Determination of adrenal volume by MRI in healthy children - Staff of the Department of Clinical Medicine

Determination of adrenal volume by MRI in healthy children: associations with age, body size, pubertal stage and serum levels of adrenal androgens

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Determination of adrenal volume by MRI in healthy children : associations with age, body size, pubertal stage and serum levels of adrenal androgens. / Mouritsen, Annette; Johansen, Marie Lindhardt; Wohlfahrt-Veje, Christine; Hagen, Casper P; Tinggaard, Jeanette; Mieritz, Mikkel G; Tefre de Renzy-Martin, Katrine; Soeborg, Tue; Fallentin, Eva; Juul, Anders; Main, Katharina M.

In: Clinical Endocrinology, Vol. 81, No. 2, 08.2014, p. 183-189.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Mouritsen, A, Johansen, ML, Wohlfahrt-Veje, C, Hagen, CP, Tinggaard, J, Mieritz, MG, Tefre de Renzy-Martin, K, Soeborg, T, Fallentin, E, Juul, A & Main, KM 2014, 'Determination of adrenal volume by MRI in healthy children: associations with age, body size, pubertal stage and serum levels of adrenal androgens', Clinical Endocrinology, vol. 81, no. 2, pp. 183-189. https://doi.org/10.1111/cen.12414

APA

Mouritsen, A., Johansen, M. L., Wohlfahrt-Veje, C., Hagen, C. P., Tinggaard, J., Mieritz, M. G., Tefre de Renzy-Martin, K., Soeborg, T., Fallentin, E., Juul, A., & Main, K. M. (2014). Determination of adrenal volume by MRI in healthy children: associations with age, body size, pubertal stage and serum levels of adrenal androgens. Clinical Endocrinology, 81(2), 183-189. https://doi.org/10.1111/cen.12414

Vancouver

Mouritsen A, Johansen ML, Wohlfahrt-Veje C, Hagen CP, Tinggaard J, Mieritz MG et al. Determination of adrenal volume by MRI in healthy children: associations with age, body size, pubertal stage and serum levels of adrenal androgens. Clinical Endocrinology. 2014 Aug;81(2):183-189. https://doi.org/10.1111/cen.12414

Author

Mouritsen, Annette ; Johansen, Marie Lindhardt ; Wohlfahrt-Veje, Christine ; Hagen, Casper P ; Tinggaard, Jeanette ; Mieritz, Mikkel G ; Tefre de Renzy-Martin, Katrine ; Soeborg, Tue ; Fallentin, Eva ; Juul, Anders ; Main, Katharina M. / Determination of adrenal volume by MRI in healthy children : associations with age, body size, pubertal stage and serum levels of adrenal androgens. In: Clinical Endocrinology. 2014 ; Vol. 81, No. 2. pp. 183-189.

Bibtex

@article{9ce810ba09ac4581885c2172dd99865a,

title = "Determination of adrenal volume by MRI in healthy children: associations with age, body size, pubertal stage and serum levels of adrenal androgens",

abstract = "BACKGROUND: Adrenal disorders such as congenital adrenal hyperplasia result in abnormal adrenal size and morphology, but little is known about the clinical value of magnetic resonance imaging (MRI) in determining adrenal volume.OBJECTIVE: To evaluate the potential usefulness of MR methodology, to estimate adrenal size in healthy children and to evaluate determinants of adrenal volume such as age, gender, body size, pubic hair stage and serum levels of adrenal androgens.DESIGN: Two hundred and thirty-five healthy children (116 girls and 119 boys) (age range 10.0-14.8 years) were examined by MRI. Clinical examinations (anthropometry and pubertal staging) were performed, and five androgen metabolites were measured in blood samples by liquid chromatography-tandem mass spectrometry (LC-MS/MS).RESULTS: It was possible to determine adrenal volume in 115/235 children using MRI. The adrenals were not measurable in 51% of children due to breathing and moving artefacts. The median volume of the right adrenal gland was 0.46 ml in girls and 0.46 ml in boys. The median volume of the left adrenal gland was 0.34 ml in girls and 0.40 ml in boys. Adrenal size was positively associated with body surface area (estimate B = 0.34 ml/year, P = 0.03), age (estimate B = 0.05 ml/year, P = 0.021) and pubic hair stage (estimate B = 0.05 ml/stage, P = 0.075). No associations between adrenal size and serum levels of adrenal androgens were observed.CONCLUSION: It was possible to determine adrenal volume by MRI in only 50% of healthy children aged 10-15 years. Adrenal volume increased with age and Tanner stage of pubic hair. Future studies will unravel whether adrenal MRI is useful when evaluating children with adrenal diseases.",

keywords = "Adolescent, Adrenal Glands, Androgens, Anthropometry, Body Size, Child, Chromatography, Liquid, Female, Humans, Magnetic Resonance Imaging, Male, Sexual Maturation, Tandem Mass Spectrometry",

author = "Annette Mouritsen and Johansen, {Marie Lindhardt} and Christine Wohlfahrt-Veje and Hagen, {Casper P} and Jeanette Tinggaard and Mieritz, {Mikkel G} and {Tefre de Renzy-Martin}, Katrine and Tue Soeborg and Eva Fallentin and Anders Juul and Main, {Katharina M}",

note = "{\textcopyright} 2014 John Wiley & Sons Ltd.",

year = "2014",

month = aug,

doi = "10.1111/cen.12414",

language = "English",

volume = "81",

pages = "183--189",

journal = "Clinical Endocrinology",

issn = "0300-0664",

publisher = "Wiley-Blackwell",

number = "2",

}

RIS

TY - JOUR

T1 - Determination of adrenal volume by MRI in healthy children

T2 - associations with age, body size, pubertal stage and serum levels of adrenal androgens

