Ole Hyldegaard

Ole Hyldegaard

Clinical Professor

Member of:

  • Anaesthesiology


  1. 2023
  2. Published
  3. Published

    Effects of an early intervention with Hyperbaric Oxygen Treatment on arm lymphedema and quality of life after breast cancer-an explorative clinical trial

    Ammitzboll, G., Hyldegaard, Ole, Forchhammer, M., Rottensten, H., Lanng, C., Kroman, Niels Thorndahl, Zerahn, B., Jensen, Lars Thorbjørn, Johansen, Christoffer & Dalton, Susanne Oksbjerg, 2023, In: Supportive Care in Cancer. 31, 5, 12 p., 313.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Hyperbaric oxygen treatment in the management of necrotising soft-tissue infections: results from a Danish nationwide registry study

    Hedetoft, M., Madsen, M. B. & Hyldegaard, Ole, 2023, In: BMJ Open. 13, 2, e066117.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Interplay between human STING genotype and bacterial NADase activity regulates inter-individual disease variability

    Movert, E., Bolarin, J. S., Valfridsson, C., Velarde, J., Skrede, S., Nekludov, M., Hyldegaard, Ole, Arnell, P., Svensson, M., Norrby-Teglund, A., Cho, K. H., Elhaik, E., Wessels, M. R., Råberg, L. & Carlsson, F., 2023, In: Nature Communications. 14, 10 p., 4008.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Key pathways and genes that are altered during treatment with hyperbaric oxygen in patients with sepsis due to necrotizing soft tissue infection (HBOmic study)

    Vinkel, J., Rib, Leonor, Buil, A., Hedetoft, M. & Hyldegaard, Ole, 2023, In: European Journal of Medical Research. 28, 1, 14 p., 507.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Neutrophil-derived reactive agents induce a transient SpeB negative phenotype in Streptococcus pyogenes

    INFECT Study Group, I. S. G., 2023, In: Journal of Biomedical Science. 30, 1, 16 p., 52.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Systemic immune activation profiles in streptococcal necrotizing soft tissue infections: A prospective multicenter study

    INFECT Study Group, I. S. G., 2023, In: Clinical Immunology. 249, 11 p., 109276.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    The Mechanisms of Action of Hyperbaric Oxygen in Restoring Host Homeostasis during Sepsis

    Vinkel, J., Arenkiel, B. & Hyldegaard, Ole, 2023, In: Biomolecules. 13, 8, 19 p., 1228.

    Research output: Contribution to journalReviewResearchpeer-review

  10. 2022
  11. Published

    Hyperbaric oxygen treatment of mandibular osteoradionecrosis: Combined data from the two randomized clinical trials DAHANCA-21 and NWHHT2009-1

    Forner, L. E., Dieleman, F. J., Shaw, R. J., Kanatas, A., Butterworth, C. J., Kjeller, G., Alsner, J., Overgaard, J., Hillerup, S., Hyldegaard, Ole, Arnell, P., von Buchwald, Christian, Kaanders, J. H. A. M., Smeele, L. E., Specht, Lena, Johansen, J., Witjes, M. J. H., Merkx, M. A. W. & Jansen, E. C., Jan 2022, In: Radiotherapy and Oncology. 166, p. 137-144 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Analysis of host-pathogen gene association networks reveals patient-specific response to streptococcal and polymicrobial necrotising soft tissue infections

    Jahagirdar, S., Morris, L., Benis, N., Oppegaard, O., Svenson, M., Hyldegaard, Ole, Skrede, S., Norrby-Teglund, A., INFECT Study Group, I. S. G., Martins dos Santos, V. A. P. & Saccenti, E., 2022, In: BMC Medicine. 20, 173.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Decision support system and outcome prediction in a cohort of patients with necrotizing soft-tissue infections

    Katz, S., Suijker, J., Hardt, C., Madsen, M. B., Vries, A. M. D., Pijpe, A., Skrede, S., Hyldegaard, Ole, Solligård, E., Norrby-Teglund, A., Saccenti, E. & Martins dos Santos, V. A. P., 2022, In: International Journal of Medical Informatics. 167, 9 p., 104878.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Hyperbaric Oxygen Treatment May Advance the Outcome of Antibiotic Treatment of Biofilm Infections

    Jensen, Peter Østrup, Møller, S. A., Stjernekilde, S., Olsen, P., Moser, Claus Ernst, Schwartz, F. A., Lerche, C. J., Høiby, Niels, Hyldegaard, Ole, Faurholt-jepsen, D. & Kolpen, Mette, 2022, Antibiofilm Strategies: Current and Future Applications to Prevent, Control and Eradicate Biofilms. Springer, p. 201-223 (Antibiofilm Strategies, Vol. 11).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  15. Published

    Increase in the Complement Activation Product C4d and the Terminal Complement Complex sC5b-9 Is Associated with Disease Severity and a Fatal Outcome in Necrotizing Soft-Tissue Infection

