A single early postnatal estradiol injection affects morphology and gene expression of the ovary and parametrial adipose tissue in adult female rats

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A single early postnatal estradiol injection affects morphology and gene expression of the ovary and parametrial adipose tissue in adult female rats. / Alexanderson, Camilla; Stener-Victorin, Elisabet; Kullberg, Joel; Nilsson, Staffan; Levin, Max; Cajander, Stefan; Lönn, Lars; Lönn, Malin; Holmäng, Agneta; Alexanderson, Camilla; Stener-Victorin, Elisabet; Kullberg, Joel; Nilsson, Staffan; Levin, Max; Cajander, Stefan; Lönn, Lars; Lönn, Malin; Holmäng, Agneta.

In: Journal of Steroid Biochemistry and Molecular Biology, Vol. 122, No. 1-3, 01.10.2010, p. 82-90.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Alexanderson, C, Stener-Victorin, E, Kullberg, J, Nilsson, S, Levin, M, Cajander, S, Lönn, L, Lönn, M, Holmäng, A, Alexanderson, C, Stener-Victorin, E, Kullberg, J, Nilsson, S, Levin, M, Cajander, S, Lönn, L, Lönn, M & Holmäng, A 2010, 'A single early postnatal estradiol injection affects morphology and gene expression of the ovary and parametrial adipose tissue in adult female rats', Journal of Steroid Biochemistry and Molecular Biology, vol. 122, no. 1-3, pp. 82-90. https://doi.org/10.1016/j.jsbmb.2009.10.006, https://doi.org/10.1016/j.jsbmb.2009.10.006

APA

Alexanderson, C., Stener-Victorin, E., Kullberg, J., Nilsson, S., Levin, M., Cajander, S., Lönn, L., Lönn, M., Holmäng, A., Alexanderson, C., Stener-Victorin, E., Kullberg, J., Nilsson, S., Levin, M., Cajander, S., Lönn, L., Lönn, M., & Holmäng, A. (2010). A single early postnatal estradiol injection affects morphology and gene expression of the ovary and parametrial adipose tissue in adult female rats. Journal of Steroid Biochemistry and Molecular Biology, 122(1-3), 82-90. https://doi.org/10.1016/j.jsbmb.2009.10.006, https://doi.org/10.1016/j.jsbmb.2009.10.006

Vancouver

Alexanderson C, Stener-Victorin E, Kullberg J, Nilsson S, Levin M, Cajander S et al. A single early postnatal estradiol injection affects morphology and gene expression of the ovary and parametrial adipose tissue in adult female rats. Journal of Steroid Biochemistry and Molecular Biology. 2010 Oct 1;122(1-3):82-90. https://doi.org/10.1016/j.jsbmb.2009.10.006, https://doi.org/10.1016/j.jsbmb.2009.10.006

Author

Alexanderson, Camilla ; Stener-Victorin, Elisabet ; Kullberg, Joel ; Nilsson, Staffan ; Levin, Max ; Cajander, Stefan ; Lönn, Lars ; Lönn, Malin ; Holmäng, Agneta ; Alexanderson, Camilla ; Stener-Victorin, Elisabet ; Kullberg, Joel ; Nilsson, Staffan ; Levin, Max ; Cajander, Stefan ; Lönn, Lars ; Lönn, Malin ; Holmäng, Agneta. / A single early postnatal estradiol injection affects morphology and gene expression of the ovary and parametrial adipose tissue in adult female rats. In: Journal of Steroid Biochemistry and Molecular Biology. 2010 ; Vol. 122, No. 1-3. pp. 82-90.

Bibtex

@article{ccac7ed056aa11df928f000ea68e967b,

title = "A single early postnatal estradiol injection affects morphology and gene expression of the ovary and parametrial adipose tissue in adult female rats",

abstract = "Events during early life can affect reproductive and metabolic functions in adulthood. We evaluated the programming effects of a single early postnatal estradiol injection (within 3h after birth) in female rats. We assessed ovarian and parametrial adipose tissue morphology, evaluated gene expression related to follicular development and adipose tissue metabolism, and developed a non-invasive volumetric estimation of parametrial adipose tissue by magnetic resonance imaging. Estradiol reduced ovarian weight, increased antral follicle size and number of atretic antral follicles, and decreased theca interna thickness in atretic antral follicles. Adult estradiol-injected rats also had malformed vaginal openings and lacked corpora lutea, confirming anovulation. Estradiol markedly reduced parametrial adipose tissue mass. Adipocyte size was unchanged, suggesting reduced adipocyte number. Parametrial adipose tissue lipoprotein lipase activity was increased. In ovaries, estradiol increased mRNA expression of adiponectin, complement component 3, estrogen receptor a, and glucose transporter 3 and 4; in parametrial adipose tissue, expression of complement component 3 was increased, expression of estrogen receptor a was decreased, and expression of leptin, lipoprotein lipase, and hormone-sensitive lipase was unaffected. These findings suggest that early postnatal estradiol exposure of female rats result in long-lasting effects on the ovary and parametrial adipose tissue at adult age.",

