Association between women's age and stage, morphology, and implantation of the competent blastocyst: a multicenter cohort study
Research output: Contribution to journal › Journal article › Research › peer-review
Objective: To study if the age of women undergoing assisted reproductive technology treatment associates with stage, morphology, and implantation of the competent blastocyst. Design: Multicenter historical cohort study based on exposure (age) and outcome data (blastocyst stage and morphology and initial human chorionic gonadotrophin [hCG] rise) from women undergoing single blastocyst transfer resulting in singleton pregnancy/birth. Setting: Sixteen private and university-based facilities. Patient(s): In this study, 7,246 women who, between 2014 and 2018, underwent controlled ovarian stimulation (COS) or frozen-thawed embryo transfer (FET) with a single blastocyst transfer resulting in singleton pregnancy were identified. Linking data to the Danish Medical Birth Registry resulted in a total of 4,842 women with a live birth being included. Intervention(s): None. Main Outcome Measure(s): The competent blastocyst development stage (1–6), inner cell mass (A, B, C), trophectoderm (A, B, C), and initial serum hCG value. Result(s): Adjusted analysis of age and stage in COS treatments showed that for every 1-year increase in age there was a 5% reduced probability of the competent blastocyst assessed as being in a high stage at transfer. Comparison between hCG values in women 18–24 years and 25–29 years in both COS and FET showed significantly lower levels in the youngest women. Conclusion(s): The initial hCG rise was influenced by the age of the woman, with an identical pattern for hCG values in COS and FET treatments. In COS, the competent blastocyst had a reduced stage with increasing women's age.
Original language | English |
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Journal | Fertility and Sterility |
Volume | 115 |
Issue number | 3 |
Pages (from-to) | 646-654 |
Number of pages | 9 |
ISSN | 0015-0282 |
DOIs | |
Publication status | Published - 2021 |
Bibliographical note
Publisher Copyright:
© 2020 American Society for Reproductive Medicine
- competent blastocyst, implantation, morphology, Women's age
Research areas
ID: 302200773