    Hedetoft, M., Madsen, M. B., Hansen, C. B., Hyldegaard, Ole & Garred, Peter, 2022, In: Journal of Innate Immunity. 14, 4, p. 355-365 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Investigating the Effects of Hyperbaric Oxygen Treatment in Necrotizing Soft Tissue Infection With Transcriptomics and Machine Learning (the HBOmic Study): Protocol for a Prospective Cohort Study With Data Validation

    Vinkel, J., Rib, Leonor, Buil, A., Hedetoft, M. & Hyldegaard, Ole, 2022, In: JMIR Research Protocols. 11, 11, e39252.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Potential Advances of Adjunctive Hyperbaric Oxygen Therapy in Infective Endocarditis

    Lerche, C. J., Schwartz, F., Pries-Heje, M. M., Fosbøl, E. L., Iversen, Kasper, Jensen, Peter Østrup, Høiby, Niels, Hyldegaard, Ole, Bundgård, Henning & Moser, Claus Ernst, 2022, In: Frontiers in Cellular and Infection Microbiology. 12, 805964.

    Research output: Contribution to journalReviewResearchpeer-review

  18. 2021
  19. Published

    Risk Factors and Predictors of Mortality in Streptococcal Necrotizing Soft-tissue Infections: A Multicenter Prospective Study

    INFECT Study Group, I. S. G., 27 Jan 2021, In: Clinical Infectious Diseases. 72, 2, p. 293-300 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Non-invasive monitoring of carboxyhemoglobin during hyperbaric oxygen therapy

    Bidstrup, D., Ravn, F., Smidt-Nielsen, I. G., Wahl, A. M., Jansen, E. C. & Hyldegaard, Ole, 1 Jan 2021, In: Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc. 48, 1, p. 33-42 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Associations between YKL-40 and markers of disease severity and death in patients with necrotizing soft-tissue infection

    Hedetoft, M., Hansen, M. B., Madsen, M. B., Johansen, Julia Sidenius & Hyldegaard, Ole, 2021, In: BMC Infectious Diseases. 21, 1046.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Discriminatory plasma biomarkers predict specific clinical phenotypes of necrotizing soft-tissue infections

    Palma Medina, L. M., Rath, E., Jahagirdar, S., Bruun, T., Madsen, M. B., Strålin, K., Unge, C., Hansen, M. B., Arnell, P., Nekludov, M., Hyldegaard, Ole, Lourda, M., Martins dos Santos, V. A. P., Saccenti, E., Skrede, S., Svensson, M. & Norrby-Teglund, A., 2021, In: Journal of Clinical Investigation. 131, 14, e149523.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Effect of immunoglobulin G on cytokine response in necrotising soft-tissue infection: A post hoc analysis

    Hedetoft, M., Madsen, M. B., Perner, Anders, Garred, Peter & Hyldegaard, Ole, 2021, In: Acta Anaesthesiologica Scandinavica. 65, 9, p. 1293-1299 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Hyperbaric oxygen treatment impacts oxidative stress markers in patients with necrotizing soft-tissue infection

    Hedetoft, M., Jensen, Peter Østrup, Moser, Claus Ernst, Vinkel, J. & Hyldegaard, Ole, 2021, In: Journal of Investigative Medicine. 69, 7, p. 1330-1338

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Soluble ICAM-1 is modulated by hyperbaric oxygen treatment and correlates with disease severity and mortality in patients with necrotizing soft-tissue infection

    Hedetoft, M., Moser, Claus Ernst, Jensen, Peter Østrup, Vinkel, J. & Hyldegaard, Ole, 2021, In: Journal of Applied Physiology. 130, 3, p. 729-736 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. 2020
  27. Published

    Effects of adding adjunctive hyperbaric oxygen therapy to standard wound care for diabetic foot ulcers: a protocol for a systematic review with meta-analysis and trial sequential analysis

    Vinkel, J., Holm, N. F. R., Jakobsen, J. C. & Hyldegaard, Ole, 29 Jun 2020, In: BMJ Open. 10, 6, 14 p., e031708.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Periocular necrotizing soft tissue infection in Greater Copenhagen

    Würtz, N. S., Mikkelsen, L. H., Jørgensen, J. S., Hansen, M. S., Madsen, M. B., Hyldegaard, Ole & Heegaard, Steffen, Mar 2020, In: Acta Ophthalmologica. 98, 2, p. 207-212

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Complement Activation Is Associated With Mortality in Patients With Necrotizing Soft-Tissue Infections—A Prospective Observational Study

    Kristensen, M. K., Hansen, M. B., Madsen, M. B., Hansen, Cecilie Bo, Pilely, K., Hyldegaard, Ole & Garred, Peter, 2020, In: Frontiers in Immunology. 11, 17.

    Research output: Contribution to journalJournal articleResearchpeer-review

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