author = "Camilla Alexanderson and Elisabet Stener-Victorin and Joel Kullberg and Staffan Nilsson and Max Levin and Stefan Cajander and Lars L{\"o}nn and Malin L{\"o}nn and Agneta Holm{\"a}ng and Camilla Alexanderson and Elisabet Stener-Victorin and Joel Kullberg and Staffan Nilsson and Max Levin and Stefan Cajander and Lars L{\"o}nn and Malin L{\"o}nn and Agneta Holm{\"a}ng",

year = "2010",

month = oct,

day = "1",

doi = "10.1016/j.jsbmb.2009.10.006",

language = "English",

volume = "122",

pages = "82--90",

journal = "Journal of Steroid Biochemistry and Molecular Biology",

issn = "0960-0760",

publisher = "Pergamon Press",

number = "1-3",

}

RIS

TY - JOUR

T1 - A single early postnatal estradiol injection affects morphology and gene expression of the ovary and parametrial adipose tissue in adult female rats

AU - Alexanderson, Camilla

AU - Stener-Victorin, Elisabet

AU - Kullberg, Joel

AU - Nilsson, Staffan

AU - Levin, Max

AU - Cajander, Stefan

AU - Lönn, Lars

AU - Lönn, Malin

AU - Holmäng, Agneta

AU - Alexanderson, Camilla

AU - Stener-Victorin, Elisabet

AU - Kullberg, Joel

AU - Nilsson, Staffan

AU - Levin, Max

AU - Cajander, Stefan

AU - Lönn, Lars

AU - Lönn, Malin

AU - Holmäng, Agneta

PY - 2010/10/1

Y1 - 2010/10/1

N2 - Events during early life can affect reproductive and metabolic functions in adulthood. We evaluated the programming effects of a single early postnatal estradiol injection (within 3h after birth) in female rats. We assessed ovarian and parametrial adipose tissue morphology, evaluated gene expression related to follicular development and adipose tissue metabolism, and developed a non-invasive volumetric estimation of parametrial adipose tissue by magnetic resonance imaging. Estradiol reduced ovarian weight, increased antral follicle size and number of atretic antral follicles, and decreased theca interna thickness in atretic antral follicles. Adult estradiol-injected rats also had malformed vaginal openings and lacked corpora lutea, confirming anovulation. Estradiol markedly reduced parametrial adipose tissue mass. Adipocyte size was unchanged, suggesting reduced adipocyte number. Parametrial adipose tissue lipoprotein lipase activity was increased. In ovaries, estradiol increased mRNA expression of adiponectin, complement component 3, estrogen receptor a, and glucose transporter 3 and 4; in parametrial adipose tissue, expression of complement component 3 was increased, expression of estrogen receptor a was decreased, and expression of leptin, lipoprotein lipase, and hormone-sensitive lipase was unaffected. These findings suggest that early postnatal estradiol exposure of female rats result in long-lasting effects on the ovary and parametrial adipose tissue at adult age.

AB - Events during early life can affect reproductive and metabolic functions in adulthood. We evaluated the programming effects of a single early postnatal estradiol injection (within 3h after birth) in female rats. We assessed ovarian and parametrial adipose tissue morphology, evaluated gene expression related to follicular development and adipose tissue metabolism, and developed a non-invasive volumetric estimation of parametrial adipose tissue by magnetic resonance imaging. Estradiol reduced ovarian weight, increased antral follicle size and number of atretic antral follicles, and decreased theca interna thickness in atretic antral follicles. Adult estradiol-injected rats also had malformed vaginal openings and lacked corpora lutea, confirming anovulation. Estradiol markedly reduced parametrial adipose tissue mass. Adipocyte size was unchanged, suggesting reduced adipocyte number. Parametrial adipose tissue lipoprotein lipase activity was increased. In ovaries, estradiol increased mRNA expression of adiponectin, complement component 3, estrogen receptor a, and glucose transporter 3 and 4; in parametrial adipose tissue, expression of complement component 3 was increased, expression of estrogen receptor a was decreased, and expression of leptin, lipoprotein lipase, and hormone-sensitive lipase was unaffected. These findings suggest that early postnatal estradiol exposure of female rats result in long-lasting effects on the ovary and parametrial adipose tissue at adult age.

U2 - 10.1016/j.jsbmb.2009.10.006

DO - 10.1016/j.jsbmb.2009.10.006

M3 - Journal article

C2 - 19857573

VL - 122

SP - 82

EP - 90

JO - Journal of Steroid Biochemistry and Molecular Biology

JF - Journal of Steroid Biochemistry and Molecular Biology

SN - 0960-0760

IS - 1-3

ER -

ID: 19524024