge Marie, Jan 2015, In: Basic & Clinical Pharmacology & Toxicology. 116, 1, p. 19-24 6 p.

    Research output: Contribution to journalReviewResearchpeer-review

  46. Published

    Tryptophan 2,3-dioxygenase (TDO)-reactive T cells differ in their functional characteristics in health and cancer

    Hjortsø, M. D., Larsen, S. K., Kongsted, P., Met, Özcan, Frøsig, T. M., Andersen, G. H., Ahmad, S. M., Svane, Inge Marie, Becker, J. C., Straten, P. T. & Andersen, Mads Hald, Jan 2015, In: OncoImmunology. 4, 1, e968480.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Indoleamine 2,3-dioxygenase vaccination

    Andersen, Mads Hald & Svane, Inge Marie, 2015, In: OncoImmunology. 4, 1, p. 1-3 3 p., e983770.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Tumor infiltrating lymphocyte therapy for ovarian cancer and renal cell carcinoma

    Andersen, R., Donia, M., Westergaard, M. C. W., Pedersen, M., Hansen, M. & Svane, Inge Marie, 2015, In: Human Vaccines & Immunotherapeutics. 11, 12, p. 2790-5 6 p.

    Research output: Contribution to journalComment/debateResearch

  49. 2014
  50. Published

    Successful treatment with Ipilimumab and Interleukin‑2 in two patients with metastatic melanoma and systemic autoimmune disease

    Pedersen, M., Andersen, R., Larsen, P. N., Jacobsen, Søren, Thielsen, P., Thor Straten, P. & Svane, Inge Marie, Dec 2014, In: Cancer immunology, immunotherapy : CII. 63, 12, p. 1341-6 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    Simplified protocol for clinical-grade tumor-infiltrating lymphocyte manufacturing with use of the Wave bioreactor

    Donia, M., Larsen, S. M., Met, Özcan & Svane, Inge Marie, Aug 2014, In: Cytotherapy. 16, 8, p. 1117–1120 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    Late development of splenic sarcoidosis-like lesions in a patient with metastatic melanoma and long-lasting clinical response to ipilimumab

    Andersen, R., Nørgaard, P. H., Al-Jailawi, M. K. M. & Svane, Inge Marie, 23 Jan 2014, In: OncoImmunology. 3, 8, e954506.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published

    Long-lasting Disease Stabilization in the Absence of Toxicity in Metastatic Lung Cancer Patients Vaccinated with an Epitope Derived from Indoleamine 2,3 Dioxygenase

    Iversen, T. Z., Engell-Noerregaard, L., Ellebaek, E., Andersen, R. S., Larsen, S. K., Bjoern, J., Zeyher, C., Gouttefangeas, C., Thomsen, B. M., Holm, B., Thor Straten, P., Mellemgaard, A., Andersen, Mads Hald & Svane, Inge Marie, 1 Jan 2014, In: Clinical Cancer Research. 20, 1, p. 221-232 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Published

    Spontaneous presence of FOXO3-specific T cells in cancer patients

    Larsen, S. K., Ahmad, S. M., Idorn, M., Met, Özcan, Martinenaite, E., Svane, Inge Marie, Straten, P. T. & Andersen, Mads Hald, 1 Jan 2014, In: OncoImmunology. 3, 8, e953411.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 4054758