AU - Mouritsen, Annette

AU - Johansen, Marie Lindhardt

AU - Wohlfahrt-Veje, Christine

AU - Hagen, Casper P

AU - Tinggaard, Jeanette

AU - Mieritz, Mikkel G

AU - Tefre de Renzy-Martin, Katrine

AU - Soeborg, Tue

AU - Fallentin, Eva

AU - Juul, Anders

AU - Main, Katharina M

PY - 2014/8

Y1 - 2014/8

N2 - BACKGROUND: Adrenal disorders such as congenital adrenal hyperplasia result in abnormal adrenal size and morphology, but little is known about the clinical value of magnetic resonance imaging (MRI) in determining adrenal volume.OBJECTIVE: To evaluate the potential usefulness of MR methodology, to estimate adrenal size in healthy children and to evaluate determinants of adrenal volume such as age, gender, body size, pubic hair stage and serum levels of adrenal androgens.DESIGN: Two hundred and thirty-five healthy children (116 girls and 119 boys) (age range 10.0-14.8 years) were examined by MRI. Clinical examinations (anthropometry and pubertal staging) were performed, and five androgen metabolites were measured in blood samples by liquid chromatography-tandem mass spectrometry (LC-MS/MS).RESULTS: It was possible to determine adrenal volume in 115/235 children using MRI. The adrenals were not measurable in 51% of children due to breathing and moving artefacts. The median volume of the right adrenal gland was 0.46 ml in girls and 0.46 ml in boys. The median volume of the left adrenal gland was 0.34 ml in girls and 0.40 ml in boys. Adrenal size was positively associated with body surface area (estimate B = 0.34 ml/year, P = 0.03), age (estimate B = 0.05 ml/year, P = 0.021) and pubic hair stage (estimate B = 0.05 ml/stage, P = 0.075). No associations between adrenal size and serum levels of adrenal androgens were observed.CONCLUSION: It was possible to determine adrenal volume by MRI in only 50% of healthy children aged 10-15 years. Adrenal volume increased with age and Tanner stage of pubic hair. Future studies will unravel whether adrenal MRI is useful when evaluating children with adrenal diseases.

AB - BACKGROUND: Adrenal disorders such as congenital adrenal hyperplasia result in abnormal adrenal size and morphology, but little is known about the clinical value of magnetic resonance imaging (MRI) in determining adrenal volume.OBJECTIVE: To evaluate the potential usefulness of MR methodology, to estimate adrenal size in healthy children and to evaluate determinants of adrenal volume such as age, gender, body size, pubic hair stage and serum levels of adrenal androgens.DESIGN: Two hundred and thirty-five healthy children (116 girls and 119 boys) (age range 10.0-14.8 years) were examined by MRI. Clinical examinations (anthropometry and pubertal staging) were performed, and five androgen metabolites were measured in blood samples by liquid chromatography-tandem mass spectrometry (LC-MS/MS).RESULTS: It was possible to determine adrenal volume in 115/235 children using MRI. The adrenals were not measurable in 51% of children due to breathing and moving artefacts. The median volume of the right adrenal gland was 0.46 ml in girls and 0.46 ml in boys. The median volume of the left adrenal gland was 0.34 ml in girls and 0.40 ml in boys. Adrenal size was positively associated with body surface area (estimate B = 0.34 ml/year, P = 0.03), age (estimate B = 0.05 ml/year, P = 0.021) and pubic hair stage (estimate B = 0.05 ml/stage, P = 0.075). No associations between adrenal size and serum levels of adrenal androgens were observed.CONCLUSION: It was possible to determine adrenal volume by MRI in only 50% of healthy children aged 10-15 years. Adrenal volume increased with age and Tanner stage of pubic hair. Future studies will unravel whether adrenal MRI is useful when evaluating children with adrenal diseases.

KW - Adolescent

KW - Adrenal Glands

KW - Androgens

KW - Anthropometry

KW - Body Size

KW - Child

KW - Chromatography, Liquid

KW - Female

KW - Humans

KW - Magnetic Resonance Imaging

KW - Male

KW - Sexual Maturation

KW - Tandem Mass Spectrometry

U2 - 10.1111/cen.12414

DO - 10.1111/cen.12414

M3 - Journal article

C2 - 24455980

VL - 81

SP - 183

EP - 189

JO - Clinical Endocrinology

JF - Clinical Endocrinology

SN - 0300-0664

IS - 2

ER -

ID: 138139372