Epidural analgesia and postoperative complications in colorectal cancer surgery: An observational registry-based study
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Background: In colorectal cancer, surgical resection is fundamental for curative treatment. Epidural analgesia mitigates the perioperative physiologic stress response caused by surgery, and reduction in perioperative stress may reduce postoperative complications. Nevertheless, epidural analgesia also causes hypotension and lower limb motor weakness that can impair postoperative recovery. Here, we aimed to assess the association between epidural analgesia and postoperative complications after colorectal cancer surgery. Methods: We identified patients undergoing colorectal cancer surgery 2008–2018 in Denmark in the Danish Colorectal Cancer Group Database and obtained anaesthesia data from the Danish Anaesthesia Database. The Danish National Prescription Registry was used to obtain data on prescriptions filled preoperatively reflecting current comorbidities. Databases were linked using the Danish Central Person Registry number and the operation day. Patients were classified according to preoperative insertion of an epidural catheter for analgesia. Confounders were adjusted by propensity score matching. Logistic regression was used to compute effect estimates of epidural analgesia on postoperative complications. Results: We identified 19 932 individuals undergoing colorectal cancer surgery with available anaesthesia data. Propensity score matching yielded 5691 individuals in each group with balanced preoperative covariates. In the epidural analgesia group 1400 (24.6%) experienced complications compared with 1453 (25.5%) without epidural analgesia. We found no statistically significant association between epidural use and postoperative complications (OR 0.95, 95% CI 0.87–1.04). Conclusion: In total, in this observational study based on Danish registries, we found no association between epidural analgesia and postoperative complications after colorectal cancer surgery.
Original language | English |
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Journal | Acta Anaesthesiologica Scandinavica |
Volume | 66 |
Issue number | 7 |
Pages (from-to) | 869-879 |
ISSN | 0001-5172 |
DOIs | |
Publication status | Published - 2022 |
Bibliographical note
Funding Information:
Funding was provided from the Danish Cancer Research Fund and the Research Fund of Region Zealand and Region Southern Denmark. Moreover, we thank the Danish Colorectal Cancer Group Database and the Danish Anaesthesia Database for providing data for the study.
Funding Information:
Dansk Kræftforsknings Fond; Region sjælland og Region Syds Fælles Forskningsfond; Region Zealand; Danish Cancer Research Fund Funding information
ID: 320107775