Genetic contribution to the etiology of Achilles tendon rupture. A Danish nationwide register study of twins
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Genetic contribution to the etiology of Achilles tendon rupture. A Danish nationwide register study of twins. / Cramer, Allan; Barfod, Kristoffer Weisskirchner; Hölmich, Per; Pedersen, Dorthe Almind; Christensen, Kaare.
In: Foot and Ankle Surgery, Vol. 28, No. 7, 2022, p. 1050-1054.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Genetic contribution to the etiology of Achilles tendon rupture. A Danish nationwide register study of twins
AU - Cramer, Allan
AU - Barfod, Kristoffer Weisskirchner
AU - Hölmich, Per
AU - Pedersen, Dorthe Almind
AU - Christensen, Kaare
N1 - Publisher Copyright: © 2022
PY - 2022
Y1 - 2022
N2 - Background: It is unknown if genetics contribute to the etiology of acute Achilles tendon rupture (ATR). The aims of the present study were, 1) To calculate the concordance rate for monozygotic (MZ) twins and same-sex dizygotic (SSDZ) twins and 2) to estimate the heritability of ATR. Methods: The study was performed as a registry study using the Danish Twin Registry and the Danish National Patient Registry. Results: The study sample consisted of 85,534 twins born from 1895 to 1995. Of these, 572 (0.67%) were registered with ATR in the period from 1994 to 2014. The concordance rate was 8.1% (95% CI 1.4–14.7%) for MZ twins and 4.3% (95% CI 0.7–7.9%) for SSDZ twins. The heritability of ATR was 47% (95% CI 31–62%). Conclusion: This study found that genetics contribute substantially to the etiology of ATR with an estimated heritability of the liability to ATR of approximately 50%. The finding generates the hypothesis that genetics play a role in the pathological changes that occur in the Achilles tendon before a rupture. The risk of ATR for a twin within a 20 year period, if the co-twin has had an ATR, was 8% for MZ twins and 4% for SSDZ twins.
AB - Background: It is unknown if genetics contribute to the etiology of acute Achilles tendon rupture (ATR). The aims of the present study were, 1) To calculate the concordance rate for monozygotic (MZ) twins and same-sex dizygotic (SSDZ) twins and 2) to estimate the heritability of ATR. Methods: The study was performed as a registry study using the Danish Twin Registry and the Danish National Patient Registry. Results: The study sample consisted of 85,534 twins born from 1895 to 1995. Of these, 572 (0.67%) were registered with ATR in the period from 1994 to 2014. The concordance rate was 8.1% (95% CI 1.4–14.7%) for MZ twins and 4.3% (95% CI 0.7–7.9%) for SSDZ twins. The heritability of ATR was 47% (95% CI 31–62%). Conclusion: This study found that genetics contribute substantially to the etiology of ATR with an estimated heritability of the liability to ATR of approximately 50%. The finding generates the hypothesis that genetics play a role in the pathological changes that occur in the Achilles tendon before a rupture. The risk of ATR for a twin within a 20 year period, if the co-twin has had an ATR, was 8% for MZ twins and 4% for SSDZ twins.
KW - Achilles tendon
KW - Achilles tendon rupture
KW - ATR
KW - Etiology
KW - Genetics
KW - Heritability
KW - Pathogenesis
KW - Risk factor
KW - Rupture
KW - tendon
KW - Twin registry
KW - Twin-study
U2 - 10.1016/j.fas.2022.02.015
DO - 10.1016/j.fas.2022.02.015
M3 - Journal article
C2 - 35227591
AN - SCOPUS:85125472230
VL - 28
SP - 1050
EP - 1054
JO - Foot and Ankle Surgery
JF - Foot and Ankle Surgery
SN - 1268-7731
IS - 7
ER -
ID: 312762255